Gallagher, US
Andrew James Gallagher, Haymarket, VA US
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20110200120 | Methods and Systems for Detecting Temporally Oscillating Sources in Video Signals Using a Recursive Infinite Impulse Response (IIR) Filter Technique - A method for detecting a temporally oscillating source in digital video signals includes: using an imaging device to capture a sequence of input images of a scene; generating digital video signals from the sequence of input images; and processing the digital video signals using a recursive Infinite Impulse Response (IIR) filter technique based on a differentiated version of Goertzel's Algorithm to detect a temporally oscillating source in the digital video signals. In various embodiments, the method also includes generating a visual display of the scene including one or more graphical elements at least one of which pertains to a detected temporally oscillating source. | 08-18-2011 |
Anthony David Gallagher, Seven Hills, OH US
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20130014851 | COUPLING FOR PVC PIPING SECTIONS - A coupling ( | 01-17-2013 |
Bernard Luke Gallagher, Seattle, WA US
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20120185926 | Directory Driven Mailbox Migrations - An example method for migrating communication data from a source server to a target server includes obtaining, using a computing device, a set of credentials to access the source server, and accessing the source server using the set of credentials. The method also includes requesting, automatically by the computing device, a directory structure associated with communication data from the source server, populating, by the computing device, the target server using the directory structure, requesting the communication data from the source server, and populating the target server with the communication data. | 07-19-2012 |
Bradley Gallagher, Royal Oak, MI US
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20140230336 | EFFECTIVE VIBRATION DAMPING ACROSS A BROAD TEMPERATURE RANGE - Assemblies, methods and systems useful for reducing the noise and vibration characteristics associated with hollow spaces or cavities of vehicles by positioning damping foam material within and spanning the space between a first substrate surface and a second substrate surface. The damping foam material is comprised of a first region and a second region, wherein the first region has an E′ value at −10° C. that is lower than the E′ value at −10° C. of the second region and an E′ value at 25° C. that is higher than the E′ value at 25° C. of the second region; and the second region has a variable cross-sectional width. | 08-21-2014 |
Brian Gallagher, Simpsonville, SC US
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20090241510 | Pressure control method and system to reduce gas turbine fuel supply pressure requirements - A system and method to reduce the gas fuel supply pressure requirements of a gas turbine, which results in an increased operability range and a reduction in gas turbine trips. According to the method, the gas turbine is allowed to start and operate at supply pressures determined as a function of ambient conditions and gas turbine compressor pressure ratio. This increases the operability window, and reduces or eliminates the need for gas fuel compressors. | 10-01-2009 |
Brian J. Gallagher, Litchfield, NH US
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20100288681 | TWO STAGE PULP SCREENING DEVICE WITH TWO STATIONARY CYLINDRICAL SCREENS - A device including a hollow cylindrical body, first and second stationary coaxial annular screening screens disposed within the body, and a rotor within the body and positioned between the screens to conduct the slurry through the first screen and then through the second screen, the rotor being driven in rotation. The pulp slurry passes through a central entry pipe, radially outward and then upward along the inside of the rotor, further inward through a coarse screen cylinder, and then around the end of the rotor to pass between the outer surface of the rotor and the inner surface of a fine screen cylinder. The pulp slurry then finally passes outward through the fine screen cylinder. Coarse rejects, such as knots or other coarse material, are collected at the end of the coarse screening chamber and led away for further processing. Fine rejects are similarly collected at the end of the fine screening chamber, also to be led away separately for further processing. | 11-18-2010 |
20120318721 | GROOVED SCREEN USED IN A TRAMP MATERIAL SEPARATOR - A screen cylinder for screening papermaker's stock, the screen cylinder having slots over substantially all of the screen, and blind grooves in at least one of the screen cylinder surfaces, the grooves extending along that surface at an angle to the slots. | 12-20-2012 |
Brian M. Gallagher, Simpsonville, SC US
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20100307158 | SYSTEMS RELATING TO TURBINE ENGINE CONTROL AND OPERATION - A combustion turbine engine that includes: a compressor; a combustor that receives fuel from a fuel line; a turbine; a heat exchange portion comprising a portion of the fuel line in heat transfer relationship with a heat source for heating the fuel; a rapid heating value meter disposed to test the heating value of the fuel that is configured to provide heating value test results within approximately 1 minute; a cold leg bypass comprising a fuel line that bypasses the heat exchange portion, the cold leg bypass being connected to the fuel line at an upstream fork and at a fuel mixing junction; and valves for controlling the fuel being directed through the heat exchange portion and the fuel being direct through the cold leg bypass; wherein the length of fuel line between the fuel mixing junction and the combustor is less than 20 meters. | 12-09-2010 |
Brian Michael Gallagher, Simpsonville, SC US
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20110185702 | FUEL HEATER SYSTEM INCLUDING HOT AND WARM WATER SOURCES - A system is provided and includes first and second water supplies at first and second relatively high and low temperatures, respectively, a heat exchanger, coupled to the water supplies, through which fuel and relative amounts of the water supplies at the first and second temperatures flow for fuel heating and a controller, operably interposed between the water supplies and the heat exchanger, to select and/or modulate the relative amounts of the water supplies permitted to flow through the heat exchanger to heat the fuel to a temperature based on a heating requirement to meet a modified wobbe index (MWI) rating. | 08-04-2011 |
20130098038 | SYSTEM FOR HEATING A FUEL - An embodiment of the present invention takes the form of a system that uses exhaust from the combustion turbine engine to heat the fuel gas consumed by a combustion turbine engine. The benefits of the present invention include reducing the need to use a parasitic load to heat the fuel gas. | 04-25-2013 |
20130179374 | CUSTODY TRANSFER SYSTEM AND METHOD FOR GAS FUEL - A system includes a custody transfer system configured to transfer a gas fuel from a gas supply to a gas turbine. The custody transfer system includes a plurality of small flow meters running in parallel with each other, each of the small flow meters configured to obtain a measurement of a portion of a flow rate of the gas fuel flowing through the custody transfer system. Further, the custody transfer system includes a large flow meter in series with the plurality of small flow meters, configured to obtain a measurement of a flow rate of the gas fuel flowing from the plurality of small flow meters. Additionally, the custody transfer system includes communications circuitry coupled to each of the small flow meters and the large flow meter, configured to provide metering metrics to a flow computer. | 07-11-2013 |
20130291971 | CUSTODY TRANSFER SYSTEM AND METHOD FOR GAS FUEL - A system includes a custody transfer system configured to transfer a gas fuel from a gas supply to a plurality of gas turbines. The custody transfer system includes a first plurality of flow meters arranged in parallel with each other, wherein each of the first plurality of flow meters is configured to obtain a first measurement of a portion of a flow rate of the gas fuel flowing through the custody transfer system, and a second plurality of flow meters in series with the first plurality of flow meters, wherein each of the second plurality of flow meters is configured to obtain a second measurement of the flow rate of the gas fuel flowing through the custody transfer system, and wherein each of the first and second plurality of flow meters is configured to be blocked or unblocked from receiving the gas fuel based on a number of the plurality of gas turbines in operation. | 11-07-2013 |
20140290260 | SYSTEM AND METHOD FOR GENERATING NITROGEN FROM A GAS TURBINE - A system includes a gas turbine. The gas turbine includes a first compressor configured to provide a first portion of a discharge air to a combustor. The gas turbine also includes the combustor configured to combust a mixture of the first portion of the discharge air and fuel to generate an exhaust gas and to provide the exhaust gas to a turbine. The gas turbine also includes an exhaust outlet coupled to the turbine and configured to enable the exhaust gas to exit the gas turbine. The system also includes a nitrogen purification system coupled to the gas turbine. The nitrogen purification system includes a membrane nitrogen generator configured to receive a second portion of the discharge air from the compressor or a portion of the exhaust gas from the exhaust outlet, wherein the membrane nitrogen generator is configured to generate nitrogen from the second portion of the discharge air or the portion of the exhaust gas. | 10-02-2014 |
Chris Gallagher, Snohomish, WA US
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20130097124 | AUTOMATICALLY AGGREGATING CONTACT INFORMATION - A communication application automatically aggregates contact information. The communication application classifies contact information retrieved from data sources as either duplicate or complimentary contact information to a contact. The communication application aggregates the contact information and the contact into a unified contact object by eliminating the duplicate contact information and adding the complimentary contact information. The application presents the unified contact object through a user interface. | 04-18-2013 |
Christopher Gallagher, Broken Arrow, OK US
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20080295395 | Additives for Reduction of Exhaust Emissions From Compression Ignition Engines - Exhaust emissions resulting from the combustion of hydrocarbon fuels in compression ignition engines may be reduced using a homopolymer that may be polyisobutylene, polypropylene, and/or hyperbranched polyalpha-olefins. Optionally, an alkyl nitrate such as 2-ethylhexylnitrate (2EHN), and/or a peroxide, such as hydrogen peroxide, may also be used together with the homopolymer. Both NOx and particulate matter emissions (PM) may be reduced using ppm quantities of the additive compositions; alternatively, NOx emissions may be lowered or reduced while PM emissions do not substantially increase. | 12-04-2008 |
Christopher G. Gallagher, Baltimore, MD US
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20110305408 | FABRIC WRAP - A dimpled fabric creation system and method is provided to form a dimpled fabric using a mold or machine having a plurality of protrusions and grooves, while avoiding the repetitive steps to manually shape each protrusion individually by tying portions of fabric individually. The protrusions may be of complex three dimensional shapes to form dimples in the fabric having corresponding complex three dimensional shapes. The system and method provide for creation of a dimpled fabric container, wherein the dimpled fabric container may be utilized in gift wrapping. | 12-15-2011 |
20150049963 | FABRIC WRAP - A dimpled fabric creation system and method is provided to form a dimpled fabric using a mold or machine having a plurality of protrusions and grooves, while avoiding the repetitive steps to manually shape each protrusion individually by trying portions of fabric individually. The protrusions may be of complex three dimensional shapes to form dimples in the fabric having corresponding complex three dimensional shapes. The system and method provide for creation of a dimpled fabric container, wherein the dimpled fabric container may be utilized in gift wrapping. | 02-19-2015 |
Christopher G. Gallagher, Akron, OH US
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20100000890 | SECURITY STORAGE CONTAINER - A lockable media storage box includes a base and a lid connected to the base with at least one hinge. The base and lid include elements that cooperate with a lock to allow the lid to be locked in the closed position. In one embodiment, the lock is received in the concave opening disposed at the front of the storage container. The lock may be unlocked with a special key or may be unlocked by destroying portions of the lock that are designed to be destroyed. In another embodiment of the invention, a sliding lock is carried by the container. The sliding lock may be carried inside the container or on the front wall of the container. | 01-07-2010 |
Daniel Gerard Gallagher, Portland, OR US
