Patent application number | Description | Published |
20100037890 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF - Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described. | 02-18-2010 |
20100040560 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF - Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described. | 02-18-2010 |
20100087386 | TOPICAL USE OF LEVOFLOXACIN FOR REDUCING LUNG INFLAMMATION - The present invention relates to methods and compositions for the treatment of pulmonary inflammation. In particular, methods and compositions using aerosol levofloxacin or ofloxacin to reduce pulmonary inflammation are provided. | 04-08-2010 |
20100087416 | AEROSOL FLUOROQUINOLONE FORMULATIONS FOR IMPROVED PHARMACOKINETICS - The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to the use of aerosolized fluoroquinolones formulated with divalent or trivalent cations and having improved pulmonary availability for the treatment and management of bacterial infections of the lung and upper respiratory tract. | 04-08-2010 |
20100158957 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF - Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described. | 06-24-2010 |
20100166673 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF - Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described. | 07-01-2010 |
20120040932 | CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF - Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents. | 02-16-2012 |
20120213707 | Riboflavin Based Aerosol and Use as Placebo in Trials - A method for evaluating an aerosolized test compound includes administering a test compound to a first population of individuals, via inhalation of an aerosol; administering a placebo comprising riboflavin 5′-phosphate to a second population of individuals, via inhalation of an aerosol; and comparing a biological marker for the individuals in the two populations. An aerosol comprising riboflavin 5′-phosphate (also known as flavin mononucleotide) may be used either as a placebo in clinical trials, or therapeutically. | 08-23-2012 |
20120237564 | Use of Aerosolized Antibiotics for Treating Chronic Obstructive Pulmonary Disease - The present invention relates to methods and compositions for treating obstructive pulmonary disorders. In particular, compositions and methods described herein relate to the use of an aerosolized antibiotic for treating obstructive pulmonary disorders including chronic obstructive pulmonary disorder (COPD) and chronic bronchitis (CB). | 09-20-2012 |
20120276153 | USE OF AEROSOLIZED LEVOFLOXACIN FOR TREATING CYSTIC FIBROSIS - Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising | 11-01-2012 |
20130331355 | CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF - Method of treating or ameliorating a bacterial infection comprising administering a composition comprising a cyclic boronic acid ester compound in combination with a carbapenem antibacterial agent such as Biapenem, and the pharmacokinetics studies thereof are provided. | 12-12-2013 |
20130345172 | CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF - Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents. | 12-26-2013 |
20140066441 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF - Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described. | 03-06-2014 |
20140105985 | TOPICAL USE OF LEVOFLOXACIN FOR REDUCING LUNG INFLAMMATION - The present invention relates to methods and compositions for the treatment of pulmonary inflammation. In particular, methods and compositions using aerosol levofloxacin or ofloxacin to reduce pulmonary inflammation are provided. | 04-17-2014 |
20140194393 | TETRACYCLINE COMPOSITIONS - The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation. | 07-10-2014 |
20140329810 | AEROSOL FLUOROQUINOLONE FORMULATIONS FOR IMPROVED PHARMACOKINETICS - The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to the use of aerosolized fluoroquinolones formulated with divalent or trivalent cations and having improved pulmonary availability for the treatment and management of bacterial infections of the lung and upper respiratory tract. | 11-06-2014 |
20150094282 | TETRACYCLINE COMPOSITIONS - The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation. | 04-02-2015 |
Patent application number | Description | Published |
20110040350 | FSK telemetry for cochlear implant - An apparatus for stimulating a sensory organ includes an external portion and an internal portion. The external portion is configured for wireless transmission of an FSK signal having encoded therein information indicative of sensory stimuli. The internal portion, which is in data communication with the external portion, is configured for wireless reception of the FSK signal and for causing stimulation of the sensory organ in response to the information encoded in the FSK signal. | 02-17-2011 |
20110224789 | COCHLEAR IMPLANT SYSTEMS INCLUDING MAGNETIC FLUX REDIRECTION MEANS - Cochlear implant systems include a circuit board having electronic circuitry configured to generate one or more signals configured to direct electrical stimulation of one or more stimulation sites within a patient, an induction coil configured to transmit a telemetry signal by generating a telemetry magnetic field, and a telemetry flux guide positioned between the induction coil and the circuit board. The telemetry flux guide is configured to direct magnetic flux of the telemetry magnetic field away from the circuit board. | 09-15-2011 |
20140233775 | MODULAR ADAPTER ASSEMBLY FOR TELECOIL AND AUXILIARY AUDIO INPUT DEVICE MIXING - An exemplary apparatus for use with an auditory prosthesis system includes a housing, a connector port disposed at least partially within the housing and configured to be communicatively coupled to an auxiliary audio input device, a telecoil disposed at least partially within the housing, and a multi-position switch disposed at least partially within the housing and configured to selectively enable the auxiliary audio input device and the telecoil. The auxiliary audio input device is enabled and the telecoil is disabled when the switch is in a first position, both the auxiliary audio input device and the telecoil are enabled when the switch is in a second position, and the telecoil is enabled and the auxiliary audio input device is disabled when the switch is in a third position. Corresponding apparatuses, systems, and methods are also disclosed. | 08-21-2014 |
