Fryer, US
Andrew M. Fryer, Erie, CO US
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20080242656 | N-Substituted-N-Sulfonylaminocyclopropane Compounds and Pharmaceutical Use Thereof - The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1) | 10-02-2008 |
20080261994 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF - The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 10-23-2008 |
20080306258 | Cyclopropane compounds and pharmaceutical use thereof - The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 12-11-2008 |
20090047246 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 02-19-2009 |
20100105894 | Cyclopropane compounds and pharmaceutical use thereof - The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 04-29-2010 |
Andrew M. Fryer, Austin, TX US
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20100234378 | ALKYLSULFONAMIDE-SUBSTITUTED TRIAZOLES AS MATRIX METALLOPROTEASE INHIBITORS - Provided are MMP-2, MMP-3, MMP-9, MMP-12 and/or MMP-13 inhibitors having the Formula (I): wherein R | 09-16-2010 |
Benjamin Fryer, Skillman, NJ US
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20090215177 | METHODS, SURFACE MODIFIED PLATES AND COMPOSITIONS FOR CELL ATTACHMENT, CULTIVATION AND DETACHMENT - The present invention relates to the field of mammalian cell culture, and provides methods and compositions for cell attachment to, cultivation on and detachment from a solid substrate surface containing from at least about 0.5% N, a sum of O and N of greater than or equal to 17.2% and a contact angle of at least about 13.9 degrees, lacking a feeder cell layer and lacking an adlayer. In one embodiment of the present invention, the cells are treated with a compound capable of inhibiting Rho kinase activity. In another embodiment, the cells are treated with a compound capable of inhibiting Rho activity. | 08-27-2009 |
20100087002 | Methods, Surface Modified Plates and Compositions for Cell Attachment, Cultivation and Detachment - The present invention relates to the field of mammalian cell culture, and provides methods and compositions for cell attachment to, cultivation on and detachment from a solid substrate surface containing from at least about 0.5% N, a sum of O and N of greater than or equal to 17.2% and a contact angle of at least about 13.9 degrees, lacking a feeder cell layer and lacking an adlayer. In one embodiment of the present invention, the cells are treated with a compound capable of inhibiting Rho kinase activity. In another embodiment, the cells are treated with a compound capable of inhibiting Rho activity. | 04-08-2010 |
20100112693 | Differentiation of Human Embryonic Stem Cells - The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependant kinase inhibitor to cause an increase in expression of MAFA. | 05-06-2010 |
20100124783 | Methods and Compositions for Cell Attachment and Cultivation on Planar Substrates - The present invention is directed to methods for the growth, expansion and differentiation of pluripotent stem cells on planar substrates lacking an adlayer and a feeder cell layer. | 05-20-2010 |
20110104805 | Pluripotent Stem Cells - The present invention provides methods to produce pluripotent stem cells from adult cells. In particular, the present invention provides methods to produce pluripotent stem cells from somatic cells without the use of a feeder-cell layer or an agent that increases efficiency of retroviral transfection. | 05-05-2011 |
Benjamin Fryer, Horsham, PA US
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20140242693 | Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells - The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation. | 08-28-2014 |
20140295552 | SUSPENSION AND CLUSTERING OF HUMAN PLURIPOTENT STEM CELLS FOR DIFFERENTIATION INTO PANCREATIC ENDOCRINE CELLS - The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation. Specifically, the invention discloses methods of differentiating pluripotent cells into beta cell, cardiac cell and neuronal cell lineages using suspension clustering. The methods involve preparing the aggregated cell clusters followed by differentiation of these clusters. | 10-02-2014 |
Colleen Fryer, Towson, MA US
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20100234841 | System and Method for Magnetic Tissue Ablation - Herein it is described a magnetic medical device, and a system and method in which the magnetic medical device is implemented, that enables bipolar, minimally invasive, tissue ablation. The magnetic medical device may include magnetic means for magnetically coupling the medical device to a second medical device, wherein the magnetic medical devices may be separated by the tissue to be ablated. The magnetic medical device may also include electrical means for transferring electrical energy between the magnetic medical device and the second medical device. The magnetic medical device may further include control means whereby the physical location of the magnetic medical device may be controlled and thereby, as a result of the magnetic coupling, the physical location of the second magnetic medical device may also be controlled. | 09-16-2010 |
David Fryer, Hillsboro, OR US
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20090002706 | Wafer level alignment structures using subwavelength grating polarizers - In one embodiment, a wafer alignment system, comprises a radiation source to generate radiation, a radiation directing assembly to direct at least a portion of the radiation onto a surface of a wafer, the radiation having a polarization state, an optical analyzer to collect at least a portion of the radiation reflected from the wafer, the wafer including at least a first region having a first grating pattern oriented in a first direction and at least a second region having a second grating pattern oriented in a second direction, different from the first direction. | 01-01-2009 |
David Thomas Fryer, Fleetwood, PA US
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20080271324 | Spring biased nipper with replaceable blades - A nipper is disclosed having light-weight alloy handles which are ergonomically shaped narrowly to accommodate smaller hands or one-handed use, and biased outwardly by a torsion type spring which additionally limit the open handle width. The nipper utilizes carbide tool steel blades affixed with fasteners for easy replacement. The nipper has a friction reducing bushing at the pivot for ease of movement. | 11-06-2008 |