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20090063134 | Media Content Assessment and Control Systems - Computer implemented methods and computing systems wherein relationships of words or phrases within a textual corpus are assessed via frequencies of occurrence of particular words or phrases and via frequencies of co-occurrence of particular pairs of words or phrases within defined tracts of text from within the textual corpus. | 03-05-2009 |
20090177463 | Media Content Assessment and Control Systems - Computer implemented methods, computing devices, and computing systems, wherein relationships of words or phrases within a textual corpus are assessed via frequencies of occurrence of particular words or phrases and via frequencies of co-occurrence of particular pairs of words or phrases within defined tracts of text from within the textual corpus. | 07-09-2009 |
Daniel L. Gallagher, Silverton, OR US
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20080299286 | PALATABILITY ENHANCING COMPOSITIONS AND FOODS FOR PETS, AND METHODS REGARDING THE SAME - Palatability enhancing compositions for pet foods, and pet foods with increased palatability, are provided. In some embodiments, the compositions and pet foods contain tea, such as green tea. In some embodiments, the compositions and pet foods contain brewer's yeast, liver hydrolysate, phosphate, and green tea. Shrimp meal and Tuna meal can also be utilized in these embodiments. In some embodiments, the compositions and pet foods comprise an ingredient having at least one of theanine; glutamine; tea; 1,5 octadien-3 one; 1,5-octadien-3-ol; and | 12-04-2008 |
20110159149 | PERFORMANCE OF COMPANION ANIMAL PALATABILITY SYSTEMS LEADING TO INCREASED PET FOOD CONSUMPTION PREFERENCES - The invention concerns a palatability enhancing composition comprising at least one palatant and/or at least one tasteant modified by glycerol and/or propylene glycol. Said palatability enhancing composition is intended to be applied onto the surface of a companion animal food. The invention also extends to companion pet foods which are prepared with such palatability enhancing composition. | 06-30-2011 |
Daniel R. Gallagher, Huntsville, AL US
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20110029243 | System and Method for Determining Road Conditions - A road data apparatus is disclosed that predicts road conditions comprising a land surface data generator which derives a land surface data output from a plurality of current and forecast weather and location data, said current and forecast weather and location data comprising surface temperature, subsurface temperature, and precipitation depth, a pavement data generator which derives a road temperature and a road condition from said land surface data output and a plurality of pavement generator input data, said plurality of pavement generator input data comprising road layer data; and a roadway status indicator generator which derives a roadway status indicator from said road temperature, road condition and precipitation data. In one embodiment, the roadway status indicator is communicated to an end user through a distribution network. | 02-03-2011 |
David Andrew Gallagher, Plaistow, NH US
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20110108306 | RIGHT ANGLE TWISTED PAIR CONNECTOR - The invention relates to a twisted pair cable and connector combination comprising a cable having a plurality of twisted pairs, each twisted pair comprising a first conductor and a second conductor, an electrical connector having an electrical connection element for each conductor of the cable and a window through which the conductors of the cable enter the connector, wherein each conductor in the cable is electrically coupled to a one of the electrical connection elements in the electrical connector, and a guide element disposed adjacent the window for guiding the twisted pairs into the connector, the guide element having a distal end and a proximal end and a length there between, the guide element curved over the length and including at least one channel running along the length of the guide element body for each twisted pair, the guide element gradually transitioning over the length from a first cross sectional shape wherein said channels are disposed in a pattern relative to each other corresponding to the relative positions of the twisted pairs in the cable to a second cross sectional shape wherein the channels are disposed in a pattern relative to each other corresponding to the relative positions of the electrical connection elements of the connector. | 05-12-2011 |
Dennis J. Gallagher, Boulder, CO US
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20110025877 | Imaging System Including Distributed Phase Modification And Associated Methods - An imaging system for imaging a range of field points over on- and off-axis fields includes an image sensor for capturing image data, and first and second optical elements that are spaced apart and cooperate to image light at the image sensor. The first and second optical elements are configured to jointly modify phase of the light transmitted therethrough such that point-spread functions (“PSFs”) corresponding to the range field points are substantially uniform over on- and off-axis fields. | 02-03-2011 |
20120200671 | Apparatus And Method For Three-Dimensional Image Capture With Extended Depth Of Field - An optical system for capturing three-dimensional images of a three-dimensional object is provided. The optical system includes a projector for structured illumination of the object. The projector includes a light source, a grid mask positioned between the light source and the object for structured illumination of the object, and a first Wavefront Coding (WFC) element having a phase modulating mask positioned between the grid mask and the object to receive patterned light from the light source through the grid mask. The first WFC element is constructed and arranged such that a point spread function of the projector is substantially invariant over a wider range of depth of field of the grid mask than a point spread function of the projector without the first WFC element. | 08-09-2012 |
20120200943 | Two-Stage Optical Object Molding Using Pre-Final Form - A lens, such as a lens for use in a wafer-level camera, is made by forming a polymeric material with at least one master to form a pre-final lens. The pre-final lens forms a majority of a final volume of the lens. The pre-final lens is allowed to harden, during which it may sag or shrink An aliquot of polymeric material is added to the lens and formed with the same master with a spacer, or with a second master, to form a first surface layer that provides correction between the pre-final lens shape and a final desired lens shape. In an embodiment, the surface layer has similar or identical index of refraction to the pre-final lens. In an embodiment the lens is formed on a substrate. In an embodiment, a send master, or master pair, are used to form a lens having upper and lower curvature, with a second aliquot of polymeric material forming a second surface layer on a surface of the lens opposite to the first surface layer. | 08-09-2012 |
20120224263 | Optical Systems Utilizing Diffraction Gratings To Remove Undesirable Light From A Field Of View - An optical system has a lens assembly for imaging an object. The lens assembly includes a lens wherein at least a portion of a peripheral part of the lens includes a diffraction grating arranged to divert light arriving on the peripheral part of the lens from an object. The diffraction grating diverts the light away from a focal region, where a central part of the lens focuses light arriving on the central part of the lens from the object, into an image of the object. | 09-06-2012 |
20140139934 | Two-Stage Optical Object Molding Using Pre-Final Form - A lens, such as a lens for use in a wafer-level camera, is made by forming a polymeric material with at least one master to form a pre-final lens. The pre-final lens forms a majority of a final volume of the lens. The pre-final lens is allowed to harden, during which it may sag or shrink. An aliquot of polymeric material is added to the lens and formed with the same master with a spacer, or with a second master, to form a first surface layer that provides correction between the pre-final lens shape and a final desired lens shape. In an embodiment, the surface layer has similar or identical index of refraction to the pre-final lens. In an embodiment the lens is formed on a substrate. In an embodiment, a send master, or master pair, are used to form a lens having upper and lower curvature, with a second aliquot of polymeric material forming a second surface layer on a surface of the lens opposite to the first surface layer. | 05-22-2014 |
Dennis P. Gallagher, Stafford Springs, CT US
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20110162264 | Organic fuel brick - A method or process for creating ecologically friendly organically composed fuel bricks whose composition includes, but is not limited to, the following ingredients: 58 to 60 per cent decomposed straw, 38 per cent horse or cow manure, two per cent hay mixture from various blends used as feed, and two per cent straw dust from material pounded on by animals wherein the above ingredients are subjected to a number of processing steps with the end product being a hydraulically compressed fuel brick, block, briquette, blank, pellet, etc., weighing approximately two pounds and dried to a less than 10 per cent moisture content. While the process is primarily applicable to the creation of eco friendly organic fuel bricks, it is conceivably possible that other ingredients than those to be described hereinafter could undergone the discloses process to produce other types of fuel items, both organic and inorganic, with the ingredients comprising wood chips, other kinds of animal manure, and wood chips. | 07-07-2011 |
Edward F. Gallagher, Westfield, NJ US
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20120197774 | Systems, Methods, and Media for Generating and Sending Indications of Interest in Trading Systems - Systems, methods, and media for generating and sending indications of interest in trading systems are provided. In some embodiments, systems for generating and sending indications of interest in trading systems are provided, the systems comprising: at least one hardware processor that: determines whether an order is blocked from inclusion in an indication of interest; determines whether the order is marketable; generates the indication of interest so that it includes at least a portion of the order when the order is determined to not be blocked and the order is marketable; determines whether the indication of interest is blocked from being sent to a destination; and sends the indication of interest to the destination when the indication of interest is determined to not be blocked from being sent to the destination. | 08-02-2012 |
Edward J. Gallagher, West Harford, CT US
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20130014488 | EFFICIENT, LOW PRESSURE RATIO PROPULSOR FOR GAS TURBINE ENGINES - A gas turbine engine includes a spool, a turbine coupled to drive the spool, and a propulsor that is coupled to be driven by the turbine through the spool. A gear assembly is coupled between the propulsor and the spool such that rotation of the turbine drives the propulsor at a different speed than the spool. The propulsor includes a hub and a row of propulsor blades that extends from the hub. The row includes no more than 20 of the propulsor blades. | 01-17-2013 |
Emily E. Gallagher, Burlington, VT US
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20110085723 | Mask Program Defect Test - A method and programmed defect test database for designing and building programmed defect test masks. The method uses a defect free mask that is compared to a ‘defective’ database. A variety of defect types and sizes is programmed into the database and used to inspect the defect-free mask. All defects programmed into the database are not affected by performing the method, regardless of size, so the resolution capability of an inspection tool can be determined. | 04-14-2011 |
20120070064 | METHOD FOR DETERMINING MASK OPERATION ACTIVITIES - A method and system arrangement for controlling and determining mask operation activities. Upon obtaining chip physical layout design data and running resolution enhancement technology on the chip physical layout design to generate mask features which may include any sub-resolution assist features, a placement sensitivity metric is determined for each of the generated mask features or edge fragments. In one alternative embodiment an edge placement sensitivity metric is determined for each edge of the generated mask features or edge fragments. The determined sensitivity metrics for each feature are classified and applied to subsequent mask operational activities such as post processing, write exposure and mask repair. The types of decisions based on the sensitivity metric may include minimizing or maximizing OPC processing; e-beam exposure adjustment in mask write; and selection of which mask features to repair as well as what repair criteria to then apply, and adjusting quality requirement criteria for manufacturing assessment. | 03-22-2012 |
20140038087 | EXTREME ULTRAVIOLET (EUV) MULTILAYER DEFECT COMPENSATION AND EUV MASKS - Methods and structures for extreme ultraviolet (EUV) lithography are disclosed. A method includes determining a phase error correction for a defect in an EUV mask, determining an amplitude error correction for the EUV mask based on both the defect in the EUV mask and the phase error correction, and modifying the EUV mask with the determined phase error correction and the determined amplitude error correction. | 02-06-2014 |