20150028798 | HIGH EFFICIENCY MAGNETIC LINK FOR IMPLANTABLE DEVICES - Systems and devices for a high-efficiency magnetic link for implantable devices are disclosed herein. These devices can include a charging coil located in the implantable device and a charging coil located in a charge head of a charger. The charging coils can each include an elongate core and wire windings wrapped around a longitudinal axis of the elongate core. The charging coil of the charge head can be attached to a rotatable mount, which can be used to align the longitudinal axis of the charging coil of the charge head with longitudinal axis of the implantable device such that the axes of the charging coils are parallel. | 01-29-2015 |
20150045855 | COCHLEAR IMPLANT SYSTEMS INCLUDING MAGNETIC FLUX REDIRECTION MEANS - An exemplary cochlear implant system includes a component that houses a circuit board comprising electronic circuitry that generates one or more signals, an induction coil that transmits the one or more signals by generating a telemetry magnetic field, and a telemetry flux guide positioned between and in direct contact with a top surface of the induction coil and a bottom surface of the circuit board. | 02-12-2015 |
20150127069 | HIGH EFFICIENCY MAGNETIC LINK FOR IMPLANTABLE DEVICES - Systems and devices for a high-efficiency magnetic link for implantable devices are disclosed herein. These devices can include a charging coil located in the implantable device and a charging coil located in a charge head of a charger. The charging coils can each include an elongate core and wire windings wrapped around a longitudinal axis of the elongate core. The charging coil of the charge head can be attached to a rotatable mount, which can be used to align the longitudinal axis of the charging coil of the charge head with longitudinal axis of the implantable device such that the axes of the charging coils are parallel. | 05-07-2015 |
20160036244 | WIRELESS POWER TRANSFER AND COMMUNICATIONS - An inductive wireless power transfer and communication system includes an electrostatic shield for one of the coils. The electrostatic shield is inductively coupled with the coil and is configured as an open circuit. A signal processing element or elements, especially a modulator or a demodulator, are connected across the electrical discontinuity in the electrostatic shield. Because the electrostatic shield is inductively coupled to the coil, the modulator or demodulator can operate on the signal on the coil. | 02-04-2016 |
Patent application number | Description | Published |
20110306542 | NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS - Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided. | 12-15-2011 |
20120288913 | NOVEL FUSION PARTNERS FOR THE PURPOSE OF CRYSTALLIZING G-PROTEIN COUPLED RECEPTORS - GPCR-fusion partner proteins comprising G protein coupled receptors (GPCRs) of GPCRs and fusion partners such as rubredoxin, cytochrome b562 RIL (Bril, bRIL, BRIL), T4 lysozyme C-terminal fragment (Cterm-T4L), flavodoxin, or xylanase either substituted for some or all of the third intracellular loop of the GPCR between the fifth and sixth helix of the GPCR are described or attached to an terminus or C terminus of the GPCR. GPCR-fusion partner proteins in crystalline form, optionally of a quality suitable for x-ray crystallographic structure determination of the GPCR, are described. Methods of using fusion partners in GPCR-fusion partner proteins to support crystallization of GPCR-fusion partner proteins for x-ray crystallographic structure determination of the GPCR, are described. Methods of identifying other suitable fusion partners through screening of protein data banks are also described. | 11-15-2012 |
20140031290 | NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS - Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided. | 01-30-2014 |
Patent application number | Description | Published |
20090203077 | METHOD OF PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT METHODS - Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked to a promoter, wherein the promoter is characterized by the ability to produce commercially viable Factor VIII protein; and incubating the cell under conditions for producing commercially viable Factor VIII protein. Also provided are nucleic acid molecules which encode a Factor VIII protein operably linked to a Chinese hamster elongation factor 1-α (CHEF1) promoter, which may be used in the methods provided herein. | 08-13-2009 |
20110039302 | Method of Producing Factor VIII Proteins by Recombinant Methods - Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked to a promoter, wherein the promoter is characterized by the ability to produce commercially viable Factor VIII protein; and incubating the cell under conditions for producing commercially viable Factor VIII protein. Also provided are nucleic acid molecules which encode a Factor VIII protein operably linked to a Chinese hamster elongation factor 1-α (CHEF1) promoter, which may be used in the methods provided herein. | 02-17-2011 |
20120028900 | METHOD OF PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT METHODS - Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked to a promoter, wherein the promoter is characterized by the ability to produce commercially viable Factor VIII protein; and incubating the cell under conditions for producing commercially viable Factor VIII protein. Also provided are nucleic acid molecules which encode a Factor VIII protein operably linked to a Chinese hamster elongation factor 1-α (CHEF1) promoter, which may be used in the methods provided herein. | 02-02-2012 |
