Gruskin, US
Edward Gruskin, Verona, NJ US
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20140256281 | ALARM SIGNAL CONVERSION FOR TRANSMISSION OVER PACKET-BASED NETWORKS - A computing device is configured to receive an analog alarm signal from an alarm receiving device; convert the analog alarm signal into a packet-based message having information equivalent information as the analog alarm signal; and provide the packet-based message to a server device associated with an alarm monitoring station. The packet-based message may contain information that is used to identify the alarm signal or used to respond to the alarm signal. | 09-11-2014 |
20150049865 | LINE SEIZURE IN AN ALARM SYSTEM HAVING AN ALARM SIGNAL PROCESSING DEVICE - A system and method of seizing a landline is disclosed. In seizing the landline, a first device may identify that a switch has been toggled by a second device; receive an alarm signal from the second device via a landline based on identifying that the switch has been toggled; determine a particular processing instruction, of one or more processing instructions, based on information included in the alarm signal; and execute the particular processing instruction to provide the alarm signal to a third device. | 02-19-2015 |
Elliot A. Gruskin, Malvern, PA US
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20130289621 | Drug-Impregnated Encasement - A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material, hi one embodiment, the sleeve may be made in least in part from caprolactone to add stretchability to the sleeve. | 10-31-2013 |
20130309240 | Compositions and Methods including a Recombinant Human MAB that Promotes CNS Remyelination - Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animals, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in above referenced therapeutic applications, and to pharmaceutical compositions containing them, that may be administered in desirably low doses to treat conditions involving demyelination and to promote remyelination. | 11-21-2013 |
Elliott Gruskin, Malvern, PA US
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20100041770 | POLYMER-CERAMIC COMPOSITE AND METHOD - Methods and devices are shown for a composite material that is easily applied to a surface such as a bone defect in need of filling or reinforcement, etc. The composite material provides good mechanical properties such as compressive strength upon curing in the presence of water. Selected materials and methods as described are further bioabsorbable with absorption rates that are controllable to provide desired morphology over time. In selected embodiments a pharmaceutical agent further provides benefits such as bone growth, infection resistance, pain management, etc. | 02-18-2010 |
20100056654 | BONE CEMENT WITH ADAPTED MECHANICAL PROPERTIES - A bone cement is shown that includes a monomer, and a non-reactive substance that is fully miscible with the monomer. A resulting cured bone cement exhibits desirable properties such as modification in a stiffness of the material. Modified properties such a stiffness can be tailored to match bone properties and reduce an occurrence of fractures adjacent to a region repaired with bone cement. One example includes adjacent vertebral body fractures in vertebroplasty procedures. | 03-04-2010 |
20100119492 | Method and device for activating stem cells - Invention embodiments described herein include methods and devices for stimulating mesenchymal stem cells in a stem cell source to differentiate into osteoblasts capable of forming bone. Devices and methods described include exposing a stem cell source, such as bone marrow aspirate, adipose tissue and/or purified allogenic stem cells, to an active agent, in a manner effective to form activated stem cells. | 05-13-2010 |
20110038912 | COMPOSITIONS AND METHODS FOR DELIVERY OF GLYCOPEPTIDE ANTIBIOTICS TO MEDICAL DEVICE SURFACES - The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions. | 02-17-2011 |
Elliott Gruskin, West Chester, PA US
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20140100297 | Bone Cement With Adapted Mechanical Properties - A bone cement is shown that includes a monomer, and a non-reactive substance that is fully miscible with the monomer. A resulting cured bone cement exhibits desirable properties such as modification in a stiffness of the material. Modified properties such a stiffness can be tailored to match bone properties and reduce an occurrence of fractures adjacent to a region repaired with bone cement. One example includes adjacent vertebral body fractures in vertebroplasty procedures. | 04-10-2014 |
Elliott A. Gruskin, West Chester, PA US
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20150018969 | Drug-Impregnated Encasement - A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material. | 01-15-2015 |
Elliott A. Gruskin, Killingworth, CT US
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20090028829 | Fusion proteins for the treatment of CNS - This disclosure relates to compositions capable of use in the treatment of spinal cord injuries and related disorders of the central nervous system (CNS), and in particular, compositions including proteoglycan degrading molecules and compositions capable of blocking and/or over coming the activity of neuronal growth inhibitory molecules, as well as fusion proteins which includes a proteoglycan degrading domain and a domain capable of blocking and or over coming the activity of neuronal growth inhibitory molecules. | 01-29-2009 |
20090041728 | Proteoglycan Degrading Mutants for the Treatment of CNS - The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease. | 02-12-2009 |
20110250631 | PROTEOGLYCAN DEGRADING MUTANTS FOR TREATMENT OF CNS - The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease. | 10-13-2011 |
20110262413 | METHODS OF REDUCING EXTRAVASATION OF INFLAMMATORY CELLS - A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue. The present invention provides methods of reducing penetration of cells associated with inflammation into tissue of a patient. Several methods are also provided for the regulation and suppression of inflammation comprising administering enzymes that digest chondroitin sulfates. Also provided are methods of treating and preventing inflammation associated with infection, injury and disease. | 10-27-2011 |
