Patent application number | Description | Published |
20100293771 | Process and apparatus for corner tucking a covering sheet of an upholstered article - An apparatus and process for causing excess covering material at a workpiece corner to be gathered, folded and secured to a back side of the panel. A corner tucking apparatus includes a gathering plate positioned adjacent a positioning structure, and moves inwardly across the back side of the workpiece, from the corner, to gather and fold the corner flap. The gathering plate has a generally V-shaped notch which causes excess material to be gathered together as the plate moves inwardly. The gathered material upon reaching the apex of the notch is folded downwardly into contact with the back side of the workpiece. A securing structure which is carried inwardly with the gathering plate is then activated to fixedly secure the folded flap to the pad or workpiece. | 11-25-2010 |
20100328852 | Modular electrical distribution system for a building - A universal power distribution system is provided for routing electrical circuits within a building structure to comprehensively provide electrical power to the building in ceiling configurations, wall-mounted configurations, raised floor configurations and in office furniture configurations. The system components for all of these configurations have common plug connectors that are engagable with each other so as to be readily usable in a wide variety of applications. The system is readily adaptable to form virtually any conventional circuit configuration found within conventional hard-wired systems yet is formed simply through the routing of the cables through the building cavities and interconnection is accomplished merely by plugging components together rather than through labor-intensive manual wiring. | 12-30-2010 |
20100328853 | Modular electrical distribution system for a building - A universal power distribution system is provided for routing electrical circuits within a building structure to comprehensively provide electrical power to the building in ceiling configurations, wall-mounted configurations, raised floor configurations and in office furniture configurations. The system components for all of these configurations have common plug connectors that are engagable with each other so as to be readily usable in a wide variety of applications. The system is readily adaptable to form virtually any conventional circuit configuration found within conventional hard-wired systems yet is formed simply through the routing of the cables through the building cavities and interconnection is accomplished merely by plugging components together rather than through labor-intensive manual wiring. | 12-30-2010 |
20120312199 | Table with storable monitor - A table arrangement having a guide rail structure secured to the table adjacent the underside of the table top. A carriage is movable along a guide structure from a retracted position under the table top to an extended position disposed adjacent one table edge. A supporting frame is hingedly carried on the carriage and mounts a flat-panel video monitor thereon, the latter being storable directly under the table top when the carriage is in the retracted position. Movement of the carriage to the extended position causes the supporting frame and monitor to project beyond the adjacent table edge, whereupon the supporting frame and monitor can be swung upwardly about the hinge axis into an upright use position wherein the monitor protrudes above the table top adjacent the one edge, and the monitor screen fronts onto the region above the table top. | 12-13-2012 |
Patent application number | Description | Published |
20090104647 | METHODS FOR SELECTING ACTIVE AGENTS FOR CANCER TREATMENT - The present invention provides methods for individualizing chemotherapy, and particularly methods for individualizing neoadjuvant chemotherapy. The present invention provides methods for predicting a cancer patient's response to neoadjuvant chemotherapy, including assessing the probability of a positive response upon treatment with candidate agents prior to surgery. In various aspects, the invention involves culturing a monolayer of malignant cells from an explant of a patient's biopsy specimen, such as a transcutaneous biopsy-sized specimen, and testing the malignant cells for resistance or sensitivity to one or a plurality of candidate agents for neoadjuvant therapy. In other aspects, the invention provides methods for accurately scoring and interpreting such assays, and discloses in vitro chemoresponse results that are predictive of a patient's pathological complete response (pCR) upon receiving the corresponding treatment regimen. | 04-23-2009 |
20120219982 | METHODS FOR SELECTING ACTIVE AGENTS FOR CANCER TREATMENT - The present invention provides methods for individualizing chemotherapy, and particularly methods for individualizing neoadjuvant chemotherapy. The present invention provides methods for predicting a cancer patient's response to neoadjuvant chemotherapy, including assessing the probability of a positive response upon treatment with candidate agents prior to surgery. In various aspects, the invention involves culturing a monolayer of malignant cells from an explant of a patient's biopsy specimen, such as a transcutaneous biopsy-sized specimen, and testing the malignant cells for resistance or sensitivity to one or a plurality of candidate agents for neoadjuvant therapy. In other aspects, the invention provides methods for accurately scoring and interpreting such assays, and discloses in vitro chemoresponse results that are predictive of a patient's pathological complete response (pCR) upon receiving the corresponding treatment regimen. | 08-30-2012 |
