Patent application number | Description | Published |
20090162374 | SPECIFIC REMOVAL OF ACTIVATED IMMUNE CELLS - The present invention provides a method of detecting an immune response in a mammalian subject by (a) withdrawing blood or a blood fraction containing immune cells from the subject, (b) contacting the blood with an antibody that specifically binds to the cell surface HLA-F histocompatibility protein of activated mammalian immune cells and then (c) detecting the presence or absence of binding of immune cells to the antibody, wherein the presence of binding indicates the presence of an immune response in the subject. | 06-25-2009 |
20150212084 | SPECIFIC REMOVAL OF ACTIVATED IMMUNE CELLS - The present invention provides a method of detecting an immune response in a mammalian subject by: (a) withdrawing blood or a blood fraction containing immune cells from the subject; (b) contacting the blood or blood fraction to an antibody (e.g., a monoclonal antibody) that specifically binds to the cell surface HLA-F histocompatibility protein of activated mammalian immune cells, which antibody does not bind to the cell surface of non-activated mammalian immune cells; and then (c) detecting the presence or absence of binding of the immune cells to the antibody, the presence of binding indicating the presence of an immune response in the subject. A further aspect of the invention is a composition comprising, consisting of or consisting essentially of a solid support having an antibody (e.g., a monoclonal antibody) coupled thereto, which antibody specifically binds to the cell surface HLA-F histocompatibility protein of activated mammalian T-lymphocytes, and which antibody does not bind to theācell surface of non-activated mammalian T-lymphocytes. Further aspects of the invention include a pharmaceutically acceptable composition comprising a mammalian blood or blood fraction; a monoclonal antibody that specifically binds to the cell surface HLA-F histocompatibility protein of activated mammalian T-lymphocytes, and which antibody does not bind to the cell surface of non-activated mammalian T-lymphocytes; and a method of treating an undesired immune response in a subject in need thereof, comprising administering the subject a monoclonal antibody as described herein in an amount effective to treat the disease. | 07-30-2015 |
20160045594 | DIRECTED IMMUNE STIMULATION - A synthetic polypeptide vaccine is employed for directed targeting of an individual's immune response to an antigen of interest. The synthetic polypeptide contains a carrier epitope specific for open conformers of an individual's MHC-I molecules in the presence of HLA-F, and also contains an effector epitope which elicits an immune response to the antigen of interest. The effect- or epitope may modulates an immune response to a tumor, pathogen, or autoantigen associated with an autoimmune disorder. The present vaccine exploits a role for the interaction between HLA-F and open conformers of MHC-I in the uptake of extracellular antigen for cross presentation. | 02-18-2016 |
Patent application number | Description | Published |
20080269642 | ANGLE INDICATOR FOR CAPSULAR BAG SIZE MEASUREMENT - Implantation of an accommodating intraocular lens in an eye may require the accurate measurement of the size, circumference, or diameter of the capsular bag of the eye. After the natural crystalline lens has been surgically removed, a flexible ring may be temporarily or permanently inserted into the capsular bag for measuring the circumference of the capsular bag. The ring is generally compressible to fit through a surgical incision, then expands to fill the capsular bag along an equatorial region. The ring has a central component that changes shape as the ring is compressed. The shape change is generally correlated to the size of the capsular bag and may be measured visually or with a camera through the cornea, the measurement being generally independent of corneal magnification. | 10-30-2008 |
20090012609 | MULTIFOCAL ACCOMMODATING INTRAOCULAR LENS - An intraocular lens for providing accommodative visions to a subject includes an adjustable optic and a haptic that is operably coupled to the optic. The adjustable optic comprises an optical axis, a central zone disposed about the optical axis, and an annular zone surrounding the central zone. The optic may also comprise additional annular zones disposed about the central zone and the first annular zone. The haptic comprises a transparent portion protruding into the adjustable optic. The intraocular lens has a disaccommodative configuration in which the central zone has a base optical power and an accommodative configuration in which the central zone has an add optical power that is at least about 1 Diopter greater than the base optical power, preferably at least about 2 Diopters greater than the base optical power. In some embodiments, the add optical power is at least 3 Diopters, or even 4 Diopters, greater than the base optical power. The central zone and the annular zone have different optical powers when the adjustable intraocular lens is in the accommodative configuration and/or when the adjustable intraocular lens is in the disaccommodative configuration. | 01-08-2009 |
