Haigis
Harald Haigis, Elzach DE
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20150034802 | ENDOSCOPE - An endoscope is provided having a first beam path formed at least in a distal end region, a second beam path formed at the end region, which second beam path is arranged offset with respect to the first beam path for recording a stereoscopic image, and an image recording chip, which is configured for electronically recording images captured via the first beam path and the second beam path. A beam deflection device is provided having at least one deflection element arranged for displacement along a straight line adjustment travel path between a first position and a second position, and the beam deflection device, in the first position, guides an image captured using the first beam path to the image recording chip and, in the second position, guides an image captured using the second beam path to the image recording chip. | 02-05-2015 |
Marcia Haigis, Winchester, MA US
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20110287026 | SIRT4 AND USES THEREOF - Provided herein are SIRT4 compositions and methods of use thereof. The invention provides functional information for use in the identification and design of compounds that modulate SIRT4 enzyme activity (e.g., inhibition of fatty acid oxidation, ADP ribosylation, and/or downregulation of glutamate dehydrogenase), and to the compounds identified by such methods and the research, diagnostic and therapeutic uses of such compounds. | 11-24-2011 |
Marcia C. Haigis, Stoneham, MA US
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20110098190 | SIRT4 ACTIVITIES - Methods of screening for compounds that modulate the expression or activity of Sirt4 are provided. Also provided are methods of modulating insulin secretion, treating metabolic disorders, and treating neurodegenerative disorders by modulating the expression or activity of Sirt4. | 04-28-2011 |
20130096179 | SIRT4 ACTIVITIES - Methods of modulating insulin secretion and treating metabolic disorders by modulating the expression or activity of Sirt4 are provided. | 04-18-2013 |
Marcia C. Haigis, Winchester, MA US
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20130171125 | Methods for the Regulation of Cellular Metabolism Through the Modulation of SIRT3 Activity - The present invention relates to methods of preventing or treating cancer and/or decreasing damage to organs or tissues exposed to hypoxic conditions through the use of agents that modulate the expression or activity of SIRT3. | 07-04-2013 |
20140186325 | Methods of Cancer Treatment and Prevention Through the Modulation of SIRT4 Activity - The present invention relates to methods of preventing or treating cancer through the use of agents that enhance the activity or expression of SIRT4. | 07-03-2014 |
Robert Haigis, San Diego, CA US
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20100133118 | ELECTROCHEMICAL METHODS OF DETECTING NUCLEIC ACID HYBRIDIZATION - In accordance with the present invention, there are provided systems for detecting hybridization of nucleic acids using electrochemical methods having improved sensitivity. Such systems include an electrode having a variably charged oligonucleotide probe and a redox probe. In some embodiments, the systems may further include a binding nexus having an immobilized reporter oligonucleotide probe, which hybridizes to a target nucleic acid sequence. The reporter oligonucleotide probe may be naturally charged, uncharged, or either partially negatively or positively charged. Further provided are methods for detecting the presence of a nucleic acid sequence of interest in a sample. | 06-03-2010 |
Wolfgang Haigis, Wurzburg DE
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20080231809 | Method for Measuring Intraocular Lens - The invention relates to a method for measuring an optimally adapted intraocular lens for patients having a refractively modified cornea. The inventive method includes the following steps: determining the formula-specific corneal refractive powers before the refractive intervention; determining the formula-specific corneal refractive powers after the refractive intervention, and; putting the formula-specific corneal refractive powers before and after the refractive intervention into the respective IOL formula. | 09-25-2008 |