20140051015 | REDUCING EDGE DIE REFLECTIVITY IN EXTREME ULTRAVIOLET LITHOGRAPHY - Extreme ultraviolet lithography (EUVL) masks and methods of manufacturing are provided. A method includes forming a sub-resolution phase shift grating in a multilayer reflective film beneath a border region of an absorber layer of an extreme ultraviolet lithography (EUVL) mask. The sub-resolution phase shift grating reduces a reflectivity of the border region of the mask. | 02-20-2014 |
20140272687 | EXTREME ULTRAVIOLET (EUV) MULTILAYER DEFECT COMPENSATION AND EUV MASKS - Methods and structures for extreme ultraviolet (EUV) lithography are disclosed. A method includes determining a phase error correction for a defect in an EUV mask, determining an amplitude error correction for the EUV mask based on both the defect in the EUV mask and the phase error correction, and modifying the EUV mask with the determined phase error correction and the determined amplitude error correction. | 09-18-2014 |
Emily E. F. Gallagher, Burlington, VT US
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20110165502 | METHOD AND SYSTEM FOR FEATURE FUNCTION AWARE PRIORITY PRINTING - A method and system for photomask pattern generation is provided, and more specifically, a method and system for feature function aware priority printing is provided. The method of printing a photolithographic mask includes fracturing mask design data into write shapes that are multiples of a spot size and passing fractured mask design data to a write tool. Additionally, the method includes writing one or more non-critical shapes according to one or more time-saving rules. | 07-07-2011 |
20120204136 | METHOD AND SYSTEM FOR FEATURE FUNCTION AWARE PRIORITY PRINTING - A method and system for photomask pattern generation is provided, and more specifically, a method and system for feature function aware priority printing is provided. The method of printing a photolithographic mask includes fracturing mask design data into write shapes that are multiples of a spot size and passing fractured mask design data to a write tool. Additionally, the method includes writing one or more non-critical shapes according to one or more time-saving rules. | 08-09-2012 |
Genevieve L. Gallagher, Mendota Heights, MN US
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20100198278 | COMPOSITE ANTIMICROBIAL ACCESSORY INCLUDING A MEMBRANE LAYER AND A POROUS LAYER - An antimicrobial accessory may include a membrane layer defining a major surface comprising a first lateral portion, a second lateral portion, and a third lateral portion. The membrane layer may comprise a first biodegradable polymer. The antimicrobial accessory may further include a first porous layer overlying the first lateral portion and a second porous layer overlying the second lateral portion. The first porous layer comprises a second biodegradable polymer and a first antimicrobial, while the second porous layer comprises a third biodegradable polymer and a second antimicrobial. | 08-05-2010 |
20100203100 | ANTIMICROBIAL ACCESSORY FOR AN IMPLANTABLE MEDICAL DEVICE - An antimicrobial accessory may include a pressure sensitive adhesive and an antimicrobial mixed in the pressure sensitive adhesive. In some examples, an antimicrobial accessory may include at least one first domain comprising a pressure sensitive adhesive and a first antimicrobial and at least one second domain including a second polymer and a second antimicrobial. The antimicrobial accessory may be configured to be attached to a housing of an implantable medical device (IMD). | 08-12-2010 |
20100317629 | DISSOLVABLE PHARMACEUTICAL IMPLANT - A pharmaceutical implant may include a pharmaceutical and at least one excipient, and may be configured to be implanted in a body of a patient. The at least one excipient may dissolve after implantation of the pharmaceutical implant in the body of the patient and release the pharmaceutical. In some examples, the pharmaceutical implant includes at least two pharmaceuticals. The at least one excipient may be selected to provide a desired release profile of the pharmaceutical. For example, the pharmaceutical implant may be configured to dissolve and release the pharmaceutical over a length of time between about one day and about 30 days. In some examples, the pharmaceutical implant may be implanted in the body of the patient proximate to an implantable medical device. | 12-16-2010 |
20110123517 | DISSOLVABLE PHARMACEUTICAL IMPLANT - A pharmaceutical implant may include a pharmaceutical and at least one excipient, and may be configured to be implanted in a body of a patient. The at least one excipient may dissolve after implantation of the pharmaceutical implant in the body of the patient and release the pharmaceutical. In some examples, the pharmaceutical implant includes at least two pharmaceuticals. The at least one excipient may be selected to provide a desired release profile of the pharmaceutical. For example, the pharmaceutical implant may be configured to dissolve and release the pharmaceutical over a length of time between about one day and about 30 days. In some examples, the pharmaceutical implant may be implanted in the body of the patient proximate to an implantable medical device. | 05-26-2011 |
20110125241 | LEAD INCLUDING COMPOSITE DEVICE FOR ELUTING A STEROID AND AN ANTIMICROBIAL - A lead may include a lead body including a proximal end and a distal end, an electrode proximate to the distal end of the lead body, and a monolithic controlled release device located proximate to the electrode. According to this aspect of the disclosure, the monolithic controlled release device includes a polymer, a steroid mixed in the polymer, and an antimicrobial mixed in the polymer. | 05-26-2011 |
20120165795 | THERAPEUTIC AGENT RESERVOIR DELIVERY SYSTEM - A therapeutic agent reservoir comprises a reservoir body comprising a polymer and a therapeutic agent mixed within the polymer, and an outer coating enclosing the reservoir body, wherein at least a portion of the outer coating comprises a rate-controlling membrane configured to provide a predetermined release rate of the therapeutic agent through the rate-controlling membrane. | 06-28-2012 |
20140336573 | STEERING ACTUATOR FOR DEFLECTABLE CATHETER - Catheter shaft handles and deflection actuators are disclosed. The actuators include at least one pull wire guide wall and a means for anchoring the proximal portion of a pull wire or of a fiber attached to a pull wire. Each actuator is pivotable relative to the catheter handle housing, and may comprise at least one boss for pivoting the actuator relative to the catheter handle housing. The actuators transfer rotational motion based upon user input on a boss into longitudinal motion of a pull wire. The actuators may include a tensioning mechanism comprising a tension adjustment pin and a pin block, wherein the tension adjustment pin is rotatably attached to the pin block to enable adjustment of tension in a pull wire (e.g., during assembly of the catheter handle). | 11-13-2014 |
Genevieve Louise Eichenberg Gallagher, Mendota Heights, MN US
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20090047413 | CONDUCTIVE THERAPEUTIC COATING FOR MEDICAL DEVICE - An implantable medical device includes a housing and a coating disposed on the housing. The coating includes a conductive carrier and a therapeutic agent, e.g. an anti-infective agent such as silver particles. The conductive carrier can be any suitable conductive material, such as iridium oxide, titanium nitride, diamond-like carbon, graphite, polyaniline, platinum, carbon nanotubes, carbon black, platinum black, or poly 3,4,-ethylenedioxythiophene. Coatings containing iridium oxide and metallic silver particles are effective in inhibiting bacterial growth in vitro. | 02-19-2009 |
Gerard J. Gallagher, Severna Park, MD US
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20120281352 | Data center aisle containment system utilizing a movable sash that is integral to the computer rack cabinet - An embodiment includes a transparent sash mounted integral to the perforated doors on racks which hold computer servers typically installed in data centers. The racks are arrayed in rows forming cold aisles and hot aisles. Cooled air introduced into the cold aisle flows through the racks and cools the servers, and subsequently is removed from the hot aisle. Embodiment sashes slide vertically and extend above the tops of the racks and form a sealing relationship with the data center ceiling and adjacent sashes, thereby preventing wasteful mixing and recirculation of cooled and heated air over the tops of the racks. Embodiments are raised and lowered manually or automatically. The controls for the movement of the sashes are tied to the building automation and fire alarm systems and the sashes are lowered automatically upon activation of the data center fire suppression system, thereby complying with code requirements and avoiding interference with the fire sprinkler and suppression systems. | 11-08-2012 |
Gina R. Gallagher, Broken Arrow, OK US
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20110137003 | Classified Catalyst Composition, Apparatus, and Method - The present disclosure is directed to an apparatus and process for producing a catalyst composition and a low-fines catalyst composition in particular. A crossflow classification device is used to separate large catalyst particles from catalyst fines, A slurry of a catalyst composition is introduced into the crossflow classification device. A classified catalyst composition is retrieved from a retentate produced as a result of subjecting the catalyst slurry to a crossflow classification process. The solids content of the pre-classified and/or post-classified catalyst slurry is determined by way of NMR spectroscopy. The solids content determination accounts for migration of wash liquid from the catalyst composition and into the slurry liquid phase, The classified catalyst composition has a low-fines content and produces a polyolefin composition with a low polymer fines content. | 06-09-2011 |
Grant Gallagher, East Brunswick, NJ US
Patent application number | Description | Published |
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20090220511 | Ifn-alpha/beta-independent mechanism of antiviral protection through a novel ligand-receptor pair: Ifn- ligands engage a novel receptor Ifn-Rn (CRF2-12) and IL-10R2 (CRF2-4) for signaling andinduction of biological activities - A novel IFN-α/β independent ligand receptor system which upon engagement leads, among other things, to the establishment of an anti-viral state is disclosed. Further disclosed are three closely positioned genes on human chromosome 19 that encode distinct but highly homologous proteins, designated IFN-λ1, IFN-λ2, IFN-λ3, based, inter alia, in their ability to induce antiviral protection. Expression of these proteins is induced upon viral infection. A receptor complex utilized by all three IFN-λ proteins for signaling is also disclosed. The receptor complex is generally composed of two subunits, a novel receptor designated IFN-λR1 or CRF2-12, and a second subunit, IL-10R2 or CRF2-4, which is also a shared receptor component for the IL-10 and IL-22 receptor complexes. The gene encoding IFN-λR1 is generally widely expressed, including many different cell types and tissues. Expression of these proteins is induced by immune events, including, for example, upon viral infection. Apoptotosis may also be induced under effective conditions. | 09-03-2009 |
Grant Gallagher, Milltown, NJ US
Patent application number | Description | Published |
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20090311694 | Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a delta 9 isoform in predicting inflammatory bowel diseases - There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R. | 12-17-2009 |
20110237643 | Identification of a Novel repressor on IFN-lambda promoter and siRNA against ZEB1 and BLIMP-1 to increase IFN-lambda gene activity - The present invention is directed to the identification of a novel repressor located between ˜1.2 kb to ˜1.6 kb from the translation start site of the IFN-λ1 promoter. The present invention provides a method of using siRNAs against ZEB1 (binds to the repressor region) and BLIMP-1 (binds outside the repressor region) and increases the promoter activity of IFN-λ1 (i.e., increases the production of IFN-λ1 protein). siRNAs against ZEB1 mRNA or BLIMP-1 mRNA increase IFN-λ1 gene activity. There is provided a therapeutic application of siRNAs against ZEB1 and BLIMP-1 mRNAs in treating a mammal (including a human) by increasing the production of IFN-λ1 protein that promotes an anti-viral response as well as treats asthma diseases. | 09-29-2011 |
20110268707 | Ex-vivo treatment of peripheral blood leukocytes with IFN-lambda - The present invention provides an ex vivo method of treating plasmacytoid dendritic cells (pDC) in Th2- or Th17-associated diseases by modulating the cytokine expression or secretion using interferon lambda (IFN-λ). For the Th-2 or Th17-associated diseases, pDC cells from a patient having the disease are exposed ex vivo with IFN-λ in an effective amount to inhibit cytokine releases. The IFN-λ exposed pDC are administered back into the patient. The present invention also provides a method of ex vivo IFN-λ treatment of pDC, in conjunction with co-administration of a composition comprising IFN-λ. | 11-03-2011 |