20140357565 | METHOD OF PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT METHODS - Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked to a promoter, wherein the promoter is characterized by the ability to produce commercially viable Factor VIII protein; and incubating the cell under conditions for producing commercially viable Factor VIII protein. Also provided are nucleic acid molecules which encode a Factor VIII protein operably linked to a Chinese hamster elongation factor 1-a (CHEF1) promoter, which may be used in the methods provided herein. | 12-04-2014 |
Patent application number | Description | Published |
20100081187 | RECOMBINANT VITAMIN K DEPENDENT PROTEINS WITH HIGH SIALIC ACID CONTENT AND METHODS OF PREPARING SAME - Methods of isolating highly sialylated recombinant vitamin K dependent proteins, particularly Factor IX, by chromatographic methods are described. The highly sialylated recombinant proteins are characterized. The improved Factor IX has at least 62% N-glycosylation with 3 or 4 sialic acid residues and improved bioavailability and pharmokinetic properties. | 04-01-2010 |
20100316625 | STABILIZED FACTOR IX FORMULATIONS CONTAINING TREHALOSE - Methods of preparing lyophilized preparations of Factor IX which preserve more than 90% of the calcium binding property of Factor IX are disclosed. Factor IX formulated with trehalose shows a superior stability profile after 12 weeks storage at 25° C./60% relative humidity (RH) and 40° C./75% RH relative to Factor IX formulated without trehalose. The data suggest that the inclusion of trehalose in the formulation could allow for temperature excursions or even long-term room temperature storage of a Factor IX lyophilized product. The formulations tested contained 10 mM histidine pH 6.8, 3% mannitol, 66 mM sodium chloride, 0.0075% Polysorbate 80, with and without 1% trehalose. Upon storage at 40° C./75% RH or 25° C./60% RH over 12 weeks the trehalose-containing formulation was comparable to product stored at 2-8° C. while the formulation without trehalose was found to undergo significant aggregation and loss of activity. The two formulations demonstrated comparable stability over 26 weeks of real time storage at −20° C. and 2-8° C. | 12-16-2010 |
20120276079 | METHOD OF PRODUCING RECOMBINANT VITAMIN K DEPENDENT PROTEINS - Methods for producing cell lines with high levels of biologically active recombinant vitamin K dependent proteins are described. The transfected cell lines do not include heterologous genes for processing enzymes and are not subject to selection pressure such as methotrexate resistance. Cell lines producing Factor VII/VIIa and Factor IX are described. These cell lines can be used for isolation of Factor VII/VIIa and/or Factor IX for treatment of Hemophilia. | 11-01-2012 |
20130266982 | METHOD OF PRODUCING BIOLOGICALLY ACTIVE VITAMIN K DEPENDENT PROTEINS BY RECOMBINANT METHODS - The invention relates to commercially viable methods for producing biologically active vitamin K dependent proteins, particularly Factor IX. Factor IX is produced at a level of at least about 15 mg/L and is at least 25% biologically active. The method relies upon co-expression of one or more of paired basic amino acid converting enzyme (PACE), vitamin K dependent epoxide reductase (VKOR) and vitamin K dependent γ-glutamyl carboxylase (VKGC) at a preferred ratio so that the vitamin K dependent protein is efficiently produced and processed by a recombinant cell. | 10-10-2013 |
20140369994 | METHOD OF PRODUCING RECOMBINANT VITAMIN K DEPENDENT PROTEINS - Methods for producing cell lines with high levels of biologically active recombinant vitamin K dependent proteins are described. The transfected cell lines do not include heterologous genes for processing enzymes and are not subject to selection pressure such as methotrexate resistance. Cell lines producing Factor VII/VIIa and Factor IX are described. These cell lines can be used for isolation of Factor VII/VIIa and/or Factor IX for treatment of Hemophilia. | 12-18-2014 |
20160108449 | METHOD OF PRODUCING BIOLOGICALLY ACTIVE VITAMIN K DEPENDENT PROTEINS BY RECOMBINANT METHODS - The invention relates to commercially viable methods for producing biologically active vitamin K dependent proteins, particularly Factor IX. Factor IX is produced at a level of at least about 15 mg/L and is at least 25% biologically active. The method relies upon co-expression of one or more of paired basic amino acid converting enzyme (PACE), vitamin K dependent epoxide reductase (VKOR) and vitamin K dependent γ-glutamyl carboxylase (VKGC) at a preferred ratio so that the vitamin K dependent protein is efficiently produced and processed by a recombinant cell. | 04-21-2016 |
Patent application number | Description | Published |
20160114174 | IMPLANTABLE HEAD LOCATED RADIOFREQUENCY COUPLED NEUROSTIMULATION SYSTEM FOR HEAD PAIN - An implantable head-mounted, radiofrequency (RF) coupled, unibody peripheral neurostimulation system is provided for implantation in the head for the purpose of treating chronic head pain, including migraine. The system may include an implantable pulse generator (IPG) from which multiple stimulating leads may extend sufficient to allow for adequate stimulation over multiple regions of the head, preferably including the frontal, parietal and occipital regions. A lead may include an extended body, along which may be disposed a plurality of surface metal electrodes (SME), which may be subdivided into a plurality of electrode arrays. A plurality of internal metal wires may run a portion of its length and connect the IPG's internal circuit to the SME. The IPG may include an RF receiver coil and an application specific integrated circuit. The IPG may be capable of functional connection to an external RF unit for purposes that may include power, diagnostics, and programming. | 04-28-2016 |
20160114175 | IMPLANTABLE HEAD LOCATED RADIOFREQUENCY COUPLED NEUROSTIMULATION SYSTEM FOR HEAD PAIN - A method is provided for controlling power delivery from an external power transfer system (EPTS) to at least one implantable neurostimulator system (INS). The method comprises driving a first transmit coil within the EPTS using a transmit coil driver circuit, receiving, using a receive coil, power transferred from the first transmit coil, coupling the received power to a regulator circuit, monitoring the regulator circuit, communicating a message to the EPTS using a back telemetry circuit, receiving the message, and adjusting the transmit coil driver circuit. | 04-28-2016 |
