Patent application number | Description | Published |
20100265835 | SYSTEM, METHOD, AND COMPUTER READABLE MEDIUM FOR MEASURING NETWORK LATENCY FROM FLOW RECORDS - The disclosure presents a system, method, and computer readable medium for computing network latencies. Network devices using flow processors create network traffic summary information in the form of flow records. A harvester may gather, process, and analyze flow records to find matching flows. Using matching flows, a harvester computes the latency, either one-way or round-trip, between two devices on the network. This information may be exported or stored on other devices on the network. The teachings of the present disclosure enable wide network coverage through the use of existing network traffic summary records. Further, the present disclosure mitigates network slowdowns associated with monitoring equipment. The present disclosure also reduces or eliminates the need for clock synchronization between devices on the network. | 10-21-2010 |
20110145694 | Method and System for Transforming an Integrated Webpage - A method and system for transforming an integrated webpage into native text and image representations. A webpage containing an embedded object is loaded into a browser. A portable text representation of an image of the embedded object is captured by invoking the embedded object to rasterize itself. The portable text representation is then streamed to a web server and converted to a native image representation. A URL is generated for the native image representation and the embedded object on the integrated webpage is replaced with its native image representation. | 06-16-2011 |
20140040015 | SYSTEM AND METHOD FOR CONTROLLING REAL-TIME BIDDING FOR ONLINE ADVERTISEMENTS - A method and system for controlling real-time bidding for online advertisements is disclosed. According to one embodiment, a computer-implemented method comprises receiving a real-time bidding (RTB) request from a bidder. The RTB request contains a campaign target. An online advertisement campaign corresponding to the RTB request is placed. Campaign performance data is received from an impression server and/or an event server. The campaign performance data is compared to the campaign target. Based on the result of comparison, it is determined whether to enable or disable the online advertisement campaign. | 02-06-2014 |
Patent application number | Description | Published |
20100227812 | METHOD OF SUPPLEMENTING THE DIET AND AMELIORATING OXIDATIVE STRESS - A method of supplementing a diet and ameliorating oxidative stress in a mammal includes administering a pharmaceutically effective amount of an active compound having the chemical structure: | 09-09-2010 |
20110076246 | THIOL-CONTAINING COMPOUNDS FOR THE REMOVAL OF ELEMENTS FROM CONTAMINATED MILIEU AND METHODS OF USE - Sulfur-containing ligands and methods of their utilization for binding metals and/or main group elements and removing them from fluids, solids, gases and/or tissues are disclosed. The ligands are of the general structure: | 03-31-2011 |
20110160150 | THIOL-CONTAINING COMPOUNDS FOR THE REMOVAL OF ELEMENTS FROM TISSUES AND FORMULATIONS THEREFOR - Methods and pharmaceutical formulations for ameliorating heavy metal toxicity and/or oxidative stress are disclosed, comprising administering pharmaceutically effective amounts of ligands according to the present disclosure. The ligands are of the general structure: | 06-30-2011 |
20110237525 | METHOD OF AMELIORATING OXIDATIVE STRESS AND SUPPLEMENTING THE DIET - A method of supplementing a diet and ameliorating oxidative stress in a mammal includes administering a pharmaceutically effective amount of lipid soluble, hydrophobic active compounds having a chemical structure: | 09-29-2011 |
20110237776 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS - Compounds useful as nutritional supplements, antioxidants, heavy metal chelators and/or as intermediates for producing other related compounds with like uses have a formula: | 09-29-2011 |
20120302780 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS - Compounds useful as nutritional supplements, antioxidants, heavy metal chelators and/or as intermediates for producing other related compounds with like uses have a formula: | 11-29-2012 |
20130108605 | METHOD OF AMELIORATING OXIDATIVE STRESS AND SUPPLEMENTING THE DIET | 05-02-2013 |
20130165630 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS - Compounds useful as nutritional supplements, antioxidants, heavy metal chelators and/or as intermediates for producing other related compounds with like uses have a formula: | 06-27-2013 |
20130224170 | METHOD OF AMELIORATING OXIDATIVE STRESS AND SUPPLEMENTING THE DIET - A method of supplementing a diet and ameliorating oxidative stress in a mammal includes administering a pharmaceutically effective amount of lipid soluble, hydrophobic active compounds having a chemical structure: | 08-29-2013 |
20140128571 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS - Compounds useful as nutritional supplements, antioxidants, heavy metal chelators and/or as intermediates for producing other related compounds with like uses have a formula: | 05-08-2014 |
Patent application number | Description | Published |
20100053851 | APPARATUS FOR PREVENTING ELECTRICAL SHOCK IN DEVICES - A device for preventing electrical shock from a device with electrical interfaces. A shutter or other barrier associated with the device that physically prevents access or contact to one of the electrical interfaces while another electrical interface is in use. | 03-04-2010 |
20100152765 | BODY LUMEN FILTERS WITH STRUCTURES TO REDUCE PARTICULATES AND METHODS FOR FILTERING A BODY LUMEN - As described herein, a body lumen filter is provided that includes a body configured to move between a pre-deployed state and a deployed state, a filtering structure operatively associated with the body to filter particulates, and a separating structure operatively associated with the body. The separating structure can be configured to break up at least one of the particulates. | 06-17-2010 |
20100255517 | Apparatus for Preventing Electrical Shock in Devices - A device for preventing electrical shock from a device with electrical interfaces. A shutter or other barrier associated with the device that physically prevents access or contact to one of the electrical interfaces while another electrical interface is in use. | 10-07-2010 |
20100255564 | Apparatus for Preventing Electrical Shock in Devices - A device for preventing electrical shock from a device with electrical interfaces. A shutter or other barrier associated with the device that physically prevents access or contact to one of the electrical interfaces while another electrical interface is in use. | 10-07-2010 |
20100255565 | Apparatus for Preventing Electrical Shock in Devices - A device for preventing electrical shock from a device with electrical interfaces. A shutter or other barrier associated with the device that physically prevents access or contact to one of the electrical interfaces while another electrical interface is in use. | 10-07-2010 |
20100255566 | Apparatus for Preventing Electrical Shock in Devices - A device for preventing electrical shock from a device with electrical interfaces. A shutter or other barrier associated with the device that physically prevents access or contact to one of the electrical interfaces while another electrical interface is in use. | 10-07-2010 |
