Gerdes
Christian Gerdes, Erlenbach/zh CH
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20100081796 | BISPECIFIC ANTI-EGFR/ANTI-IGF-1R ANTIBODIES - The present invention relates to bispecific antibodies against EGFR and against IGF-1R, methods for their production, pharmaceutical compositions containing said antibodies, and methods of treatment using the antibodies. | 04-01-2010 |
20120149879 | BISPECIFIC ANTI-EGFR/ANTI-IGF-1R ANTIBODIES - The present invention relates to bispecific antibodies against EGFR and against IGF-1R, methods for their production, pharmaceutical compositions containing said antibodies, and methods of treatment using the antibodies. | 06-14-2012 |
20120258073 | IMMUNOTHERAPY - The present invention provides combinations of (a) an immunoconjugate comprising at least one antigen-binding moiety and an effector moiety, and (b) an antibody engineered to have increased effector function, for use in treating a disease in an individual in need thereof. Further provided are pharmaceutical compositions comprising the combinations, and methods of using them. | 10-11-2012 |
Christian Gerdes, Erlenbach CH
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20110200595 | TREATMENT WITH A HUMANIZED IgG CLASS ANTI EGFR ANTIBODY AND AN ANTIBODY AGAINST INSULIN LIKE GROWTH FACTOR 1 RECEPTOR - The present invention provides a humanized IgG-class anti-EGFR antibody and an anti-IGF-1R antibody for combined use in treating cancer, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. The invention also encompasses a pharmaceutical composition that is comprised of a combination of a humanized IgG-class anti-EGFR antibody and an anti-IGF-1R antibody in a pharmaceutically acceptable carrier. | 08-18-2011 |
20130195854 | PREDICTIVE BIOMARKER FOR CANCER TREATMENT WITH ADCC-ENHANCED ANTIBODIES - The present invention is directed to methods for identifying which patients diagnosed with cancer will most benefit from treatment with an anti-cancer therapy comprising an ADCC-enhanced antibody. | 08-01-2013 |
20130273032 | PREDICTIVE BIOMARKER FOR CANCER TREATMENT WITH ADCC-ENHANCED ANTIBODIES - The present invention is directed to methods for identifying which patients diagnosed with cancer will most benefit from treatment with an anti-cancer therapy comprising an ADCC-enhanced antibody. | 10-17-2013 |
20140065097 | Immunotherapy - The present invention provides combinations of (a) an immunoconjugate comprising at least one antigen-binding moiety and an effector moiety, and (b) an antibody engineered to have increased effector function, for use in treating a disease in an individual in need thereof. Further provided are pharmaceutical compositions comprising the combinations, and methods of using them. | 03-06-2014 |
20140072528 | IMMUNOTHERAPY - The present invention provides combinations of (a) an immunoconjugate comprising a first antibody engineered to have reduced effector function and an effector moiety, and (b) a second antibody engineered to have increased effector function, for use in treating a disease in an individual in need thereof. Further provided are pharmaceutical compositions comprising the combinations, and methods of using them. | 03-13-2014 |
20160058891 | IN VIVO ADCC MODEL - The present invention relates to a non-human animal comprising a humanized low affinity FcgR locus. Also provided herein is the use of said non-human animal for determining in vivo efficacy of antibodies, and methods for determining in vivo efficacy of antibodies. | 03-03-2016 |
Christian Gerdes, Erlenbach/ Zh CH
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20160045597 | COMBINATION THERAPY OF ANTIBODIES ACTIVATING HUMAN CD40 AND ANTIBODIES AGAINST HUMAN PD-L1 - The present invention relates to a pharmaceutical product for the treatment of a proliferative disease, comprising the combination of an antibody, or an antigen-binding portion thereof, that specifically binds to human CD40; and a PD-L1 antibody; and optionally a 3 | 02-18-2016 |
Claus Gerdes, Rutihof CH
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20120000577 | PROCESS FOR PRODUCING A SINGLE-CRYSTAL COMPONENT MADE OF A NICKEL-BASED SUPERALLOY - In a process for producing a large single-crystal component or directionally solidified component made of a nickel-based superalloy, the component is first cast into shape in a known manner to form a microstructure comprising dendrites, and then solution annealing for homogenizing the cast microstructure of the component and two-stage precipitation heat treatment are carried out. In order to avoid chemical inhomogeneities and internal stresses caused thereby, a HIP process with a pressure of higher than 160 MPa is carried out following the solution annealing. | 01-05-2012 |