20160114177 | IMPLANTABLE HEAD LOCATED RADIOFREQUENCY COUPLED NEUROSTIMULATION SYSTEM FOR HEAD PAIN - A system is provided for driving an implantable neurostimulator lead, the lead having an associated plurality of electrodes disposed in at least one array on the lead. The system comprises an implantable pulse generator (IPG), the IPG including an electrode driver, a load system for determining load requirements, an IPG power coupler, and an IPG communication system. The system also includes an external unit, which includes an external variable power generator, an external power coupler, an external communication system, and a controller for varying the power level of the variable power generator. | 04-28-2016 |
Patent application number | Description | Published |
20080319497 | Architectures for an Implantable Medical Device System - An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicate with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG without the need for a major redesign of the main IPG IC. | 12-25-2008 |
20110015705 | Architectures for an Implantable Medical Device System - An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicate with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG without the need for a major redesign of the main IPG IC. | 01-20-2011 |
20120095529 | Architectures for an Implantable Medical Device System Having Daisy-Chained Electrode-Driver Integrated Circuits - Architectures for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. A parallel bus operating in accordance with a communication protocol couples the ICs, and certain functional blocks not needed in the slave are disabled. Stimulation parameters are loaded via the bus into each IC, and a stimulation enable command is issued on the bus to ensure simultaneous stimulation from the electrodes on both ICs. Clocking strategies are also disclosed to allow clocking of the master and slave ICs to be independently controlled, and to ensure that relevant internal and bus clocks used in the system are synchronized. | 04-19-2012 |
20130184794 | Architectures for an Implantable Stimulator Device Having a Plurality of Electrode Driver Integrated Circuits with Shorted Electrode Outputs - Disclosed is a new architecture for an IPG having a master and slave electrode driver integrated circuits. The electrode outputs on the integrated circuits are wired together. Each integrated circuit can be programmed to provide pulses with different frequencies. Active timing channels in each of the master and slave integrated circuits are programmed to provide the desired pulses, while shadow timing channels in the master and slave are programmed with the timing data from the active timing channels in the other integrated circuit so that each chip knows when the other is providing a pulse, so that each chip can disable its recovery circuitry so as not to defeat those pulses. In the event of pulse overlap at a given electrode, the currents provided by each chip will add at the affected electrode. Compliance voltage generation is dictated by an algorithm to find an optimal compliance voltage even during periods when pulses are overlapping. | 07-18-2013 |
20130289661 | Timing Channel Circuitry for Creating Pulses in an Implantable Stimulator Device - Timing channel circuitry for controlling stimulation circuitry in an implantable stimulator is disclosed. The timing channel circuitry comprises a addressable memory. Data for the various phases of a desired pulse are stored in the memory using different numbers of words, including a command indicative of the number of words in the phase, a next address for the next phase stored in the memory, and a pulse width or duration of the current phase, control data for the stimulation circuitry, pulse amplitude, and electrode data. The command data is used to address through the words in the current phase via the address bus, which words are sent to a control register for the stimulation circuitry. After the duration of the pulse width for the current phase has passed, the stored next address is used to access the data for the next phase stored in the memory. | 10-31-2013 |
20140107752 | Current Generation Architecture for an Implantable Stimulator Device Having Coarse and Fine Current Control - A current generation architecture for an implantable stimulator device such as an Implantable Pulse Generator (IPG) is disclosed. Current source and sink circuitry are both divided into coarse and fine portions, which respectively can provide coarse and fine current resolutions to a specified electrode on the IPG. The coarse portion is distributed across all of the electrodes and so can source or sink current to any of the electrodes. The coarse portion is divided into a plurality of stages, each of which is capable via an associated switch bank of sourcing or sinking a coarse amount of current to or from any one of the electrodes on the device. The fine portion of the current generation circuit preferably includes source and sink circuitry dedicated to each of the electrode on the device, which can comprise digital-to-analog current converters (DACs). | 04-17-2014 |
20140194947 | Current Generation Architecture for an Implantable Stimulator Device Having Coarse and Fine Current Control - Disclosed herein are current output architectures for implantable stimulator devices. Current source and sink circuitry is divided into a plurality of stages, each of which is capable via an associated switch bank of sourcing or sinking an amount of current to or from any one of the electrodes of the device. The current source circuitry is distinct from the current sink circuitry, and the two share no common circuit nodes prior to connection to the electrodes. In other words, the current source circuitry and the current sink circuitry do not share a common node other than the electrodes. Each stage is preferably formed of a current mirror for receiving a reference current and outputting a scaled version of current to that stage's switch bank. The scalar at each stage can be set by wiring a desired number of output transistors in parallel. | 07-10-2014 |