20110133698 | Apparatus for Preventing Electrical Shock in Devices - A device for preventing electrical shock from a device with electrical interfaces. A shutter or other barrier associated with the device that physically prevents access or contact to one of the electrical interfaces while another electrical interface is in use. | 06-09-2011 |
Patent application number | Description | Published |
20100160784 | Wireless Ultrasound Probe With Audible Indicator - A wireless ultrasound probe has a probe case enclosing a transducer array, an acquisition circuit, a transceiver and a battery. The probe also includes a loudspeaker which produces audible sounds during use of the probe. The loudspeaker, which may be a piezoelectric loudspeaker, issues an alert when battery power is low or signal strength of the wireless transmission is poor or nonexistent. The loudspeaker can provide user feedback to the actuation of a button or control on the probe. The loudspeaker can provide haptic feedback during use of the probe, and can be used to produce audio Doppler tones or heart sounds during probe use. | 06-24-2010 |
20100160785 | Wireless Ultrasound Probe Cable - A wireless ultrasound probe has a probe case enclosing a transducer array, an acquisition circuit, a transceiver, a power circuit, and a rechargeable battery. The wireless probe also has a cable connector accessible from the exterior of the probe, for connection of a cable providing battery charging potential and/or imaging signal conductors for wire communication with a host system. An example is given of a magnetically attachable cable which requires no openings or indentations that could trap gel and other contaminants. Preferably the remote end of the cable uses a standardized connector, enabling the wireless probe to be recharged from standard devices like computers. | 06-24-2010 |
20100277305 | Wireless Ultrasound Probe Asset Tracking - A wireless ultrasound probe has a probe case enclosing a transducer array, an acquisition circuit, a transceiver and a battery. The probe also includes a loudspeaker which produces audible sounds as a function of the range between the wireless probe and a host system. When the probe is within a near field range of the host system, the loudspeaker is silent. But if the probe is moved to an intermediate or a far field range from the host system, the loudspeaker sounds an alert. This audible alert can be used to locate the probe by transmitting a paging signal which, upon reception by the probe, causes the probe to sound its alert. If the probe is moved to an unauthorized location where it is within range of a transmitter or receiver, the reception of a signal by the probe, the transmitter, or receiver will sound an alert signaling the unauthorized presence of the wireless probe. | 11-04-2010 |
Patent application number | Description | Published |
20090191738 | Connector Assembly Having A Movable Plug - A connector assembly configured to connect a plug body into a receiving module of an electrical device is provided. The connector assembly has a cable end and a plug end and a cable channel extending therethrough. The connector assembly includes an inner body having and an outer housing that is coupled to and surrounds at least a portion of the inner body. The outer housing is configured to attach to the electrical device. The connector assembly further includes a plug having the plug body and at least one cable conductor extending through the cable channel and connecting to the plug body. The plug body is held near or within the inner body and is movable from a first position near or within the inner body to a second position engaged with the receiving module. | 07-30-2009 |
20090191750 | Connector Assembly Having A Slider Element - A connector assembly is provided that has a plug end and a cable end and is configured to insert a plug that is coupled to a cable into a receiving module of an electrical device. The connector assembly includes an inner body that has a cable channel extending in an axial direction between the plug end and the cable end. The connector assembly also includes a slider element that is configured to hold a plug proximate to the plug end. The slider element is held by and movable along the inner body in an axial direction. The connector assembly further includes an outer housing that surrounds the inner body and the slider element. The outer housing is movable in the axial direction with respect to the inner body and the slider element, and the outer housing is also configured to attach to the electrical device. | 07-30-2009 |
20100329611 | FIBER OPTIC CONNECTOR ASSEMBLY - A fiber optic connector assembly includes a coupling interface component, a connector housing, and an optical fiber connector. The coupling interface component extends along a center axis from a back end to a coupling end and includes an interior chamber. The connector housing is disposed within the interior chamber of the coupling interface component. The optical fiber connector is joined to an optical fiber and is interconnected with the connector housing. The optical fiber connector is configured to optically couple the optical fiber with a mating connector. The coupling interface component engages the connector housing and the mating connector and prevents movement of the connector housing relative to the coupling interface component and the mating connector. | 12-30-2010 |
20120033920 | OPTICAL FIBER FERRULE - The invention pertains to an optical ferrule and a method of manufacturing the optical ferrule that can compensate for the fact that the end faces of the fibers contained in the ferrule initially may not be coplanar of each other within required or desired tolerances or otherwise not the exact correct length. Particularly, a cavity is provided within the ferrule to provide room for the fibers to freely bend within at least a range of curvatures within the ferrule so that any difference in the lengths of the fibers can be compensated for by a unique amount of bend in each individual fiber. | 02-09-2012 |
20120033921 | HERMAPHRODITIC OPTICAL FIBER FERRULE - The invention pertains to an optical coupling method and apparatus in which the connectors are hermaphroditic and each connector comprises a ferrule that provides ( | 02-09-2012 |
20120263419 | FIBER OPTIC CONNECTOR ASSEMBLY - A fiber optic connector assembly includes a front housing and a rear housing that is movably coupled to the front housing. The rear housing is movable between a retracted position and an advanced position. In the retracted position, the rear housing is spaced apart from the front housing. A drive mechanism is coupled to the rear housing. The drive mechanism moves the rear housing from the retracted position to the advanced position. At least one fiber optic connector fixedly coupled to the rear housing. The fiber optic connector has a mating end received by the front housing. The mating end driven with respect to the front housing in a mating direction for mating with a corresponding connector when the rear housing is moved from the retracted position to the advanced position. Optionally, the fiber optic connector assembly may be side-loaded into position with respect to a fixed connector assembly, and then the fiber optic connector is driven to the advanced position in a direction generally perpendicular to the direction of loading. | 10-18-2012 |
