Patent application number | Description | Published |
20100086481 | DIFFERENTIAL EXPRESSION OF MOLECULES ASSOCIATED WITH INTRA-CEREBRAL HEMORRHAGE - Methods are provided for evaluating a stroke, for example for determining whether a subject has had a hemorrhagic stroke, determining the severity or likely neurological recovery of a subject who has had a hemorrhagic stroke, and determining a treatment regimen for a subject who has had a hemorrhagic stroke, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes screening for expression of hemorrhagic stroke related genes (or proteins), such as genes (or proteins) involved in suppression of the immune response, genes (or proteins) involved in vascular repair, genes (or proteins) involved in the acute inflammatory response, genes (or proteins) involved in cell adhesion, genes (or proteins) involved in hypoxia, genes (or proteins) involved in signal transduction, and genes (or proteins) involved in the response to the altered cerebral microenvironment. Arrays and kits are provided that can be used in the disclosed methods. Also provided are methods of identifying one or more agents that alter the activity (such as the expression) of a hemorrhagic stroke-related molecule. | 04-08-2010 |
20100267582 | DIFFERENTIAL EXPRESSION OF MOLECULES ASSOCIATED WITH ACUTE STROKE - Methods are provided for evaluating a stroke, for example for determining whether a subject has had an ischemic stroke, determining the severity or likely neurological recovery of a subject who has had an ischemic stroke, and determining a treatment regimen for a subject who has had an ischemic stroke, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes screening for expression in ischemic stroke related genes (or proteins), such as white blood cell activation and differentiation genes (or proteins), genes (or proteins) related to hypoxia, genes (or proteins) involved in vascular repair, and genes (or proteins) related to a specific peripheral blood mononuclear cell (PBMC) response to the altered cerebral microenvironment. Also provided are methods of identifying one or more agents that alter the activity (such as the expression) of an ischemic stroke-related molecule. | 10-21-2010 |
20140249145 | SUBSTITUTED PYRAZOLOPYRIMIDINES AS GLUCOCEREBROSIDASE ACTIVATORS - Substituted pyrazolopyrimidines and dihydropyrazolopyrimidines and related compounds, their methods of manufacture, compositions containing these compounds, and methods of use of these compounds in treating lysosomal storage disorders such as Gaucher disease are described herein. The compounds are of general Formula (I) | 09-04-2014 |
20150065469 | SALICYLIC ACID DERIVATIVES USEFUL AS GLUCOCEREBROSIDASE ACTIVATORS - Compounds of Formula (I) and the pharmaceutically acceptable salts thereof are disclosed. The variables. R | 03-05-2015 |
Patent application number | Description | Published |
20080294398 | Method and apparatus for the automated construction of models of activities from textual descriptions of the activities - A method of automatically constructing a model of an activity from an unsupervised examination of a plurality of textual documents describing the activity is comprised of: extracting prototypical steps from the plurality of textual documents; sequencing the extracted steps; aligning the sequenced steps; and constructing the model based on the aligned steps. The model may take the form of a step vs. position matrix which identifies the prototypical steps that make up the activity and provides the probability of each step occupying each position within the activity. The model thus constitutes common sense knowledge that encodes the stereotypical steps of an activity and the stereotypical sequencing of the steps. | 11-27-2008 |
20080294425 | Method and apparatus for performing semantic update and replace operations - A method of changing semantic information comprises changing a first bi-directional coupling between a surface region in a document and a first semantic object to a second bi-directional coupling between the surface region and a second semantic object. More particularly, the method may be comprised of identifying an occurrence of a surface region in a document, the surface region having a first link for coupling the surface region to a first semantic object, and the first semantic object having a first association for coupling the first semantic object with the surface region. The first link is replaced with a second link for coupling the surface region to a second semantic object. The first association is changed to a second association for coupling the second semantic object with the surface region. Another method for changing semantic information comprising selecting a semantic object stored in a data repository and changing the selected semantic object. A scope is then selected, either manually or automatically. A set of semantically anchored expressions associated with the semantic object is identified in response to the scope. A determination is made if the semantically anchored expressions are consistent with the changed semantic object and, if not, the semantically anchored expressions are updated so as to be consistent with the changed semantic object. | 11-27-2008 |
20080294426 | Method and apparatus for anchoring expressions based on an ontological model of semantic information - A method and apparatus for the recording and maintenance of semantic elements in electronically-held information objects provide for grounding semantic objects in an ontology, such that inheritance and other relations between concepts are preserved in persistent storage. The disclosed method and apparatus provide semantic document authors with a means to anchor concept references to specific, persistent, semantic objects, thereby providing the system with access to all properties of the underlying data model of the semantic objects being referenced, while also specifying the type and scope of their relations, as well as behavioral aspects of the visual and editing environment. | 11-27-2008 |
20080294427 | Method and apparatus for performing a semantically informed merge operation - A method and apparatus for performing an informed semantic merge operation comprises selecting a source region in a document and a target region in the same or a different document. A bi-directionally coupled surface region is identified in the source region and a bi-directionally coupled surface region is identified in the target region. A first semantic object coupled to the surface region in the source region is identified and a second semantic object coupled to the surface region in the target region is identified. The subcomponents of the first semantic object are combined with the subcomponents of the second semantic object by merging. | 11-27-2008 |
