Garofalo, US
Albert Garofalo, Allegan, MI US
Albert Garofalo, South San Francisco, CA US
Patent application number | Description | Published |
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20100280066 | ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS - This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula I. The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is further directed to a method for inhibiting β-amyloid peptide release and/or synthesis, a method for inhibiting γ-secretase activity, and a method for treating neurological disorders associated with β-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula I. The compounds of Formula I are useful in the prevention and treatment of Alzheimer's disease. | 11-04-2010 |
Albert W. Garofalo, South San Francisco, CA US
Patent application number | Description | Published |
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20090099235 | Pyrazolopyrrolidines as Inhibitors of Gamma Secretase - The invention provides compounds of Formula I | 04-16-2009 |
20100081680 | N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS - The current invention provides compounds having a structure according to Formulae 1, 2, 3, and 4: | 04-01-2010 |
20100267747 | 5-(Arylsulfonyl)-Pyrazolopiperidines - The invention provides N-cyclic sulfonamido compounds of Formula I | 10-21-2010 |
20110003802 | Bridged N-Cyclic Sulfonamido Inhibitors of Gamma Secretase - The invention provides N-cyclic sulfonamido compounds and salts of Formula I: | 01-06-2011 |
20150157736 | HYDRAZINYL-PYRROLO COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE - The present disclosure provides conjugate structures and hydrazinyl-pyrrolo compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same. | 06-11-2015 |
20150352225 | Anti-Her2 Antibody-Maytansine Conjugates and Methods of Use Thereof - The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same. | 12-10-2015 |
Albert W. Garofalo, Cambridge, MA US
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20150284337 | INHIBITORS OF LRRK2 KINASE ACTIVITY - The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease. | 10-08-2015 |
Anthony Garofalo, Belmar, NJ US
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20090045233 | Baby swaddler - A baby holder including a cushioned support having pairs of curved channel or indent undersides at substantially right angles to one another to allow resting of the support on the upper legs of a seated parent with the baby facing the parent's chest or sideways, and with its head supported by the cushion and its legs extended along the cushion. | 02-19-2009 |
20130091633 | Infant bonding lap seat - A lap seat that allows for the comfortable and safe securement of an infant on its cover overlay in resting its inserted base support either forwardly along the upper thigh areas of a caregiver facing the infant, or across the upper thigh areas of the caregiver in facing the infant sideways, as a means of enhancing bonding with the infant while reducing the possibilities of colic and reflux development. | 04-18-2013 |
Donald Garofalo, Austin, TX US
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20080235745 | System and method to provide video communication with a service provider - Methods and systems for providing a video link are provided. A method may include receiving a request to establish a first video link to a healthcare service provider. The method may also include selecting a first healthcare service provider from at least two healthcare service providers and establishing the first video link to the first healthcare service provider. | 09-25-2008 |
20080250468 | System and method for scheduling presentation of future video event data - A method is disclosed for presenting video data comprising receiving at a first end user device, displayable video data for advertising a future video event; scanning the displayable video data for scheduling data associated with the future video event; and queuing the future video event for presenting data for the future video event based on the scheduling data. A system is disclosed for performing the method. A data structure is disclosed for containing data embedded in a computer readable medium for providing a functional and structural interrelationship between a processor, the data structure and data stored in the data structure. | 10-09-2008 |
20090064255 | SYSTEM AND METHOD OF PROVIDING PERFORMANCE DATA - A method of providing performance data is disclosed that includes sending a data packet from customer premises equipment to a set-top box device via a network path at a transmission rate. The transmission rate is based on Network Layer performance metrics associated with the network path. The method also includes receiving performance data at the customer premises equipment from the set-top box device. The performance data relates to Physical Layer measurements. In addition, the performance data indicates a condition of a physical component of the network path. | 03-05-2009 |
20090158369 | System and Method to Display Media Content and an Interactive Display - A method of displaying an interactive display at a set top box (STB) device is disclosed. The method includes receiving a media content stream. The media content stream includes a first content segment and a second content segment, where the second content segment is received at the STB device after the first content segment. The method also includes displaying a first interactive display, where the first interactive display includes at least one field to receive user input. The method also includes displaying a second interactive display after displaying the first interactive display but before displaying the second content segment. The method also includes performing a user-designated transition with respect to the second content segment based on a user input received via the second interactive display. | 06-18-2009 |