20120058081 | Ex-vivo treatment of peripheral blood leukocytes with IFN-lambda - The present invention provides a method of treating Th2-associated diseases and disorders by modulating the expression or secretion of IL-4, IL-5 and IL-13 using interferon lambda (IFN-λ). For Th2-associated diseases and disorders, cells of a patient having a Th2-associated disease or disorder are treated ex vivo, with IFN-λ and returned to the patient. The present invention also provides a method of ex vivo treatment, in conjunction with co-administration of IFN-λ | 03-08-2012 |
20120071422 | Therapeutic application of isolated naturally-occuring soluble truncated forms of IL-23 receptor - The present invention relates to an isolated naturally-occurring soluble truncated IL-23Rα protein, which is a translated protein resulting from a mRNA splice variant of IL-23Rα. The soluble IL-23Rα proteins (e.g., Δ9 and Δ8,9) represents a novel soluble IL-23Rα protein, which is lacking a transmembrane domain and has a unique eight (8) amino acids (GLKEGSYC) at its C-terminus end (due to frame-shift). ELISA reveals that Δ9 is present in blood and can serve as a diagnostic tool for auto-immune diseases including Crohn's disease. There is also provided a method of recombinant production for this soluble truncated form of IL-23Rα protein. More importantly, the present invention provides an utility application of the Δ9 and Δ8,9 protein in inhibit IL-23R-mediated cell signaling. More particularly, Δ9 and Δ8,9 blocks STAT3 formation as well as Th17 maturation. There is provided a therapeutic application of Δ9 and Δ8,9 in treating a human patient inflicted with Crohn's disease. | 03-22-2012 |
20120171704 | Elisa for a naturally-occurring soluble truncated form of IL-23 receptor - A naturally-occurring soluble truncated IL-23Rα protein (i.e., Δ9 IL-23Rα) is shown to be present in a biological sample and can serve as a diagnostic tool for autoimmune diseases. There is provided an enzyme-linked immunosorbent assay (ELISA) and test kit for the serological detection of the soluble truncated form of IL-23Rα protein. More particularly, antibody-sandwich ELISA method and kits for Δ9 IL-23Rα as an antigen were developed to detect Δ9 IL-23Rα levels in biological samples from a mammal and a human patient and are used as a diagnostic index. The present disclosed ELISA has utility as a diagnostic tool to detect Crohn's disease in patients using EDTA-plasma. | 07-05-2012 |
20120244542 | SPLICE VARIANTS OF HUMAN IL-23 RECEPTOR (IL-23R) mRNA AND USE OF A DELTA9 ISOFORM IN PREDICTING INFLAMMATORY BOWEL DISEASES - There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R. | 09-27-2012 |
20120245325 | SPLICE VARIANTS OF HUMAN IL-23 RECEPTOR (IL-23R) mRNA AND USE OF A DELTA9 ISOFORM IN PREDICTING INFLAMMATORY BOWEL DISEASES - There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R. | 09-27-2012 |
20130029907 | Novel Polypeptides That Bound to IL-23 Receptor and Inhibit Binding of IL-23 and Cell Signaling Thereof - The present invention relates to novel polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The novel polypeptides of the present invention has a core structure of WX | 01-31-2013 |
20130035365 | Anti-sense oligonucleotides targeted against exon 9 of IL-23R alpha gene and method of using same to induce exon skipping and to treat inflammatory bowel diseases - The present invention relates to anti-sense oligonucleotides (AONs) used to induce exon 9 skipping in IL-23Rα gene. Exon 9 skipping of the IL23Rα gene ultimately causes specific induction of a novel soluble truncated IL-23Rα (Δ9) protein, characterized by a lack in a transmembrane domain and has a unique eight (8) amino acids (GLKEGSYC) at its C-terminus end as a result of frame-shift. The present invention provides a utility application of the use of AONs to induce production of a Δ9 protein which inhibits IL-23R-mediated cell signaling. More particularly, Δ9 protein blocks STAT3 formation as well as Th17 maturation. There is provided a therapeutic application of AONs in treating a mammal such as a human patient inflicted with Crohn's disease. | 02-07-2013 |
20130172272 | Novel Polypeptides That Bound to IL-23 Receptor and Inhibit Binding of IL-23 and Cell Signaling Thereof - The present invention relates to novel polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The novel polypeptides of the present invention has a core structure of WX | 07-04-2013 |
20130183755 | THERAPEUTIC APPLICATION OF ISOLATED NATURALLY-OCCURRING SOLUBLE TRUNCATED FORMS OF IL-23 RECEPTOR - The present invention relates to an isolated naturally-occurring soluble truncated IL-23Rα protein, which is a translated protein resulting from a mRNA splice variant of IL-23Rα. The soluble IL-23Rα proteins (e.g., Δ9 and Δ8,9) represents a novel soluble IL-23Rα protein, which is lacking a transmembrane domain and has a unique eight (8) amino acids (GLKEGSYC) at its C-terminus end (due to frame-shift). ELISA reveals that Δ9 is present in blood and can serve as a diagnostic tool for auto-immune diseases including Crohn's disease. There is also provided a method of recombinant production for this soluble truncated form of IL-23Rα protein. More importantly, the present invention provides an utility application of the Δ9 and Δ8,9 protein in inhibit IL-23R-mediated cell signaling. More particularly, Δ9 and Δ8,9 blocks STAT3 formation as well as Th17 maturation. There is provided a therapeutic application of Δ9 and Δ8,9 in treating a human patient inflicted with Crohn's disease. | 07-18-2013 |
20130196333 | SPLICE VARIANTS OF HUMAN IL-23 RECEPTOR (IL-23R) mRNA AND USE OF A DELTA 9 ISOFORM IN PREDICTING INFLAMMATORY BOWEL DISEASES - There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R. | 08-01-2013 |
20130338211 | NOVEL REPRESSOR ON IFN-LAMBDA PROMOTER AND SIRNA AGAINST ZEB1 AND BLIMP-1 TO INCREASE IFN-LAMBDA GENE ACTIVITY - The present invention is directed to the identification of a novel repressor located between ˜1.2 kb to ˜1.6 kb from the translation start site of the IFN-λ1 promoter. The present invention provides a method of using siRNAs against ZEB1 (binds to the repressor region) and BLIMP-1 (binds outside the repressor region) and increases the promoter activity of IFN-λ1 (i.e., increases the production of IFN-λ1 protein). siRNAs against ZEB1 mRNA or BLIMP-1 mRNA increase IFN-λ1 gene activity. There is provided a therapeutic application of siRNAs against ZEB1 and BLIMP-1 mRNAs in treating a mammal (including a human) by increasing the production of IFN-λ1 protein that promotes an anti-viral response as well as treats asthma diseases. | 12-19-2013 |
20140050700 | EX-VIVO TREATMENT OF PERIPHERAL BLOOD LEUKOCYTES WITH IFN-Lambda - The present invention provides a method of treating Th2-associated diseases and disorders by modulating the expression or secretion of IL-4, IL-5 and IL-13 using interferon lambda (IFN-λ). For Th2-associated diseases and disorders, cells of a patient having a Th2-associated disease or disorder are treated ex vivo, with IFN-λ and returned to the patient. The present invention also provides a method of ex vivo treatment, in conjunction with co-administration of IFN-λ | 02-20-2014 |
20140057960 | NOVEL REPRESSOR ON IFN-LAMBDA PROMOTER AND SIRNA AGAINST ZEB1 AND BLIMP-1 TO INCREASE IFN-LAMBDA GENE ACTIVITY - The present invention is directed to the identification of a novel repressor located between ˜1.2 kb to ˜1.6 kb from the translation start site of the IFN-λ1 promoter. The present invention provides a method of using siRNAs against ZEB1 (binds to the repressor region) and BLIMP-1 (binds outside the repressor region) and increases the promoter activity of IFN-λ1 (i.e., increases the production of IFN-λ1 protein). siRNAs against ZEB1 mRNA or BLIMP-1 mRNA increase IFN-λ1 gene activity. There is provided a therapeutic application of siRNAs against ZEB1 and BLIMP-1 mRNAs in treating a mammal (including a human) by increasing the production of IFN-λ1 protein that promotes an anti-viral response as well as treats asthma diseases and colon diseases. | 02-27-2014 |
20140187602 | Anti-Sense Oligonucleotides Targeted Against Exon 9 of IL-23R alpha Gene and Method of Using Same to Induce Exon Skipping and to Treat Inflammatory Bowel Diseases - The present invention relates to anti-sense oligonucleotides (AONs) used to induce exon 9 skipping in IL-23Rαgene. Exon 9 skipping of the IL23Rα gene ultimately causes specific induction of a novel soluble truncated IL-23Rα (Δ9) protein, characterized by a lack in a transmembrane domain and has a unique eight (8) amino acids (GLKEGSYC) at its C-terminus end as a result of frame-shift. The present invention provides a utility application of the use of AONs to induce production of a Δ9 protein which inhibits IL-23R-mediated cell signaling. More particularly, Δ9 protein blocks STAT3 formation as well as Th17 maturation. There is provided a therapeutic application of AONs in treating a mammal such as a human patient inflicted with Crohn's disease. | 07-03-2014 |
20140272994 | METHODS AND REAGENTS THAT SPECIFICALLY DETECT, DISTINGUISH AND QUANTIFY IFN-LAMBDA2 mRNA FROM IFN-LAMBDA3 mRNA IN HUMANS - The present invention provides a method of specifically detecting IFN-λ2 mRNA or IFN-λ3 mRNA. There is provided a qRT-PCR method specifically detecting, discriminating and quantifying IFN-λ2 and IFN-λ3 mRNA in a biological sample obtained from a human. There is provided qRT-PCR methods and primers and probes that specifically detect IFN-λ2 mRNA but not IFN-λ3 mRNA and vice versa in humans in order to detect, quantify and discriminate IFN-λ2 mRNA and IFN-λ3 mRNA. | 09-18-2014 |
20140350072 | NOVEL REPRESSOR ON IFN-LAMBDA PROMOTER AND SIRNA AGAINST ZEB1 AND BLIMP-1 TO INCREASE IFN-LAMBDA GENE ACTIVITY - The present invention is directed to the identification of a novel repressor located between ˜1.2 kb to ˜1.6 kb from the translation start site of the IFN-λ1 promoter. The present invention provides a method of using siRNAs against ZEB1 (binds to the repressor region) and BLIMP-1 (binds outside the repressor region) and increases the promoter activity of IFN-λ1 (i.e., increases the production of IFN-λ1 protein). siRNAs against ZEB1 mRNA or BLIMP-1 mRNA increase IFN-λ1 gene activity. There is provided a therapeutic application of siRNAs against ZEB1 and BLIMP-1 mRNAs in treating a mammal (including a human) by increasing the production of IFN-λ1 protein that promotes an anti-viral response as well as treats asthma diseases. | 11-27-2014 |
Grant E. Gallagher, Milltown, NJ US
Patent application number | Description | Published |
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20120058081 | Ex-vivo treatment of peripheral blood leukocytes with IFN-lambda - The present invention provides a method of treating Th2-associated diseases and disorders by modulating the expression or secretion of IL-4, IL-5 and IL-13 using interferon lambda (IFN-λ). For Th2-associated diseases and disorders, cells of a patient having a Th2-associated disease or disorder are treated ex vivo, with IFN-λ and returned to the patient. The present invention also provides a method of ex vivo treatment, in conjunction with co-administration of IFN-λ | 03-08-2012 |
20140272994 | METHODS AND REAGENTS THAT SPECIFICALLY DETECT, DISTINGUISH AND QUANTIFY IFN-LAMBDA2 mRNA FROM IFN-LAMBDA3 mRNA IN HUMANS - The present invention provides a method of specifically detecting IFN-λ2 mRNA or IFN-λ3 mRNA. There is provided a qRT-PCR method specifically detecting, discriminating and quantifying IFN-λ2 and IFN-λ3 mRNA in a biological sample obtained from a human. There is provided qRT-PCR methods and primers and probes that specifically detect IFN-λ2 mRNA but not IFN-λ3 mRNA and vice versa in humans in order to detect, quantify and discriminate IFN-λ2 mRNA and IFN-λ3 mRNA. | 09-18-2014 |
Grant E. Gallagher, Hamilton, NJ US
Patent application number | Description | Published |
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20110268707 | Ex-vivo treatment of peripheral blood leukocytes with IFN-lambda - The present invention provides an ex vivo method of treating plasmacytoid dendritic cells (pDC) in Th2- or Th17-associated diseases by modulating the cytokine expression or secretion using interferon lambda (IFN-λ). For the Th-2 or Th17-associated diseases, pDC cells from a patient having the disease are exposed ex vivo with IFN-λ in an effective amount to inhibit cytokine releases. The IFN-λ exposed pDC are administered back into the patient. The present invention also provides a method of ex vivo IFN-λ treatment of pDC, in conjunction with co-administration of a composition comprising IFN-λ. | 11-03-2011 |
20140050700 | EX-VIVO TREATMENT OF PERIPHERAL BLOOD LEUKOCYTES WITH IFN-Lambda - The present invention provides a method of treating Th2-associated diseases and disorders by modulating the expression or secretion of IL-4, IL-5 and IL-13 using interferon lambda (IFN-λ). For Th2-associated diseases and disorders, cells of a patient having a Th2-associated disease or disorder are treated ex vivo, with IFN-λ and returned to the patient. The present invention also provides a method of ex vivo treatment, in conjunction with co-administration of IFN-λ | 02-20-2014 |
Grant F. Gallagher, Milltown, NJ US
Patent application number | Description | Published |