20120269485 | FIBER OPTIC CABLE ASSEMBLY - A fiber optic cable assembly includes a connector that has a mating end and a cable end. A fiber optic cable is terminated to the cable end of the connector. A cable director is coupled to the fiber optic cable rearward of the connector. The cable director includes a flexible support sleeve and a clip extending from the support sleeve. The support sleeve includes a raceway that receives the fiber optic cable. The support sleeve has a first end segment and a second end segment. The support sleeve has a first attachment point proximate to the first end segment and a second attachment point proximate to the second end segment. The support sleeve is held in a bent shape when the clip is attached to both the first attachment point and the second attachment point. The support sleeve is configured to be straightened to a loading position in which the raceway is substantially linear when the clip is removed from at least one of the first or second attachment points. | 10-25-2012 |
20120285740 | CABLE ASSEMBLY - A cable assembly includes a cable having a cable jacket. A cable stacker couples the cable to a neighboring cable assembly. The cable stacker has a mounting channel. The cable is received in the mounting channel. The cable stacker has a coupler configured to be coupled to the neighboring cable assembly to hold the cable in position with respect to the neighboring cable assembly. | 11-15-2012 |
20130016947 | PHOTONIC ASSEMBLY FOR OPTICAL FIBERSAANM ROITBERG; LEE JACOBO JOSEAACI AUSTINAAST TXAACO USAAGP ROITBERG; LEE JACOBO JOSE AUSTIN TX USAANM HALEY; EDMUND J.AACI DILLSBURGAAST PAAACO USAAGP HALEY; EDMUND J. DILLSBURG PA US - A photonic assembly includes a midplane connector having connector channels extending therethrough. Fiber optic connectors are positioned within the connector channels of the midplane connector. The fiber optic connectors retain ferrules of midplane optical fibers and aligning the ferrules of the midplane optical fibers within the midplane connector. A midplane substrate is provided having an opening extending therethrough. The midplane connector is positioned within the opening of the midplane substrate. The midplane connector floats within the opening of the midplane substrate to position the ferrules of the midplane optical fibers. | 01-17-2013 |
20130216190 | OPTICAL ASSEMBLY WITH FERRULE AND FRAME - An optical cable assembly is provided for being connected to an opto-electric device assembly having a substrate, an opto-electric device (OED) mounted on the substrate, and a frame mounted on the substrate. The optical cable assembly includes an optical cable including an optical conductor having an end. A ferrule terminates the optical cable. The ferrule includes a body having a chamber. The optical conductor is held by the ferrule such that at least a portion of the end of the optical conductor extends within the chamber of the body of the ferrule. The body of the ferrule is configured to be engaged with and removably connected to the frame of the electro-optical device assembly to optically connect the optical conductor to the OED. | 08-22-2013 |
Patent application number | Description | Published |
20120039569 | Modular Optical Connector Apparatus and Method - The invention pertains to a modular optical connection system that permits simple swapping of optical connectors of different form factor types. Furthermore, it allows a single optical connector design of a given form factor to be used to make optical connectors in various different board-to-board configurations, such as orthogonal, coplanar, and backplane. In accordance with the invention, an outer housing is mounted on a board which housing allows two inner housings to mate with each other through the outer housing. A single outer housing can be used with different inner housings adapted to accept various different connector form factors therein and permits the two mating inner housings to float longitudinally within the outer housing. It also allows the two mating inner housings to engage and disengage via simple push engagement and pull disengagement. The external dimensions and features of all of the different connector housings are essentially identical to each other so that they all can mate with each other and with the outer housing, but have different internal dimensions and features depending on the particular connector form factor style for which they are designed. | 02-16-2012 |
20130121645 | OPTICAL COMMUNICATION CONNECTORS WITH MODULES MOVABLE IN A MATING DIRECTION - An optical communication connector having a connector housing that includes opposite mating and loading sides and a housing cavity that extends therebetween. The optical communication connector also includes an optical module that is positioned within the housing cavity and a biasing element that is positioned between the optical module and the loading side in the housing cavity. The biasing element has a module end, a back end, and a resilient spring portion that extends between the module and back ends. The spring portion includes an elongated body having a plurality of flexible bend segments that wrap back-and-forth within a spring plane. The spring portion is compressible between first and second states during a mating operation between the optical module and an optical connector. | 05-16-2013 |
20130330957 | CONNECTOR ASSEMBLY HAVING A SLIDABLE CONNECTOR - A connector assembly including an outer housing having a front end, a back end, and a central axis extending therebetween. The outer housing has a passage that extends therethrough. The connector assembly also includes a slidable connector that is disposed within the passage. The slidable connector includes a communication module. The connector assembly also includes a spring frame that is positioned between the slidable connector and the outer housing. Prior to mating with a mating connector, the spring frame mechanically couples the slidable connector with respect to the outer housing. After the mating connector and the communication module are communicatively coupled, the spring frame releases the slidable connector from the outer housing such that the slidable connector is permitted to move relative to the outer housing. The spring frame mechanically couples the slidable connector relative to the mating connector. | 12-12-2013 |
20140270646 | OPTICAL CONNECTOR HOUSING ASSEMBLY WITH DUAL INSERTION AND EXTRACTION OPTIONS - A housing for an optical connector including a top wall, a bottom wall, a first side wall and a second side wall forming a passageway and a rear opening; a rear portion for receiving a first optical connector; a rectangular opening located on the top wall of the rear portion, wherein the rectangular opening extending from the rear opening along length of the rear portion of the top wall; a rectangular channel located on the bottom wall extending from the rear opening, wherein width of the channel is substantially equal to width of a stop located on distal end of the bottom wall of the connector; and a first notch located on the first side wall and a second notch located on the second side wall, wherein the first and second notches are capable of engaging with projections located on the connector when the connector is inserted into the housing. | 09-18-2014 |
Patent application number | Description | Published |
