Graziani
Davide Graziani, Milan IT
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20090042841 | NOVEL HETEROCYCLIC DERIVATIVES AS M-GLU5 ANTAGONISTS - This invention relates to novel heterocyclic compounds having selective affinity for the mGlu5 subtype of metabotropic receptors, pharmaceutical compositions thereof and uses for such compounds and compositions in the treatment of lower urinary tract disorders, such as neuromuscular dysfunction of the lower urinary tract, and in the treatment of migraine and gastroesophagael reflux disease (GERD). | 02-12-2009 |
20100317630 | NOVEL HETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS - The invention is directed to methods of using antagonists selective for the metabotropic mGlu5 receptor to treat conditions of neuromuscular dysfunction of the lower urinary tract in a mammal. Provided are methods of treating a mammal suffering from a condition of neuromuscular dysfunction of the lower urinary tract by administering a selective mGlu5 antagonist. The selective mGlu5 antagonist may be administered alone or in combination with one or more additional therapeutic agents for treating such a condition. Also provided are methods of identifying selective mGlu5 antagonists that are useful for treating neuromuscular dysfunction of the lower urinary tract in a mammal. Methods for treating migraine and gastroesophageal reflux disease (GERD) using selective mGlu5 antagonists are also disclosed. | 12-16-2010 |
20120028931 | HETEROCYCLIC M-GLU5 ANTAGONISTS - Compounds I | 02-02-2012 |
20120059015 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS - The invention is directed to methods of using antagonists selective for the metabotropic mGlu5 receptor to treat conditions of neuromuscular dysfunction of the lower urinary tract in a mammal. Provided are methods of treating a mammal suffering from a condition of neuromuscular dysfunction of the lower urinary tract by administering a selective mGlu5 antagonist. The selective mGlu5 antagonist may be administered alone or in combination with one or more additional therapeutic agents for treating such a condition. Also provided are methods of identifying selective mGlu5 antagonists that are useful for treating neuromuscular dysfunction of the lower urinary tract in a mammal. Methods for treating migraine and gastroesophageal reflux disease (GERD) using selective mGlu5 antagonists are also disclosed. | 03-08-2012 |
Dominic Graziani, Emeryville, CA US
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20110068793 | SOLVATED HYPERPOLARIZED XeNMR AND MRI SIGNAL AMPLIFICATION BY GAS EXTRACTION - The present invention provides a method and apparatus of amplifying the signal of at least one NMR spectrum and of at least one MRI of hyperpolarized xenon. In an embodiment, the invention includes dissolving the hyperpolarized xenon in a liquid via an input membrane, thereby resulting in xenon in liquid phase, encoding information in the longitudinal magnetization of the nuclear spins of the xenon in liquid phase via an encoding coil surrounding an encoding phantom coupled to an output of the input membrane and via an encoding magnet, thereby resulting in encoded xenon, extracting the encoded xenon into the gas phase from the liquid phase via an extraction membrane coupled to an output of the encoding phantom, thereby resulting in encoded xenon in the gas phase, and decoding the encoded information from the encoded xenon in gas phase via a detection coil coupled to an output of the extraction membrane. | 03-24-2011 |
Dominic Michael Graziani, Loudonville, NY US
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20130281822 | IMAGE CORRECTION USING MULTICHANNEL BLIND DECONVOLUTION WITH HOMOMORPHIC FILTERING - A method includes obtaining a plurality of magnetic resonance (MR) coil images of a subject of interest, each MR coil image being generated from one of an array of MR receiving coils; combining the plurality of coil images to generate an image estimate of the subject of interest; performing a multichannel blind deconvolution (MBD) process including: deriving coil sensitivity information for every one of the array of MR receiving coils based on the image estimate or a filtered image estimate derived from the image estimate; updating the image estimate or the filtered image estimate using the derived coil sensitivity information to generate an updated image estimate; and applying a homomorphic filter to the image estimate to derive the filtered image estimate, or to the updated image estimate to derive a filtered updated image estimate, or a combination thereof. | 10-24-2013 |