20100130888 | Systems and Methods for Ocular Measurements - A system for measuring the size of a capsular bag of an eye of a subject includes a size indicator and a sizing gauge. The size indicator is configured for insertion into a capsular bag and includes a peripheral portion and a pair of arms. The peripheral portion is configured to engage the capsular bag. Each of the arms has a proximal end and a distal end, the arms being joined to one another at the proximal ends. The peripheral portion is joined to the distal ends of the arms. The arms form an angle that depends on a size of the capsular bag into which the size indicator is placed. The sizing gauge has a body having a front surface, along with first and second features disposed along or behind the front surface. The features are configured to correspond to an angle that is within a predetermined range of angles of the arms of the size indicator when the size indicator is placed within a capsular bag. | 05-27-2010 |
20110292336 | ANGLE INDICATOR FOR OCULAR MEASUREMENTS - Implantation of an accommodating intraocular lens in an eye may require the accurate measurement of the size, circumference, or diameter of the capsular bag of the eye. A flexible ring or ring portion may be temporarily or permanently inserted into the capsular bag for measuring the circumference of the capsular bag, for example, after extraction of a natural lens from the capsular bag. The ring or ring portion is generally compressible to fit through a surgical incision, then expands to fill the capsular bag along an equatorial region. The ring or ring portion includes a central component that changes shape and/or angle as the ring or ring portion is compressed. The shape change is generally correlated to the size of the capsular bag and may be visually measured through the cornea, the measurement being generally independent of corneal magnification. The measurement may be used to determine or calculate information about the capsular bag such as its size, elasticity, accommodative range, and so forth. | 12-01-2011 |
20110306902 | SYSTEMS AND METHODS FOR OCULAR MEASUREMENTS - A system for measuring the size of a capsular bag of an eye of a subject includes a size indicator and a sizing gauge. The size indicator is configured for insertion into a capsular bag and includes a peripheral portion and a pair of arms. The peripheral portion is configured to engage the capsular bag. Each of the arms has a proximal end and a distal end, the arms being joined to one another at the proximal ends. The peripheral portion is joined to the distal ends of the arms. The arms form an angle that depends on a size of the capsular bag into which the size indicator is placed. The sizing gauge has a body having a front surface, along with first and second features disposed along or behind the front surface. The features are configured to correspond to an angle that is within a predetermined range of angles of the arms of the size indicator when the size indicator is placed within a capsular bag. | 12-15-2011 |
20120059363 | CAPSULAR MEMBRANE TREATMENTS TO INCREASE ACCOMMODATIVE AMPLITUDE - Methods and apparatus treat the lens capsule so as to increase accommodation of the eye. The treatment of the lens capsule may comprise treating a portion of the lens capsule so as to stiffen the treated portion and improve accommodation of the eye. The intermediate portion of the lens capsule may located between an optically used central portion of the lens capsule and a peripheral portion of the lens capsule connected to zonules of the eye. The stiffened intermediate portion of the lens capsule can improve coupling of the peripheral portion of the lens capsule to the central portion of the lens capsule, such that an amount of accommodation of the optically used central portion of the lens is increased. As the force of the lens capsule to a lens disposed within the lens capsule is increased, the lens may comprise the natural lens of the eye or an artificial lens such as an accommodative IOL. The treatment of the eye to stiffen the intermediate portion may comprise application of one or more of an energy or a substance to the intermediate portion. | 03-08-2012 |
20120059465 | CAPSULAR MEMBRANE IMPLANTS TO INCREASE ACCOMMODATIVE AMPLITUDE - A support is coupled to the lens capsule to increase accommodation. The support may be adjustable, such that patient refraction and accommodation can be adjusted following surgery. The support may comprise rigidity sufficient to decrease radial movement of the intermediate portion of the lens capsule. The support can be placed on the intermediate portion to decrease radial movement of the intermediate portion of the lens capsule and increase radial stretching of an outer portion of the lens capsule extending between the zonules and the intermediate portion coupled to the support, such that the amount of accommodation of the eye is increased. The support may comprise a biocompatible material capable of stable coupling to the lens capsule following implantation, such that the far vision refraction and accommodation of the eye can be stable following surgery. | 03-08-2012 |
20120253458 | MULTIFOCAL ACCOMMODATING INTRAOCULAR LENS - An intraocular lens for providing accommodative vision includes an adjustable optic and a haptic that is operably coupled to the optic. The adjustable optic comprises a central zone and an annular zone surrounding the central zone. The optic may also comprise additional annular zones. The haptic comprises a transparent portion protruding into the adjustable optic. The intraocular lens has a disaccommodative configuration in which the central zone has a base optical power and an accommodative configuration in which the central zone has an add optical power that is at least about 1 Diopter greater than the base optical power. The central zone and the annular zone have different optical powers when the adjustable intraocular lens is in the accommodative configuration and/or when the adjustable intraocular lens is in the disaccommodative configuration. | 10-04-2012 |