20110045265 | Polyolefin composition and film thereof - A polyolefin composition is disclosed. The composition comprises a single-site linear low density polyethylene (mLLDPE) and an elastoplastic polypropylene. The elastoplastic polypropylene is present in an amount sufficient to improve the processability and physical property of the mLLDPE. The composition preferably comprises from 70 wt % to 99 wt % of mLLDPE and from 1 wt % to 30 wt % of the elastoplastic polypropylene. The polyolefin composition of the invention exhibits improved bubble stability in the blown film extrusion compared to the mLLDPE and improved film properties such as tear strength and modulus compared to the traditional blend of mLLDPE and low density polyethylene. | 02-24-2011 |
20110136997 | PREPARATION OF MULTIMODAL, HIGH DENSITY, ETHYLENE HOMOPOLYMER BARRIER RESINS AND FILMS - Disclosed is a multimodal, high density, homopolyethylene barrier resin. The resin is preferably made by a multistage process. The process comprises a first stage in which ethylene is homopolymerized in the presence of a Ziegler-Natta catalyst, organoaluminum cocatalyst, alkoxysilane modifier, and hydrogen. The reaction mixture from the first stage is devolatilized to remove all or substantially all of the hydrogen. The polymerization continues in a second stage wherein ethylene is added to the devolatilized reaction mixture to produce the barrier resin. The barrier resin provides films with improved barrier properties. | 06-09-2011 |
20110201729 | Polyethylene composition having reduced warpage in molded articles - Disclosed is a colored high density polyethylene composition. The composition comprises a high density polyethylene, phthalocyanine blue, and talc. The composition exhibits reduced warpage in molded articles compared to those which do not contain talc. The composition is useful for injection molding and many other applications where a blue color is needed and low warpage is desired. | 08-18-2011 |
20110300391 | Multilayer films having reduced curling - Disclosed is a multilayer film. The multilayer film has the general structure of A/B/A/C or B/A/B/C, wherein A is a nucleated high density polyethylene (HDPE) layer, B is a single or multilayer structure, and C is a seal layer. Adding a nucleating agent to HDPE improves the water vapor barrier property of the HDPE layer and the multilayer film, but it also causes the multilayer film to curl in the conventional multilayer film structures. The invention provides a multilayer film, which includes at least one layer of nucleated HDPE, with reduced or eliminated curling while retaining high water vapor barrier. | 12-08-2011 |
Patent application number | Description | Published |
20090169489 | COBALAMIN COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING MUCOSITIS - The present invention relates to troches, patches, gels, or viscous liquids for topical treatment or prevention of mucosal surfaces containing as an active ingredient molecules of cobalamin for the treatment of inflammatory, ulcerative and painful conditions of mucosal surfaces such as mucositis, stomatitis, vestibulitis, aphthous ulcerations, and Behcet's syndrome. For reducing the incidence, duration, and pain levels of recurrent aphthous ulcers, bioactive cobalamin may delivered with adhering discs that stick to a tooth. | 07-02-2009 |
20100285098 | ADHERING TROCHES WITH SANTACID FOR TREATMENT OF THROAT ESOPHAGUS AND STOMACH - A method for combating unwanted conditions downstream of the mouth with adhering troches. A method to treat or reduce replication of a virus in throat tissues by releasing an anti-viral from an adhering disc. A method to treat sore throat with time release of Glycyrrhiza extract or collagen from an adhering disc. A method to treat sore throat with topically applied cobalamin. An adhering troche that releases antacid, alginate, bismuth subsalicylate, soluble zinc, such as zinc gluconate, bioactive vitamin B12 (methylcobalamin), antibiotic, or anti-viral. A method to combat bacterial effects downstream of the mouth with topically applied xylitol. | 11-11-2010 |
Patent application number | Description | Published |
20090010997 | Multi-layer medical patch with impermeable center - A muco-adhesive patch for delivery of drugs into mucous membranes. On the muco-contact side, a water impermeable layer covers the center of the patch and less than half of the muco-contact side of the patch. Drugs may be added by mixing the drug with an adhesive material and placing a spot of the drug plus adhesive onto the exposed side of the water impermeable layer. A lenticular medical patch with a thin, tapered edge can be made with multiple layers by passing a single sheet such as a sheet of plastic through a production line in which each layer is applied in turn maintaining registration by reference to edges of the sheet or to marks on the sheet. | 01-08-2009 |
20090104128 | Denture adhesive compositions with anti-ucler agents - The present invention relates to methods and compositions for reducing, inhibiting, and/or preventing denture sores, comprising a denture adhesive component and an effective amount of an anti-ulcer agent selected from the group consisting of | 04-23-2009 |
20100092543 | Dimpled adhering troche for use on teeth or orthodontic braces - A dissolving oral adhering disc with a dimple on at least one side to improve adhesion to hard convex surfaces in the mouth, including teeth, orthodontic braces, and gums (keratinized gingiva). The disc may be designed to prevent or treat a sore in the mouth opposite a tooth or brace and/or to release a medication into the mouth, to treat such as sore or to treat or prevent conditions elsewhere in the mouth or throat or stomach with the medication may be a form a glycyrrhetinic acid that is soluble in water at human mouth temperatures. | 04-15-2010 |
20120251622 | CELLULOSE GUM AND POLYOL TROCHE - A troche with 2.5-6% cellulose gum and at least 75% polyol molecules is disclosed. It may be an adherent troche, preferably adhered to teeth or gums or cheek with acacia gum. Consumers are instructed to use the troches to relieve the sensations of dry mouth, particularly while sleeping. The polyol molecules are preferably xylitol. The troches may be made with a bi-layer tablet press rounded on one side and flat on the other, preferably using acacia gum in the flat side layer for adhesion. | 10-04-2012 |
20130250083 | System to monitor vehicle drivers with a camera - A system for monitoring vehicle drivers with a camera. The camera may capture an image with infra-red frequency. The camera may be coupled to a crypto-authenticating chip and/or a GPS circuit. | 09-26-2013 |
20150054934 | Teleproctor reports use of a vehicle and restricts functions of drivers phone - A device in an automobile includes a camera that takes images of drivers while they are driving. It detects and reports when eyes are not on the road for longer than a glance with automated image processing. It also reports how much the car is driven, by whom, when, where, carrying what load, at what speed compared to the speed limit, with what pattern of hard breaking or hard cornering, whether the driver looked into the blind spot before changing lanes, and whether the driver allowed their phone to enter a restricted state while driving. The device may be built in or retrofit. The retrofit device can detect if it is depowered or removed from the vehicle and report this to the insurance company, rental company, parents, and employers. | 02-26-2015 |