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20110171173 | IFN-ALPHA/BETA-INDEPENDENT MECHANISM OF ANTIVIRAL PROTECTION THROUGH A NOVEL LIGAND-RECEPTOR PAIR: IFN- LIGANDS ENGAGE A NOVEL RECEPTOR IFN-RN (CRF2-12) AND IL-10R2 (CRF2-4) FOR SIGNALING ANDINDUCTION OF BIOLOGICAL ACTIVITIES - A novel IFN-α/β independent ligand receptor system which upon engagement leads, among other things, to the establishment of an anti-viral state is disclosed. Further disclosed are three closely positioned genes on human chromosome 19 that encode distinct but highly homologous proteins, designated IFN-λ1, IFN-λ2, IFN-λ3, based, inter alia, in their ability to induce antiviral protection. Expression of these proteins is induced upon viral infection. A receptor complex utilized by all three IFN-λ proteins for signaling is also disclosed. The receptor complex is generally composed of two subunits, a novel receptor designated IFN-λR1 or CRF2-12, and a second subunit, IL-10R2 or CRF2-4, which is also a shared receptor component for the IL-10 and IL-22 receptor complexes. The gene encoding IFN-λR1 is generally widely expressed, including many different cell types and tissues. Expression of these proteins is induced by immune events, including, for example, upon viral infection. Apoptotosis may also be induced under effective conditions. | 07-14-2011 |
20120114603 | IFN-ALPHA/BETA-INDEPENDENT MECHANISM OF ANTIVIRAL PROTECTION THROUGH A NOVEL LIGAND-RECEPTOR PAIR: IFN- LIGANDS ENGAGE A NOVEL RECEPTOR IFN-RN (CRF2-12) AND IL-10R2 (CRF2-4) FOR SIGNALING ANDINDUCTION OF BIOLOGICAL ACTIVITIES - A novel IFN-α/β independent ligand receptor system which upon engagement leads, among other things, to the establishment of an anti-viral state is disclosed. Further disclosed are three closely positioned genes on human chromosome 19 that encode distinct but highly homologous proteins, designated IFN-λ1, IFN-λ2, IFN-λ3, based, inter alia, in their ability to induce antiviral protection. Expression of these proteins is induced upon viral infection. A receptor complex utilized by all three IFN-λ proteins for signaling is also disclosed. The receptor complex is generally composed of two subunits, a novel receptor designated IFN-λR1 or CRF2-12, and a second subunit, IL-10R2 or CRF2-4, which is also a shared receptor component for the IL-10 and IL-22 receptor complexes. The gene encoding IFN-λR1 is generally widely expressed, including many different cell types and tissues. Expression of these proteins is induced by immune events, including, for example, upon viral infection. Apoptotosis may also be induced under effective conditions. | 05-10-2012 |
Jeff Gallagher, Covington, LA US
Patent application number | Description | Published |
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20100134089 | SYSTEM AND METHOD FOR PHASE LOAD DISCOVERY - A system and method for determining the relative phase of each of a plurality of load meters connected to a three-phase power distribution system. The system includes a gateway that communicates information to and from each of the individual load meters. The gateway generates a timing pulse that is received by each of the load meters. Based upon the delay from the receipt of the timing pulse to the next zero crossing of the single phase power supply received by the meter, the utility can determine the phase of the individual meter. The system can include a feeder meter connected to each phase of the electrical supply system to determine the energy consumption for each of the meters connected to a specific phase. The utility can compare the energy consumption information from the feeder meter to all of the load meters connected to the same phase to determine whether any energy theft is occurring. | 06-03-2010 |
Jeffery M. Gallagher, Greenfield, IN US
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20080251975 | MOLDING PROCESSES AND TOOL THEREFOR - A molding process and apparatus suitable for use in molding processes, including rapid prototyping processes and short run production processes. The molding process and apparatus entail the use of a reconfigurable screen tool having a housing defining a manifold cavity and a plurality of substantially parallel pins, each having a head protruding from the housing and a shank protruding into the housing. The heads of the pins define a screen surface through which air is able to flow, for example, through gaps between adjacent heads or through internal passages within the pins. The process further includes axially moving the pins to configure the screen surface, preventing further axial movement of the pins relative to each other, and then drawing a vacuum within the manifold cavity and creating a vacuum at the screen surface. | 10-16-2008 |
Jeffrey Gallagher, Covington, LA US
Patent application number | Description | Published |
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20080272981 | Low Profile Helical Planar Radio Antenna with Plural Conductors - A low profile, compact planar antenna having an approximately flat, dual helical or helix shape is affixed to a supporting substrate. The resonant frequency of the device is determined by parameters including and not limited to length, width, and pitch angle of the helix. An additional helical element is added to induce a second resonant frequency and increase bandwidth. The antenna has an omni-directional radiation pattern, is highly efficient, and is provided in a compact profile suitable for use in a small battery operated device, such as water, gas or electricity meters as well as industrial sensors and security devices. | 11-06-2008 |
Jeffrey Gallagher, Huber Heights, OH US
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20090059063 | Camera mount bracket for mounting a thermal imaging camera to a protective helmet - A camera mount bracket ( | 03-05-2009 |
Jeremy James Gallagher, Spokane, WA US
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20080296060 | Structured Cabling Chassis - Structured cabling solutions may include techniques and systems usable to route, organize, and otherwise manager wires, optical fibers, and other cables. Structured cabling solutions may include one or more chassis coupled to and movable relative to a frame to provide access to signal connectors on the chassis. Structured cabling solutions may also include labeling schemes that identify patch connectors that correspond to outlets in a structured cabling installation. | 12-04-2008 |
20080297987 | Intuitive Labeling Schemes for Structured Cabling Solutions - Structured cabling solutions may include techniques and systems usable to route, organize, and otherwise manager wires, optical fibers, and other cables. Structured cabling solutions may include one or more chassis coupled to and movable relative to a frame to provide access to signal connectors on the chassis. Structured cabling solutions may also include labeling schemes that identify patch connectors that correspond to outlets in a structured cabling installation. | 12-04-2008 |
20080298762 | Structured Cabling Solutions - Structured cabling solutions may include techniques and systems usable to route, organize, and otherwise manager wires, optical fibers, and other cables. Structured cabling solutions may include one or more chassis coupled to and movable relative to a frame to provide access to signal connectors on the chassis. Structured cabling solutions may also include labeling schemes that identify patch connectors that correspond to outlets in a structured cabling installation. | 12-04-2008 |
20080310810 | EXPANDABLE FIBER MANAGEMENT - A communications management system includes a cabinet, a chassis, and a panel for mounting optical circuits. In one implementation, the chassis is coupled to the cabinet and slides outward from the cabinet and the panel is coupled to the chassis and pivots about an axis that is perpendicular to the direction that the chassis slides. A communications management system my include a cabinet with substantially parallel first and second surfaces. In one implementation, one of the surfaces contains a provision for attaching the cabinet to a second cabinet and a feature for passing a communications fiber from the cabinet to the second cabinet. A second communications management system includes panel for mounting optical circuits. In one implementation, the panel includes a feed adapter for terminating optical fibers that are in use and a parking lot for terminating optical fiber that are not in use. | 12-18-2008 |
20090316706 | STRUCTURED PREMISE NETWORKING SYSTEM - A data network to manage the distribution of network services and content throughout a home or residence is described. Generally, the data network includes a media gateway to receive, manage, and distribute services and content throughout the residence. The media gateway may include a structured wiring panel, a services switch to manage the network, and a communications module to provide an interface between the services switch and the residence. | 12-24-2009 |
20090316707 | Services Switch Form Factor - A media gateway to distribute network services and content throughout a home or residence is described. Generally, the media gateway includes a structured wiring panel, a services switch mounted within the structured wiring panel to receive network services from one or more network service providers, and to distribute the network services to a number of data outlets located at the residence. The media gateway may also include one or more patch panels mounted within the structured wiring panel to provide connectivity between the services switch and the data outlets, and an uninterruptable power supply (UPS) mounted within the structured wiring panel to supply backup electrical power to the services switch and/or one or more of the plurality of data outlets in the event of a main power failure. | 12-24-2009 |
John F. Gallagher, Hopewell, NJ US
Patent application number | Description | Published |
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20110099277 | NETWORK ARCHITECTURE FOR RESOURCE REQUESTS - A method may include receiving a primary resource in a user device, wherein the resource includes a plurality of addresses and each of the plurality of addresses identifying one of a plurality of additional resources. The method may further include aggregating the plurality of addresses and sending the aggregated addresses to a network device. The method may further include receiving the additional resources in the user device. | 04-28-2011 |
20120023152 | Methods and Systems for Providing Location-Based Interactive Golf Content for Display by a Mobile Device - An exemplary method includes an interactive golf content computing system detecting a geographic location of a mobile device associated with a golfer while the golfer is playing a golf hole, selecting interactive golf content associated with one or more other golfers who played the golf hole previous to the playing of the golf hole by the golfer in accordance with the detected geographic location, and providing the selected interactive golf content for display by the mobile device. Corresponding methods and systems are also described. | 01-26-2012 |
20120066495 | MOBILE CONTENT DELIVERY OPTIMIZATION - A device receives, from a target user device, a request for encrypted content, where the request is sent via a wireless access network. The device identifies a donor user device that is available to provide the encrypted content via a local wireless network connection, where the donor user device has previously downloaded the encrypted content. The device sends, to the target user device and/or the donor user device, instructions to establish a peer-to-peer connection, via the local wireless network, to provide the encrypted content to the target user device, where the encrypted content is decrypted by the target user device using a license key provided over a different network than the local wireless connection. | 03-15-2012 |
20120143918 | MOBILE USER DATA COLLECTION - A device receives, from multiple user devices, event information associated with the multiple user devices, where the event information includes one or more actions, user information, content information, and one or more attributes. The device stores the event information in a database, and analyzes one or more portions of the event information stored in the database. The device also recommends, based on the analyzed event information, one or more adjustments to a network that delivers content to the multiple user devices. | 06-07-2012 |
20120155358 | ADAPTIVE MOBILE MULTICASTING FOR WIRELESS NETWORKS - Video streams may be adaptively switched between multicast and unicast transmission over a wireless interface of a wireless network. A device may track a quantity of videos that are being streamed over the wireless network. The device may determine, based on the tracked quantity of videos, whether to dedicate a radio channel, of at least one cell in the wireless network, to streaming a first of the videos. The device may transmit, in response to a request, from a mobile device, for the first video, an identification of the dedicated radio channel so that the mobile device can receive the first video as a streaming video over the dedicated radio channel. | 06-21-2012 |
20120227002 | Methods and Systems for Managing an e-Reader Interface - Exemplary methods and systems for managing an e-reader interface are disclosed herein. An exemplary method includes an e-reader interface management system directing an e-reader device to display a plurality of graphical objects representative of a plurality of segments of an e-publication, detecting a user interaction with a graphical object within the plurality of graphical objects and representative of a segment within the plurality of segments, and directing the e-reader device to remove at least one other graphical object within the graphical objects from the display of the graphical objects, wherein the at least one other graphical object is representative of at least one other segment within the plurality of segments that is unrelated to the segment. Corresponding methods and systems are also disclosed. | 09-06-2012 |