20130274627 | SYSTEMS AND METHODS FOR OCULAR MEASUREMENTS - A system for measuring the size of a capsular bag of an eye of a subject includes a size indicator and a sizing gauge. The size indicator is configured for insertion into a capsular bag and includes a peripheral portion and a pair of arms. The peripheral portion is configured to engage the capsular bag. Each of the arms has a proximal end and a distal end, the arms being joined to one another at the proximal ends. The peripheral portion is joined to the distal ends of the arms. The arms form an angle that depends on a size of the capsular bag into which the size indicator is placed. The sizing gauge has a body having a front surface, along with first and second features disposed along or behind the front surface. The features are configured to correspond to an angle that is within a predetermined range of angles of the arms of the size indicator when the size indicator is placed within a capsular bag. | 10-17-2013 |
20130297018 | INTRAOCULAR LENS WITH SHAPE CHANGING CAPABILITY TO PROVIDE ENHANCED ACCOMODATION AND VISUAL ACUITY - An intraocular lens for providing a range of accommodative vision, an extended depth of focus, or enhanced performance through the asymmetric transfer of ocular forces to the lens. The intraocular lens contains an optic and a haptic. The shape and/or material of the haptic results in the transmission of ocular forces to particular regions in the optic. Greater forces applied to particular regions result in deformation of that region and increased power. | 11-07-2013 |
Patent application number | Description | Published |
20120016473 | ACCOMMODATING INTRAOCULAR LENS - An intraocular lens for implantation in a capsular bag of an eye includes an optic disposed about an optical axis and a haptic including a protruding portion disposed inside the optic. The optic has an anterior face and an opposing posterior face that are configured to provide a lens power. In response to an ocular force of the eye, the haptic transmits a force that alters one or more of a shape of the optic and an axial thickness of the optic. The protruding portion of the haptic has a refractive index that is equal to a refraction index of the optic for at least one a wavelength within the visible spectrum. | 01-19-2012 |
20130030525 | PRE-STRESSED HAPTIC FOR ACCOMMODATING INTRAOCULAR LENS - An intraocular lens is disclosed, with an optic that changes shape in response to a deforming force exerted by the zonules of the eye. A haptic supports the optic around its equator and couples the optic to the capsular bag of the eye. The haptic may be pre-stressed before the optic is placed within it. After such placement, the pre-stress may be relieved, and the haptic may produce stress in the optic. The pre-stress may produce a radial tension or a radial compression in the optic. Alternatively, once the optic is placed within the haptic, both may undergo a process that changes the size and/or shape of one with respect to the other, causing a stress within the optic. This process may produce a radial tension or a radial compression in the optic. | 01-31-2013 |
20150320548 | INTRAOCULAR LENS WITH SHAPE CHANGING CAPABILITY TO PROVIDE ENHANCED ACCOMODATION AND VISUAL ACUITY - An intraocular lens for providing a range of accommodative vision, an extended depth of focus, or enhanced performance through the asymmetric transfer of ocular forces to the lens. The intraocular lens contains an optic and a haptic. The shape and/or material of the haptic results in the transmission of ocular forces to particular regions in the optic. Greater forces applied to particular regions result in deformation of that region and increased power. | 11-12-2015 |
Patent application number | Description | Published |
20120158954 | METHODS AND APPARATUS TO DETERMINE IMPRESSIONS USING DISTRIBUTED DEMOGRAPHIC INFORMATION - Example methods and apparatus to determine media impressions using distributed demographic information are disclosed. A disclosed example method to monitor media content exposure involves receiving, at a first internet domain, a first request from a client computer, the first request indicative of access to the media at the client computer, sending, from the first internet domain, a response to the client computer, the response to instruct the client computer to send a second request to an intermediary associated with a sub-domain of a second internet domain, the second request to be indicative of the access to the media at the client computer, the intermediary to transmit an indication of the second request to an entity of the second internet domain, and logging an impression of the media. | 06-21-2012 |
20120215621 | METHODS AND APPARATUS TO DETERMINE MEDIA IMPRESSIONS USING DISTRIBUTED DEMOGRAPHIC INFORMATION - Example methods involve based on a first request to log a first media impression, generating a first identifier associated with a first client device that generated the first request, and sending a communication to the first client device. The communication includes the first identifier, and the communication is to cause the first client device to send the first identifier associated with the first client device to a database proprietor in association with a cookie identifier of the first client device. Second media impressions are logged in association with the first identifier of the first client device and second identifiers associated with second client devices based on second requests received from the first and second client devices. A batch including the second media impressions and the first and second identifiers is sent to the database proprietor. Demographic information associated with the second media impressions is received from the database proprietor. | 08-23-2012 |