Patent application number | Description | Published |
20080312260 | Biological markers predictive of anti-cancer response to kinase inhibitors - The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with inhibitors of EGFR kinase, PDGFR kinase, or FGFR kinase. Based on the surprising discovery that tumors cells after having undergone an EMT, while being mesenchymal-like, still express characteristics of both epithelial and mesenchymal cells, and that such cells have altered sensitivity to inhibition by receptor protein-tyrosine kinase inhibitors, in that they have become relatively insensitive to EGFR kinase inhibitors, but have frequently acquired sensitivity to inhibitors of other receptor protein-tyrosine kinases such as PDGFR or FGFR, methods have been devised for determining levels of specific epithelial and mesenchymal biomarkers that identify such “hybrid” tumor cells (e.g. determination of co-expression of vimentin and epithelial keratins), and thus predict the tumor's likely sensitivity to inhibitors of EGFR kinase, PDGFR kinase, or FGFR kinase. Improved methods for treating cancer patients with EGFR, PDGFR or FGFR kinase inhibitors that incorporate such methodology are also provided. | 12-18-2008 |
20090092596 | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors - The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell has undergone an epithelial to mesenchymal transition (EMT), by determining the expression level of epithelial and/or mesenchymal biomarkers, wherein tumor cells that have undergone an EMT are substantially less sensitive to inhibition by IGF-1R kinase inhibitors. Improved methods for treating cancer patients with IGF-1R kinase inhibitors that incorporate the above methodology are also provided. Additionally, methods are provided for the identification of new biomarkers that are predictive of responsiveness of tumors to IGF-1R kinase inhibitors. Furthermore, methods for the identification of agents that restore the sensitivity of tumor cells that have undergone EMT to inhibition by IGF-1R kinase inhibitors are also provided. pErk, HER3 and pHER are also demonstrated to be effective biomarkers for predicting sensitivity of tumor cells to IGF-1R kinase inhibitors. | 04-09-2009 |
20120101084 | Biological Markers Predictive of Anti-Cancer Response to Insulin-Like Growth Factor-1 Receptor Kinase Inhibitors - The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell has undergone an epithelial to mesenchymal transition (EMT), by determining the expression level of epithelial and/or mesenchymal biomarkers, wherein tumor cells that have undergone an EMT are substantially less sensitive to inhibition by IGF-1R kinase inhibitors. Improved methods for treating cancer patients with IGF-1R kinase inhibitors that incorporate the above methodology are also provided. Additionally, pErk, HER | 04-26-2012 |
20120122841 | Biological Markers Predictive Of Anti-Cancer Response To Insulin-like Growth Factor-1 Receptor Kinase Inhibitors - The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell has undergone an epithelial to mesenchymal transition (EMT), by determining the expression level of epithelial and/or mesenchymal biomarkers, wherein tumor cells that have undergone an EMT are substantially less sensitive to inhibition by IGF-1R kinase inhibitors. Improved methods for treating cancer patients with IGF-1R kinase inhibitors that incorporate the above methodology are also provided. | 05-17-2012 |
20130210026 | BIOLOGICAL MARKERS PREDICTIVE OF ANTI-CANCER RESPONSE TO KINASE INHIBITORS - The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with inhibitors of EGFR kinase, PDGFR kinase, or FGFR kinase. Based on the surprising discovery that tumors cells after having undergone an EMT, while being mesenchymal-like, still express characteristics of both epithelial and mesenchymal cells, and that such cells have altered sensitivity to inhibition by receptor protein-tyrosine kinase inhibitors, in that they have become relatively insensitive to EGFR kinase inhibitors, but have frequently acquired sensitivity to inhibitors of other receptor protein-tyrosine kinases such as PDGFR or FGFR, methods have been devised for determining levels of specific epithelial and mesenchymal biomarkers that identify such “hybrid” tumor cells (e.g. determination of co-expression of vimentin and epithelial keratins), and thus predict the tumor's likely sensitivity to inhibitors of EGFR kinase, PDGFR kinase, or FGFR kinase. Improved methods for treating cancer patients with EGFR, PDGFR or FGFR kinase inhibitors that incorporate such methodology are also provided. | 08-15-2013 |
20140018375 | BIOLOGICAL MARKERS PREDICTIVE OF ANTI-CANCER RESPONSE TO EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITORS - The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an EGFR kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an EGFR kinase inhibitor, comprising assessing whether the tumor cell has undergone an epithelial to mesenchymal transition (EMT), by determining the expression level of epithelial and/or mesenchymal biomarkers, wherein tumor cells that have undergone an EMT are substantially less sensitive to inhibition by EGFR kinase inhibitors. Improved methods for treating cancer patients with EGFR kinase inhibitors that incorporate the above methodology are also provided. Additionally, methods are provided for the identification of new biomarkers that are predictive of responsiveness of tumors to EGFR kinase inhibitors. Furthermore, methods for the identification of agents that restore the sensitivity of tumor cells that have undergone EMT to inhibition by EGFR kinase inhibitors are also provided. | 01-16-2014 |
Patent application number | Description | Published |
20110003343 | CONJUGATES OF BIOMOLECULES TO NANOPARTICLES - Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced aggregation and improved stochiometries wherein the average biomolecule:nanoparticle ratio approaches or equals 1:1. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing. | 01-06-2011 |
20110155969 | METHODS FOR ISOLATING AND PURIFYING NANOPARTICLES FROM A COMPLEX MEDIUM - A method for isolating a nanoparticle is disclosed. A medium containing a nanoparticle is provided. The medium is acidified with a weak acid. An alcoholic solvent is added to induce the nanoparticle to precipitate from the medium. The precipitated nanoparticles are separated from the medium. | 06-30-2011 |
20110306079 | WATER-DISPERSABLE NANOPARTICLES - Provided herein are methods for making water-soluble nanoparticles comprising a core/shell nanocrystal that is coated with a surface layer comprising enough hydrophilic ligands to render the nanoparticle water soluble or water dispersable. Methods for crosslinking molecules on the surface of a nanoparticle, which methods can be used on the above water-soluble nanoparticles also are provided. Nanoparticle compositions resulting from these methods are also provided. | 12-15-2011 |
20140308730 | CONJUGATES OF BIOMOLECULES TO NANOPARTICLES - Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced aggregation and improved stochiometries wherein the average biomolecule:nanoparticle ratio approaches or equals 1:1. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing. | 10-16-2014 |
Patent application number | Description | Published |
