Patent application number | Description | Published |
20100035234 | VACCINE ASSAYS - The present invention is directed to methods, assays and compositions for implementing such methods and assays for assessing efficacy of individual components in multi-component vaccines and for assessing efficacy of a vaccine against a pathogen. In one aspect, the method of assessing efficacy of a vaccine against a pathogen is a quick assay that tests for an activity correlated with efficacy such as binding in an ELISA rather than requiring the time and expense of an assay that detects actual bactericidal activity. In another aspect, the method for testing the efficacy of an individual component in a multi-component vaccine includes obtaining an immune sample from a subject inoculated with the multi-component vaccine; blocking the portion of the immune sample that recognizes the individual component such as by addition of the individual component, and testing the efficacy of the immune sample to respond to the pathogen. | 02-11-2010 |
20110008279 | Methods and Compositions Relating to Adhesins as Adjuvants - This invention is in the field of immunology and relates to the discovery that adhesins are potent activators of dendritic cells. | 01-13-2011 |
20110020390 | MENINGOCOCCAL FHBP POLYPEPTIDES - fHBP is a protein in | 01-27-2011 |
20110076300 | Hybrid Polypeptides Including Meningococcal fHBP Sequences - fHBP is a protein in | 03-31-2011 |
20110104193 | COMBINATION NEISSERIAL COMPOSITIONS - Compositions comprising a first biological molecule from a | 05-05-2011 |
20110166323 | CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870 - NMB1870 is a protein in | 07-07-2011 |
20120064103 | COMBINATIONS OF MENINGOCOCCAL FACTOR H BINDING PROTEIN AND PNEUMOCOCCAL SACCHARIDE CONJUGATES - An immunogenic composition comprising: (i) a conjugated pneumococcal capsular saccharide; and (ii) a meningococcal factor H binding protein (fHBP) antigen, and not including meningococcal outer membrane vesicles, is useful for immunising a subject against bacterial meningitis. | 03-15-2012 |
20120135026 | COMBINATION NEISSERIAL COMPOSITIONS - Compositions comprising a first biological molecule from a | 05-31-2012 |
20120283413 | CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870 - NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other. | 11-08-2012 |
20120328643 | OUTER MEMBRANE VESICLE (OMV) VACCINE COMPRISING N. MENINGITIDIS SEROGROUP B OUTER MEMBRANE PROTEINS - A composition comprising (a) | 12-27-2012 |
20130115238 | MENINGOCOCCAL FHBP POLYPEPTIDES - fHBP is a protein in | 05-09-2013 |
20130196352 | BACTERICIDAL ANTIBODY ASSAYS TO ASSESS IMMUNOGENICITY AND POTENCY OF MENINGOCOCCAL CAPSULAR SACCHARIDE VACCINES - The disclosure provides compositions, methods and kits for assessing immunogenicity, potency, or both, of meningococcal capsular saccharide vaccines. The assessment is based upon measurement of binding of a bactericidal antibody to a capsular saccharide component in the vaccine. | 08-01-2013 |
20130217859 | CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870 - NMB 1870 is a protein in | 08-22-2013 |
20140037668 | COMBINATION NEISSERIAL COMPOSITIONS - Compositions comprising a first biological molecule from a | 02-06-2014 |
20140294885 | HETEROLOGOUS EXPRESSION OF NEISSERIAL PROTEINS - Alternative and improved approaches to the heterologous expression of the proteins of | 10-02-2014 |
20140363462 | HETEROLOGOUS EXPRESSION OF NEISSERIAL PROTEINS - Alternative and improved approaches to the heterologous expression of the proteins of | 12-11-2014 |