Claus Paul Gerdes, Ruetihof CH
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20120128527 | NICKEL-BASED SUPERALLOY - A nickel-base superalloy is characterized by the following chemical composition (details in % by weight): 7.7-8.3 Cr, 5.0-5.25 Co, 2.0-2.1 Mo, 7.8-8.3 W, 5.8-6.1 Ta, 4.9-5.1 Al, 1.0-1.5 Ti, 1.0-2.0 Re, 0.11-0.15 Si, 0.1-0.7 Hf, 0-0.5 Nb, 0.02-0.17 C, 50-400 ppm B, remainder Ni and production-related impurities. The alloy is distinguished by a very high resistance to oxidation, resistance to corrosion and good creep properties at high temperatures. | 05-24-2012 |
20120187093 | FILLER MATERIAL FOR WELDING - A filler material for welding is characterized by the following chemical composition (amounts in % by weight): | 07-26-2012 |
Claus Paul Gerdes, Rutihof CH
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20100150727 | ROTOR BLADE FOR A GAS TURBINE - A rotor blade ( | 06-17-2010 |
Claus Paul Gerdes, Baden CH
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20140299581 | METHOD FOR WELDING ROTORS FOR POWER GENERATION - The invention relates to a method for welding rotors for power generation such as gas turbines, steam turbines, and generators having a plurality of rotor discs arranged along a rotor axis. The method includes providing said discs with a weld seam preparation. The weld seam preparation includes a root, a first, gap-like welding section adjoining the root in radial direction, and a second, gap-like welding section adjoining the first welding section in radial direction. The method further includes melting the root by means of a first welding process; making a weld in the first welding section by means of a second welding process; and filling up the second welding section by means of a third welding process. | 10-09-2014 |
Claus Paul Gerdes, Baden-Ruetihof CH
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20110194972 | NICKEL-BASE SUPERALLOY WITH IMPROVED DEGRADATION BEHAVIOR - A nickel-base superalloy with improved degradation behavior consists essentially of the following chemical composition (details in % by weight): 7.7-8.3 Cr, 5.0-5.25 Co, 2.0-2.1 Mo, 7.8-8.3 W, 5.8-6.1 Ta, 4.9-5.1 Al, 1.3-1.4 Ti, 0.1-0.6 Pt, 0.1-0.5 Nb, 0.11-0.15 Si, 0.11-0.15 Hf, 200-750 ppm C, 50-400 ppm B, and the remainder Ni and production-related impurities. | 08-11-2011 |
Hans-Hermann Gerdes, Bergen NO
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20090081775 | Microscope system and screening method for drugs, physical therapies and biohazards - Method and device for automated cell analysis and determination of transport and communication between living cells by analyzing the formation of tunneling nanotubes (TNTs) between cells. This method comprising the steps of singularizing cells in a culture medium and staining the cells with a fluorescent or luminescent dyes for staining of cytoplasm and membranes as well as TNTs, flagella and other cell particles for 3-D cell microscopy. The method comprises further an image analysis system. | 03-26-2009 |
Hans-Hermann Gerdes, Nesttun NO
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20150153326 | QUANTITATIVE ANALYSIS OF CONTACT-DEPENDENT CELL-TO-CELL TRANSFER AND DISEASE TRANSMISSION - A method for a microscope-based quantitative analysis of contact-dependent cell-to-cell transfer between cells. Single donor cells containing a traceable marker are cultured in a lawn of acceptor cells to allow cell-to-cell transfers. The donor and acceptor cells are then imaged and/or stained for microscopy to determine the location, shape and volumes of donor cells and of surrounding acceptor cells within selected regions of interest. The spatial distribution of the traceable marker in each volumetric picture element of the region of interest is determined and analyzed to determine quantitatively and qualitatively the substance transfer. The method allows a reliable quantitative evaluation of the effect of an active agent on cell-to-cell molecular communication and disease transmission. | 06-04-2015 |
James T. Gerdes, London CA
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20130254927 | MOLECULAR MARKERS FOR LOW PALMITIC ACID CONTENT IN SUNFLOWER (HELIANTHUS ANNUS), AND METHODS OF USING THE SAME - This disclosure concerns methods and compositions for identifying sunflower plants that have a low palmitic acid content phenotype. Some embodiments concern molecular markers to identify, select, and/or construct low palmitic acid content plants and germplasm, or to identify and counter-select relatively high palmitic acid content plants. This disclosure also concerns sunflower plants comprising a low palmitic acid content phenotype that are generated by methods utilizing at least one marker described herein. | 09-26-2013 |