20130054378 | DATA USAGE PLAN ASSOCIATED WITH USER DEVICE - A method includes providing identifying application information associated with a user device in a network. The application information is information associated with at least one application running on the at least one user device. The method may further include identifying data usage information associated with the user device. The data usage information includes information associated with data used by the user device. In addition, the method may include associating the application information and the data usage information to determine application data usage for the user device. The method may also include identifying a data usage plan associated with the user device, and applying the data usage plan in the network based on the application data usage. | 02-28-2013 |
20130091239 | OPTIMIZING SELECTION OF A NETWORK FOR VIDEO STREAMING - A method includes receiving a request to provide streaming video content from a user device. A location is identified for the user device. Available networks to deliver the streaming video content are identified based on the location of the at least one user device. Network preference for delivery of the streaming video content is identified. The method also includes selecting an optimal network for delivering the streaming video content based on the location of the at least one user device, the available networks and the network preference for delivery of the streaming video content. The method may also include providing the streaming video content using the optimal network. | 04-11-2013 |
20130125175 | DELIVERING VIDEO ON DEMAND (VOD) USING MOBILE MULTICAST NETWORKS - A system and method are provided for obtaining video content using wireless multicast for video content data in combination with wireless unicast for requests of the video content and transmissions of licenses to use the video content. A method can include: receiving an instruction to obtain particular content; sending a first wireless unicast signal requesting the particular content; receiving the obtained particular content in response to sending the first wireless unicast signal; obtaining a license for the particular content; and providing a notification that the particular content is available for display by a mobile device. | 05-16-2013 |
20130145383 | MULTI-SCREEN VIDEO - One or more network devices receive, from a third-party system, catalog metadata for physical media assets available to order and combine the catalog metadata with catalog entries for digital content to form a unified catalog file. The one or more devices receive, from a user device, a request to view a directory of available video content and send, to the user device, the unified catalog file for presentation to a user. The one or more devices receive, from the user device, a selection of an item in the unified catalog file. The one or more devices provide, to the user device, video content corresponding to the selection when the selection corresponds to one of the catalog entries for digital content and provide, to the third-party system and via a billing gateway, user payment information when the selection corresponds to the catalog metadata for one of the physical media assets. | 06-06-2013 |
20130267207 | REDUCING CELLULAR NETWORK TRAFFIC - A system is configured to store a user profile associated with a user, the user profile including: a first time, a time period, a list of content accessed by the one or more devices from one or more servers. The system may further be configured to identify particular content based on the list of content from the user profile; determine an amount of particular content to transfer based on the time period; and automatically transfer at least the amount of particular content from one or more servers to the one or more devices over a local area network, prior to the first time. | 10-10-2013 |
John P. Gallagher, Fall City, WA US
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20120116888 | Advertising that is Relevant to a Person - A person is viewing a display. By evaluating tracked information about the person, the display and/or the content being viewed, a tracking system determines that an opportunity exists to present an advertisement that is relevant to the person in the context of the person currently viewing the display. The tracking system provides advertiser data for the advertisement and instructions for generating the advertisement to a synthesis system local to the viewer and the viewer's display system, which dynamically synthesizes the advertisement and provides it to the display. | 05-10-2012 |
John Paul Gallagher, Hockessin, DE US
Patent application number | Description | Published |
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20090019086 | Method for matching color and appearance of a coating containing effect pigments - The present invention is directed to a method for identifying one or more matching formulas for matching color and appearance of a target coating containing effect pigments. The present invention is also directed to a system for identifying one or more matching formulas for matching color and appearance of a target coating containing effect pigments. | 01-15-2009 |
20110131009 | METHOD FOR CHARACTERIZING HIDING OF COATING COMPOSITIONS AND APPARATUS USED THEREFOR - The present invention is directed to an apparatus and a method that characterizes the hiding of coating compositions, such as automotive OEM and refinishes paints. The method is directed to sequentially storing in a computing device hiding data obtained by measuring the color difference (ΔRGB) in reflections of light and dark portions of target areas of a monotonic coating resulting from a coating composition applied over hiding test panel and by measuring coating thicknesses of the monotonic coating that correspond to the target areas, classifying the type of the hiding data, selecting fitting equations applicable to the classified hiding data, fitting the selected equation to match the classified hiding data and locating a hiding thickness on the monotonic coating that corresponds to the threshold value of the color difference at that location to determine the hiding thickness of the coating composition. | 06-02-2011 |
Joseph J. Gallagher, Seattle, WA US
Patent application number | Description | Published |
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20120240050 | INTERNET PRIVACY USER INTERFACE - A method and system that provide an intuitive user interface and related components for making Internet users aware of Internet cookie-related privacy issues, and enabling users to control Internet privacy through automatic cookie handling. Default privacy settings for handling cookies are provided, and through the user interface, the privacy settings may be customized to a user's liking. Further, through the user interface, for each individual site that forms a page of content, the site's privacy policy may be reviewed and/or the privacy controlled by specifying how cookies from that site are to be handled. To make users aware, the user interface provides an active alert on a first instance of a retrieved web site's content that fails to include satisfactory privacy information, and thereafter, provides a distinctive passive alert to allow the user selective access to privacy information, per-site cookie handling and cookie handling settings. | 09-20-2012 |
Katherine A. Gallagher, Ellicott City, MD US
Patent application number | Description | Published |
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20100272684 | HYPERBARIC TREATMENT IN WOUND HEALING - This invention relates to methods for treating chronic dermal ulcers using hyperbaric treatment in combination with progenitor cells and chemokine homing factors. Specifically, the invention relates to treatment of chronic wounds resulting from diabetes mellitus using compositions comprising EPC and SDF-1A, under hyperbaric condition to accelerate wound healing. | 10-28-2010 |
Kevin Gallagher, Lincroft, NJ US
Patent application number | Description | Published |
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20120230927 | CYCLOMETHICONE-FREE COSMETIC AND PERSONAL CARE PRODUCTS - A personal care or cosmetic composition that includes from about 0.1% to about 99% of at least one ester of alkoxylated aromatic alcohol and fatty carboxylic acid, and from about 0.1% to 60% of at least one functional ingredient is provided. The functional ingredients in the composition may include active ingredients and additional ingredients. Especially suitable active ingredients are sunscreen active ingredients and antiperspirant active ingredients. These compositions include a reduced amount of a cyclomethicone and preferably one substantially cyclomethicone-free. | 09-13-2012 |
Kevin C. Gallagher, Atlanta, GA US
Patent application number | Description | Published |
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20100251641 | Systems and Methods for Modular Floor Installation - Connectors for joining adjacent modular floor covering units. The connectors include a base or film and one or more attachment members. As an exemplary use of a connector to install tiles, a first tile is placed on the floor and a connector is positioned so that an attachment member faces upward and attaches to the first tile. One or more other tiles are then positioned adjacent the first tile so that the same or other attachment members of the connector attach to the adjacent tiles. In certain embodiments, an attachment member comprises projections that form a mechanical connection with the undersides of the tiles. For example, a connector may comprise a plastic unit with raised ridges that interact with corresponding indentations on the undersides of the tiles. A connector can also or alternatively form a connection with tiles and/or the underlying floor surface by having a high coefficient of friction. | 10-07-2010 |
Kevin N. Gallagher, Greenwich, CT US
Patent application number | Description | Published |
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20110173060 | Guest Check Presenter Having a Wireless Communication Device - A guest check presenter for a food establishment is provided. The guest check presenter includes a holder for holding a guest check information and a wireless communication device attached to the holder and adapted to communicate with a wireless mobile device of the guest. The wireless communication device contains a guest check identifier that identifies the guest check. The guest check identifier is adapted to be retrieved by the wireless mobile device of the guest for use in providing various useful mobile services that are associated with the food establishment or the food consumed by the guest. Thus, the check presenter is used as a platform for providing such mobile services as mobile payment of the guest check and loyalty coupons. | 07-14-2011 |
Laura A. Gallagher, Cincinnati, OH US
Patent application number | Description | Published |
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20100262172 | ULTRASONIC SURGICAL BLADE HAVING TRANSVERSE AND LONGITUDINAL VIBRATION - An ultrasonic surgical blade includes an ultrasonic-surgical-blade body having a longitudinal axis, a distal tip, a proximal end adapted for longitudinal ultrasonic vibrational excitation, a most-distal longitudinal vibration node, a treatment portion extending from the distal tip toward the most-distal longitudinal vibration node, and a functional asymmetry. The functional asymmetry is asymmetric about the longitudinal axis and translates longitudinal ultrasonic vibrational movement of the proximal end into a combination of a longitudinal ultrasonic vibration and a transverse ultrasonic vibration in at least some of the treatment portion of the ultrasonic-surgical-blade body. An amplitude of the transverse ultrasonic vibration at the distal tip is less than substantially ten percent of a maximum amplitude of the transverse ultrasonic vibration of the treatment portion of the ultrasonic-surgical-blade body. An alternate embodiment of the ultrasonic surgical blade includes at least one functional asymmetry and at least one balance asymmetry. | 10-14-2010 |
Mark Gallagher, Altamonte Springs, FL US
Patent application number | Description | Published |
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20120174678 | Wireless saw sensors having integrated antennas - A wireless surface acoustic wave sensor includes a piezoelectric substrate, a surface acoustic wave device formed on the substrate, and an antenna formed on the substrate. In some embodiments, the antenna is formed on the surface of the substrate using one or more of photolithography, thin film processing, thick film processing, plating, and printing. | 07-12-2012 |
Mark Gallagher US
Patent application number | Description | Published |
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20100056132 | SYSTEM AND METHOD FOR FEMTOCELL MANAGEMENT - The present invention provides a method of operating a femtocell control module in control of a femtocell, comprising transmitting a request to operate the femtocell to an external control system; receiving a response from the external control system, where the response comprises an operational constraint on the femtocell; and causing the femtocell to conduct cellular communications according to the operational constraint. | 03-04-2010 |
