Patent application number | Description | Published |
20080269068 | MULTIPLEX DECODING OF SEQUENCE TAGS IN BARCODES - Methods and compositions for performing multiplex reactions are provided. | 10-30-2008 |
20090018024 | NANOGRID ROLLING CIRCLE DNA SEQUENCING - The present invention relates to methods for sequencing a polynucleotide immobilized on an array having a plurality of specific regions each having a defined diameter size, including synthesizing a concatemer of a polynucleotide by rolling circle amplification, wherein the concatemer has a cross-sectional diameter greater than the diameter of a specific region, immobilizing the concatemer to the specific region to make an immobilized concatemer, and sequencing the immobilized concatemer. | 01-15-2009 |
20090099041 | METHODS FOR MAKING NUCLEOTIDE PROBES FOR SEQUENCING AND SYNTHESIS - Compositions and methods for making a plurality of probes for analyzing a plurality of nucleic acid samples are provided. Compositions and methods for analyzing a plurality of nucleic acid samples to obtain sequence information in each nucleic acid sample are also provided. | 04-16-2009 |
20090137407 | GENOMIC LIBRARY CONSTRUCTION - Compositions and methods for amplifying nucleic acid sequences from a single cell are provided. Compositions and methods for constructing a genomic library from a single cell are also provided. | 05-28-2009 |
20090317910 | MULTIPLEX AUTOMATED GENOME ENGINEERING - The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells. | 12-24-2009 |
20090318298 | Methods for Sequencing DNA - The invention is directed to methods for using sequence by ligation to sequence DNA immobilized on miniaturized, high density bead-based arrays. Methods are provided to fabricate an array of beads where the beads are coupled directly to a solid support. Methods are also provided to improve signal and reduce background in ligation-mediated DNA sequencing. In addition, methods are provided to improve the accuracy of reported tag counts when performing DNA sequencing by fluorescent nonamer ligation. | 12-24-2009 |
20100047876 | HIERARCHICAL ASSEMBLY OF POLYNUCLEOTIDES - Methods, compositions and apparatuses for hierarchical assembly of oligonucleotide sequences are provided. | 02-25-2010 |
20100062494 | ENZYMATIC OLIGONUCLEOTIDE PRE-ADENYLATION - Methods and compositions for making and using pre-adenylated oligonucleotide sequences are provided. | 03-11-2010 |
20100081140 | CHEMICALLY CLEAVABLE PHOSPHORAMIDITE LINKERS FOR SEQUENCING BY LIGATION - Linkers and methods for determining a nucleotide sequence of a reference oligonucleotide are provided. | 04-01-2010 |
20100092988 | Methods and Compounds For Chemical Ligation - Compositions and methods for chemical ligation are provided. Methods for nucleic acid sequencing, nucleic acid assembly and nucleic acid synthesis are also provided. | 04-15-2010 |
20100093064 | Metagenomic Functional Selection - Methods and compositions for directly selecting a nucleic acid sequence that confers resistance to an inhibitory compound are provided. Methods and compositions for decontaminating contaminated substances are provided. Microorganisms having resistance to an inhibitory compound are also provided. | 04-15-2010 |
20100099080 | NUCLEIC ACID MEMORY DEVICE - This invention pertains to methods of imparting information onto nucleic acid sequences. In specific embodiments, the present invention provides site-specific recombinase systems and error-prone polymerase systems to alter nucleotide sequences such as DNA and mini-genomes, as well as for the production of microarrays. The present invention also provides methods of analyzing the modified nucleotides sequences provided herein. Methods of engineering and screening for novel modified polymerases that incorporate chain terminating nucleotides and/or labeled nucleotides more efficiently than wild-type polymerases are also provided. | 04-22-2010 |
20100159565 | Toxin-Eating Bacteria and Bioremediation - Bacteria that can use antibiotics as a carbon source are provided. Methods and bacteria useful for bioremediation are also provided. | 06-24-2010 |
20100273164 | Targeted and Whole-Genome Technologies to Profile DNA Cytosine Methylation - Methods and compositions for determining a methylated cytosine profile of a target nucleic acid sequence are provided. | 10-28-2010 |
20100304994 | Oligonucleotide Paints - Novel methods for making high resolution oligonucleotide paints are provided. Novel, high resolution oligonucleotide paints are also provided. | 12-02-2010 |
20110039304 | Methods to Generate Oligonucleotide Pools and Enrich Target Nucleic Acid Sequences - Methods and compositions for generating oligonucleotide pools are provided. Methods and compositions for enriching target nucleic acid sequences are also provided. | 02-17-2011 |