20120239809 | METHODS AND APPARATUS TO DETERMINE IMPRESSIONS USING DISTRIBUTED DEMOGRAPHIC INFORMATION - Example methods and apparatus to determine impressions using distributed demographic information are disclosed. A disclosed example method to monitor media exposure involves receiving, at a first internet domain, a first request from a client computer, the first request indicative of access to the media at the client computer. The example method also involves determining if the client computer is known. If the client computer is not known, a response is sent from the first internet domain to the client computer, the response to instruct the client computer to send a second request to a second internet domain, the second request to be indicative of access to the media at the client computer. If the client computer is known, an impression of the media is logged. | 09-20-2012 |
20130097311 | METHODS AND APPARATUS TO DETERMINE IMPRESSIONS USING DISTRIBUTED DEMOGRAPHIC INFORMATION - Example methods and apparatus to determine impressions using distributed demographic information are disclosed. A disclosed example method to monitor media exposure involves receiving, at a first internet domain, a first request from a client computer, the first request indicative of access to the media at the client computer. The example method also involves determining if the client computer is known. If the client computer is not known, a response is sent from the first internet domain to the client computer, the response to instruct the client computer to send a second request to a second internet domain, the second request to be indicative of access to the media at the client computer. If the client computer is known, an impression of the media is logged. | 04-18-2013 |
20130097312 | METHODS AND APPARATUS TO DETERMINE IMPRESSIONS USING DISTRIBUTED DEMOGRAPHIC INFORMATION - Example methods and apparatus to determine impressions using distributed demographic information are disclosed. A disclosed example method to monitor media exposure involves receiving, at a first internet domain, a first request from a client computer, the first request indicative of access to the media at the client computer. The example method also involves determining if the client computer is known. If the client computer is not known, a response is sent from the first internet domain to the client computer, the response to instruct the client computer to send a second request to a second internet domain, the second request to be indicative of access to the media at the client computer. If the client computer is known, an impression of the media is logged. | 04-18-2013 |
20130282898 | METHODS AND APPARATUS TO DETERMINE MEDIA IMPRESSIONS USING DISTRIBUTED DEMOGRAPHIC INFORMATION - Examples to determine media impressions using distributed demographic information are disclosed. Some disclosed example methods involve sending a request to an impression monitor system in response to detecting a login event at a client device. The login event is associated with an Internet-based service of a first Internet domain different from a second internet domain of the impression monitor system. Such disclosed example methods also involve sending a login reporting message to a database proprietor that provides the Internet-based service. The login reporting message including first and second cookie identifiers. The first cookie identifier is associated with the first Internet domain of the Internet-based service, and the second cookie identifier is associated with the second Internet domain of the impression monitor system. | 10-24-2013 |
20140095702 | METHODS AND APPARATUS TO DETERMINE MEDIA IMPRESSIONS USING DISTRIBUTED DEMOGRAPHIC INFORMATION - Examples to determine media impressions using distributed demographic information are disclosed. Some disclosed example methods involve sending a request to an impression monitor system in response to detecting a login event at a client device. The login event is associated with an Internet-based service of a first Internet domain different from a second internet domain of the impression monitor system. Such disclosed example methods also involve sending a login reporting message to a database proprietor that provides the Internet-based service. The login reporting message including first and second cookie identifiers. The first cookie identifier is associated with the first Internet domain of the Internet-based service, and the second cookie identifier is associated with the second Internet domain of the impression monitor system. | 04-03-2014 |
20140250223 | METHODS AND APPARATUS TO DETERMINE IMPRESSIONS USING DISTRIBUTED DEMOGRAPHIC INFORMATION - Methods and apparatus to determine media impressions using distributed demographic information are disclosed. An method includes sending to a client computer, via a processor serving a first internet domain, a response to a first request, the first request sent to the first internet domain and indicative of access to media at the client computer, the response to instruct the client computer to send a second request to an intermediary serving a sub-domain of a second internet domain, the second request to be indicative of the access to the media at the client computer, wherein the intermediary is to transmit first data about the second request to a data collection server of an audience measurement entity and second data about the second request to an entity of the second internet domain and logging an impression of the media. | 09-04-2014 |