20080295013 | Method and apparatus for performing semantically informed text operations - One example of a semantically informed text operation comprises selecting a source region of a document and determining if the source region has a surface region bi-directionally coupled to a semantic object. The coupled semantic object is identified as are the presentation(s) associated with the semantic object. A target region of the same or anther document is selected. Any of the presentations that cannot be expressed in the target region are eliminated to identify a set of remaining presentations. A set of semantic choices based on the remaining presentations is determined. One of the semantic choices is selected and executed in the target region. | 11-27-2008 |
Patent application number | Description | Published |
20080294166 | EXTENDABLE CUTTING MEMBER - Provided is a minimally invasive cavity formation instrument for forming tissue cavities. The instrument includes an end effector having an aperture through which a cutting element is laterally extended and retracted. The cutting element may be retracted for minimally invasive insertion into a tissue region and extended to form a tissue cavity. The end effector of the instrument may be articulated or rotated to facilitate cavity formation. | 11-27-2008 |
20080294167 | ARTICULATING CAVITATION DEVICE - Provided is an articulating cavitation device configured to cut cancellous bone wholly within a vertebra. The articulating cavitation device includes an end effector, having an extendable cutting element, configured to articulate relative to an insertion tube. The end effector of the cavitation device may be articulated and rotated with the cutting element extended to form a tissue cavity about multiple axes. | 11-27-2008 |
20090131952 | DELIVERY SYSTEM AND METHOD FOR INFLATABLE DEVICES - Provided is a flowable material delivery system and method comprising one or a plurality of tentacles associated with an inflatable member. The tentacles are configured to deliver bone cement to a vertebral cavity upon reduction of a vertebral compression fracture. The tentacles may be coupled with the outer surface of an inflatable member or pass through the inflatable member to deliver a flowable material to a tissue cavity. | 05-21-2009 |
20130103068 | EXTENDABLE CUTTING MEMBER - Provided is a minimally invasive cavity formation instrument for forming tissue cavities. The instrument includes an end effector having an aperture through which a cutting element is laterally extended and retracted. The cutting element may be retracted for minimally invasive insertion into a tissue region and extended to form a tissue cavity. The end effector of the instrument may be articulated or rotated to facilitate cavity formation. | 04-25-2013 |
20140046328 | ARTICULATING CAVITATION DEVICE - Provided is an articulating cavitation device configured to cut cancellous bone wholly within a vertebra. The articulating cavitation device includes an end effector, having an extendable cutting element, configured to articulate relative to an insertion tube. The end effector of the cavitation device may be articulated and rotated with the cutting element extended to form a tissue cavity about multiple axes. | 02-13-2014 |
20140046330 | TISSUE CAVITATION DEVICE AND METHOD - Provided is a medical device for forming or modifying cavities in tissue. Versions include a blade extendable laterally from a first shape to a second shape to cut tissue in a controlled manner. The first shape may be configured for insertion in accordance with minimally invasive procedures and the second shape may be configured for cutting or forming cavities. | 02-13-2014 |
20140135772 | EXTENDABLE CUTTING MEMBER - Provided is a minimally invasive cavity formation instrument for forming tissue cavities. The instrument includes an end effector having an aperture through which a cutting element is laterally extended and retracted. The cutting element may be retracted for minimally invasive insertion into a tissue region and extended to form a tissue cavity. The end effector of the instrument may be articulated or rotated to facilitate cavity formation. | 05-15-2014 |
Patent application number | Description | Published |
20110225592 | Contention Analysis in Multi-Threaded Software - A contention log contains data for contentions that occur during execution of a multi-threaded application, such as a timestamp of the contention, contention length, contending thread identity, contending thread call stack, and contended-for resource identity. After execution of the application ends, contention analysis data generated from the contention log shows developers information such as total number of contentions for particular resource(s), total number of contentions encountered by thread(s), a list of resources that were most contended for, a list of threads that were most contending, a plot of the number of contentions per time interval during execution of the application, and so on. A developer may pivot between details about threads and details about resources to explore relationships between thread(s) and resource(s) involved in contention(s). Other information may also be displayed, such as call stacks, program source code, and process thread ownership, for example. | 09-15-2011 |
20140068569 | USER DIRECTED PROFILING - A user can control when data sampling takes place, what data is collected and where in the code the data sampling profiler is invoked. By identifying a section of user code to the profiler, the profiler is instructed to dynamically instrument the identified user code executing in a target application process. The instrumentation invokes the profiler before or after or both before and after the identified section of user code is executed. By identifying an entry point of a component or technology external to the user code, the profiler is instructed to dynamically instrument the external component so that data sampling is logged when the user code calls the entry point of the external component. The data sampling process can be monitored and the sampling rate can be dynamically adjusted. | 03-06-2014 |