Patent application number | Description | Published |
20150271311 | Independent Smart Headset Networked Via Wireless Mobile Telecommunications Technology - The present invention relates to an independent smart headset apparatus networked via mobile wireless technology. The apparatus may comprise of a host portion and a headset portion. The host portion can include, among other things, a printed circuit board, a tactile sensor board, a user interface, a power source, a memory card, a wireless mobile telecommunications (e.g., 3G or 4G) module, a wireless local area network (e.g., WiFi) module, and a wireless data exchange (e.g., Bluetooth®) module. The headset portion can include a tactile sensor device, a matching wireless data exchange (e.g., Bluetooth®) module, a power source, a left earshell, a right earshell, a microphone (MIC), and an audio cable interface. The independent smart headset apparatus can also utilize a mobile operating system (e.g., Android™). The present invention improves over the current generation of music listening and socializing devices that require multiple independent devices. | 09-24-2015 |
20150271596 | Independent Smart Headset with a Host Releasably Attached Via Magnet Attraction - The present invention relates to an independent smart headset apparatus with a host releasably attached via magnet attraction. The apparatus may comprise of smart host and headset portions. The host can include a pair of magnet contacts and four metal wafers. The headset portion can include an earshell which is provided with a pair of magnet contacts corresponding to the pair of magnets included in the host. The earshell can also include four metal styluses corresponding to the four metal wafers included in the host. The independent smart headset apparatus constitutes a single device with the host and the headset that releasably and magnetically attach to one another without affecting data transmission between the two portions. The present invention overcomes the complexities associated with human-computer interaction and provides a convenient platform on which to listen to music and engage in online messaging and social activities. | 09-24-2015 |
Patent application number | Description | Published |
20140331000 | Computer System, Method for Accessing Peripheral Component Interconnect Express Endpoint Device, and Apparatus - A computer system and a method are provided for accessing a peripheral component interconnect express (PCIe) endpoint device. The computer system includes: a processor, a PCIe bus, and an access proxy. The access proxy connects to the processor and the PCIe endpoint device; the processor acquires an operation instruction, where the operation instruction instructs the processor to access the PCIe endpoint device through the access proxy, and send an access request to the access proxy according to the operation instruction; and the access proxy sends a response message of the access request to the processor after receiving the access request sent by the processor. Because the processor does not directly access the PCIe endpoint device to be accessed but completes access through the access proxy, thereby avoiding an MCE reset for the processor. | 11-06-2014 |
20150324268 | Method, Device, and System for Processing PCIe Link Fault - In a Peripheral Component Interconnect Express (PCIe) system, a first PCIe apparatus determines that at least one of lanes of a link between the first PCIe apparatus and a second PCIe apparatus is disabled, wherein the link includes M lanes numbered in a first order. Based upon the determination, the first PCIe apparatus obtains a number N indicating a number of available lanes of the link by performing a lane negotiation with the second PCIe apparatus. Then, a processor determines that N11-12-2015 | |
Patent application number | Description | Published |
20140181672 | INFORMATION PROCESSING METHOD AND ELECTRONIC APPARATUS - The present disclosure discloses an information processing method and an electronic apparatus, for solving a technical problem that when a user inputs a voice instruction different from the fixed voice instruction due to incapability of remembering the fixed voice instruction, the electronic devices cannot respond or will mistakenly respond. The method including determining a current application corresponding to a current application interface on the display unit as a first application, the current application interface being a first application interface to which the first application corresponds; obtaining M input objects on the first application interface, M being an integer equal to or larger than one; processing the M input objects to obtain M pieces of prompt information of M character phrases corresponding to the M input objects, the M pieces of prompt information being capable of being displayed on the display unit. | 06-26-2014 |