Patent application number | Description | Published |
20110129822 | MULTI DRUG RESPONSE MARKERS FOR BREAST CANCER CELLS - The present invention provides methods for preparing a gene expression profile of a breast cancer cell, tumor, or cell line, where the gene expression profile may be evaluated for one or more gene expression signatures indicative of multidrug resistance. The signature may be indicative of resistance to one or more chemotherapeutic agents selected from a Taxol (e.g., Docetaxel or Paclitaxel), an antibiotic (e.g., Doxorubicin or Epirubicin), an antimetabolite (e.g., Fluorouracil and/or Gemcitabine), and an alkylating agent (e.g., Cyclophosphamide). Generally, the gene expression profile contains the level of expression for a plurality of genes listed in FIGS. | 06-02-2011 |
20110130302 | BIOLOGICAL PATHWAYS ASSOCIATED WITH CHEMOTHERAPY OUTCOME FOR BREAST CANCER - The present invention provides methods for preparing drug response and/or resistance profiles for breast tumor specimens, or cells derived therefrom. The drug response and/or resistance profiles are useful for determining effective chemotherapeutic agents for treatment of the tumor or cell to thereby individualize patient therapy. In other aspects, the invention provides a method for identifying a pathway or gene expression signature indicative of a breast cancer cell's sensitivity to a chemotherapeutic agent, which is useful for identifying a population response rate, or patient sub-population likely to respond to the drug candidate. | 06-02-2011 |
Patent application number | Description | Published |
20090221555 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS - The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R | 09-03-2009 |
20100152196 | Novel Fused Pyrrolocarbazoles - The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles. | 06-17-2010 |
20110053920 | SUBSTITUTED BICYCLIC PYRIMIDINES - The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): | 03-03-2011 |
20120004253 | Novel Fused Pyrrolocarbazoles - The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles. | 01-05-2012 |
20120028919 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS - The present invention provides a compound of formula I | 02-02-2012 |
20120165519 | Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors - The present invention provides a compound of formula I or II | 06-28-2012 |
20130296312 | Preparation and Uses of 1,2,4-Triazolo [1,5a] Pyridine Derivatives - This application relates, in part, to compounds of the general Formula I | 11-07-2013 |
20140350011 | Imidazo[4,5-b]pyridine Derivatives as ALK and JAK Modulators for the Treatment of Proliferative Disorders - This application relates to compounds of the Formula I | 11-27-2014 |
Patent application number | Description | Published |
20090283053 | Hoof Bath System - The present invention is directed to methods for applying bovine foot and hoof treatment compositions having two or more specific and complimentary antimicrobial components in a hoof bath just prior to use to work more effectively. These antimicrobial components may include antimicrobial inorganic salts of certain heavy metals, cationic agents, peroxides, aldehydes, fatty acids, iodines or other suitable compounds effective in the killing of microorganisms. The invention also relates to a foot bath system for delivery, retention, and drainage of foot bath chemicals and waste material. | 11-19-2009 |
20100218731 | Hoof bath system - The present invention is directed to methods for applying bovine foot and hoof treatment compositions having two or more specific and complimentary antimicrobial components in a hoof bath just prior to use to work more effectively. These antimicrobial components may include antimicrobial inorganic salts of certain heavy metals, cationic agents, peroxides, aldehydes, fatty acids, iodines or other suitable compounds effective in the killing of microorganisms. | 09-02-2010 |
20120192805 | Hoof Bath System - The present invention is directed to methods for applying bovine foot and hoof treatment compositions having two or more specific and complimentary antimicrobial components in a hoof bath just prior to use to work more effectively. These antimicrobial components may include antimicrobial inorganic salts of certain heavy metals, cationic agents, peroxides, aldehydes, fatty acids, iodines or other suitable compounds effective in the killing of microorganisms. The invention also relates to a foot bath system for delivery, retention, and drainage of foot bath chemicals and waste material. | 08-02-2012 |
Patent application number | Description | Published |
20120204844 | Dedicated EGR Control Strategy For Improved EGR Distribution And Engine Performance - The present disclosure relates to methods, apparatuses and systems to manage exhaust gas expelled from cylinders of an internal combustion engine. An exemplary system may comprise at least one cylinder of the engine configured to operate as a dedicated exhaust gas recirculation (EGR) cylinder, and wherein substantially all exhaust gas expelled from the dedicated EGR cylinder is recirculated to an intake system of the engine. In one embodiment, the system may include a flow restrictor configured and arranged to restrict a flow of the recirculated exhaust gas to the dedicated EGR cylinder without restricting a flow of the recirculated exhaust gas to the remaining cylinders of the engine. In another embodiment, exhaust gas may be expelled from the dedicated EGR cylinder in pulsations, and the intake system may be configured to reduce an amplitude of the pulsations of the exhaust gas expelled from the dedicated EGR cylinder. | 08-16-2012 |