20120323776 | System and Method to Display Media Content and an Interactive Display - A method includes displaying a second user interface while a subscriber is interacting with a first user interface during playback of at least a portion of a first content segment. The second user interface includes one or more selectable transition options associated with performing a transition with respect to a second content segment. The first user interface includes one or more selectable options associated with the first content segment. The method includes receiving input indicating a selection of a particular transition option of the one or more transition options via the second user interface. | 12-20-2012 |
Frances C. Garofalo, Woodstock, NY US
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20090063707 | Shared Resource Support for Internet Protocols - Creating a unique identification for each stack in partitions of a host data computer such that a plurality of partitions may share a single adapter card during an Input/Output operation wherein the adapter card is exchanging data between the host and a Local Area Network. The adapter card includes a unique identifier pool for maintaining values of unique identifiers which are available for identifying the stacks. A deleted unique identifier for a stack may be reused by newly created stacks and may be reassigned to a recreated stack, if still available, when the stack had previously been deleted by the operating system, but is then recreated. | 03-05-2009 |
Frank Joseph Garofalo, Redlands, CA US
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20120324006 | MULTI-TOUCH FOR CLOUD COMPUTING - Systems and methods are presented in this document for connecting multiple users in remote locations to simultaneously collaborate through multi-touch devices. Any number of multi-touch devices will be capable of being connected through an Internet connection to a web server (also referred to as “cloud computing”). The user interface displays of the multi-touch devices will update each of the displays in real-time through the Internet connection to the web servers. This system will enable users to host sessions, such as conference meetings, with participants in various remote locations. At each location participants will be able to utilize the physical and interactive capabilities of a multi-touch device. | 12-20-2012 |
James Garofalo, Peekskill, NY US
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20120112900 | SAFETY BELT COMPLIANCE INDICATOR - The present invention provides methods and apparatus for operating a wireless signal indicating safety belt compliance. The wireless signal may in turn cause a visual indicator that is ascertainable from a position external to the vehicle to indicate safety belt compliance. | 05-10-2012 |
James Garofalo, Reedsburg, WI US
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20140242830 | CHILD-RESISTANT PLUG - A child-resistant plug includes a plug body, at least one prong, and at least one tab extending from the plug body. In one embodiment, a tab is positioned adjacent each of the upper and lower portions of the plug body and each tab is attached to the plug body by a hinging member. The hinging member allows the tabs to rotate between a folded and an unfolded position. When a tab is in its unfolded position, the tab is sized and positioned such that an aperture in the tab aligns with a pre-existing aperture in an electrical outlet cover plate. A fastening member may be used to attach the tab to the cover plate, preventing a child from unplugging a device or accessing the electrical socket. When the tab is attached to the cover plate, and a person pulls the plug or cord with a pre-determined amount of force, the hinging member will break, and the plug will release from the electrical socket. | 08-28-2014 |
20140322959 | CHILD SAFETY PLUG LOCK - A child safety plug lock for releasably securing a plug within a power outlet. The plug lock comprises a body portion including a through-hole and left and right sides. The plug lock also includes left and right arm portions which extend from the left and right sides, respectively, of the body portion. Each arm portion includes an inwardly facing flange. The plug lock is designed to be secured to an outlet via the through-hole in the body portion. The flanges are sized and positioned to engage and retain a plug in the power outlet when the plug lock is attached to the power outlet via the through-hole. The left and right arm portions are flexible, and are sized and positioned such that pressure applied to an arm portion causes that arm portion to flex laterally away from the plug. | 10-30-2014 |
James C. Garofalo, Hadley, NY US
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20090019790 | Tile and strut construction system for geodesic dome - The present invention sets forth a tile and strut construction system for a geodesic dome. The tile has a generally triangular shape, with the corners cut out to accommodate hubs which retain supporting struts in position. The tile has a faceted 3-dimensional upper surface, integrally molded reinforcing ribs, a recess in the lower surface at each of its 3 edges. | 01-22-2009 |
James Charles Garofalo, Hadley, NY US
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20110162310 | Tile And Strut Construction System For Geodesic Dome - The present invention sets forth a tile and strut construction system for a geodesic dome. The tile has a generally triangular shape, with the corners cut out to accommodate hubs which retain supporting struts in position. The tile has a faceted 3-dimensional upper surface, integrally molded reinforcing ribs, and a recess in the lower surface at each of its 3 edges. | 07-07-2011 |
James W. Garofalo, Hadley, NY US
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20090019790 | Tile and strut construction system for geodesic dome - The present invention sets forth a tile and strut construction system for a geodesic dome. The tile has a generally triangular shape, with the corners cut out to accommodate hubs which retain supporting struts in position. The tile has a faceted 3-dimensional upper surface, integrally molded reinforcing ribs, a recess in the lower surface at each of its 3 edges. | 01-22-2009 |
James William Garofalo, Lexington, SC US