20140275962 | METHODS AND SYSTEMS USING MAGNETIC RESONANCE AND ULTRASOUND FOR TRACKING ANATOMICAL TARGETS FOR RADIATION THERAPY GUIDANCE - Methods and systems using magnetic resonance and ultrasound for tracking anatomical targets for radiation therapy guidance are provided. One system includes a patient transport configured to move a patient between and into a magnetic resonance (MR) system and a radiation therapy (RT) system and an ultrasound transducer coupled to the patient transport, wherein the ultrasound transducer is configured to acquire four-dimensional (4D) ultrasound images concurrently with one of an MR acquisition or an RT radiation therapy session. The system also includes a controller having a processor configured to use the 4D ultrasound images and MR images from the MR system to control at least one of a photon beam spatial distribution or intensity modulation generated by the RT system. | 09-18-2014 |
20160054410 | SYSTEM AND METHOD FOR LOCATING AND QUANTIFYING A BIOMARKER FOR NEUROLOGICAL DISEASE - In embodiments of the invention, the habenulae have been identified and localized in normal volunteers. Aspects of the invention determine the location, volume and magnetic susceptibility of the habenulae. Furthermore, diagnosing and monitoring patient disorders are enabled using the herein disclosed methodologies and techniques. | 02-25-2016 |
Dominic Michael Graziani, Niskayuna, NY US
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20140159712 | SYSTEMS AND METHODS FOR MAGNETIC MATERIAL IMAGING - Magnetic material imaging (MMI) system including first and second sets of field-generating coils. Each of the field-generating coils of the first and second sets has an elongated segment that extends along an imaging axis of the medical imaging system. The imaging axis extends through a region-of-interest (ROI) of an object. The elongated segments of the first set of field-generating coils are positioned opposite the elongated segments of the second set of field-generating coils and the ROI is located between the first and second sets of field-generating coils. The MMI system also includes a coil-control module configured to control a flow of current through the first and second sets of field-generating coils to generate a selection field and to generate a drive field. The selection and drive fields combine to form a movable 1D field free region (FFR) that extends through the ROI. | 06-12-2014 |
Edmund I. Graziani, Ridgewood, NJ US
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20100022593 | Process for Producing Anticancer Agent LL-D45042 - The disclosure describes the production of anticancer agent LL-D45042, having the structure: | 01-28-2010 |
Edmund Idris Graziani, Chestnut Ridge, NY US
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20090088448 | Rapamycin Derivatives and the Uses Thereof in the Treatment of Neurological Disorders - Provided is a method of treating neurodegenerative disorders comprising administering to a subject in need thereof a compound of formula I: | 04-02-2009 |
20090105294 | Biosynthetic Gene Cluster for the Production of a Complex Polyketide - A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel | 04-23-2009 |
20090203682 | Rapamycin Analogues and the Uses Thereof in the Treatment of Neurological Disorders - Method of treatment of neurological disorders or complications due to stroke or head injury through the administration of a pharmaceutical composition including a pharmaceutically acceptable excipient or carrier and a compound of formula I are provided: | 08-13-2009 |
20090239855 | Rapamycin Analogues and the Uses Thereof in the Treatment of Neurological, Proliferative, and Inflammatory Disorders - The present invention provides for methods of treating neurological disorders or complications due to stroke or head injury; benign or malignant neoplastic disease, carcinomas and adenocarcinomas; proliferative disorders; and inflammatory disorders using compounds of the following structure: | 09-24-2009 |
20100196355 | Immunophilin Ligands and Methods for Modulating Immunophilin and Calcium Channel Activity - Immunophilin ligands and their uses as modulators of calcium channel activity are disclosed. Screening, therapeutic and prophylactic methods for conditions associated with calcium channel dysfunction, e.g., neurodegenerative and cardiovascular disorders, are also disclosed. | 08-05-2010 |
20110144176 | MACROLIDES AND METHODS FOR PRODUCING SAME - This invention relates, in part, to macrolide compounds, actinomycete strains for producing them, and pharmaceutical compositions containing them. | 06-16-2011 |
20130129753 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF - The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer. | 05-23-2013 |
20140363452 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF - The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer. | 12-11-2014 |