20120204845 | EGR Distributor Apparatus For Dedicated EGR Configuration - The present disclosure relates to methods, apparatuses and systems to manage exhaust gas expelled from an internal combustion engine. More particularly, the present disclosure provides an exhaust gas recirculation apparatus to distribute recirculated exhaust gas in an air stream to be introduced to an internal combustion engine, with the apparatus comprising an intake passage defined by a wall structure, the wall structure including a plurality of apertures therein configured to distribute recirculated exhaust gas into the intake passage. | 08-16-2012 |
20130104861 | Enhanced Combustion for Compression Ignition Engine Using Electromagnetic Energy Coupling | 05-02-2013 |
20130104862 | Enhanced Combustion for Spark Ignition Engine Using Electromagnetic Energy Coupling | 05-02-2013 |
20130220286 | Fuel Injection Strategy for Internal Combustion Engine Having Dedicated EGR Cylinders - A method using exhaust gas recirculation (EGR) in an internal combustion engine. The engine has at least one “dedicated EGR cylinder”, whose entire exhaust is recirculated back to all the engine cylinders. The dedicated EGR cylinder is operated at a rich air-fuel ratio, and the other cylinders are operated stoichiometrically so that a conventional three way catalyst may be used to treat the exhaust. A fuel injector is used to inject fuel into the combustion chamber of the dedicated EGR cylinder after initiation of the main combustion event. This post injection method overcomes flammability limits of a dedicated EGR cylinder, and increases the hydrogen (H2) and carbon monoxide (CO) in its exhaust. | 08-29-2013 |
20130239547 | Integrated WGS/ECD Exhaust Treatment Device for Internal Combustion Engine Having Dedicated EGR - An integrated water-gas-shift (WGS) and emissions control device (ECD) catalyst for treating exhaust from an internal combustion engine. The engine is assumed to have an EGR loop, such that exhaust is recirculated back to the engine's intake. A WGS catalyst on the EGR loop, for conditioning the EGR flow, is integrated with a catalyzed ECD on the main exhaust line, for reducing pollutant emissions. | 09-19-2013 |
20140069082 | EGR Control in Engine Equipped With Cylinders Having Dual Exhaust Valves - A method and system for controlling recirculated exhaust gas composition and quantity provided to an internal combustion engine, which has one or more separately controllable combustion cylinders, a main exhaust line and an exhaust gas recirculation (EGR) loop. A first exhaust valve is connected to the main exhaust line, and a second exhaust valve is connected to the EGR loop. The operation of the exhaust valves is controlled such that exhaust does not flow through both exhaust valves at the same time. Control of the exhaust valves is coordinated with the main fueling event used to control the exhaust composition exiting each valve for every cylinder on every cycle. During each engine cycle, a post-combustion fuel injection event is also used to add fuel to the exhaust in-cylinder, which flows only through the second (EGR) exhaust valve. | 03-13-2014 |
20140142833 | Catalyst Light-Off for Turbocharged Internal Combustion Engine Having Dedicated EGR Cylinder(s) - A method of decreasing the light-off time of a catalytic exhaust aftertreatment device, using exhaust gas recirculation (EGR) in a turbocharged internal combustion engine. The engine has at least one “dedicated EGR cylinder”, whose entire exhaust is recirculated back to all the engine cylinders. The dedicated EGR cylinder(s) may be operated to produce a differently compositioned exhaust gas than the other cylinders. During light-off, EGR gas is optimized for heat, diverted from the EGR loop and routed to a point directly upstream the aftertreatment device. | 05-22-2014 |
20140190458 | EGR Rate Control For Internal Combustion Engine With Dual Exhaust-Ported Cylinders - A method of using exhaust gas recirculation (EGR) in an internal combustion engine. At least two of the cylinders are “dual exhaust-ported cylinders” having two exhaust ports. For each of these cylinders, one of the exhaust ports is connected to the EGR loop and the other of the exhaust ports is connected to the main exhaust line. These cylinders are controlled such that one exhaust port is open and the other exhaust port is closed during each engine cycle, and are operated, on a cycle-by-cycle basis so that all of the exhaust produced by a cylinder may be delivered to the EGR loop at any cycle. The number of cylinders operating as EGR cylinders per engine cycle is in response to a desired EGR rate. | 07-10-2014 |
20140196702 | Ignition and Knock Tolerance in Internal Combustion Engine by Controlling EGR Composition - A method for improving ignition of a spark ignited internal combustion engine by controlling the composition of recirculated exhaust gas. It is assumed that the engine has a spark ignition system and an exhaust gas recirculation (EGR) loop such that at least one of the combustion cylinders is an EGR cylinder that generates an EGR stream carried by the EGR loop. Thus, the combustion charge is a mixture of air, fuel and recirculated exhaust. A first step is receiving combustibility data representing the current ignitability of the charge. It is then determined whether the energy of the ignition system is sufficient to ignite the charge. If not, the amount of hydrogen in the EGR stream is increased, which increases the ignitability of the charge. | 07-17-2014 |