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20110162310 | Tile And Strut Construction System For Geodesic Dome - The present invention sets forth a tile and strut construction system for a geodesic dome. The tile has a generally triangular shape, with the corners cut out to accommodate hubs which retain supporting struts in position. The tile has a faceted 3-dimensional upper surface, integrally molded reinforcing ribs, and a recess in the lower surface at each of its 3 edges. | 07-07-2011 |
John Garofalo, Las Vegas, NV US
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20090325683 | Methods Employing Action Buttons - The claimed embodiments contemplate methods, systems and apparatuses directed to an active display button. In various embodiments, an active display button may generally be a button containing one or more elements that move when the button is engaged. By example, and not limitation, these elements may include one or more reels, be they mechanical or video, or perhaps a rotating indicator. The active display button may also include lights, vibratory motors and other experience-enhancing implements. The active display button may be installed on a gaming machine and operated in conjunction with the gaming device, separate from the gaming machine on which it is installed or perhaps as part of the operation of the gaming machine. | 12-31-2009 |
20090325684 | Systems Employing Action Buttons - The claimed embodiments contemplate methods, systems and apparatuses directed to an active display button. In various embodiments, an active display button may generally be a button containing one or more elements that move when the button is engaged. By example, and not limitation, these elements may include one or more reels, be they mechanical or video, or perhaps a rotating indicator. The active display button may also include lights, vibratory motors and other experience-enhancing implements. The active display button may be installed on a gaming machine and operated in conjunction with the gaming device, separate from the gaming machine on which it is installed or perhaps as part of the operation of the gaming machine. | 12-31-2009 |
20090325695 | Action Button Apparatus - The claimed embodiments contemplate methods, systems and apparatuses directed to an active display button. In various embodiments, an active display button may generally be a button containing one or more elements that move when the button is engaged. By example, and not limitation, these elements may include one or more reels, be they mechanical or video, or perhaps a rotating indicator. The active display button may also include lights, vibratory motors and other experience-enhancing implements. The active display button may be installed on a gaming machine and operated in conjunction with the gaming device, separate from the gaming machine on which it is installed or perhaps as part of the operation of the gaming machine. | 12-31-2009 |
Joseph Garofalo, Palo Alto, CA US
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20140181570 | SIGNAL PROCESSING CIRCUITRY WITH FRONTEND AND BACKEND CIRCUITRY CONTROLLED BY SEPARATE CLOCKS - An apparatus comprises read channel circuitry and associated signal processing circuitry comprising frontend processing circuitry and backend processing circuitry. The frontend processing circuitry comprises a loop detector and equalizer configured to determine an equalized read channel signal from a read channel signal and a decoding module configured to apply verification and scrambling processing on a decoded read channel signal. The backend processing circuitry comprises a backend detector, an interleaver, a backend decoder, and a de-interleaver configured to perform an iterative decoding process on the equalized read channel signal to determine the decoded read channel signal. The frontend processing circuitry is controlled by a first clock having an associated first clock rate and the backend processing circuitry is controlled by a selected one of the first clock and a second clock having an associated second clock rate determined at least in part by the first clock rate and a maximum clock rate. | 06-26-2014 |
Joseph Garofalo, San Jose, CA US
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20140270050 | DESIGN AND DEPLOYMENT OF CUSTOM SHIFT ARRAY MACRO CELLS IN AUTOMATED APPLICATION SPECIFIC INTEGRATED CIRCUIT DESIGN FLOW - An automated method is provided for designing an integrated circuit. A net list of an integrated circuit design is generated, wherein the net list includes a scan chain having a sequence of individual scan cells. A sequence of two or more individual scan cells of the scan chain is identified as a candidate for replacement by a custom shift array macro cell. The identified sequence of two or more individual scan cells is then replaced with a custom shift array macro cell that provides a functionally equivalent shift function as the replaced sequence of two or more individual scan cells. The custom shift array macro cell includes only two input pins and one output pin. | 09-18-2014 |
Joseph Gerard Garofalo, Palo Alto, CA US
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20130173077 | POWER SWITCH HAVING SERIES-CONNECTED SWITCHING STAGES - A power switch of a processing device comprises a plurality of series-connected switching stages, with each switching stage comprising a plurality of parallel-connected switching devices and an inverter chain. The switching devices are coupled between a power supply input and a power supply output of the power switch. Each of the switching devices of a given one of the switching stages is driven by an output of a corresponding one of the inverters of the inverter chain of that stage. A control input of the first switching stage receives a control signal for controlling a state of the power switch, and a control input of each remaining switching stage is driven by a control output of an immediately preceding switching stage. The switching devices in one or more of the switching stages are configured to have different switching characteristics than the switching devices in at least one other stage. | 07-04-2013 |
Martin Joseph Garofalo, Menasha, WI US