20150307551 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF - The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer. | 10-29-2015 |
Enrico Graziani, Bentivoglio (bo) IT
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20160102959 | APPARATUS FOR CHECKING DIMENSIONS AND/OR SHAPE OF A MECHANICAL PART - An apparatus for checking dimensions and/or shape includes one or more feelers ( | 04-14-2016 |
Franco Graziani, Firenze IT
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20080276737 | Crank Gear for a Reciprocating Compressor - Crank gear ( | 11-13-2008 |
Giordano Graziani, Corridonia IT
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20110167679 | SHOE WITH VENTILATION SYSTEM OBTAINED BY DIRECT INJECTION METHOD ON UPPER AND MOULD THEREFOR | 07-14-2011 |
Giordano Graziani, Corridonia (mc) IT
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20120198729 | SHOE WITH VENTILATION SYSTEM - A shoe comprising upper, bottom fixed to the upper, ventilation system and insole disposed above the bottom and obtained by injection molding of polyurethane foam. The ventilation system is integrated inside the insole in such a way not to interfere with the bottom and with an outsole that must be applied under the bottom. | 08-09-2012 |
Giorgio Graziani, Milano IT
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20080312575 | Haemofilters for Blood Detoxification - The present invention regards the use of hemofilters for the removal of bacterial toxins (lipopolysaccharides) from the blood, said hemofilters comprising a solid support to which cyclodextrins are covalently bonded. The solid support can be a fabric or non-woven fabric or a polymeric resin obtained by means of cross-linking of the cyclodextrins with appropriate cross-linking agents, for example epichlorohydrin. | 12-18-2008 |
Giulio Graziani, Ottawa CA
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20090119742 | Methods for authenticating and authorizing a mobile device using tunneled extensible authentication protocol - Methods for authenticating and authorizing a mobile device using tunneled extensible authentication protocol are provided. The methods include evaluating an inner user identifier against a policy engine to determine a home AAA server to route an access request for inner user authentication. Instead of having a static route configured based on an outer identifier/roaming identity, the policy engine can have multiple rules and actions for routing the request. The evaluation can be based on the conditions of the inner user identifier and or other AAA attributes received in the request. The request is transmitted within a secure communication tunnel. There are several embodiments of evaluating an inner user identifier against a policy engine. | 05-07-2009 |
20090249452 | Systems and Methods for Flexible Service Delivery Network Services - A system and method are described that use a subscriber-centric approach to scalably support the delivery of network services across numerous access protocols and across a multitude of access devices. By allowing the use of a service engine that can range in complexity from a simple macro to a rules engine, this approach is suitable for bundled services, as well as single services. | 10-01-2009 |
Jose Graziani, Shrewsbury, MA US
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20150095486 | FACILITATING THE RESOLUTION OF ADDRESS CONFLICTS IN A NETWORKED MEDIA PLAYBACK SYSTEM - Examples are disclosed and described to facilitate resolution of Internet Protocol address conflicts. An example method includes listening, by a first playback device having a first IP address, to a specified server port, receiving, by the first playback device from a second playback device via the specified server port, a message, wherein the message identifies a second IP address, wherein the second IP address has been assigned to the second playback device, determining, by the first playback device, whether the first IP address is the same as the second IP address, and when the first IP address is the same as the second IP address, obtaining, by the first playback device, a new IP address, wherein the new IP address is different from the first IP address and the second IP address. | 04-02-2015 |
Jose Graziani, Santa Barbara, CA US