20150174419 | Timing Channel Circuitry for Creating Pulses in an Implantable Stimulator Device - Timing channel circuitry for controlling stimulation circuitry in an implantable stimulator is disclosed. The timing channel circuitry comprises a addressable memory. Data for the various phases of a desired pulse are stored in the memory using different numbers of words, including a command indicative of the number of words in the phase, a next address for the next phase stored in the memory, and a pulse width or duration of the current phase, control data for the stimulation circuitry, pulse amplitude, and electrode data. The command data is used to address through the words in the current phase via the address bus, which words are sent to a control register for the stimulation circuitry. After the duration of the pulse width for the current phase has passed, the stored next address is used to access the data for the next phase stored in the memory. | 06-25-2015 |
20160082260 | Architectures for an Implantable Medical Device System - An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicates with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG. | 03-24-2016 |
Patent application number | Description | Published |
20100036832 | SEARCHING BY OBJECT CATEGORY FOR ONLINE COLLABORATION PLATFORM - In an example embodiment, an online advertising management platform receives a login that identifies a user as a user allowed access to an account maintained by the platform. The platform displays a toolbar having a textbox that allows the user to search for data relating to all accounts to which the user has access. The platform displays a first page of initial search results after the user enters an initial search term in the textbox and launches a search. The first page includes a list of data objects relevant to the initial search term grouped by object category and a list box that allows the user to select an object category. The platform displays a second page after the user selects an object category from the list box. The second page includes an entry box that is related to the selected object category and that facilitates subsequent search. | 02-11-2010 |
20100037163 | FACILITATED SEARCH FOR ONLINE COLLABORATION PLATFORM - In an example embodiment, an online advertising management platform receives a login that identifies a user as a user allowed access to an account maintained by the platform. The platform displays a toolbar having a textbox that allows the user to search for data relating to all accounts to which the user has access. The platform displays a combo box after the user enters a fixed number of characters in the textbox. The combo box includes a list of descriptions of each data object that is accessible and that is relevant to the fixed number of characters. The platform locates the combo box contiguous to the toolbar over some but not all of the view displaying the data relating to the order. The platform displays a data object, rather than a page of search results, after the user clicks a description of a data object from the combo box. | 02-11-2010 |
20100037171 | UTILITY TOOLBAR FOR ONLINE COLLABORATION PLATFORM - In an example embodiment, an online advertising management platform maintains an account that includes data relating to an order for advertising provided by an ad network affiliated with the platform. When the platform receives a login that identifies a user as having access rights to the account, the platform displays a view that includes a window displaying data relating to the order and a toolbar in a standardized location relative to the window. The toolbar includes a tab that displays a count of each informational message (e.g., alert or tip) which relates to the displayed data and which has not been dismissed by the current user. When the user clicks on the tab, the platform displays a tabbed window that includes a list of the informational messages, regardless of whether an informational message on the list has been read or dismissed by another user allowed access to the account. | 02-11-2010 |
20100037172 | NOTIFICATION CONTROLS FOR ONLINE COLLABORATION PLATFORM - In an example embodiment, an online advertising management platform maintains an account that includes data relating to an order for advertising provided by an ad network affiliated with the platform. When the platform receives a login that identifies a user as having access rights to the account, the platform displays a view that includes a window displaying data relating to the order and a toolbar in a standardized location relative to the window. The toolbar includes a tab that displays a count of each informational message (e.g., alert or tip) which relates to the displayed data and which has not been dismissed by the current user. When the user clicks on the tab, the platform displays a tabbed window that includes a list of the informational messages, regardless of whether an informational message on the list has been read or dismissed by another user allowed access to the account. | 02-11-2010 |
20100037305 | WINDOW OVERLAY FOR ONLINE COLLABORATION PLATFORM - In an example embodiment, an online advertising management platform maintains an account that includes data relating to an order for advertising provided by an ad network affiliated with the platform. When the platform receives a login that identifies a user as having access rights to the account, the platform displays a view that includes a window displaying data relating to the order and a toolbar in a standardized location relative to the window. The toolbar includes a tab. When the user clicks on the tab, the platform displays a tabbed window that includes a list of the informational messages, regardless of whether an informational message on the list has been read or dismissed by another user allowed access to the account. The platform locates the window contiguous to the toolbar over some but not all of the view displaying the data relating to the order. | 02-11-2010 |