20100082022 | DELIVERED ENERGY GENERATOR FOR MICROWAVE ABLATION - A microwave system for generating microwave energy to tissue according to an energy control algorithm is disclosed. The system includes a microwave generator configured to select an energy control algorithm, programmed in the microwave generator that corresponds to a microwave energy delivery device connected to the generator. | 04-01-2010 |
20110077636 | Management of Voltage Standing Wave Ratio at Skin Surface During Microwave Ablation - A dielectric spacer for use during microwave ablation of tissue is disclosed. The dielectric spacer includes a housing having a predetermined thickness and a skin-contacting bottom surface. The housing is configured to be filled with a dielectric material having a predetermined dielectric permittivity. The housing is further configured to be placed on the tissue in proximity with at least one microwave antenna assembly, wherein the thickness and the dielectric permittivity are configured to shift a maximum voltage standing wave ratio of the at least one microwave antenna assembly. | 03-31-2011 |
20120203220 | Tissue Dissectors - A tissue dissector is provided. The tissue dissector includes a cannula and an introducer coaxially coupled to the cannula and movable therein from a retracted position to an extended position. An introducer is coaxially coupleable to the cannula and movable therein from a retracted position to an extended position. The introducer including a generally annular lumen disposed in fluid communication with an inflation port operably disposed on the introducer and in fluid communication with an inflatable balloon that couples to the introducer. The inflatable balloon is movable from a deflated condition for positioning the introducer adjacent target tissue, to an inflated condition for separating the target tissue from nearby tissue and for providing a barrier therebetween such that the nearby tissue is not affected during the electrosurgical procedure. | 08-09-2012 |
20120303018 | Tissue Dissectors - A tissue dissector is provided. The tissue dissector includes an introducer including a lumen extending along a length thereof and defining a longitudinal axis therethrough. The introducer configured for placement adjacent target tissue. A shaft operably coupled to the introducer is deployable from a distal end thereof and includes a proximal end for approximating the distal end of the shaft adjacent target tissue. The distal end of the shaft is movable from a non-expanded configuration to an expanded configuration for separating target tissue from neighboring tissue. | 11-29-2012 |
20130317407 | Energy-Delivery System and Method for Controlling Blood Loss from Wounds - An energy delivery system for controlling blood loss is provided. The system includes an energy-activated patch configured for placement on tissue. The patch includes an energy-delivering layer configured to deliver energy to the tissue. The system also includes an energy source in operative engagement with the energy-activated patch for energizing the energy-delivering layer. | 11-28-2013 |
20140000098 | MICROWAVE ANTENNA PROBES AND METHODS OF MANUFACTURING MICROWAVE ANTENNA PROBES | 01-02-2014 |
20140005657 | MICROWAVE ANTENNA PROBES | 01-02-2014 |
20140046174 | MICROWAVE ABLATION CATHETER AND METHOD OF UTILIZING THE SAME - A microwave ablation system configured for use in luminal network is provided. The microwave ablation system includes a microwave energy source. A tool for treating tissue is provided with the microwave ablation system. An extended working channel is configured to provide passage for the tool. A locatable guide catheter is positionable through the extended working channel and configured to navigate the extended working channel adjacent the target tissue. The microwave ablation system includes a navigation system that is configured for guiding the tool, extended working channel or the locatable guide through a luminal network following a predetermined determined pathway to the target tissue. One or more imaging modalities may be utilized for confirming placement of the tool within target tissue. | 02-13-2014 |
20140046175 | MICROWAVE ABLATION CATHETER AND METHOD OF UTILIZING THE SAME - A microwave ablation system configured for use in luminal network is provided. The microwave ablation system includes a microwave energy source and a tool for treating tissue. An extended working channel is configured to provide passage for the tool. A locatable guide, translatable through the extended working channel, is configured to navigate the extended working channel adjacent a target. | 02-13-2014 |
20140046176 | MICROWAVE ABLATION CATHETER AND METHOD OF UTILIZING THE SAME - A method for treating lung tissue of a patient is provided. A pathway to a point of interest in a lung of a patient is generated. An extended working channel is advanced transorally into the lung and along the pathway to the point of interest. The extended working channel is positioned in a substantially fixed orientation at the point interest. A tool is advanced though the extended working channel to the point of interest. The lung tissue is treated at the point of interest. | 02-13-2014 |
20140046211 | MICROWAVE ABLATION CATHETER AND METHOD OF UTILIZING THE SAME - A method for treating tissue through a branched luminal network of a patient is provided. A pathway to a point of interest in branched luminal network of a patient is generated. An extended working channel is advanced transorally into the branched luminal network and along the pathway to the point of interest. The extended working channel may be positioned in a substantially fixed orientation at the point interest. A tool is advanced though the extended working channel to the point of interest. Tissue at the point of interest is treated. | 02-13-2014 |
20140046315 | MICROWAVE ABLATION CATHETER AND METHOD OF UTILIZING THE SAME - A microwave ablation catheter is provided. The microwave ablation catheter includes a coaxial cable connected at its proximal end to a microwave energy source and at its distal end to a distal radiating section. The coaxial cable includes inner and outer conductors and a dielectric positioned therebetween. The inner conductor extends distally past the outer conductor and is in sealed engagement with the distal radiating section. A balun is formed in part from a conductive material electrically connected to the outer conductor of the coaxial cable and extends along at least a portion of the coaxial cable. The conductive material has a braided configuration and is covered by at least one insulative material. | 02-13-2014 |
20140046316 | MICROWAVE ABLATION CATHETER AND METHOD OF UTILIZING THE SAME - A microwave ablation system configured for use in luminal network is provided. The microwave ablation system includes a microwave energy source and a tool for treating tissue. An extended working channel is configured to provide passage for the tool. A locatable guide, translatable through the extended working channel, is configured to navigate the extended working channel adjacent a target. | 02-13-2014 |
Patent application number | Description | Published |