20150160907 | INFORMATION PROCESSING METHOD AND ELECTRONIC DEVICE - An information processing method is provided, which is applied to an electronic device. The electronic device includes a main body, a display unit and a projection unit. The method includes: obtaining trigger information for instructing the electronic device to switch from a first state to a second state; controlling the electronic device to switch from the first state to the second state in response to the trigger information; obtaining at least one parameter information; determining whether to enable the projection unit based on the at least one parameter information; and controlling the projection unit to be in the enabled state, in a case that it is determined to enable the projection unit based on the at least one parameter information. | 06-11-2015 |
20150160912 | METHOD AND ELECTRONIC DEVICE FOR PROCESSING INFORMATION - The present disclosure discloses a method and an electronic device for processing information to address the technical problem that the electronic device cannot be used for the user to view the data information because the display screen of the electronic device is blocked or occupied due to demands of operating an electronic device. The method comprises: establishing a communication connection to a second electronic device via the communication unit; acquiring a first trigger operation indicating to turn on the first projection unit;turning on the first projection unit in response to the first trigger operation during the communication between the first electronic device and the second electronic device; and projecting to obtain a first projection display interface in a projection area of the first projection unit, wherein the first projection display interface is formed in the projection area when the projection area is present on a first bearing plane. | 06-11-2015 |
20150378662 | Display Switching Method, Information Processing Method And Electronic Device - A wearable electronic device and a display switching method thereof, includes turning on a first display apparatus of the wearable electronic device to make the first display apparatus in a working state; rendering a first image in a first display region of the first display apparatus with a first display effect by the first display apparatus; obtaining first parameter information related to an input operation, by a sensing apparatus of the wearable electronic device; judging whether a second display apparatus of the wearable electronic device is to be turned on or not, according to the sensing parameter; and rendering a second image in a second display region of the second display apparatus with a second display effect by the second display apparatus, when the second display apparatus is to be turned on to make the second display apparatus in the working state. | 12-31-2015 |
Patent application number | Description | Published |
20130332888 | METHOD AND DEVICE FOR OPERATING LIST IN HANDHELD DEVICE - Disclosed are methods and devices for operating a list in a handheld device. An exemplary method can be provided by first monitoring a list and acquiring list touch initial information and then determining whether the acquired list touch initial information is multi-area touch information. When the acquired list touch initial information is determined to be the multi-area touch information, list touch final information can be acquired and stored. Based on the acquired list touch initial information and the list touch final information, whether a list operation is an expansion operation or a contraction operation is then determined. The list is expanded, when the expansion operation is determined. The list is collapsed, when the contraction operation is determined. The disclosed methods and devices can improve using experiences for users and improve use performance of the handheld device. | 12-12-2013 |
20140137042 | MENU DISPLAY METHOD AND SYSTEM, RADIAL MENU, AND STORAGE MEDIUM - A menu implementing method, comprising: establishing a mapping set between a sub-area and an operation; obtaining an operation event at a starting point being located at the edge of a screen, and popping-up a fan-shaped menu at the edge of the screen according to the operation event; obtaining a distance and an angle between a user's operation point and the starting point; searching a corresponding operation in the mapping set according to the obtained distance and angle; performing the found operation. This menu implementing method enables triggering a menu at the edge of the screen and improves the expansibility of the menu in the same direction. Furthermore, a menu implementing system, a fan-shaped menu and storage medium are provided. | 05-15-2014 |
20140139619 | COMMUNICATION METHOD AND DEVICE FOR VIDEO SIMULATION IMAGE - A method and device for communicating a video with a simulation image is provided. The method includes: acquiring, by a sender, video data, transforming the acquired video data into vector data in image recognition algorithm, and sending the vector data to a receiver; and calling, by the receiver, a cartoon rendering model and rendering the received vector data in the video with a corresponding cartoon simulation image according to the cartoon rendering model. By using the present invention, the amount of data transmitted in a network may be reduced, and network bandwidth resources are saved. | 05-22-2014 |