James Todd Gerdes, London CA
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20130298280 | INBRED SUNFLOWER (HELIANTHUS ANNUUS) LINE, DESIGNATED OIN807A/B - The present invention relates to an inbred sunflower line, designated OIN807A/B. The invention relates to the seeds of inbred sunflower line OIN807A/B, to the plants of inbred sunflower line OIN807A/B and to the methods for producing a sunflower plant, either inbred or hybrid, by crossing the inbred line OIN807A/B with itself or another sunflower line. The invention further relates to methods for producing a sunflower plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other inbred sunflower lines derived from the inbred OIN807A/B. | 11-07-2013 |
James Todd Gerdes, Ontario CA
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20130137097 | HIGH THROUGHPUT SINGLE NUCLEOTIDE POLYMORPHISM ASSAY - A method consisting of a homogeneous assay detection system for a PCR process using FRET for detection and zygosity analysis of the HaAHASL1-A122(At)T single nucleotide polymorphism in sunflower is provided. The method provides specific sunflower-genome primers that can be used to detect the presence or absence of the HaAHASL1-A122(At)T single nucleotide polymorphism. The primer combinations for use in an endpoint PCR assay capable of determining zygosity and for assisting in breeding introgression are described. | 05-30-2013 |
Jens Gerdes, Kobenhavn O DK
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20160051234 | Collecting Unit for a Stool Sample - The application relates to a unit for collecting a stool sample for medical use. The unit may be used both in the clinic and in the home. | 02-25-2016 |
Kenn Gerdes, Odense S DK
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20080206840 | CYTOTOXIN-BASED BIOLOGICAL CONTAINMENT - Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including | 08-28-2008 |
Klaus Gerdes, Wien AT
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20100150995 | PROCESS FOR THE PRODUCTION OF HIGH-PURITY 2,4'-DIMETHYL-3-PIPERIDINO-PROPIOPHENONE (TOLPERISONE), PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THE LATTER, AS WELL AS ACTIVE INGREDIENT FORMULATIONS THAT CONTAIN TOLPERISONE - The invention relates to a method for producing highly pure 2,4′-dimethyl-3-piperidino-propiophenone (tolperisone) (formula I) and the pharmaceutically acceptable salts, hydrochlorides, and hydrates thereof. The method allows the content of the undesired byproduct 2-methyl-1-(4-methylphenyl) propenone (4-MMPPO) to be kept significantly lower than in previously known methods. The invention further relates to active substance formulations which contain tolperisone and are suitable, among other things, for producing combination preparations used for treating patients suffering from Alzheimer's disease. The invention also relates to topical formulations, controlled release (CR) formulations, and transdermal therapeutic systems, such as active substance patches, which contain less than 50 ppm, preferably less than 10 ppm, more preferably less than 7 ppm, and most preferably less than 3 ppm or 0 ppm (i.e. less than the detectable amount) of the undesired byproduct 2-methyl-1-(4-methylphenyl) propenone (4-MMPPO) in relation to 100 percent by weight of active substance. | 06-17-2010 |
Klaus Gerdes, Vienna AT
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20090253743 | COMPOSITIONS OF TOLPERISONE - The present disclosure is directed to methods for providing tolperisone having extremely low levels of 4-MMPPO (2-methyl-1-(4-methylphenyl)-propenone), as well as related compositions. The invention further relates to methods of treating a subject with tolperisone under conditions that limit exposure of the subject to tolerable levels of 4-MMPPO, among other features. | 10-08-2009 |
20100324090 | COMPOSITIONS OF TOLPERISONE - The present disclosure is directed to methods for providing tolperisone having extremely low levels of 4-MMPPO (2-methyl-1-(4-methylphenyl)-propenone), as well as related compositions. The invention further relates to methods of treating a subject with tolperisone under conditions that limit exposure of the subject to tolerable levels of 4-MMPPO, among other features. | 12-23-2010 |
Paul Claus Gerdes, Baden-Rutihof CH
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20100206937 | WELDING ADDITIVE MATERIAL - A steel has the following chemical composition (amounts in % by weight): | 08-19-2010 |