20100209697 | METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES, NON-AQUEOUS DISPERSIONS THEREOF AND ARTICLES PREPARED THEREWITH - Described are non-aqueous dispersions of photosensitive polymeric microparticles, comprising: a) an organic continuous phase comprising an organic solvent; and b) photosensitive polymeric microparticles dispersed in the organic continuous phase. The microparticles comprise an at least partially polymerized component having integral surface and interior domains, wherein the surface domain comprises a polymeric material that is solubilized by the organic solvent, the interior domain comprises a polymeric material that is insoluble in the organic solvent, and the surface domain and/or interior domain is photosensitive. Also described are methods of producing such non-aqueous dispersions, curable film-forming compositions containing them, and photosensitive coated substrates. | 08-19-2010 |
20100221661 | METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES - Described are various methods of producing non-aqueous dispersions of photosensitive polymeric microparticles, comprising: (a) preparing one or more aqueous dispersions of a polymerizable component, at least one of which contains a photosensitive material and, wherein the polymerizable components comprise at least one hydrophilic functional group and/or at least one hydrophobic functional group; (b) subjecting the dispersion of (a) to conditions sufficient to form microparticles; (c) at least partially polymerizing the polymerizable component; (d) combining the dispersion with an organic continuous phase comprising an organic solvent; (e) removing water from the dispersion such that the final water content of the non-aqueous dispersion is less than 30 percent by weight; wherein e) is performed before or after d); and (f) reacting any acid functional groups on the surface of the microparticles with a reactive material having at least one epoxy functional group, at least one thiocarbonylthio functional group, at least one alkoxyamine functional group, or at least one halide functional group. | 09-02-2010 |
20120136148 | Photochromic Compounds Having At Least Two Photochromic Moieties - The present invention relates to photochromic compounds that include at least two photochromic moieties that are linked together by a multivalent linking group. The multivalent linking group can be selected so as to be flexible and/or substantially prevent electronic interaction between any two photochromic moieties through the multivalent linking group. The present invention also relates to photochromic compositions and articles that include at least a photochromic amount of one or more photochromic compounds of the present invention. | 05-31-2012 |
Patent application number | Description | Published |
20110142885 | SPRAY-DRIED HUMAN PLASMA - The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder. | 06-16-2011 |
20120103536 | SYSTEM AND METHOD FOR SPRAY DRYING A LIQUID - Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material. | 05-03-2012 |
20120167405 | SPRAY DRIED HUMAN PLASMA - The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder. | 07-05-2012 |
20120222326 | SYSTEM AND METHOD FOR SPRAY DRYING A LIQUID - Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material. | 09-06-2012 |
20130048225 | SYSTEM AND METHOD FOR SPRAY DRYING A LIQUID - Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material. | 02-28-2013 |
20130056158 | SYSTEM AND METHOD FOR SPRAY DRYING A LIQUID - Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material. | 03-07-2013 |
20130078324 | SPRAY DRIED HUMAN PLASMA - The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder. | 03-28-2013 |
20130126101 | SPRAY DRIED HUMAN PLASMA - The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder. | 05-23-2013 |
20130230599 | Spray Dried Human Plasma - The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma power, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder. | 09-05-2013 |
20130243877 | Spray-Dried Human Plasma - The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma power, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder. | 09-19-2013 |
20140083627 | AUTOMATED SPRAY DRIER - A spray drier system is provided for spray drying a liquid sample such as blood plasma. The spray drier system may include a spray drier device and a spray drier assembly. The spray drier device may be configured to receive flows of an aerosolizing gas, a drying gas, and blood plasma from respective sources and couple with the spray drier assembly for transmission of the received aerosolizing gas, drying gas, and plasma to the spray drier assembly. Spray drying of the plasma is performed in the spray drier assembly under the control of the spray drier device. | 03-27-2014 |
20140088768 | AUTOMATED SPRAY DRIER CONTROL SYSTEM - A spray drier monitoring and control system is provided for a spray drier device adapted to spray dry a liquid sample such as blood plasma. The system may receive information regarding an operator of the device, the liquid sample, a spray drier assembly used by the device for spray drying, and spray drying process parameters. The spray drier system may also conduct a plurality of checks to ensure that traceability and conformance with attendant quality/safety standards are maintained throughout the spray drying process. The information may be output by the system to a remote computing device (e.g., a blood center computing system) that tracks the sample history. Beneficially, the spray drier system allows information regarding spray drying to be easily integrated with the sample information for enhanced tracking and quality control of the sample. | 03-27-2014 |
Patent application number | Description | Published |
20090205361 | COAXIAL ECONOMIZER ASSEMBLY AND METHOD - A coaxial economizer for use in a chiller system comprising an inner housing and an outer housing having a common longitudinal axis. The outer housing has an inlet for receiving a fluid from a upstream compressor stage of a multistage compressor and an outlet for conveying a fluid to a downstream compressor stage of a multistage compressor. A flow chamber forms a fluid flow path about the inner housing. A flash chamber is coterminous with the flow chamber and flashes fluid in a liquid state to a gas state. A flow passage between said flash chamber and the flow chamber for conveying a flashed gas from the flash chamber to the flow chamber; wherein the flashed gas conveyed from the flash chamber and the fluid received from the inlet of the outer housing mix along the fluid flow path toward the outlet of the outer housing. | 08-20-2009 |
20090205362 | CENTRIFUGAL COMPRESSOR ASSEMBLY AND METHOD - A centrifugal compressor assembly for compressing refrigerant in a 250-ton capacity or larger chiller system comprising a motor, preferably a compact, high energy density motor or permanent magnet motor, for driving a shaft at a range of sustained operating speeds under the control of a variable speed drive. Another embodiment of the centrifugal compressor assembly comprises a mixed flow impeller and a vaneless diffuser sized such that a final stage compressor operates with an optimal specific speed range for targeted combinations of head and capacity, while a non-final stage compressor operates above the optimum specific speed of the final stage compressor. Another embodiment of the centrifugal compressor assembly comprises an integrated inlet flow conditioning assembly comprising a flow conditioning nose, a plurality of inlet guide vanes and a flow conditioning body that positions inlet guide vanes to condition flow of refrigerant into an impeller to achieve a target approximately constant angle swirl distribution with minimal guide vane turning. | 08-20-2009 |