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20150095470 | Identifying a Useful Wired Connection - Certain examples identify a device's useful wired connection and, when found, facilitate network configuration according to that useful wired connection. An example method includes periodically transmitting, by a first device, a first message over a wireless network interface. The example method includes listening, by the first device, for the first message over a wired network interface. The example method includes, when the first device at least receives the first message over the wired network interface, transmitting, by the first device to at least one additional device over the wireless network interface, a second message, wherein the second message includes an indication, the indication indicating that the at least one additional device can change its network configuration to utilize the wired network interface of the first device. | 04-02-2015 |
Kenneth R. Graziani, Fairfax, VA US
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20150315492 | SYSTEMS AND METHODS FOR IMPROVING LIQUID PRODUCT YIELD OR QUALITY FROM DISTILLATION UNITS - Methods and systems are provided for improving liquid product quality or yield from atmospheric or vacuum distillation unit by subjecting fractionated streams from such distillation units to hydrodynamic cavitation. | 11-05-2015 |
Marcelo Beck Graziani, Campinas BR
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20130277279 | Blends of Polypropylene Polyglycol and Phenolic Glycol Ethers and Method of Foam Control Using Such Blend - A blend comprising from 1 to 99 weight percent one or more polypropylene glycols wherein each polypropylene glycol has a weight average molecular weight of greater than or equal to 1000 grams/mole and from 1 to 99 weight percent one or more dipropylene glycol phenyl ethers and/or diethylene glycol phenyl ethers wherein the blend has a viscosity (ASTM D445, @ 25° C.) of less than or equal to 400 cSt and viscosity (ASTM D445, @ 40° C. of less than or equal to 200 cSt, is provided. Processes using the blend in mining applications are also provided. | 10-24-2013 |
Michael Dominic Graziani, Niskayuna, NY US
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20150073264 | SYSTEMS AND METHODS FOR MAGNETIC MATERIAL IMAGING - Magnetic material imaging (MMI) system including a first array of elongated wire segments that extend substantially parallel to an imaging plane. The imaging plane is configured to extend through a region-of-interest (ROI) of an object. The MMI system also includes a second array of elongated wire segments that extend substantially parallel to the imaging plane. The first and second arrays of wire segments are spaced apart with the imaging plane therebetween. The first and second arrays of wire segments form segment pairs. Each segment pair includes a wire segment of the first array and a wire segment of the second array, wherein the wire segments substantially coincide along a segment plane. The MMI system also includes a phase-control module configured to control a flow of current through the wire segments of the segment pairs to generate and move a one-dimensional field free region (1D FFR) within the imaging plane. | 03-12-2015 |
Paul Graziani, Wayne, PA US
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20140176606 | RECORDING AND VISUALIZING IMAGES USING AUGMENTED IMAGE DATA - A device and method for presenting augmented image data. An image capture device captures an image together with information about the image. Alternatively a data logger may capture additional information about a particular image. The image and additional information is sent to a database where a server analyzes the augmented image and relates the augmented image to other images in the database. A subsequent user may query the database for all images and augmented information for a particular area, location, or object and retrieve that collected information for subsequent analysis. | 06-26-2014 |
Paul Leonard Graziani, Wayne, PA US
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20090021516 | METHOD FOR VISUALIZING DATA CLOUDS USING COLOR AND OPACITY BLENDING - In order to address the challenge associated with the analysis and visualization of large datasets, a method and apparatus provides for visualizing data clouds using color and opacity blending. The information stored within the data cloud is represented using a data container object. The colors and opacities associated with the container object's data point or points is blended to develop two-dimensional computer generated imagery that is unique to the virtual reference point chosen, typically within an OpenGL environment. The result is the ability to understand the sample density of large interactively rendered datasets from different reference points and as the datasets change over time. | 01-22-2009 |
Rodolfo Graziani, Cesena IT
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20130137647 | NATURAL MEDICINAL COMPOUND - This invention refers to the sector of drugs intended for both human and animal use, and it particularly concerns a natural medicinal compound that contains a tannin-based vegetal active ingredient combined with carriers and with a synergic effect, wherein the vegetal active ingredient is natural chestnut extract ( | 05-30-2013 |