20110104787 | Fusion Peptides That Bind to and Modify Target Nucleic Acid Sequences - Novel methods and compositions for altering target nucleic acid (e.g., DNA e.g., genomic DNA) sequences are provided. Fusion proteins including one or more DNA binding domains and one or more DNA modifying domains are provided. Isolated polynucleotides encoding fusion proteins including one or more DNA binding domains and one or more DNA modifying domains are provided. | 05-05-2011 |
20120058521 | ENZYMATIC OLIGONUCLEOTIDE PRE-ADENYLATION - Methods and compositions for making and using pre-adenylated oligonucleotide sequences are provided. | 03-08-2012 |
20120142540 | Methods For Sequencing Nucleic Acid Molecules - Methods and compositions for determining the nucleic acid sequence of polynucleotides that are at least 1500 nucleotides in length are provided. | 06-07-2012 |
20120171720 | Method of Making Ribosomes - Methods for making in vitro assembled ribosomal subunits and in vitro assembled ribosomes are provided. Methods of transcribing synthetic rRNA and including the synthetic RNA in a synthetic ribosome are provided. Single vessel methods of transcribing synthetic rRNA, forming a synthetic ribosome that includes the synthetic RNA, and allowing the synthetic ribosome to translate a protein are also provided. Methods of screening for novel, synthetic ribosomal subunits and/or ribosomes are provided. Synthetic replicons and methods of making synthetic replicons are also provided. | 07-05-2012 |
20120270273 | TRANSCRIPTION ACTIVATOR-LIKE EFFECTORS - Provided herein are compositions, kits and methods useful in the construction of designer transcription activator-like effector (dTALE) polypeptides. | 10-25-2012 |
20130005025 | Multiplex Automated Genome Engineering - The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells. | 01-03-2013 |
20130224729 | Biodetection Methods and Compositions - Diagnostic methods and compositions for detecting biological material are provided. | 08-29-2013 |
20130274117 | High-Throughput Single Cell Barcoding - Methods and compositions for high-throughput, single cell analyses are provided. The methods and compositions can be used for analysis of genomes and transcriptomes, as well as antibody discovery, HLA typing, haplotyping and drug discovery. | 10-17-2013 |
20130296535 | High-Throughput Immune Sequencing - Methods and compositions for determining and/or monitoring the immune state of an individual are provided. | 11-07-2013 |
20140045267 | Methods of Introducing Nucleic Acids into Cellular DNA - A method of introducing a nucleic acid sequence into a cell is provided where the cell has impaired or inhibited or disrupted primase activity or impaired or inhibited or disrupted helicase activity, or larger or increased gaps or distance between Okazaki fragments or lowered or reduced frequency of Okazaki fragment initiation, or the cell has increased single stranded DNA (ssDNA) on the lagging strand of the replication fork including transforming the cell through recombination with a nucleic acid oligomer. | 02-13-2014 |
20140045728 | Orthogonal Amplification and Assembly of Nucleic Acid Sequences - Methods and compositions for synthesizing nucleic acid sequences of interest from heterogeneous mixtures of oligonucleotide sequences are provided. | 02-13-2014 |
20140178971 | Toxin-Eating Bacteria and Bioremediation - Bacteria that can use antibiotics as a carbon source are provided. Methods and bacteria useful for bioremediation are also provided. | 06-26-2014 |
20140342456 | RNA-Guided Human Genome Engineering - A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner. | 11-20-2014 |
20140342457 | RNA-Guided Human Genome Engineering - A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner. | 11-20-2014 |
20140342458 | RNA-Guided Human Genome Engineering - A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner. | 11-20-2014 |
20140349288 | Methods for Making Nucleotide Probes for Sequencing and Synthesis - Compositions and methods for making a plurality of probes for analyzing a plurality of nucleic acid samples are provided. Compositions and methods for analyzing a plurality of nucleic acid samples to obtain sequence information in each nucleic acid sample are also provided. | 11-27-2014 |
20140349294 | Sequencing by Structure Assembly - A method of sequencing nucleic acids is provided using sequencing by ligation and/or sequencing by hybridization. | 11-27-2014 |
20140356956 | RNA-Guided Transcriptional Regulation - Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid. | 12-04-2014 |
20140356958 | RNA-Guided Human Genome Engineering - A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner. | 12-04-2014 |
20140356959 | RNA-Guided Transcriptional Regulation - Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid. | 12-04-2014 |
20150031132 | Genome Engineering - Methods of genome engineering in cells using a TALEN lacking repeat sequences or Cas9 is provided. | 01-29-2015 |
20150031133 | Genome Engineering - Methods of genome engineering in cells using a TALEN lacking repeat sequences or Cas9 is provided. | 01-29-2015 |
20150051117 | Assembly of Nucleic Acid Sequences in Emulsions - Methods and compositions for synthesizing nucleic acid sequences in an emulsion are provided. | 02-19-2015 |