Patent application number | Description | Published |
20090054387 | Method for preparing 4-[17beta-methoxy-17alpha-methoxymethyl-3-oxestra-4,9-dien-11beta-yl]benz- aldehyde (E)-oxime (asoprisnil) - The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.). | 02-26-2009 |
20110065952 | ARRANGEMENT AND METHOD FOR PRODUCING HIGH-PURITY CRYSTALS - An arrangement and a method for producing high-purity crystals, such as temperature-sensitive pharmaceutical agents, in a countercurrent crystallization process. The arrangement comprises a plurality of crystallizers, mother liquor lines, each of which has a shut-off valve, and crystallization product lines, each of which has a shut-off valve, so that a mother liquor flow can be generated which is directed from a crystallizer to the second-next crystallizer in the direction of decreasing purity, and a crystallization product flow can be generated which is directed from a to dissolved crystallization product that is about to crystallize to the next crystallizer in the direction of higher purity. | 03-17-2011 |
20110144071 | CRYSTALLINE ACTIVE INGREDIENT MICROPARTICLES, METHOD FOR PRODUCING THE SAME AND USE THEREOF IN DRUGS - A method for producing highly crystalline and stable microparticles of an active substance with a very narrow size distribution. The microparticles being crystallized out of a suspension made of primary particles of the active substance, a solution of the active substance, a non-solvent for the active substance and inert formed pieces. The resulting microparticles hare highly stable largely independent of the physiochemical properties of the active substance and can be especially suitable for fast release dosage forms of pharmaceuticals. | 06-16-2011 |
20110257142 | METHOD FOR PREPARING 4-[17BETA-METHOXY-17ALPHA-METHOXYMETHYL-3-OXOESTRA-4,9-DIEN-11-BETA-YL]BE- NZALDEHYDE (E)-OXIME (ASOPRISNIL) - The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.). | 10-20-2011 |
20130040141 | METHOD FOR PRODUCING CRYSTALLINE ACTIVE INGREDIENT PARTICLES - A method and device for producing crystalline active ingredient particles. The active ingredient is crystallized from a supersaturated solution on the surface of particles of the active ingredient. A suspension of active ingredient particles is subjected to wet grinding in a supersaturated solution of the active ingredient in a first module. At least a part of the suspension is fed from the first module into the second module where it is cooled and simultaneously subjected to ultrasound. The suspension is fed back into the first module after cooling and being subjected to ultrasound. Active ingredient solution and optionally antisolvent are added to the suspension and active ingredient particles and liquid phase are extracted. A relative supersaturation of the active ingredient in the liquid phase of the suspension, relative to the entire liquid phase, is ≦90%, and the extracted active ingredient particles comprise a mean particle size of 10-500 μm. | 02-14-2013 |
20130165421 | 4-[17BETA-METHOXY-17ALPHA-METHOXYMETHYL-3-OXOESTRA-4,9-DIEN-11-BETA-YL]BEN- ZALDEHYDE (E)-OXIME (ASOPRISNIL) - The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.). | 06-27-2013 |
Patent application number | Description | Published |
20090090629 | CATHODIC ELECTRODEPOSITION COATING COMPOSITIONS - CED coating compositions which, apart from water, comprise (i) a resin solids content consisting of at least one film-forming, self- or externally cross-linking CED binder and the optional components: cross-linkers, paste resins, nonionic resins, and (ii) optionally, at least one component selected from the group consisting of pigments, fillers, coating additives and organic solvents, and contain relative to the resin solids content thereof, 1 to 20 wt. % of at least one resin A with functional groups selected from the group consisting of hydroxyl groups, free isocyanate groups and blocked isocyanate groups, wherein the at least one resin A is present as particles with melting temperatures from 40 to 200° C. | 04-09-2009 |
20090285992 | Non-Aqueous, Liquid Coating Compositions - Non-aqueous, liquid coating compositions which contain at least one polyurethane resin B with blocked isocyanate groups and at least one binder C with functional groups reactive towards the blocked isocyanate groups of B, wherein the at least one polyurethane resin B is present as particles having a melting temperature of 40 to 160° C. | 11-19-2009 |
20100273933 | POWDER COATING COMPOSITION - The invention provides a powder coating composition prepared from a combination, the combination comprising:
| 10-28-2010 |
20140329934 | COATING COMPOSITION - A coating composition, in particular a clear coat coating composition, with a resin solids content comprising a cross-linkable binder component having functional groups with active hydrogen and a cross-linker component, wherein the cross-linker component comprises at least one isocyanate-functional urethane component comprising at least one aliphatic polyether polyol having —OCH | 11-06-2014 |
20140364542 | CLEAR COAT COATING COMPOSITION - A clear coat coating composition with a resin solids content comprising a hydroxyl-functional binder component and a crosslinker component, wherein the hydroxyl-functional binder component comprises at least one hydroxyl-functional urethane component comprising at least one aliphatic polyether polyol having —OCH | 12-11-2014 |