Patent application number | Description | Published |
20090048189 | TRICYCLIC-NUCLEOSIDE COMPOUNDS FOR TREATING VIRAL INFECTIONS - Disclosed are tricyclic nucleoside compounds of formula (I), and methods thereof for treating viral infections mediated at least in part by a Flaviviridae family virus. | 02-19-2009 |
20090062223 | AMINO TRICYCLIC-NUCLEOSIDE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE - Provided are compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions are useful for treating viral infections caused by the Flaviviridae family of viruses. | 03-05-2009 |
20090081165 | BICYCLIC HETEROARYL DERIVATIVES - Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections. | 03-26-2009 |
20090197856 | ANTIVIRAL COMPOUNDS - Provided are compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions are useful for treating viral infections caused by the Flaviviridae family of viruses. | 08-06-2009 |
20090253648 | Tricyclic-Nucleoside Compounds for Treating Viral Infections - Disclosed are compounds represented by formulae I, II, and III, and the compositions and methods thereof for treating viral infections caused by a Flaviviridae family virus. | 10-08-2009 |
20100004441 | N-(5-Membered Aromatic Ring)-Amido Anti-Viral Compounds - Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R | 01-07-2010 |
Patent application number | Description | Published |
20090033098 | Controlling power extraction for wind power generation - A power generation system is disclosed. The power generation system comprises a kite connected to a line. The line is alternatively let out during a traction phase and recovered during a recovery phase. A power extractor connected to the line to extract power during the traction phase. And, a power extraction controller configured to target a preferred traction phase line velocity and a preferred recovery phase line velocity. | 02-05-2009 |
20090072092 | Bimodal kite system - A kite is disclosed. The kite comprises a first control element coupled to the kite in a first tether-force configuration, wherein the first control element is used to maintain controlled flight of the kite in the first tether-force configuration during a power generating phase. The kite further comprises a second control element coupled to the kite in a second tether-force configuration, wherein the second control element is used to maintain controlled flight of the kite in the second tether-force configuration during a recovery phase, and wherein during the recovery phase a tether force associated with the second tether-force configuration is reduced as compared to the tether force associated with the first tether-force configuration during the power generating phase | 03-19-2009 |
20090289148 | Faired tether for wind power generation systems - A tether for a kite wind power system is disclosed. The tether has a cross-section that is designed to have less aerodynamic drag than a tether with a circular-shaped cross-section. | 11-26-2009 |
20120158369 | SURFACING ALGORITHM FOR DESIGNING AND MANUFACTURING 3D MODELS - Techniques are described for decomposing three-dimensional (3D) geometry into an assemblable collection of two-dimensional (2D) panels. Importantly, the 3D geometry is automatically encoded into the 2D panels, allowing the 3D geometry to be recreated simply by joining the 2D panels at the appropriate seams and creating the appropriate bends/folds in each panel. Further, each panel has edges, vertices, and faces which can be encoded in the panelization, allowing assembly instructions to be algorithmically generated, Doing so allows users to be provided with a step-by-step instructions carried out to realize the 3D geometry encoded in the 2D panels. | 06-21-2012 |
20130191083 | TECHNIQUES FOR CREATING POP-UP CARDS FROM 3D MODELS - One embodiment of the invention is a pop-up engine that generates a pop-up card from a sliced 3D graphics model. In operation, the pop-up engine processes a sliced 3D model to identify locations where the sliced 3D model is to attach to a plane surface of a pop-up card. For a given set of slices associated with a sliced 3D model, the pop-up engine identifies at least two slices that intersect at a folding line of the plane surface. The pop-up engine then identifies locations on the slices that are the farthest from the folding line. The pop-up engine marks the identified locations as connection points, where the 3D model is to attach to the plane surface. | 07-25-2013 |
20130197872 | TECHNIQUES FOR CREATING POP-UP CARDS FROM 3D MODELS - One embodiment of the invention is a pop-up engine that generates a pop-up card from a sliced 3D graphics model. In operation, a pop-up engine processes a sliced 3D model to identify locations where each slice of the 3D model is to attach to the pop-up card or to other slices of the 3D model. The pop-up engine traverses the boundary of each slice and, at intervals along the boundary, projects a ray toward the upper portion of the card. If the ray intersects a neighboring slice, then the slice attaches to the neighboring slice at that location. If, however, the ray does not intersect a neighboring slice, then the slice attaches to the upper portion of the card at that location. The pop-up engine then modifies the slice to include a hinge portion that connects the slice to either a neighboring slice or the upper portion at that location. | 08-01-2013 |
