Gomes, MA
Ana P. Gomes, Boston, MA US
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20150265642 | NAD BIOSYNTHESIS AND PRECURSORS IN THE PREVENTION AND TREATMENT OF INFLAMMATION - Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. | 09-24-2015 |
20150266946 | TREATMENT OF AGE-RELATED AND MITOCHONDRIAL DISEASES BY INHIBITION OF HIF-1 ALPHA FUNCTION - Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction. | 09-24-2015 |
Bruce Charles Gomes, Ashburnham, MA US
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20100068199 | PCSK9 ANTAGONISTS - The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia. | 03-18-2010 |
20110229489 | Antibodies with pH Dependent Antigen Binding - The present invention relates to antibodies with pH dependent binding to its antigen such that the affinity for antigen binding at physiological pH (i.e., pH 7.4) is greater than at endosomal pH (i.e., pH 6.0 or 5.5). In other words, the K | 09-22-2011 |
20120014951 | PCSK9 ANTAGONISTS - The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia. | 01-19-2012 |
20120015435 | PCSK9 ANTAGONISTS - The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia. | 01-19-2012 |
20130273069 | PCSK9 ANTAGONISTS - The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia. | 10-17-2013 |
20150266974 | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING - The present invention relates to antibodies with pH dependent binding to its antigen such that the affinity for antigen binding at physiological pH (i.e., pH 7.4) is greater than at endosomal pH (i.e., pH 6.0 or 5.5). In other words, the K | 09-24-2015 |
Gerard Gomes, West Boylston, MA US
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20110138639 | PHOTOLUMINESCENT OPTICAL SIGHTS AND DEVICES AND METHODS THEREFROM - The present invention provides for photoluminescent optical fibers that are used to illuminate sighting reticles. The fibers are activated by electromagnetic radiation and emit electromagnetic radiation of various wavelengths at high intensity and for long periods of time. The emission from the photoluminescent fiber can only be seen coming from one terminal end of the fiber, which is designed to be positioned inside the sighting device to illuminate a reticle. The photoluminescent fiber contains a base optical fiber which is covered at least in part by a photoluminescent composition which itself is fully covered by a second composition that allows the activating electromagnetic radiation to pass through to activate the photoluminescent layer while preventing the emissive electromagnetic radiation of the photoluminescent layer from passing back through. | 06-16-2011 |
Jen Gomes, Norton, MA US
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20100170902 | DRINKING CONTAINER WITH STRAW - A drinking container including a main body and a removable lid. The lid includes an opening configured to receive a straw. The lid includes a removable cover having an opening configured to receive an upper portion of the straw. The cover includes a slide mechanism adapted to move and bend the straw to close the opening. The straw is bent at an angle to prevent closing or kinking of the straw. | 07-08-2010 |
Jose Manuel Gomes, Chelmsford, MA US
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20080269132 | USE OF LOW TEMPERATURE AND/OR LOW PH IN CELL CULTURE - The present invention provides a novel method of reducing protein misfolding and aggregation in the cell culture by growing the cell culture at a reduced temperature and/or reduced pH. As a result, the quality of the protein produced in the cell culture is greatly improved. Thus, the present invention facilitates improvements in the efficacy of therapeutic proteins produced in cell culture. | 10-30-2008 |
20080274507 | METHODS OF PROTEIN PRODUCTION USING ANTI-SENESCENCE COMPOUNDS - Methods of producing a protein in cell culture comprising an anti-senescence compound, such as the antioxidant carnosine, are provided. According to teachings of the present invention, cells grown in a cell culture medium comprising an anti-senescence compound exhibit increased viability and productivity. Furthermore, cell cultures grown in the presence of an anti-senescence compound exhibit decreased levels of high molecular weight aggregates in the cell culture medium. | 11-06-2008 |
20090317867 | METHODS FOR ENHANCED PRODUCTION OF BONE MORPHOGENETIC PROTEINS - Methods and processes for improved recombinant protein production are provided. The methods are useful for production of growth factors, particularly those of the TGF-β superfamily, including bone morphogenetic proteins (BMPs), such as BMP-2. Suitable host cells are cultured in media where iron is present at a concentration of at least 2.25 μM and if pyridoxal is present, it makes up less than 55% of the molar concentration of vitamin B6 in the media. | 12-24-2009 |
Joshua Gomes, Dartmouth, MA US
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20150101932 | Side-Eluting Molecular Fractionator - The disclosure provides cassettes, electrophoresis systems, methods for making the device, and methods of fractionating a sample using the cassettes and electrophoresis systems described herein. | 04-16-2015 |
Joshua M. Gomes, Somerville, MA US
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20130154207 | Apparatus, System and Method for a Load-Bearing Cart - A cart is configured to allow a user to gain mechanical advantage in moving a load up or down a step, a curb, a flight of stairs or other obstruction while at the same time allowing them to employ a conventional lifting motion in an improved ergonomic position. | 06-20-2013 |
20140267038 | Controller and User Interface Device, Systems, and Methods - A data collection system controller that includes a housing such as a cover. The housing includes a user facing section and a support facing section defining a hole. The controller also includes a first input device adjacent the user facing section and a second input device. The second input device includes a knob comprising a third input device and a rotatable shaft extending through the hole and partially disposed within the knob. In one embodiment, the second input device is an XYZ joystick with a button. In one embodiment, the joystick and the first input device are angled relative to each other on either side of an elbow joint. In part, the invention relates to a method of controlling the display of image data obtained with respect to a blood vessel. | 09-18-2014 |
Paul Gomes, Andover, MA US
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20130252971 | Ophthalmic Formulations of Cetirizine and Methods of Use - The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye. | 09-26-2013 |
20140045803 | Ophthalmic Formulations Of Cetirizine And Methods Of Use - The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis rhinitis, and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye. | 02-13-2014 |
Paul Gomes, Haverhill, MA US
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20100240624 | Ophthalmic Formulations of Ketotifen and Methods of Use - The present invention provides topical formulations of ketotifen that provide a comfortable formulation when instilled in the eye and are effective in the treatment and prevention of ocular allergy, particularly allergic conjunctivitis. The invention further provides methods of treating and preventing ocular allergy by in a subject in need of such treatment by topical application of the ketotifen formulations of the invention to the eye of a subject in need thereof. | 09-23-2010 |
20100240625 | Ophthalmic Formulations of Cetirizine and Methods of Use - The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye. | 09-23-2010 |
20110105450 | OPHTHALMIC FORMULATIONS OF FLUTICASONE AND METHODS OF USE - The present invention provides ophthalmic formulations of fluticasone that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic conjunctivitis in a subject in need of such treatment by topical application of the fluticasone formulations of the invention directly to the eye. | 05-05-2011 |
20110257136 | Ophthalmic Formulations Of Cetirizine And Methods Of Use - The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis rhinitis, and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye. | 10-20-2011 |
Rodrigo S. Gomes, Medford, MA US
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20100097336 | TOUCH SYSTEMS AND METHODS UTILIZING CUSTOMIZED SENSORS AND GENERICIZED CONTROLLERS - Touch sensing circuit arrangements include a touch sensor and a controller board. The touch sensor includes one or more sensing elements to generate touch-related signals responsive to a touch input to the sensor, and a memory device storing computer-executable firmware instructions for determining touch positions based on the touch-related signals. The controller board includes query logic executable by the controller board to cause the controller board to query for the computer-executable firmware instructions stored on the memory device of the touch sensor, and a processor circuit to determine touch positions by executing the firmware instructions loaded onto the generic controller board in response to the query. | 04-22-2010 |