20140201676 | METHOD AND APPARATUS FOR SWITCHING PAGES IN INTERFACES, AND COMPUTER STORAGE MEDIUM THEREOF - A method for switching pages in interfaces includes obtaining an operational event on an interface, and triggering pages in a screen to move following the operational event; obtaining a sign corresponding to the moving page according to a mapping relationship between pages and signs; controlling the sign to move synchronously with the moving page; and obtaining the page to be settled in the screen according to the operational event. The above method and apparatus for switching pages in interfaces and computer storage medium trigger the pages in the screen to move along with operational events when the user operates events on the interfaces; and the signs corresponding to the pages would synchronously move with the moving pages. The signs dynamically indicate the page positions during the switch of the pages, therefore the intermediate status during the switch of the pages could be dynamically indicated, and the users' operational events on the interface is also dynamically fed back, which improves the flexibility in switching pages. | 07-17-2014 |
20140336437 | CEMENT CURING FORMULATION AND METHOD FOR HIGH-LEVEL RADIOACTIVE BORON WASTE RESINS FROM NUCLEAR REACTOR - A cement curing formulation and curing method for high-level radioactive boron waste resins from a nuclear reactor. The curing formulation comprises the following raw materials: cement, lime, water, curing aids and additives. The curing method comprises: (1) weighing the raw materials and the high-level radioactive boron waste resins, and adding lime into a curing container; (2) then adding the high-level radioactive boron waste resins; (3) feeding other raw materials under stirring; (4) adding the cement and supplementing water depending on the moisture state of the cement, and stirring until uniform; and (5) standing and maintaining after stirring until uniform. The curing formulation has the features of a high curing containment rate, high strength of the cured body, better water resistance, better freeze-thaw resistance, and low radioactive leakage. | 11-13-2014 |
Patent application number | Description | Published |
20130288589 | METHOD FOR CONTROLLING AIR VOLUME OUTPUT - A method for controlling air volume including: 1) establishing a functional relation formula for air volume in a microprocessor control unit of a motor controller; 2) inputting a target air volume into the microprocessor control unit of the motor controller; 3) starting a motor by the motor controller under a torque to enable the motor to fall on a steady state; 4) recording the rotational speed in the steady state, and calculating an air volume in the steady state; 5) comparing the target air volume with the calculated air volume; 6) re-recording a steady rotational speed after the motor falls on a new steady state under an increased or reduced torque, and recalculating the air volume in the new steady state; and 7) repeating steps 5) and 6) to adjust the torque until the calculated air volume is equal or equivalent to the target air volume. | 10-31-2013 |
20130288590 | METHOD FOR CONTROLLING AIR VOLUME OUTPUT - A method for controlling air volume including: 1) establishing a functional relation formula for air volume in a microprocessor control unit of a motor controller; 2) inputting a target air volume into the microprocessor control unit; 3) starting a motor by the motor controller to enable the motor to achieve a rotational speed and fall on a steady state; 4) recording the torque and rotational speed in the steady state, and calculating an air volume in the steady state; 5) comparing the target air volume with the calculated air volume; 6) re-recording a steady torque after the motor falls on a new steady state under an increased or reduced rotational speed, and recalculating the air volume in the new steady state; and 7) repeating steps 5) and 6) to adjust the rotational speed until the calculated air volume is equal or equivalent to the target air volume. | 10-31-2013 |
20140133999 | METHOD FOR CONTROLLING AIR VOLUME - A method for controlling air volume output by a motor. The method includes: 1) establishing functional relation formulas for air volume in a low torque interval and a high torque interval; 2) inputting a target air volume into a microprocessor control unit; 3) starting a motor under a torque to enable the motor to reach a steady state; 4) acquiring an adjustment coefficient under the torque, and calculating the air volume; 5) comparing the target air volume with the calculated air volume; 6) re-recording a steady rotational speed after the motor reaches a new steady state under an increased or reduced torque, and recalculating the air volume in the new steady state; and 7) repeating steps 5) and 6) to adjust the torque until the calculated air volume is equal or equivalent to the target air volume. | 05-15-2014 |