20130297058 | DECOMPOSITION OF 3D GEOMETRY INTO DEVELOPABLE SURFACE PATCHES AND 2D CUT PATTERNS - Embodiments disclosed herein provide techniques for decomposing 3D geometry into developable surface patches and cut patterns. In one embodiment, a decomposition application receives a triangulated 3D surface as input and determines approximately developable surface patches from the 3D surface using a variant of k-means clustering. Such approximately developable surface patches may have undesirable jagged boundaries, which the decomposition application may eliminate by generating a data structure separate from the mesh that contains patch boundaries and optimizing the patch boundaries or, alternatively, remeshing the mesh such that patch boundaries fall on mesh edges. The decomposition application may then flatten the patches into truly developable surfaces by re-triangulating the patches as ruled surfaces. The decomposition application may further flatten the ruled surfaces into 2D shapes and lay those shapes out on virtual sheets of material. A person, or machinery, may cut out those shapes from physical sheets of material based on the layout. | 11-07-2013 |
20130299503 | CONFORMABLE NATURAL GAS STORAGE - A system for storing natural gas comprises a plurality of straight sections of tube. The plurality of straight sections of tube are dense packed. The plurality of straight sections of tube are configured to fill a designated volume. | 11-14-2013 |
20140081603 | NESTING USING RIGID BODY SIMULATION - Embodiments of the invention provide systems and methods for nesting objects in 2D sheets and 3D volumes. In one embodiment, a nesting application simplifies the shapes of parts and performs a rigid body simulation of the parts dropping into a 2D sheet or 3D volume. In the rigid body simulation, parts begin from random initial positions on one or more sides and drop under the force of gravity into the 2D sheet or 3D volume until coming into contact with another part, a boundary, or the origin of the gravity. The parts may be dropped according to a particular order, such as alternating large and small parts. Further, the simulation may be translation- and/or position-only, meaning the parts do not rotate and/or do not have momentum, respectively. Tighter packing may be achieved by incorporating user inputs and simulating jittering of the parts using random forces. | 03-20-2014 |
20140194174 | 3D PUZZLE GENERATION, ALGORITHMS FOR GENERATION, AND PHYSICAL INSTANTIATIONS - A system for generating a three-dimensional puzzle comprises a processor and a memory. The processor is configured to generate a three dimensional mesh representation. The processor is further configured to convert polygons comprising the three-dimensional mesh representation to one or more puzzle piece representations. The processor is further configured to add attachment points and receiving points to the one or more puzzle piece representations. The processor is further configured to provide the one of more puzzle piece representations with attachment points and receiving points. The memory is coupled to the processor and configured, to provide the processor with instructions. | 07-10-2014 |
20140253549 | TECHNIQUES FOR SLICING A 3D MODEL FOR MANUFACTURING - One embodiment of the invention is a slicing engine that generates two or more slices of a virtual 3D model given a slice plane. The slicing engine then determines connection points on each of the slices that indicate how the 3D model is to be reconnected by the user when the 3D model is fabricated. The slicing engine also determines an optimized layout for the various slices of the 3D model on fabrication material for minimal use of the material. The user is then able to “print” the layout on the fabrication material via 3D printers, and connect the various printed slices according to the connection points to build a physical representation of the 3D model. | 09-11-2014 |
20140253550 | TECHNIQUES FOR SLICING A 3D MODEL FOR MANUFACTURING - One embodiment of the invention is a slicing engine that generates two or more slices of a virtual 3D model given a slice plane. The slicing engine then determines connection points on each of the slices that indicate how the 3D model is to be reconnected by the user when the 3D model is fabricated. The slicing engine also determines an optimized layout for the various slices of the 3D model on fabrication material for minimal use of the material. The user is then able to “print” the layout on the fabrication material via 3D printers, and connect the various printed slices according to the connection points to build a physical representation of the 3D model. | 09-11-2014 |
20140257547 | TECHNIQUES FOR SLICING A 3D MODEL FOR MANUFACTURING - One embodiment of the invention is a slicing engine that generates two or more slices of a virtual 3D model given a slice plane. The slicing engine then determines connection points on each of the slices that indicate how the 3D model is to be reconnected by the user when the 3D model is fabricated. The slicing engine also determines an optimized layout for the various slices of the 3D model on fabrication material for minimal use of the material. The user is then able to “print” the layout on the fabrication material via 3D printers, and connect the various printed slices according to the connection points to build a physical representation of the 3D model. | 09-11-2014 |
20140257548 | TECHNIQUES FOR SLICING A 3D MODEL FOR MANUFACTURING - One embodiment of the invention is a slicing engine that generates two or more slices of a virtual 3D model given a slice plane. The slicing engine then determines connection points on each of the slices that indicate how the 3D model is to be reconnected by the user when the 3D model is fabricated. The slicing engine also determines an optimized layout for the various slices of the 3D model on fabrication material for minimal use of the material. The user is then able to “print” the layout on the fabrication material via 3D printers, and connect the various printed slices according to the connection points to build a physical representation of the 3D model. | 09-11-2014 |
20140305951 | NATURAL GAS INTESTINE PACKED STORAGE TANK - A high-pressure pressure vessel for storing natural gas comprises a plurality of first vessel regions of first diameters, a plurality of couplers, and a fiber layer. A three dimensional volume is filled using at least in part the plurality of first vessel regions. Each coupler of the plurality of couplers couples each pair of first vessel regions of the plurality of first vessel regions. Each coupler of the plurality of couplers comprises a second vessel region of a second diameter and two third vessel regions that transition diameters between the first diameter and the second diameter. The three dimensional volume is filled using at least in part the plurality of couplers. The first vessel regions and the couplers comprise a material with low permeability to natural gas. The fiber layer surrounds the plurality of first vessel regions and the plurality of couplers. | 10-16-2014 |