20140305416 | Internal Combustion Engine Having Dual EGR Loops (Dedicated EGR Loop and Low Pressure EGR Loop) and Dual Cylinder Intake Ports - A dual EGR loop exhaust gas recirculation (EGR) system for an internal combustion engine. The engine has both a dedicated EGR loop and a low pressure EGR loop. This means that one or more engine cylinders is operable as a dedicated EGR cylinder, such that all of its exhaust is recirculated via the dedicated EGR loop. The other cylinders are operable as main cylinders having two intake ports, such that each main cylinder may receive a mixture of fresh air and dedicated EGR through one intake port and a mixture of fresh air and low pressure EGR through the other intake port. A control unit controls this dual loop EGR system to either provide EGR only from the dedicated EGR loop or to also provide additional EGR from the low pressure EGR loop. | 10-16-2014 |
20150219028 | Engine Fuel Control For Internal Combustion Engine Having Dedicated EGR - A method of controlling the amount of fuel delivered to an engine having at least one dedicated EGR cylinder. The method is typically performed on an engine cycle-by-cycle basis. A fueling control unit receives, from the engine's main control unit, fueling requirement data representing a current fueling requirement suitable for the main cylinders. The fueling control unit then calculates a current amount of fuel to be delivered to the dedicated EGR cylinder as a function of the number of dedicated EGR cylinders, the number of main cylinders, the current equivalence ratio for the dedicated EGR cylinder, and the fueling requirement data. With the amounts of fuel for both the dedicated EGR cylinder and the main cylinders now having been determined, the fueling control unit generates appropriate control signals to the cylinder fuel delivery mechanisms. | 08-06-2015 |
20150377188 | Powertrain for Hybrid Vehicle Having Dedicated EGR - Various methods and systems may be used to provide recirculated engine exhaust to an engine of a hybrid powertrain. It is assumed that the engine is equipped with a dedicated EGR loop. At least one cylinder is operated as a dedicated exhaust gas recirculation (EGR) cylinder, such that all exhaust of that cylinder is recirculated to the fresh air intake of the engine via the EGR loop. One or more cylinders are operated as main cylinders, such that exhaust from those cylinders exits the engine to the atmosphere. The engine itself is operable for at least part of its operation in a decoupled mode in which the dedicated EGR cylinder is mechanically decoupled from the engine crankshaft. During this decoupled mode, the dedicated EGR cylinder powers a generator. The main cylinders are operable exclusively to provide power to the crankshaft. | 12-31-2015 |
Patent application number | Description | Published |
20140097734 | ARC-RESISTANT SWITCHGEAR ENCLOSURE WITH DOOR LATCH MECHANISM - An arc-resistant switchgear enclosure has an interior compartment with a door opening and a vent outlet. The door is mounted to close the door opening. The door receives pins that extend from the enclosure. The pins have stops thereon that are received by a keyhole in the latch member. The latch member can slide so as to position the pin in a large opening in the keyhole and unlatch the door or a narrow opening in the keyhole to latch the door. The latch members are ganged so that a handle operates all of the latch members. | 04-10-2014 |
20140110232 | ARC-RESISTANT SWITCHGEAR ENCLOSURE WITH LATCH FOR VENT FLAP - An arc-resistant switchgear enclosure has a vent opening and a vent flap. Normally the vent flap is open to allow air to circulate through the enclosure. However, in the event of an arc fault explosion in the enclosure, the vent flap is forced to close by the explosion. As the vent flap closes, a flexible latch member moves along a keeper and prevents the vent flap from reopening. In some embodiments, the latch member contacts the keeper and props the vent flap open for normal operation. | 04-24-2014 |
20140131090 | ARC-RESISTANT SWITCHGEAR ENCLOSURE WITH VENT ARRANGEMENT OF A LOWER COMPARTMENT - An arc-resistant switchgear enclosure is designed so that an arc explosion in any interior compartment is isolated from the remaining interior compartments and vented to the exterior of the enclosure. The enclosure has upper and lower front compartments and a rearward compartment. The lower front compartment vents to the exterior of the enclosure between the upper front compartment and the rearward compartment. An extension extends across this vent between the upper front compartment and the rearward compartment, the extension being part of one of the upper front compartment or the rearward compartment. The extension houses electrical connections between the rearward compartment and the upper front compartment. | 05-15-2014 |
20140133071 | ARC-RESISTANT SWITCHGEAR ENCLOSURE WITH VENT PROP AND LATCH - An arc-resistant switchgear enclosure has interior compartments with outlet vent openings that are selectively closed by vent flaps. The vent flaps are propped in an open position by props that extend from the vent flaps and contact supports. The props have a latch portion that latches the vent flap when the vent flap is in the closed position. | 05-15-2014 |