20140265957 | METHOD FOR CORRECTING TORQUE FOR SUBSTITUTING PERMANENT-SPLIT CAPACITORMOTOR BY ELECTRONICALLY-COMMUTATED MOTOR - A method for correcting torque including: presetting rotational speed of each gear by corresponding gear input lines of a microprocessor; providing a mechanism to select one rotational speed set; electing N power points within a range of the rated power, acquiring a set of torque data corresponding to each set of the rotational speed at each power point, and storing a total 2×N sets of torque data; allowing the motor to enter the torque correction mode; recording a steady torque Tadj when the motor operates in a steady state; and comparing the steady torque Tadj with a maximum gear torque Tmax, and selecting the set of torque data to which T[M]max belongs when the steady torque Tadj satisfies the relationship: 110%×T[M−1]max09-18-2014 | |
20140320052 | CENTRALIZED MOTOR CONTROLLER - A centralized motor controller for receiving commands from an application system controller and for controlling operation of a plurality of independent motors. The centralized motor controller includes: a power supply; a microprocessor; and an interface circuit for motor control including at least two inverter units and two rotor position detection units. The power supply supplies power for each circuit part. The motors are controlled by the microprocessor via the interface circuit for motor control. The number of the motors is equal to or more than three, in which, at least two of the motors are permanent magnet synchronous motors in the absence of a motor controller. The permanent magnet synchronous motors are driven by the microprocessor via the inverter units, respectively. Rotor position data of the permanent magnet synchronous motors are transmitted to the microprocessor via the rotor position detection units, respectively. | 10-30-2014 |
20140324230 | HVAC CONTROL SYSTEM FOR HOUSEHOLD CENTRAL AIR CONDITIONING - An HVAC control system for a household central air conditioning, including an HVAC system controller, a centrifugal blower motor, a compressor motor, and an axial fan motor. The HVAC system controller includes an HVAC microprocessor, a sensor, an interface unit for motor control, a power supply part, and a signal processing circuit. The interface unit for motor control includes an inverter unit and a rotor position detection unit. At least one of the centrifugal blower motor, the compressor motor, and the axial fan motor is a permanent magnet synchronous motor in the absence of a motor controller. The HVAC microprocessor drives the permanent magnet synchronous motor in the absence of a motor controller via the inverter unit. The rotor position detection unit sends a rotor position signal of the permanent magnet synchronous motor in the absence of a motor controller to the HVAC microprocessor. | 10-30-2014 |
20160054025 | METHOD FOR CONTROLLING AIR OUTPUT VOLUME - A method for controlling air volume including: 1) inputting a target air volume into a microprocessor control unit of a motor controller; 2) starting a motor by the motor controller and allowing the motor to work in a steady state under a rotational speed; 3) recording the torque and rotational speed in the steady state, establishing a functional relation formula Q=F (T, n, V) for calculating the air volume, and calculating an air volume in the steady state; 4) comparing the target air volume with the calculated air volume; 5) re-recording a steady torque after the motor falls on a new steady state under an increased or reduced rotational speed, and recalculating the air volume in the new steady state; and 6) repeating steps 4) and 5) to adjust the rotational speed until the calculated air volume is equal or equivalent to the target air volume. | 02-25-2016 |
20160097558 | METHOD FOR CONTROLLING AIR OUTPUT VOLUME - A method for controlling air volume including: 1) inputting a target air volume into the microprocessor control unit of the motor controller; 2) starting a motor by the motor controller under a torque to enable the motor to work in a steady state; 3) recording the rotational speed in the steady state, and establishing a functional relation formula Q=F (T, n, V) to calculate an air volume in the steady state; 4) comparing the target air volume with the calculated air volume; 5) re-recording a steady rotational speed after the motor falls on a new steady state under an increased or reduced torque, and recalculating the air volume in the new steady state; and 6) repeating steps 4) and 5) to adjust the torque until the calculated air volume is equal or equivalent to the target air volume. | 04-07-2016 |
20160116180 | METHOD FOR CONTROLLING CONSTANT AIR VOLUME OF ECM MOTOR IN HVAC SYSTEM - A method for controlling constant air volume of an ECM motor in an HVAC system. The method includes: a) acquiring a target air volume Q | 04-28-2016 |