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20130324961 | Absorbent Article With Enclosures - An absorbent article comprises a bodyside liner, an outer cover, an absorbent body located between the bodyside liner and the outer cover, and an enclosure. The enclosure comprises a cover and backing joined together to form a pocket with an object disposed therein. The enclosure is joined with the absorbent article and is adapted to transition from a closed condition to an open condition such that the object disposed within the enclosure may be accessed. | 12-05-2013 |
Michael Garofalo, Howell, NJ US
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20090019375 | METHOD OF SHARING MULTI-MEDIA CONTENT AMONG USERS IN A GLOBAL COMPUTER NETWORK - In one embodiment of the present invention, a method for sharing multi-media content among a plurality of users in a computer network comprises creating a plurality of user accounts, each of said user accounts corresponding to one of the plurality of users, and having a plurality of interactive features including a first feature that permits the user to upload the multi-media content to the computer network; forming a user network including one or more of the plurality of user accounts in communication with one or more other user accounts and to the uploaded multi-media content via the computer network; categorizing the uploaded multi-media content in accordance with the subject matter of the uploaded multi-media content; organizing the uploaded multi-media content in a competitive format; and establishing a hierarchy for the uploaded multi-media content within the competitive format as a function of a competitive measurement system. | 01-15-2009 |
20120266086 | METHOD OF SHARING MULTI-MEDIA CONTENT AMONG USERS IN A GLOBAL COMPUTER NETWORK - In one embodiment of the present invention, a method for sharing multi-media content among a plurality of users in a computer network comprises creating a plurality of user accounts, each of said user accounts corresponding to one of the plurality of users, and having a plurality of interactive features including a first feature that permits the user to upload the multi-media content to the computer network; forming a user network including one or more of the plurality of user accounts in communication with one or more other user accounts and to the uploaded multi-media content via the computer network; categorizing the uploaded multi-media content in accordance with the subject matter of the uploaded multi-media content; organizing the uploaded multimedia content in a competitive format; and establishing a hierarchy for the uploaded multi-media content within the competitive format as a function of a competitive measurement system. | 10-18-2012 |
Michela Garofalo, Columbus, OH US
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20140351963 | MiRNAs Useful to Reduce Lung Cancer Tumorigenesis and Chemotherapy Resistance and Related Compositions and Methods - Disclosed are compositions, such as nucleic acids, vectors, cells, animal models and the like, useful to reduce tumor growth, cancer cell migration and various other cancer pathologies associated with EGFR (epidermal growth factor receptor) and MET (the receptor tyrosine kinase for hepatocyte growth factors) dyregulation, particularly in non-small cell lung carcinoma. | 11-27-2014 |
Roberto P. Garofalo, Galveston, TX US
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20150342969 | METHODS FOR TREATING VIRAL INFECTIONS USING HYDROGEN SULFIDE DONORS - Certain embodiments are directed to methods of treating respiratory infection by administering an H | 12-03-2015 |
Robert S. Garofalo, Niantic, CT US
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20090196823 | Chemokine antagonists as treatment for obesity-related and metabolic syndrome-related conditions - The present invention provides methods to decrease or maintain body weight and/or body fat in patients, e.g. humans and animals, for example in the treatment of overweight or obese patients, or as a means to produce leaner meat in food stock animals, e.g., cattle, chickens, pigs, alone or in combination with second therapeutic agent; methods to treat diabetes and/or glucose intolerance; and methods to treat metabolic syndrome disorders in patients in need thereof, by administering a CCR2 therapeutic agent, kits for the above-identified therapeutic uses, and methods of identifying CCR2 therapeutic agents for treating the above-described therapeutic uses. | 08-06-2009 |
Samuel Garofalo, Charlotte, NC US
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20100269267 | CONTINUOUS BATCH TUNNEL WASHER AND METHOD - A method of washing fabric articles in a tunnel washer includes moving the fabric articles from the intake of the washer to the discharge of the washer through first and second sectors that are a pre-wash zone. Liquid can be counter flowed in the wash interior along a flow path that is generally opposite the direction of travel of the fabric articles. The main wash zone can be heated as an option. In the wash zone, there is a pre-rinse and/or a rinse. The fabric articles are transferred to a water extraction device that enables removal of excess water. A sour solution can be added to the fabric articles while extracting excess water. | 10-28-2010 |
20130192006 | COMPOSITION AND METHOD FOR REMOVING STAINS DERIVED FROM CHLORHEXIDINE GLUCONATE - Provided herein is a composition and a method for removing CHG from textiles. The composition is an acid-surfactant-based composition that may be used to remove CHG from a textile that has not been exposed to chlorine subsequent to being exposed to CHG. | 08-01-2013 |
20130291314 | CONTINUOUS BATCH TUNNEL WASHER AND METHOD - A method of washing fabric articles in a tunnel washer includes moving the fabric articles from the intake of the washer to the discharge of the washer through first and second sectors that are a pre-wash zone. Liquid can be counter flowed in the wash interior along a flow path that is generally opposite the direction of travel of the fabric articles. The main wash zone can be heated as an option. In the wash zone, there is a pre-rinse and/or a rinse. The fabric articles are transferred to a water extraction device that enables removal of excess water. A sour solution can be added to the fabric articles while extracting excess water. | 11-07-2013 |