20090208331 | CENTRIFUGAL COMPRESSOR ASSEMBLY AND METHOD - A centrifugal compressor assembly for compressing refrigerant in a 250-ton capacity or larger chiller system comprising a motor, preferably a compact, high energy density motor or permanent magnet motor, for driving a shaft at a range of sustained operating speeds under the control of a variable speed drive. Another embodiment of the centrifugal compressor assembly comprises a mixed flow impeller and a vaneless diffuser sized such that a final stage compressor operates with an optimal specific speed range for targeted combinations of head and capacity, while a non-final stage compressor operates above the optimum specific speed of the final stage compressor. Another embodiment of the centrifugal compressor assembly comprises an integrated inlet flow conditioning assembly comprising a flow conditioning nose, a plurality of inlet guide vanes and a flow conditioning body that positions inlet guide vanes to condition flow of refrigerant into an impeller to achieve a target approximately constant angle swirl distribution with minimal guide vane turning. | 08-20-2009 |
20110296859 | COAXIAL ECONOMIZER ASSEMBLY AND METHOD - A coaxial economizer for use in a chiller system comprising an inner housing and an outer housing having a common longitudinal axis. The outer housing has an inlet for receiving a fluid from a upstream compressor stage of a multistage compressor and an outlet for conveying a fluid to a downstream compressor stage of a multistage compressor. A flow chamber forms a fluid flow path about the inner housing. A flash chamber is coterminous with the flow chamber and flashes fluid in a liquid state to a gas state. A flow passage between said flash chamber and the flow chamber for conveying a flashed gas from the flash chamber to the flow chamber; wherein the flashed gas conveyed from the flash chamber and the fluid received from the inlet of the outer housing mix along the fluid flow path toward the outlet of the outer housing. | 12-08-2011 |
20140127059 | CENTRIFUGAL COMPRESSOR ASSEMBLY AND METHOD - A centrifugal compressor assembly for compressing refrigerant in a 250-ton capacity or larger chiller system comprising a motor, preferably a compact, high energy density motor or permanent magnet motor, for driving a shaft at a range of sustained operating speeds under the control of a variable speed drive. Another embodiment of the centrifugal compressor assembly comprises a mixed flow impeller and a vaneless diffuser sized such that a final stage compressor operates with an optimal specific speed range for targeted combinations of head and capacity, while a non-final stage compressor operates above the optimum specific speed of the final stage compressor. Another embodiment of the centrifugal compressor assembly comprises an integrated inlet flow conditioning assembly to condition flow of refrigerant into an impeller to achieve a target approximately constant angle swirl distribution with minimal guide vane turning. | 05-08-2014 |
20150013360 | COAXIAL ECONOMIZER ASSEMBLY AND METHOD - A coaxial economizer for use in a chiller system comprising an inner housing and an outer housing having a common longitudinal axis. The outer housing has an inlet for receiving a fluid from a upstream compressor stage of a multistage compressor and an outlet for conveying a fluid to a downstream compressor stage of a multistage compressor. A flow chamber forms a fluid flow path about the inner housing. A flash chamber is coterminous with the flow chamber and flashes fluid in a liquid state to a gas state. A flow passage between said flash chamber and the flow chamber for conveying a flashed gas from the flash chamber to the flow chamber; wherein the flashed gas conveyed from the flash chamber and the fluid received from the inlet of the outer housing mix along the fluid flow path toward the outlet of the outer housing. | 01-15-2015 |
Patent application number | Description | Published |
20100251591 | Battery Assist Device - The present invention is a battery assist devise to aid in the locking and unlocking of the bolt in a long firearm. The battery assist devise attaches to the both catch button of the firearm and thereafter acts as an extension thereof. The battery assist device comprises an interface head and attachment plate, which secure about the bolt catch button, and a curved lever that protrudes from the head and projects around the underside of the firearm, through the trigger guard area, until it projects slightly on the opposite side of the firearm. The lever then is capable of ambidextrous operation. | 10-07-2010 |
20110017788 | Sling Fittings and Sling System for a Firearm - The present invention is a sling system utilizing a rear sling fitting for a long firearm, such as a rifle. Such fittings typically are positioned between the stock and receiver. It presents a fitting body with an aperture to slide over a rifle receiver tube and a connection bar extending from a reverse of the fitting body. A point-type sling attachment may then be attached to the connection bar and be able to slide left and right across the back of the weapon, allowing for quickly adaptable left or right positioning of the weapon. Registration geometry may be added and positioned to further allow interface with weapon geometry and prevent rotation of the fitting during use. The connection bar may be positioned on another component of the weapon, such as the receiver or the stock, should the weapon not have a receiver extension tube. A convertible sling and forward sling mount are also disclosed for cooperative use with the fitting, completing the system. | 01-27-2011 |
20120180368 | Forward Mounted Gun Sight with Illumination Apparatus - The present invention is a rail mounted back-up sight with at least one, but preferred two, illumination apparatuses mounted thereon. The back-up sight features a sight housing that is configured to selectively alternate between a stowed and a spring-biased deployed position. Any type of illumination apparatus may be used, but the preferred apparatus is a flashlight, mounted upon wither side of a sight base. Either a front or a rear sight may be utilized as could different types of illumination apparatuses. | 07-19-2012 |
20140091115 | Sling Fittings and Sling System for a Firearm - The present invention is a sling system utilizing a rear sling fitting for a long firearm, such as a rifle. Such fittings typically are positioned between the stock and receiver. It presents a fitting body with an aperture to slide over a rifle receiver tube and a connection bar extending from a reverse of the fitting body. A point-type sling attachment may then be attached to the connection bar and be able to slide left and right across the back of the weapon, allowing for quickly adaptable left or right positioning of the weapon. Registration geometry may be added and positioned to further allow interface with weapon geometry and prevent rotation of the fitting during use. The connection bar may be positioned on another component of the weapon, such as the receiver or the stock, should the weapon not have a receiver extension tube. A convertible sling and forward sling mount are also disclosed for cooperative use with the fitting, completing the system. | 04-03-2014 |