Patent application number | Description | Published |
20130330367 | COMPOSITIONS WITH ENHANCED IMMUNOGENICITY AND/OR REDUCED REACTOGENICITY - The present invention relates to improved vaccines and the design and making of such vaccines that enhance immunogenicity of the vaccine and/or reduce reactogenicity to the vaccine when administered. In particular the vaccines and immunogenic compositions of the present invention relate to flagellin-antigen fusion proteins in which the spatial orientation of the flagellin to antigen and the charge distribution of the antigen is optimized to enhance immunogenicity and/or reduce reactogenicity. The present invention also relates to methods of evaluating the vaccines by measuring the relative expression of certain gene markers. Altered expression of the genes relative to flagellin control sample may indicate that the vaccine is suitable to stimulate an adaptive immune response to the antigen component in the subject with minimal side effects. | 12-12-2013 |
20140065177 | FUSION PROTEINS AND METHODS OF USE - Compositions that include a fusion protein comprising flagellin and at least one antigen that has an isoelectric point greater than about 7.0 and that is fused to at least one domain 3 of the flagellin activate Toll-like Receptor 5. Methods of stimulating an immune response, in particular, a protective immune response include administering a composition that includes an antigen fused to a loop of domain 3 of flagellin. | 03-06-2014 |
20140235836 | Immunologic Constructs and Methods - The present invention relates to improved vaccines and the design and making of such vaccines that enhance immunogenicity of the vaccine and/or reduce reactogenicity to the vaccine when administered. In particular the vaccines and immunogenic compositions of the present invention relate to flagellin-antigen fusion proteins in which the spatial orientation of the flagellin to antigen and the charge distribution of the antigen is optimized to enhance immunogenicity and/or reduce reactogenicity and/or improve folding of the protein. | 08-21-2014 |
20140255438 | FUSION PROTEINS AND METHODS OF USE - Compositions that include a fusion protein comprising flagellin and at least one antigen that has an isoelectric point greater than about 7.0 and that is fused to at least one domain 3 of the flagellin activate Toll-like Receptor 5. Methods of stimulating an immune response, in particular, a protective immune response include administering a composition that includes an antigen fused to a loop of domain 3 of flagellin. | 09-11-2014 |
20150099859 | Deletion Mutants of Flagellin and Methods of Use - Compositions that include at least a portion of a flagellin and an antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to infection. | 04-09-2015 |
20150110827 | FUSION PROTEINS AND METHODS OF USE - Compositions that include at least three fusion proteins comprising flagellin and influenza antigens. In embodiments, the influenza antigens can include influenza A and influenza B antigens. The composition can further include at least one adjuvant. | 04-23-2015 |
20150110832 | Deletion Mutants of Flagellin and Methods of Use - Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one viral antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection. | 04-23-2015 |
Patent application number | Description | Published |
20120069958 | Systems and Methods for Bioluminescent Computed Tomographic Reconstruction - An image of an object is synergistically reconstructed using two or multiple imaging modalities. A first reconstructed image, showing structural information of the object is produced using a first imaging modality. The first reconstructed image is segmented, and known optical properties of the object are then mapped to the first reconstructed image. Optical signal emissions from the object are detected and registered with the first reconstructed image. A second reconstructed image volume is then produced using a second imaging modality, based on the mapped optical properties after registration between the first image and the data from the second modality. The second reconstructed image depicts some optical property, such as a bioluminescent source distribution, or optical properties, such as, attenuation and scattering properties, of the object. | 03-22-2012 |
20140128730 | SYSTEMS AND METHODS FOR COMPUTED TOMOGRAPHIC RECONSTRUCTION - An image of an object is synergistically reconstructed using two or multiple imaging modalities. A first reconstructed image, showing structural information of the object is produced using a first imaging modality. The first reconstructed image is segmented, and known optical properties of the object are then mapped to the first reconstructed image. Optical signal emissions from the object are detected and registered with the first reconstructed image. A second reconstructed image volume is then produced using a second imaging modality, based on the mapped optical properties after registration between the first image and the data from the second modality. The second reconstructed image depicts some optical property, such as a bioluminescent source distribution, or optical properties, such as, attenuation and scattering properties, of the object. | 05-08-2014 |