Maureen Gallagher, Orange, VA US
Patent application number | Description | Published |
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20080217447 | Machine for shredding/collecting drugs and drug packaging incident to permanent disposal - A drug and/or drug packaging shredding/collecting machine includes a cabinet defining an interior chamber which can be accessed through a front opening for housing and storing a container lid and container incident to the shredding of drugs and drug packaging by a shredder carried by a top wall of the cabinet. The top wall also includes a non-shredable drug/drug packaging opening which includes a flexible inlet guard. A door of the container includes a storage area for plastic locking ties which, after the lid is slid to a nested position with respect to a channel/flange of the container can lock the two together through registered openings thereof thereby preventing inadvertent/accidental spillage and/or providing an indication of pilfering. | 09-11-2008 |
Michael Gallagher, Clinton Township, MI US
Patent application number | Description | Published |
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20130296754 | ORTHOTIC JOINT AND KNEE-ANKLE-FOOT ORTHOTIC DEVICE INCORPORATING SAME - An orthotic joint comprising an upper plate, lower plate, cover plate, back plate, first link, second link, coil spring, and extension stop. The coil spring is situated between the lower plate and first link, and as the joint is flexed, the first end of the coil spring travels along a first arcuate edge of the first link. The extension is situated adjacent to the first link. A first pin pivotally connects the first link to the upper plate, a second pin pivotally connects the first link to the back plate, a third pin pivotally connects the second link to the upper plate, and a fourth pin pivotally connects the second link to the back plate. A knee-ankle-foot orthotic device comprising the orthotic joint of the present invention. | 11-07-2013 |
Michael Gallagher, Evansville, IN US
Patent application number | Description | Published |
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20100320188 | SALT STONE WARMER - A salt stone warmer apparatus designed to warm the salt stones and clean and ionize the air and add to the aesthetics of any massage, spa or salon room. The warmer includes a base member having a wall that defines a cavity having a flat heating surface and a central bore. A heating means is mounted to the heating surface within the cavity. The base member further includes a bottom surface having a plurality of support legs to raise the warmer above the countertop surface. | 12-23-2010 |
Michael David Gallagher, Scottsdale, AZ US
Patent application number | Description | Published |
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20110218933 | Method and Apparatus for Managing Mobile Storage - A computer system for managing and operating a mobile storage business includes a centralized database that stores route information for a plurality of drivers and routes. A mobile computer device can be used by a driver or mobile storage representative to communicate with the database. The device can be used to display route information relating to the delivery or pickup of a portable storage container and to transmit to the database the signature of the customer, comments relating to the task, images relating to the task and location associated with the container identifier. The mobile computer device includes a scanner for capturing the container identification and a global positioning system capability for capturing the location associated with the container and the location of the mobile computer device. | 09-08-2011 |
Michael P. Gallagher, Greenville, OH US
Patent application number | Description | Published |
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20100089703 | RESTRAINT SYSTEM FOR WALKIE/RIDER PALLET TRUCK - A walkie/rider pallet truck is provided comprising a power unit; a set of forks associated with the power unit; a platform associated with the power unit and defining a location upon which an operator may stand; and a restraint system comprising a pivotable restraint structure. The restraint structure is movable to one of a walkie position, a rider-driving position and a quick-exit position. | 04-15-2010 |
20140343758 | WEARABLE WIRELESS REMOTE CONTROL DEVICE FOR USE WITH A MATERIALS HANDLING VEHICLE - A supplemental remote control system for a materials handling vehicle includes a wireless remote control device that is useable by an operator interacting with the materials handling vehicle. Actuation of a travel control on the remote control device causes a wireless transmitter on the device to transmit a travel request to the vehicle. The remote control system further includes a receiver for receiving transmissions from the wireless transmitter at the vehicle and a controller at the vehicle in communication with the receiver for implementing the travel request. The wireless remote control device further includes an input component, wherein actuation of the input component causes the wireless transmitter to wirelessly transmit a second type of request to the receiver on the vehicle requesting the controller to implement a second vehicle function other than to advance the vehicle. | 11-20-2014 |
Michael T. Gallagher, Medina, OH US
Patent application number | Description | Published |
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20090247706 | Continuous extrusion process for producing grafted polymers - A continuous extrusion process for the functionalization of polymers through reactive extrusion. The process uses a continuous extrusion reactor comprising at least two sequential, very closely-coupled, independently driven screw extruders having a total effective length to diameter ratio greater than 60 to 1 and as high as 112 to 1 and providing greatly extended reaction times for efficiently producing a grafted polymer having a high level of functionalization. Drying of the polymer feed is performed in the continuous extrusion reactor. Multiple injections of reactants may be provided. Shear modification of the molecular weight of the grafted polymer is performed in the continuous extrusion reactor after the functionalization reactions. A continuous extrusion reactor and a grafted polymer having a high level of functionalization are also disclosed. | 10-01-2009 |
Michela Gallagher, Baltimore, MD US
Patent application number | Description | Published |
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20100081648 | Methods for Characterizing and Treating Cognitive Impairment In Aging and Disease - This invention provides methods for identifying genes associated with cognitive impairment and for identifying compounds useful in the treatment of cognitive impairment. The methods can in particular be used to identify genes associated with, and compounds useful in treating, cognitive impairment in aging. | 04-01-2010 |
20100099735 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION - This invention relates to treating age-related cognitive impairment. This invention in particular relates to the use of inhibitors of synaptic vesicle protein 2A (SV2A), such as levetiracetam, seletracetam, and brivaracetam, in improving cognitive function in subjects that exhibit age-related cognitive impairment or are at risk thereof, including, without limitation, subjects having or at risk for Mild Cognitive Impairment (MCI), Age-related Cognitive Decline (ARCD) or Age-Associated Memory Impairment (AAMI). | 04-22-2010 |
20110065674 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION - The invention relates to methods and compositions for improving cognitive function by using a combination of valproic acid and analogs and derivatives thereof (“valproate”) and an acetylcholinesterase inhibitor (AChEI). In particular, it relates to the use of a combination of a valproate and an AChEI in treating age-related cognitive impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for Mild Cognitive Impairment (MCI), Age-Associated Memory Impairment (AAMI) or Age-Related Cognitive Decline (ARCD). | 03-17-2011 |
20110212928 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION - The invention relates to methods and compositions for improving cognitive function by using a combination of a synaptic vesicle protein 2A (SV2A) inhibitor and an acetylcholinesterase inhibitor (AChEI) or their pharmaceutically acceptable salts, hydrates, solvates, polymorphs thereof. In particular, it relates to the use of a combination of an SV2A inhibitor and an AChEI in treating a central nervous system disorder with cognitive impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, Mild Cognitive Impairment (MCI), dementia, Alzheimer's Disease (AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, amyotrophic lateral sclerosis (ALS), and cancer-therapy-related cognitive impairment. | 09-01-2011 |
20120046336 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION - This invention relates to treating age-related cognitive impairment. This invention in particular relates to the use of inhibitors of synaptic vesicle protein 2A (SV2A), such as levetiracetam, seletracetam, and brivaracetam, in improving cognitive function in subjects that exhibit age-related cognitive impairment or are at risk thereof, including, without limitation, subjects having or at risk for Mild Cognitive Impairment (MCI), Age-related Cognitive Decline (ARCD) or Age-Associated Memory Impairment (AAMI). | 02-23-2012 |
20120214859 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION - This invention relates to methods and compositions for treating central nervous system (CNS) disorders with cognitive impairment. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2A (SV2A), alone or in combination with valproate, in treating central nervous system (CNS) disorders with cognitive impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI (aMCI), Age-Associated Memory Impairment (AAMI), Age Related Cognitive Decline (ARCD), dementia, Alzheimer's Disease (AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, amyotrophic lateral sclerosis and cancer-therapy-related cognitive impairment. | 08-23-2012 |
20140057903 | METHODS FOR CHARACTERIZING AND TREATING COGNITIVE IMPAIRMENT IN AGING AND DISEASE - This invention provides methods for identifying genes associated with cognitive impairment and for identifying compounds useful in the treatment of cognitive impairment. The methods can in particular be used to identify genes associated with, and compounds useful in treating, cognitive impairment in aging. | 02-27-2014 |
20140206667 | METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA - The invention relates to methods and compositions for treating schizophrenia or bipolar disorder (in particular, mania) by using a combination of a synaptic vesicle protein 2A (SV2A) inhibitor and an antipsychotic or their pharmaceutically acceptable salts, hydrates, solvates, polymorphs thereof. In some embodiments, the methods and the compositions are for treating one or more positive and/or negative symptoms, as well as cognitive impairment, associated with schizophrenia or bipolar disorder (in particular, mania). | 07-24-2014 |
Michelle B. Gallagher, Menomonee Falls, WI US
Patent application number | Description | Published |
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20120245694 | ENDPLATE-PRESERVING SPINAL IMPLANT WITH AN INTEGRATION PLATE HAVING DURABLE CONNECTORS - An interbody spinal implant including a body having a top surface, a bottom surface, opposing lateral sides, opposing anterior and posterior portions, a substantially hollow center, and single vertical aperture, as well as an integration plate having a roughened surface topography on its top surface. The integration plate and implant body are joined together with a durable connection. | 09-27-2012 |
Paul Martin Gallagher, Ames, IA US
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20080237125 | METHOD OF CLEANING MEMBRANES - The present invention relates a method for cleaning polymeric microfiltration membranes and membrane units, and to compositions useful in such methods. The compositions include at least one soluble sulfite reducing agent and a compatible solvent. | 10-02-2008 |
Peter L. Gallagher, Lexington, KY US
Patent application number | Description | Published |
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20090240299 | DEVICE AND METHOD FOR REFLEX CARDIAC PACING - Solid state piezoelectric or Lorentzian components are utilized to generate electrical energy in an implanted device. The energy generated from tissue displacement is stored and made available for use as a cardiac pacing charge to be delivered by the device when a triggering condition, such as an arrhythmia is detected. A plurality of implanted devices can be used to collectively provide one or more pacing charges. | 09-24-2009 |
Ralph J. Gallagher, Alpharetta, GA US
Patent application number | Description | Published |
