Hakimi
Ari A. Hakimi, New Rochelle, NY US
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20160067229 | BIOMARKERS FOR RESPONSE TO RAPAMYCIN ANALOGS - The present invention relates to the use of one or more biomarkers to evaluate the likelihood that a rapamycin analog would produce an anti-cancer effect in a subject. It is based, at least in part, on the results of experiments employing an integrated next-generation sequencing approach to interrogate spatially separated tumor specimens from the same individuals to decipher intra-tumor and intertumor heterogeneity and determine the oncogenomic basis of exceptional therapeutic benefit to rapalogs in kidney cancer patients. These experiments implicated loss of function mutations in TSC1 and/or TSC2 and/or gain-of-function of mTOR in therapeutic responsiveness to rapamycin analogs. Accordingly, in non-limiting embodiments, the present invention provides for assay methods and kits for determining the presence of loss of function mutations in TSC1 and/or TSC2 and/or gain-of-function of mTOR, and methods of using such determinations in selecting a therapeutic regimen for a cancer patient and in methods of treating cancer patients. In particular non-limiting embodiments, a plurality of tumor sites are evaluated and the composite effect of the genetic background on mTOR function is assessed. | 03-10-2016 |
Bejan Hakimi, Seattle, WA US
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20160086785 | METHODS AND DEVICES FOR GENERATING DOUBLE EMULSIONS - The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer. The present disclosure further describes methods, systems, and apparatuses for using the devices and interfaces described to perform analysis, including mass spectrometry. The present disclosure also describes methods, systems, and apparatuses for generating and using multi-phase emulsions to perform analysis. | 03-24-2016 |
Daryoush Hakimi, Bloomington, IL US
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20150286929 | AGGREGATION AND CORRELATION OF DATA FOR LIFE MANAGEMENT PURPOSES - A method and computer system aggregates and correlates various types of data from an individual for life management purposes. As an example, the various types of data may include home data, vehicle data, and personal health data associated with the individual. The method and system may receive the various types of data from the individual and analyze each type of data to determine patterns associated with each type of data. The method and system may then compare each of the determined patterns with one another to determine any underlying factors and correlations that may be affecting each of the determined patterns. Based on the determined underlying factors and correlations for each of the determined patterns, the method and system may provide the individual with various benefits such as personalized recommendations, insurance discounts, and other added values or services that the individual can use to better manage and improve his or her life. | 10-08-2015 |
Farhad Hakimi, Watertown, MA US
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20120307252 | RECYCLED LIGHT INTERFEROMETRIC FIBER OPTIC GYROSCOPE - Interferometric fiber optic gyroscope. The gyroscope includes a pulsed light source for generating light pulses and a sense coil for receiving and trapping the light pulses travelling in clockwise and counter clockwise directions for a selected number of times around the sense coil. A detector receives the counter propagating light pulses to determine the phase shift between the two counter propagating light pulses, the phase shift being proportional to rotation rate of the sense coil. | 12-06-2012 |
20140153083 | RIN REDUCED OPTICAL SOURCE FOR OPTICAL COHERENCE TOMOGRAPHY - A relative intensity noise (RIN)-suppressed light source is provided that includes a light source that produces an incoming light. A semiconductor optical amplifier (SOA) arrangement receives the incoming light and provides a significant reduction in the RIN as its output. The SOA arrangement includes one or more SOAs in saturation that behave like a high pass filter for the amplitude of the incoming light. | 06-05-2014 |
Farhad Hakimi, New York, NY US
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20140090652 | INTRAORAL DEVICE FOR TREATMENT OF SNORING, SLEEP APNEA AND TMD - The invention is a device for removable placement in the mouth, which advances the lower jaw and draws the tongue forward and upward, thereby providing relief for snoring and obstructive sleep apnea. The device includes an upper portion, the upper surface of which is adapted for engagement with the user's upper dentition. A downward extension, suspended from the anterior part of the upper portion, features an anterior surface that engages the back of the lower front teeth, so as to advance the lower jaw forward with respect to the upper jaw. The posterior surface of the downward extension features a rearward extension, which is curved upward at its lateral margins to meet the upper portion, so as to define, with the hard palate of the user, a cavity that is sized and shaped to snugly engage the user's tongue. Within the defined cavity, the device preferably features a soft elastomeric surface. | 04-03-2014 |
Mohamed-Ali Hakimi, Grenoble FR
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20120034593 | CYCLIC PEPTIDES WITH AN ANTI-PARASITIC ACTIVITY - The present invention relates to a method for preparing a cyclic peptide with antiparasite activity and anticancer activity. The invention also relates to this peptide as an antiparasite agent, for example in the treatment of toxoplasmosis and as an anticancer agent. The invention also relates to the use of this cyclic peptide for treating organs ex vivo before transplantation. | 02-09-2012 |
Najeeb H. Hakimi, Edison, NJ US
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20150126479 | AQUEOUS SOLUTIONS OF 1,2-BENZISOTHIAZOLIN-3-ONE - What is described herein is an environment-friendly, highly aqueous solution of 1,2-benzisothiazolin-3-one (BIT) which is free from volatile organic compounds (VOC's), glycols, derivatives of glycols, glycerols and/or derivatives of glycerols. The composition comprises: (i) about 0.1% to about 30% by wt. of BIT; (ii) about 5% to about 15% by wt. of neutralizing agent; (iii) about 50% to about 85% by wt. of water; and (iv) about 0.1% to about 5% by wt. of chelating agent. The aqueous solution of BIT may further comprise at least one water soluble form of a co-biocide. The composition is efficient in protecting aqueous media against microbial attack in various industrial applications. | 05-07-2015 |
20150327550 | ENVIRONMENT-FRIENDLY, BIODEGRADABLE, VOC-FREE, NON-CORROSIVE AQUEOUS SOLUTION OF 1, 2-BENZISOTHIAZOLIN-3-ONE (BIT) AND PROCESS FOR PREPARING THE SAME - What is described herein is an environment-friendly, biodegradable, non-corrosive aqueous solution of isothiazolin-3-one comprising: (i) at least about 5 wt. % to about 50 wt. % of 1,2-benzisothiazolin-3-one (BIT); (ii) about 5 wt. % to 15 wt. % of neutralizing agent; (iii) about 0.01 wt. % to about 20 wt. % of at least one biodegradable chelating agent; (iv) about 0.01 wt. % to about 20 wt. % of at least one alkyl polyglucoside, a solubilizer; (v) about 0.1 wt. % to about 2.0 wt. % of polyvinyl alcohol (PVA), a crystal modifier; and (vi) about 50% to about 85% by wt. of water; and wherein said aqueous solution is free from volatile organic compounds (VOC's), glycerols, polyglycerols, derivatives of glycerols, glycols, polyglycols and/or derivatives of glycols, and wherein, the frozen aqueous solution of isothiazolin-3-one is capable of completely thawing within two hours at room temperature or at about 25° C. to about 30° C. | 11-19-2015 |
Salim M. Hakimi, Sacramento, CA US
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20110030086 | CORN EVENT DAS-59122-7 AND METHODS FOR DETECTION THEREOF - The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DAS-59122-7 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided. | 02-03-2011 |