20150019327 | METHODS AND APPARATUS TO DETERMINE IMPRESSIONS USING DISTRIBUTED DEMOGRAPHIC INFORMATION - An example method involves receiving, at a first internet domain, a first request from a client device, the first request indicative of access to media at the client. The first request includes identifying information identifying the media. A substitute value is generated at the first internet domain, the substitute value corresponding to the identifying information and obfuscating an identity of the media. If the client is not known, a response including the substitute value in place of the identifying information is sent from the first internet domain to the client. The response instructs the client to send a second request to a second internet domain, the second request includes the substitute value to hide the identity of the media within the second internet domain. If the client is known, an impression of the media is logged without sending the second request to the second internet domain. | 01-15-2015 |
Patent application number | Description | Published |
20110119205 | SYSTEMS AND METHODS FOR DETERMINING AN EARNINGS PORTION OF A DISTRIBUTION FROM A 529 PLAN - A method for determining an earnings portion of a distribution from a 529 plan. The method includes receiving information associated with a plurality of 529 plan accounts, identifying related 529 plan accounts, aggregating the information for related 529 plan accounts, and determining an earnings portion of a distribution from at least one of the 529 plan accounts. | 05-19-2011 |
20120185411 | SYSTEMS AND METHODS FOR DETERMINING AN EARNINGS PORTION OF A DISTRIBUTION FROM A 529 PLAN - A method for determining an earnings portion of a distribution from a 529 plan. The method includes receiving information associated with a plurality of 529 plan accounts, identifying related 529 plan accounts, aggregating the information for related 529 plan accounts, and determining an earnings portion of a distribution from at least one of the 529 plan accounts. | 07-19-2012 |
20140067720 | SYSTEMS AND METHODS FOR DETERMINING AN EARNINGS PORTION OF A DISTRIBUTION FROM A 529 PLAN - A method for determining an earnings portion of a distribution from a 529 plan. The method includes receiving information associated with a plurality of 529 plan accounts, identifying related 529 plan accounts, aggregating the information for related 529 plan accounts, and determining an earnings portion of a distribution from at least one of the 529 plan accounts. | 03-06-2014 |
20150187009 | SYSTEMS AND METHODS FOR DETERMINING AN EARNINGS PORTION OF A DISTRIBUTION FROM A 529 PLAN - A method for determining an earnings portion of a distribution from a 529 plan. The method includes receiving information associated with a plurality of 529 plan accounts, identifying related 529 plan accounts, aggregating the information for related 529 plan accounts, and determining an earnings portion of a distribution from at least one of the 529 plan accounts. | 07-02-2015 |
20150187010 | DATA AGGREGATION FOR PROCESSING AND ANALYZING 529 PLAN DATA - Enhanced tools and techniques are provided for collecting, processing, and analyzing 529 plan data. In one embodiment, the process includes a computer-based method for identifying related 529 plan accounts from a plurality of 529 plan accounts, including identifying 529 plan accounts having a common beneficiary or identifying 529 plan accounts having a common owner/beneficiary combination; and, aggregating the information for related 529 plan accounts in a computer implemented aggregation database. | 07-02-2015 |
Patent application number | Description | Published |
20090259522 | SYSTEM AND METHODS FOR GENERATING QUANTITATIVE PRICING POWER AND RISK SCORES - The present invention relates to a quantitative pricing power and pricing risk score generator and methods therefore, useful in association with an integrated price management system. Such a system may include a segment generator, a segment pricing power analyzer, and a segment pricing risk analyzer. The segment generator may receive or generate segments associated with a customer. Segment generation uses transaction level data which includes product attribute information, market data, and transaction history data. The segment pricing power analyzer and risk analyzer identify pricing power and risk factors, and assign raw scores to each factor, generates a weight for each raw score for each of the pricing power factors, and generates the quantitative pricing power and risk scores for each segment by computing a weighted average of the factors using the generated weights for each of the raw scores. Weights may be assigned according to default values or may be generated via an optimization. | 10-15-2009 |
20090259523 | SYSTEM AND METHODS FOR CALIBRATING PRICING POWER AND RISK SCORES - The present invention relates to a power and risk score calibrator which includes segment pricing power and risk reconcilers, a segment cartographer, segment power and risk aggregators, pricing power and risk value comparers, and pricing power and risk value calibrators. The reconcilers receive quantitative power and risk scores for each quantitative segment, and receive qualitative power and risk scores for each qualitative segment. The qualitative segment and the qualitative power and risk scores are defined by a user. The cartographer generates consolidated segments. The aggregators may then generate consolidated power and risk scores for each of the consolidated segments, respectively. The comparers then reconcile gaps between the qualitative power and risk scores and the consolidated power and risk scores. From these reconciliations adjustment factors are generated, which are applied by pricing power and risk value calibrators. The calibrators may also perform a drill down to explain the gap between the qualitative scores and the consolidated scores. | 10-15-2009 |