Garen
Alan Garen, New Haven, CT US
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20080206227 | FACTOR VII CONJUGATES FOR SELECTIVELY TREATING NEOVASCULARIZATION DISORDERS - Methods and compositions are provided for the treatment of diseases such as exudative macular degeneration, diabetic retinopathy, retinopathy of prematurity, choroidal neovascularization, retinal neovascularization, iris neovascularization, corneal neovascularization, ocular tumors, and other disorders of the eye, cancer, and inflammatory disorders. The method involves administering a conjugate, referred to as fVIIPD, containing a photosensitizer and a targeting molecule such as factor VII (“fVII”), fVIIa, or modified fVII, which binds with high affinity and specificity to tissue factor (TF). TF is more highly expressed, abnormally expressed or specifically expressed on endothelial cells lining the luminal surface of pathological neovasculature, than on normal vasculature, thus providing a specific and accessible therapeutic target. Following administration of fVIIPD, the compound specifically binds to the pathological neovasculature of the eye by interaction of the targeting molecule with TF expressed by endothelial cells within abnormal blood vessels. The photosensitizer may then be activated with a non-thermal laser light for selective destruction of abnormal vasculature. | 08-28-2008 |
20110117114 | Neovascular-Targeted Immunoconjugates - Immunoconjugates for treating diseases associated with neovascularization such as cancer, rheumatoid arthritis, the exudative form of macular degeneration, and atherosclerosis are described. The immunoconjugates typically consist of the Fc region of a human IgG1 immunoglobulin including the hinge, or other effector domain or domains that can elicit, when administered to a patient, a cytolytic immune response or cytotoxic effect against a targeted cell. The effector domain is conjugated to a targeting domain which comprises a factor VII mutant that binds with high affinity and specificity to tissue factor but does not initiate blood clotting such as factor VII having a substitution of alanine for lysine-341 or of alanine for serine-344. | 05-19-2011 |
20120082686 | Neovascular-Targeted Immunoconjugates - Immunoconjugates for treating diseases associated with neovascularization such as cancer, rheumatoid arthritis, the exudative form of macular degeneration, and atherosclerosis are described. The immunoconjugates typically consist of the Fc region of a human IgG1 immunoglobulin including the hinge, or other effector domain or domains that can elicit, when administered to a patient, a cytolytic immune response or cytotoxic effect against a targeted cell. The effector domain is conjugated to a targeting domain which comprises a factor VII mutant that binds with high affinity and specificity to tissue factor but does not initiate blood clotting such as factor VII having a substitution of alanine for lysine-341 or of alanine for serine-344. | 04-05-2012 |
Geoffrey Garen, San Jose, CA US
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20130205388 | SELECTIVE RANDOMIZATION FOR NON-DETERMINISTICALLY COMPILED CODE - A method and an apparatus for runtime compilation that generates non-deterministic and unpredictable code to protect against un-trusted code attacks are described. The runtime compilation may be based on heuristic rules without requiring deterministic behavior reduction operations for all the code generated. The heuristic rules may include estimations on, for example, runtime overhead or cost incurred for code protection, amount of code protection required and/or other applicable factors and their relationships. | 08-08-2013 |
20130239039 | ROCKET EFFECT IN A PROGRESS BAR - Some embodiments relate to providing an improved progress indicator in a graphical user interface. In addition to conveying a completion status of a task to a user, an improved progress indicator in some embodiments can convey additional information about the task to the user. For example, some embodiments can display a visual cue when a triviality threshold indicating that the task is “substantially complete” is met. | 09-12-2013 |
20140047209 | Split Heap Garbage Collection - A method and an apparatus to scan a stack for references to a heap used in executing a code via the heap are described. The heap may be allocated with fixed and varied sized slots. Each varied sized slot may be referenced by at most one fixed sized slot. Which slots are live may be identified based on the references in the stack. A fixed slot can be live if referenced by the stack. A fixed or varied slot referenced by a live slot can also be live. Varied sized slots referenced by the stack may be identified as pinned. The heap may be de-fragmented to reclaim fixed sized slots which are not live without moving live fixed sized slots and to reclaim varied sized slots which are neither live nor pinned by moving live varied slots. | 02-13-2014 |
Kirsten E. Garen, Burlingame, CA US
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20110125565 | Systems and Methods for Multi-Channel Offer Redemption - In one aspect, a system includes a transaction handler, a data warehouse to store transaction data recording transactions processed at the transaction handler and to store account data identifying an account of the user, and a portal to receive a user selection of a first portion of an advertisement and, in response, to present a user interface. The advertisement provides an offer and includes a second portion which when selected directs the user to a website of an advertiser. The data warehouse is to store data associating the offer with the account data of the user in response to a request made in the user interface. The system is to monitor transactions processed at the transaction handler to identify a purchase paid via the account and eligible for the redemption of the offer. The transaction handler is to provide statement credits to the user, if the payment transaction is identified. | 05-26-2011 |
Rune Garen, Eiksund NO
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20150367921 | Propulsion Unit for Maritime Vessel Including a Nozzle Exhibiting an Exchangable Leading Edge on the Inlet of the Nozzle - Propulsion unit for propulsion and maneuvering of a maritime vessel, including a nozzle provided with a sectioned leading edge on inlet of the nozzle, which leading edge is formed by sections of a low-weight non-metallic material, and a front ring, which front ring is arranged between main part of the nozzle and the sectioned leading edge and is arranged for providing a fastening point for the sections of the leading edge. | 12-24-2015 |