20150285238 | DIAPHRAGM COMPRESSOR SYSTEM AND METHOD - A roll-diaphragm compressor and a roll-diaphragm compressors system, including methods for manufacturing and using same. The roll-diaphragm compressor includes a compressor body having a concave portion that defines a rounded interface wall and an apex portion adjacent to the concave portion that comprises an inlet and outlet port. The roll-diaphragm compressor also includes a flexible roll-diaphragm coupled to the compressor body about a compressor body edge and a compression chamber defined by the concave portion, apex portion and roll-diaphragm. The roll-diaphragm compressor further includes a piston head rigidly coupled to a central portion of the roll-diaphragm and configured to drive the roll-diaphragm to a first configuration where the roll-diaphragm engages the interface wall as part of a compression cycle. | 10-08-2015 |
20150290794 | PNEUMATIC EXOMUSCLE SYSTEM AND METHOD - A pneumatic exomuscle system and methods for manufacturing and using same. The pneumatic exomuscle system includes a pneumatic module; a plurality of pneumatic actuators each operably coupled to the pneumatic module via at least one pneumatic line, a portion of the pneumatic actuators configured to be worn about respective body joints of a user; and a control module operably coupled to the pneumatic module, the control module configured to control the pneumatic module to selectively inflate portions of the pneumatic actuators. | 10-15-2015 |
Patent application number | Description | Published |
20090289714 | OPERATIONAL AMPLIFIER - The present invention relates generally to an operational amplifier. In one embodiment, the present invention is an operational amplifier including a transimpedance input stage, the transimpedance input stage including a first stage connected to a first resistor and a second resistor, and an output stage connected to the transimpedance input stage. | 11-26-2009 |
20110169568 | OPERATIONAL AMPLIFIER - The present invention relates generally to an operational amplifier. In one embodiment, the present invention is an operational amplifier including a transimpedance input stage, the transimpedance input stage including a first stage connected to a first resistor and a second resistor, and an output stage connected to the transimpedance input stage. | 07-14-2011 |
20120293263 | OPERATIONAL AMPLIFIER - An operational amplifier may include a transimpedance input stage. The operational amplifier is capable of self-biasing its input voltage(s) including a first stage, an input source connected to the first stage, an output stage connected to the first stage via feedback resistors, and feedback current sources connected to the first stage, wherein the feedback current sources are set to generate feedback currents flowing from the output stage back to the input stage via the feedback resistors, so as to self-bias the input voltage(s) at the input stage. A method for allowing for an op-amp to self-bias its input voltage(s), including generating feedback currents flowing from the output stage back to the input stage via feedback resistors, so as to self-bias the input voltage(s) at the input stage. | 11-22-2012 |
20130249110 | METHOD AND APPARATUS FOR REDUCED PARASITICS AND IMPROVED MULTI-FINGER TRANSISTOR THERMAL IMPEDANCE - A transistor, a method and an apparatus for forming multiple connections to a transistor for reduced gate (FET/HEMT) or base (BJT/HBT) parasitics, and improved multi-finger transistor thermal impedance. Providing for a method and an apparatus that reduces a transistor's parasitics and reduces a transistor's thermal impedance, resulting in higher device bandwidths and higher output power. More particularly, providing for a method and an apparatus for applying compact, multiple connections to the gate of a FET (or HEMT) or the base of a BJT (or HBT) from many sides resulting in reduced parasitics and improved transistor thermal impedance. | 09-26-2013 |
20140077883 | Cascode Cell Having DC Blocking Capacitor - A cascode gain stage apparatus includes an input transistor having an RF input node and a transistor output node, an output transistor having a transistor input node and an RF output node, and a DC blocking capacitor connected between the transistor input and transistor output nodes. | 03-20-2014 |
20140332853 | METHOD AND APPARATUS FOR REDUCED PARASITICS AND IMPROVED MULTI-FINGER TRANSISTOR THERMAL IMPEDANCE - A transistor, a method and an apparatus for forming multiple connections to a transistor for reduced gate (FET/HEMT) or base (BJT/HBT) parasitics, and improved multi-finger transistor thermal impedance. Providing for a method and an apparatus that reduces a transistor's parasitics and reduces a transistor's thermal impedance, resulting in higher device bandwidths and higher output power. More particularly, providing for a method and an apparatus for applying compact, multiple connections to the gate of a FET (or HEMT) or the base of a BJT (or HBT) from many sides resulting in reduced parasitics and improved transistor thermal impedance. | 11-13-2014 |
20160112014 | Power Amplifier Having Separate Interconnects For DC Bias and RF Matching Networks - An amplifier cell apparatus has an RF input node, a first power transistor in communication with the input node through a first input impedance matching network, a second power transistor in communication with the input node through a second input impedance matching network, and an RF output node in communication with the first and second power transistors through a single output impedance matching network so that two impedance matching networks are disposed on an RF input side of the amplifier cell. | 04-21-2016 |