20130243765 | CHIMERIC PROTEIN - A chimeric protein is disclosed for promoting repair and regeneration of neurons damaged by disease or physical injury wherein the chimeric protein is a combination of a first polypeptide possessing matrix modification activity and a second polypeptide possessing regenerating activity for neural cells. | 09-19-2013 |
20140193387 | METHODS OF REDUCING EXTRAVASATION OF INFLAMMATORY CELLS - A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue. The present invention provides methods of reducing penetration of cells associated with inflammation into tissue of a patient. Several methods are also provided for the regulation and suppression of inflammation comprising administering enzymes that digest chondroitin sulfates. Also provided are methods of treating and preventing inflammation associated with infection, injury and disease. | 07-10-2014 |
20140248253 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CNS INJURIES - The present invention is directed to a method of improving functional recovery following a central nervous system contusion injury. The method includes administering a therapeutically effective amount of glycosaminoglycan degrading enzyme. The glycosaminoglycan degrading enzyme may be dermatan sulfate or chondroitin sulfate degrading enzymes. The central nervous system contusion injury may include a traumatic brain injury or a spinal cord injury. The functional recovery may include autonomic functions, sensory functions, motor functions or the like. | 09-04-2014 |
20140322192 | PROTEOGLYCAN DEGRADING MUTANTS FOR TREATMENT OF CNS - The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease. | 10-30-2014 |
Elliott A. Gruskin, Killington, CT US
Patent application number | Description | Published |
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20080311642 | Methods of Purifying Chondroitinase and Stable Formulations Thereof - An aspect of the present invention relates to stable formulations of chondroitinase and to methods of purifying chondroitinase. The methods of purifying chondroitinase includes the steps of extracting the enzyme from a cell, separating the chondroitinase from the crude cell extract using cation-exchange chromatography, removing impurities through gel filtration chromatography, and removing endotoxin through an anion-exchange membrane to produce a purified chondroitinase. | 12-18-2008 |
Elliott A. Gruskin, Malvern, PA US
Patent application number | Description | Published |
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20080262630 | Drug-Impregnated Encasement - A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material, hi one embodiment, the sleeve may be made in least in part from caprolactone to add stretchability to the sleeve. | 10-23-2008 |
20120207732 | COMPOSITIONS AND METHODS FOR PROMOTING NEURONAL OUTGROWTH - Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the inhibition of nervous tissue regeneration. | 08-16-2012 |
20150023942 | COMPOSITIONS AND METHODS FOR PROMOTING NEURONAL OUTGROWTH - Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the inhibition of nervous tissue regeneration. | 01-22-2015 |
Glenn Gruskin, Nanuet, NY US
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20080314916 | SNAP OVERCAP CLOSURE FOR A CONTAINER - An overcap for a container, which container is of the type having a rim adjacent to an opening in which the rim has an exterior facing top surface, an exterior facing side surface and an exterior facing bottom surface. The overcap includes a center portion having a top surface and a skirt extending downward relative to the top surface. A wall is spaced radially inward from the skirt, defining a channel in one form of the overcap. The wall has an end portion extending downwardly from the center portion. When the overcap is disposed on the container, the end portion engages with the exterior facing top surface of the rim of the container. In one further advantageous form, the overcap skirt has a bead extending radially inward, which engages with the exterior facing side surface of the container when the overcap is disposed on the container. | 12-25-2008 |
20130327783 | Snap Resealing Closure for a Container - A overcap is provided which covers the opening of a container. The overcap, in one form, engages an exterior of the container around the rim and along an inwardly directed flange which defines an opening of the container. The overcap snappingly engages with the container to produce an audible indication that the overcap is firmly attached to the container and that air is being expelled from inside the container. In another form, the overcap includes an invertible dome which is transformable between an upward convex position and an upward concave position. | 12-12-2013 |
Glenn Stanley Gruskin, Nanuet, NY US
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20100166924 | FLEXIBLE PACKAGE HAVING MULTIPLE OPENING FEATURE - A flexible package with a multiple-opening feature is suitable for retail sale of food products and is comprised of a film material. The flexible package includes two areas of weakness defining two removable top portions. Removal of the first top portion exposes an opening in the flexible package allowing egress of the product through a first opening. Removal of the second top portion exposes a second opening in the flexible package, which, by one approach, is larger than the first opening and thereby permits increased access to the food product. | 07-01-2010 |
Michael A. Gruskin, West Bloomfield, MI US
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20080250013 | System, Method And Computer Program Product For Electronically Responding To Requests For Product Related Data - A method for electronically responding to requests for product related data, the method includes: collecting product related data from feeder systems; organizing the collected product related data into digital libraries within a document management system; receiving a discovery request from legal counsel to identify related documents; searching the product related data for documents; tagging documents identified in the search and placing copies of the documents in a holding queue; and importing the documents in the holding queue to a litigation support system. | 10-09-2008 |