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20090037203 | SYSTEMS AND METHODS FOR PROVIDING AND DYNAMICALLY UPDATING CUSTOMER-SPECIFIC SHIPPING INFORMATION ON AN ON-SITE SERVER - A commerce system for serving a customer of delivery services using dynamically updated data including platform services, an operations-management server maintained by a vendor, and a local commerce server and a remote computer system maintained by a delivery services company. The operations-management server is positioned at a customer location and operatively connected to the platform services. The commerce server is operatively connected to the operations-management server and operatively connected to the platform services and includes local programs configured for providing services of the delivery services company to the customer. The remote computer system is connected to the local commerce server by a network. The remote computer system includes a message-management system, wherein at least one of the message-management compartments holds update data connected to the local commerce server for updating the commerce data, and includes remote programs. The operations-management and local commerce servers run interactively on the platform services. | 02-05-2009 |
Rex T. Gallagher, Hampton, NH US
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20100145080 | PURIFICATION OF TAXANES - Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane. | 06-10-2010 |
Richard N. Gallagher, Phoenix, AZ US
Patent application number | Description | Published |
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20090294496 | Gun holster with articulating spine - A holster is utilized in combination with a gun including a handle, barrel, and a detent. The holster includes a spine; a first side; and a second side opposed to the first side. The first and second sides collectively form a pocket with a top and receive the barrel with the handle extending outside the top of the pocket, are connected together along the rear of the pocket, and are connected to the spine. The spine includes a first section; and, includes a second section with a locking rib attached thereto and attached to the holster. The second section is movable between a first operative position generally in alignment with the first section in which the locking rib extends into the detent to prevent the gun from being withdrawn from the holster; and, a second operative position in which the second section is moved out of alignment with the first section and the locking rib is moved free of the detent to permit the gun to be withdrawn from the holster, the second section being in the first operative position. The holster also includes a finger rest connected to the second section to manually pivotally displace with the finger of a hand, while grasping the handle of the gun with the hand, the second section from the first operative position to the second operative position to permit the gun to be withdrawn from the holster. | 12-03-2009 |
20120325871 | Autofit gun holster - A peripheral arcuate pivoting surface is mounted in a holster to roll over and engage a firearm trigger guard to secure the firearm in the holster. | 12-27-2012 |
Rosa I. Gallagher, Springfield, VA US
Patent application number | Description | Published |
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20120077843 | MALIGNANT PRECURSOR CELLS FROM DUCTAL CARCINOMA IN SITU LESIONS - Described herein are progenitor cancer cells and cell lines isolated from human breast ductal carcinoma in situ (DCIS) lesions and the uses of these cells or cell lines in drug design, drug screening, and monitoring in vivo therapy. The DCIS malignant precursor cells or cell lines are epithelial in origin, are positive for markers of autophagy, show at least one genetic difference from normal cells of said fragment, form 3-D tube-like structures or ball aggregates, or are inhibited in formation of 3-D structures and migration by treatment with chloroquine. | 03-29-2012 |
Scott Lane Gallagher, Hamilton, NJ US
Patent application number | Description | Published |
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20110129803 | Parallel parking apparatus/vehicle perimeter marking system - The parallel parking system/vehicle perimeter marking apparatus is to be used to teach drivers the perimeter of their vehicle through visual aids. This should improve parking skills. The apparatus attaches to the four corners of the vehicle enabling the driver to fully ascertain the perimeter of the vehicle while training to park. | 06-02-2011 |
Scott Patrick Gallagher, Milwaukee, WI US
Patent application number | Description | Published |
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20080269626 | FALSE POSITIVE REDUCTION IN SPO2 ATRIAL FIBRILLATION DETECTION USING AVERAGE HEART RATE AND NIBP - The method and system includes detecting atrial fibrillation in a patient by monitoring the blood oxygen saturation level over a period of time. The method and system produces a plethysmographic waveform from the monitored blood oxygen saturation level and analyzes the plethysmographic waveform and detected intervals and determines whether the patient is in atrial fibrillation. The method and system is preferably implemented in a software application and may be configured to report to the user on the current state of atrial fibrillation (AFIB) and a current trend. | 10-30-2008 |
Steve William Gallagher, Bloomfield Hills, MI US
Patent application number | Description | Published |
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20100133879 | Wheelhouse Inner Bracket for Automotive Vehicles - A wheelhouse reinforcement bracket is provided for the rear wheelhouses of an automotive vehicle to increase torsional rigidity for the vehicle. The wheelhouse bracket is positioned in alignment with the location on the vehicle body where the shock absorber is located, and in alignment with the rear suspension cross member to create a structural ring formed by the wheelhouse bracket, the C-pillar and the rear suspension cross member. The wheelhouse bracket is formed with a mounting flange positionable within the inside of the U-shaped rear side rail to facilitate welding thereto instead of being welded to the top of the underbody floor structure. The mounting flange has a first portion configured to be mated against a first generally vertically extending wall of the rear side rail and a second portion configured to be mated against a generally horizontally extending wall of the rear side rail. | 06-03-2010 |
20130067822 | TWO-SHOT SECONDARY SEAL - A seal for an automobile body opening comprising a plastic carrier, an elastomeric bulb operably connected to the plastic carrier, and a plastic clip operably connected to, and extending away from, the plastic carrier for engagement to a flange for retaining the seal to the flange. | 03-21-2013 |
Timothy C. Gallagher, Littleton, CO US
Patent application number | Description | Published |
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20100090898 | ELEMENT INDEPENDENT ROUTERLESS BEAMFORMING - Described herein are systems and methods that eliminate the need for costly and complex switching networks for routing channelized data between antenna elements and beamformers. In one aspect, a beamforming system comprises a beamformer for each antenna element of an antenna array, in which the beamformers for the different antenna elements are arranged in parallel. The beamforming system also comprises a combiner that combines the outputs of the beamformers into a single beam. In one aspect, the beamformers of antenna elements that do not contribute to a desired beam output zeros to the combiner, which when added to the subbeams of the other beamformers have no affect of the final beam. In another aspect, operations (e.g., multiplication, memory reads) of each beamformer that does not contribute to a desired beam may be turned off to conserve power. | 04-15-2010 |
Timothy Joseph Gallagher, Auburn, AL US
Patent application number | Description | Published |
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20090202393 | FLUID SAMPLE COLLECTION SYSTEM - A fluid sample collection system includes a vial, a plunger and a fluid sample collection device having an absorbent for absorbing and retaining a fluid sample therein. The plunger includes an elongated handle portion and a plunger head portion detachably connected to the handle portion. The plunger also includes a splash guard supported on the handle portion. During the sample collection process, the saturated absorbent from the sample collection device is placed into the vial and the plunger is then advanced toward a closed end of the vial to express the fluid sample from the absorbent. The plunger head portion is retained within the vial with the absorbent in a generally compressed state and the handle portion is detached and removed from the vial. | 08-13-2009 |
20090209044 | Fluid Sample Collection System and Method - A fluid sample collection system includes a vial, a plunger and a fluid sample collection device having an absorbent for absorbing and retaining a fluid sample therein. The plunger includes an elongated handle portion and a plunger head portion detachably connected to the handle portion. The plunger also includes a splash guard supported on the handle portion. During the sample collection process, the saturated absorbent from the sample collection device is placed into the vial and the plunger is then advanced toward a closed end of the vial to express the fluid sample from the absorbent. The plunger head portion is retained within the vial with the absorbent in a generally compressed state and the handle portion is detached and removed from the vial. | 08-20-2009 |
Timothy W. Gallagher, Cape Coral, FL US
Patent application number | Description | Published |
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20080250997 | THREE-SIDED WIND SCOOP - A three-sided wind scoop is provided for aerating and cooling the interior of a sailboat. The wind scoop comprises three flexible rectangular shaped panels, one side of each panel being joined together to form a center seam; the top of each said three panels being attached in an equal angel Y-shaped configuration to an essentially circular flexible fabric which forms a cap or top cover for said wind scoop. The Y-shaped configured panels of the wind scoop are designed to capture the wind and the direct the flow of air down into the boat regardless of the direction of the wind in relation to the boat and the cap of the wind scoop is designed to capture the wind flowing upward from said Y-shaped configured panels and direct it back downward, thereby adding to and facilitating the downward flow of the air. | 10-16-2008 |
Warren Gallagher, Eau Claire, WI US
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20120034594 | Methylocystis Strain SB2 Materials and Methods - The present disclosures provides isolated or purified compounds, each of which bind to a metal atom. Generally, the compounds are small in size (e.g, molecular weight of less than about 1 kDa) and peptidic in nature, inasmuch as the compounds comprise amino acids. In some embodiments, the compound comprises a structure of Formula I: | 02-09-2012 |
William Gallagher US
Patent application number | Description | Published |
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20110283266 | Software Performance Profiling in a Multi-Tenant Environment - A method for software performance analysis and debugging in a multi-tenant database network system is provided. In at least one embodiment, sampling is achieved using configuration files of each server cluster. Knowledge of the host names of each server in the cluster enables a profiler to target a single server for each sample, thereby facilitating a round-robin sample across a clustered server environment such that a CPU's load and processing cost associated to sampling is fairly and uniformly distributed across all servers in the cluster. As a result, in at least one embodiment of the analysis and debugging tool each sample is a complete stack trace dump of each thread running on the application server at that moment in time. | 11-17-2011 |
William P. Gallagher, Princeton, NJ US
Patent application number | Description | Published |
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20110295015 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER - Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or an activated carboxylic acid compound thereof, to provide a compound of Formula (IV); and (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I); wherein PAm is a protected amine group. Processes to prepare the compounds of Formulae (II), (III), and (IV) are also disclosed. | 12-01-2011 |
20120035212 | (L)-Malate salt of N-(4-phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide - Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane- | 02-09-2012 |
20140012007 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER - Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or an activated carboxylic acid compound thereof, to provide a compound of Formula (IV); and (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I); wherein PAm is a protected amine group. Processes to prepare the compounds of Formulae (II), (III), and (IV) are also disclosed. | 01-09-2014 |
20150057310 | Malate salt of N-(4-phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer - Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, including a (L)-malate salt, a (D)-malate salt, a (DL) malate salt, and mixtures thereof; and crystalline and amorphous forms of the malate salts. Also disclosed are pharmaceutical compositions comprising at least one malate salts of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)-cyclopropane-1,1-dicarboxamide; and methods of treating cancer comprising administering at least one malate salt of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide. | 02-26-2015 |