Salvatore Graziani, Nicolosi IT
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20100148164 | ALL-ORGANIC SENSOR/ACTUATOR SYSTEM - A sensor and/or actuator system in which functional circuitry is embedded in an all organic electromechanical transducer device is disclosed. The electromechanical transducer device exploits the behavior of a flexible sensible ionomeric material sheet as effective sensing or actuating member sandwiched between flexible organic electrodes when undergoing a deformation or being polarized at a certain drive voltage applied to the, electrodes, respectively. The completely embedded all organic system is realized with a process exploiting relatively low cost deposition and patterning techniques. The enhanced flexibility makes the all organic device suitable for new applications in fields ranging from biomedical to aerospace industry. | 06-17-2010 |
Stephane Graziani, Buc Cedex FR
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20150201893 | MEDICAL IMAGING SYSTEM WITH C-ARM AND PROTECTION COVER SUPPORTED BY TWO DIFFERENT VEHICLES - A medical imaging system comprising a C-arm supporting a radiation source and a radiation detector, an external protection cover of said C-arm, wherein said C-arm and said cover are separable from each other and are respectively supported by two different vehicles when separated from each other. | 07-23-2015 |
Valerio Graziani, Roma IT
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20100218002 | SECURING COMPUTER LOG FILES - A log file is secured. One implementation involves maintaining a log file including one or more log entries in a storage device connected to a computer, and entering a new log entry by generating a new message authentication code based on a preceding log entry including a preceding message authentication code, and applying the message authentication code to the new log entry. | 08-26-2010 |
20110131188 | METHOD AND SYSTEM FOR REAL TIME SYSTEM LOG INTEGRITY PROTECTION - A method and system for managing integrity of system log file data. The system comprises a first component which, using a hook in a kernel of an operating system, allows interception of a write operation by a file system on at least one log file; then the first component detects a change in the security context in which the record is written in the log file. At each change detected, the first component adds information in the log file including the context information. The system further comprises a second component which reads the log file and, using the information added by the first component, detects if the change of context is due to a malicious writing operation in the log file for instance done by an unauthorized user or process. | 06-02-2011 |
Vincent Graziani, Chabons FR
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20160030774 | FULL HOOD RESPIRATOR - A full hood respirator includes a fluidtight flexible bag intended to be slipped over the head of a user, the flexible bag being equipped with a transparent window and comprising, in its lower part, a source of oxygen-enriched gas and connected to an outlet orifice opening into the internal volume of the flexible bag, characterized in that the hood comprises a flexible suspension member arranged inside the flexible bag, the suspension member forming a hat or cap having a surface area smaller than the surface area of the outer flexible bag, at least part of the border of the suspension member is rigidly connected to the flexible bag, the suspension member being intended, when the hood is in the position of use, to rest on the top of the head of the user at a height somewhere between the base and the top of the hood. | 02-04-2016 |
20160030776 | FULL HOOD RESPIRATOR - Full hood respirator comprising a fluidtight flexible bag intended to be slipped over the head of a user, the flexible bag being provided with a transparent window and comprising, in its lower part, a rigid base element of annular overall shape intended to be positioned around the neck of the user, the base element comprising a tubular oxygen reservoir of pressurized oxygen provided with a calibrated outlet orifice opening into the internal volume of the flexible bag, characterized in that the base element comprises at least two rigid parts connected by an articulation, the two parts being movable relative to one another between a furled first position that prevents a head from entering the hood through the base element and an unfurled position of use that allows a head to enter the hood through the base element. | 02-04-2016 |