Patent application number | Description | Published |
20150157286 | STORED LUMINESCENCE COMPUTED TOMOGRAPHY - Imaging methods and imaging systems are provided. Methods and systems of the subject invention can include the use of nanoparticles (for example, nanophosphors) within a sample to be imaged. X-ray engraving can be performed and/or X-ray excitation can be used to provide energy to the sample. Stimulation with infrared light, such as near-infrared (NIR) light, and/or optical multiplexing can be used to acquire tomographic data of the sample. | 06-11-2015 |
20150193927 | ATTENUATION MAP RECONSTRUCTION FROM TOF PET DATA - Advantageous methods, systems, and computer-readable media are provided. An attenuation map for an image can be reconstructed with no known sub-region of the attenuation map prior to performing the method. Gradient data of an attenuation sinogram can be estimated, and an algorithm can be performed to reconstruct the attenuation map from the estimated gradient data of the attenuation sinogram. | 07-09-2015 |
20160113602 | DYNAMIC BOWTIE FILTER FOR CONE-BEAM/MULTI-SLICE CT - Dynamic bowties, imaging systems including a bowtie, and methods of imaging including such bowties or systems are provided. A bowtie can be a three-dimensional (3-D) dynamic bowtie and can include a highly-attenuating bowtie (HB) and a weakly-attenuating bowtie (WB). The HB can be filled with a liquid, and the WB can be immersed in the liquid of the HB. | 04-28-2016 |
20160117850 | SYSTEMS AND METHODS FOR METAL ARTIFACT REDUCTION - A method includes receiving, with at least one processor, a first projection dataset corresponding to X-rays at a first energy level projected towards a subject at a first set of view angles and receiving, with the at least one processor, a second projection dataset corresponding to X-rays at a second energy level projected towards the subject at a second set of view angles. The method further includes identifying, with the at least one processor, a metal trace from at least one of the first projection dataset and the second projection dataset. Moreover, the method includes converting, with the at least one processor, at least a portion of the first projection dataset to a pseudo dataset at the second energy level. The method also includes generating, with the at least one processor, a final image of the subject based on the second projection dataset, the pseudo dataset, and the metal trace. | 04-28-2016 |
20160135769 | X-RAY PHASE-CONTRAST IMAGING - Systems and methods for X-ray phase-contrast imaging (PCI) are provided. A quasi-periodic phase grating can be positioned between an object being imaged and a detector. An analyzer grating can be disposed between the phase grating and the detector. Second-order approximation models for X-ray phase retrieval using paraxial Fresnel-Kirchhoff diffraction theory are also provided. An iterative method can be used to reconstruct a phase-contrast image or a dark-field image. | 05-19-2016 |
Patent application number | Description | Published |
20100158911 | Compositions and Methods of Treating Disease with FGFR Fusion Proteins - The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein. | 06-24-2010 |
20110281302 | COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS - The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein. | 11-17-2011 |
20110319324 | METHODS OF AND COMPOSITIONS FOR STIMULATION OF GLUCOSE UPTAKE INTO MUSCLE CELLS AND TREATMENT OF DISEASES - The present invention relates to therapeutic uses of ErbB ligands, including betacellulin. The therapeutic uses include methods of using ErbB ligand family compounds alone, or in conjunction with other agents, for reducing blood glucose levels, treating Type I and Type II diabetes, obesity, muscle wasting diseases, and cardiotoxicity. | 12-29-2011 |
20120258071 | Compositions and Methods of Use for MGD-CSF in Disease Treatment - Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss. | 10-11-2012 |
20120301921 | COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS - The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein. | 11-29-2012 |
20130065276 | COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS - The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein. | 03-14-2013 |
20130324701 | COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS - The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein. | 12-05-2013 |
20140140995 | COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS - The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein. | 05-22-2014 |
20140170145 | COMPOSITIONS AND METHODS OF USE FOR MGD-CSF IN DISEASE TREATMENT - Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss. | 06-19-2014 |
20160096876 | COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS - The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein. | 04-07-2016 |
Patent application number | Description | Published |
20080242596 | BENZYLIC GLYCOSIDE DERIVATIVES AND METHODS OF USE - Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition. | 10-02-2008 |
20090156516 | BENZYLPHENYL CYCLOHEXANE DERIVATIVES AND METHODS OF USE - Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition. | 06-18-2009 |
20100063141 | DEUTERATED BENZYLBENZENE DERIVATIVES AND METHODS OF USE - Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition. | 03-11-2010 |
20100222599 | PROCESSES FOR THE PREPARATION OF SGLT2 INHIBITORS - Provided are processes for the preparation of complexes that are useful in purifying compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The processes can reduce the number of steps needed to obtain the target compounds and the complexes formed in the processes are typically provided in a crystalline form. | 09-02-2010 |
20150210634 | PREPARATION OF HYDROXY-BENZYLBENZENE DERIVATIVES - Methods for preparing intermediates of SGLT2 inhibitors are provided, including crystalline forms and methods of crystallizing intermediates. | 07-30-2015 |
20150266915 | CRYSTALLINE FORM OF BENZYLBENZENE SGLT2 INHIBITOR - Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides pharmaceutical compositions, methods of preparing the crystalline compound, and methods of using the crystalline compound, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT or SGLT2 inhibition. | 09-24-2015 |
Patent application number | Description | Published |
20130278315 | DUAL-TRIGGER LOW-ENERGY FLIP-FLOP CIRCUIT - One embodiment of the present invention sets forth a technique for technique for capturing and storing a level of an input signal using a dual-trigger low-energy flip-flop circuit that is fully-static and insensitive to fabrication process variations. The dual-trigger low-energy flip-flop circuit presents only three transistor gate loads to the clock signal and none of the internal nodes toggle when the input signal remains constant. One of the clock signals may be a low-frequency “keeper clock” that toggles less frequently than the other two clock signal that is input to two transistor gates. The output signal Q is set or reset at the rising clock edge using separate trigger sub-circuits. Either the set or reset may be armed while the clock signal is low, and the set or reset is triggered at the rising edge of the dock. | 10-24-2013 |
20140070847 | CLOCK GATING LATCH, METHOD OF OPERATION THEREOF AND INTEGRATED CIRCUIT EMPLOYING THE SAME - A clock gating latch, a method of gating a clock signal and an integrating circuit incorporating the clock gating latch or the method. In one embodiment, the clock gating latch includes: (1) a propagation circuit having a single, first switch configured to be driven by an input clock signal, (2) a keeper circuit coupled to the propagation circuit and having a single, first switch configured to be driven by the input clock signal and (3) an AND gate coupled to the propagation circuit and the keeper circuit and having an internal node coupled to a second switch in the propagation circuit and a second switch in the keeper circuit. | 03-13-2014 |
20140084984 | LOW POWER, SINGLE-RAIL LEVEL SHIFTERS EMPLOYING POWER DOWN SIGNAL FROM OUTPUT POWER DOMAIN AND A METHOD OF CONVERTING A DATA SIGNAL BETWEEN POWER DOMAINS - Provided herein is a voltage level shifter, an apparatus including a voltage level shifter and a method of converting voltages between input and output power domains. In one embodiment, the voltage level shifter includes: (1) an input circuit configured to receive a data signal from an input power domain and a power down signal from a output power domain and (2) a transition circuit coupled to the input circuit and configured to receive the data signal and an inverted signal of the power down signal, wherein the input circuit and the transition circuit are both configured to connect to a supply voltage of the output power domain as a power source. | 03-27-2014 |
20140122949 | EFFICIENT SCAN LATCH SYSTEMS AND METHODS - Systems and methods for latches are presented. In one embodiment a system includes scan in propagation component, data propagation component, and control component. The scan in propagation component is operable to select between a scan in value and a recirculation value. The data propagation component is operable to select between a data value and results forwarded from the scan in propagation component, wherein results of the data propagation component are forwarded as the recirculation value to the scan in propagation component. The control component is operable to control an indication of a selection by the scan in propagation component and the data propagation component. | 05-01-2014 |
20140125377 | DUAL FLIP-FLOP CIRCUIT - A dual flip-flop circuit combines two or more flip-flip sub-circuits into a single circuit. The flip-flop circuit comprises a first flip-flop sub-circuit and a second flip-flop sub-circuit. The first flip-flop sub-circuit comprises a first storage sub-circuit configured to store a first selected input signal and transfer the first selected input signal to a first output signal when a buffered clock signal transitions between two different logic levels and a dock driver configured to receive a clock input signal, generate an inverted clock signal, and generate the buffered clock signal. The second flip-flop sub-circuit is coupled to the clock driver and configured to receive the inverted clock signal and the buffered clock signal. The second flip-flop sub-circuit comprises a second storage sub-circuit configured to store a second selected input signal and transfer the second selected input signal to a second output signal when the buffered clock signal transitions. | 05-08-2014 |
20140129887 | FLIP-FLOP CIRCUIT HAVING A REDUCED HOLD TIME REQUIREMENT FOR A SCAN INPUT - A scan flip-flop circuit comprises a scan input sub-circuit and a selection sub-circuit. The scan input sub-circuit is configured to receive a scan input signal and a scan enable signal and, when the scan enable signal is activated, generate complementary scan input signals representing the scan input signal that are delayed relative to a transition of a clock input signal between two different logic levels. The selection sub-circuit is coupled to the scan input sub-circuit and configured to receive the complementary scan input signals and, based on the scan enable signal, output an inverted version of either the scan input signal or a data signal as a first selected input signal. | 05-08-2014 |
20140167828 | SMALL AREA LOW POWER DATA RETENTION FLOP - Small area low power data retention flop. In accordance with a first embodiment of the present invention, a circuit includes a master latch coupled to a data retention latch. The data retention latch is configured to operate as a slave latch to the master latch to implement a master-slave flip flop during normal operation. The data retention latch is configured to retain an output value of the master-slave flip flop during a low power data retention mode when the master latch is powered down. A single control input is configured to select between the normal operation and the low power data retention mode. The circuit may be independent of a third latch. | 06-19-2014 |
20140169108 | MITIGATING EXTERNAL INFLUENCES ON LONG SIGNAL LINES - Mitigating external influences on long signal lines. In accordance with an embodiment of the present invention, a column of a memory array includes first and second transistors configured to pull up the bit line of the column. The column includes a third transistor configured to selectively pull up the bit line of the column responsive to a level of the inverted bit line of the column and a fourth transistor configured to selectively pull up the inverted bit line of the column responsive to a level of the bit line of the column. The column further includes fifth and sixth transistors configured to selectively pull up the bit line and inverted bit line of the column responsive to the clamp signal and a seventh transistor configured to selectively couple the bit line of the column and the inverted bit line of the column responsive to the clamp signal. | 06-19-2014 |
20140313817 | SRAM CORE CELL DESIGN WITH WRITE ASSIST - A static random access memory (SRAM) cell is disclosed. The SRAM cell includes a storage unit configured to store a data bit in a storage node. The SRAM cell further includes an access unit coupled to the storage unit. The access unit is configured to transfer current to the storage node when a word line is asserted. The SRAM cell further includes a row header configured to provide current from a power supply when the word line is not asserted, and to not provide current from the power supply when the word line is asserted. The SRAM cell further includes a column header configured to provide current from a power supply when a write column line is not asserted, and to not provide current from the power supply when the write column line is asserted. | 10-23-2014 |
20160043706 | LOW POWER FLIP-FLOP ELEMENT WITH GATED CLOCK - A flip-flop element is configured to gate the clock inversions within a master-slave flip-flop element. The flip-flop element reduces the number of circuit elements within the flip-flop element by collapsing elements with common functionality into a single circuit element. Further, by making the actions of judiciously selected circuit elements conditional upon the state of the input data, the flip-flop element circuit reduces the number of internal transitions. In this manner, by reducing the number of circuit elements as well as the number of transitions, the flip-flop element achieves substantial reduction in overall system power consumption, resulting in a more efficient system. | 02-11-2016 |