Don T. Fryer, San Diego, CA US
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20090140505 | Shopping Cart Security Device - A device and method for temporarily maintaining and securing valuables in a shopping cart is disclosed. The device is manufactured to fit in the upper basket area of standard shopping carts. The device can be modified to fit in alternative shopping cart designs and sizes. The device is generally manufactured from a flat panel which forms a lid enclosure over the small basket of a shopping cart. The device is secured to the back side of a shopping cart basket and can flip up so that valuables may be stored inside the small basket. The device is then flipped down and is secured in the front of the small basket of the cart nearest to the shopper. | 06-04-2009 |
Frank D. Fryer, Lyle, MN US
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20120286446 | ADJUSTABLE THERMAL FORMING DIE ASSEMBLY - An adjustable thermal die assembly is provided. The thermal die assembly includes a thermal forming die and at least one insert. The thermal forming die has at least one die cavity of a select shape. The die further has at least one opening to the at least one die cavity. The at least one insert has at least one internal passage that is conformed to have a shape of the at least one opening to the at least one die cavity of the die. Moreover, the at least one insert is configured and arranged to be selectively coupled to the die with the at least one internal passage of the at least one insert aligning with the at least one opening of the at least one die cavity to selectively increase a depth of a forming cavity of the thermal forming assembly. | 11-15-2012 |
Jack M. Fryer, Huntington Beach, CA US
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20110100603 | MICROCHANNEL COOLING DEVICE FOR SMALL HEAT SOURCES - According to the invention, an apparatus for transferring heat with a target is disclosed. The apparatus may include a body which defines a surface, inlet and outlet ports, inlet and outlet manifold passages, and heat transfer passages. The surface may couple the target with the body. The inlet port may be configured to receive and direct a fluid into inlet manifold passages. The outlet port may be configured to receive and output the fluid. The inlet and outlet manifold passages may be configured to receive and direct the fluid to and from the heat transfer passages. The heat transfer passages may be configured to receive and direct all of the fluid from the inlet manifold passages in one or more directions substantially parallel to the surface and substantially perpendicular the input manifold passages. At least one heat transfer passages may have a plurality of fins on at least one surface. | 05-05-2011 |
Jack Merrill Fryer, Huntington Beach, CA US
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20100205933 | Regeneratively cooled porous media jacket - The fluid and heat transfer theory for regenerative cooling of a rocket combustion chamber with a porous media coolant jacket is presented. This model is used to design a regeneratively cooled rocket or other high temperature engine cooling jacket. Cooling jackets comprising impermeable inner and outer walls, and porous media channels are disclosed. Also disclosed are porous media coolant jackets with additional structures designed to transfer heat directly from the inner wall to the outer wall, and structures designed to direct movement of the coolant fluid from the inner wall to the outer wall. Methods of making such jackets are also disclosed. | 08-19-2010 |
20130276426 | Cooling Jacket with Porous Matrix - The fluids and heat transfer theory for regenerative cooling of a rocket combustion chamber with a porous media coolant jacket is presented. This model is useful for calculating temperature distributions in a coolant fluid and combustion chamber or heat source as well as the associated fluid pressure drop through the coolant jacket. This model for fluids and heat transfer theory can be used to design a regeneratively cooled rocket engine. | 10-24-2013 |
20150083369 | METALLIC THIN-FILM BONDING AND ALLOY GENERATION - Diffusion bonding a stack of aluminum thin films is particularly challenging due to a stable aluminum oxide coating that rapidly forms on the aluminum thin films when they are exposed to atmosphere and the relatively low meting temperature of aluminum. By plating the individual aluminum thin films with a metal that does not rapidly form a stable oxide coating, the individual aluminum thin films may be readily diffusion bonded together using heat and pressure. The resulting diffusion bonded structure can be an alloy of choice through the use of a carefully selected base and plating metals. The aluminum thin films may also be etched with distinct patterns that form a microfluidic fluid flow path through the stack of aluminum thin films when diffusion bonded together. | 03-26-2015 |
James I. Fryer, Morristown, NJ US
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20120219767 | FLUOROPOLYMER FILMS AND METHODS FOR MAKING THE SAME - Embodiments of films and methods for making the films are provided. The film comprises a fluoropolymer layer having a surface and comprising a melt processable fluoropolymer and a functionalized polymer dispersed throughout the fluoropolymer layer. A portion of the functionalized polymer is disposed at the surface of the fluoropolymer layer for bonding to a second layer. | 08-30-2012 |
James P. Fryer, Stewartville, MN US
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20140315225 | METHODS AND COMPOSITIONS FOR DETECTING THE PRESENCE OF ONE OR MORE AUTOANTIBODIES - This disclosure describes methods and compositions for immunohistochemically detecting the presence of a SRP autoantibody in a biological sample. | 10-23-2014 |
Kevin L. Fryer, Kansas City, MO US
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20160048540 | DATABASE BUILDING AND DATA MATCHMAKING SOFTWARE SYSTEM AND METHOD OF USE - A software application for matching a first data category with one or more additional data categories. The system provides two or more columns which can be individually scrolled through to allow for matching of data elements in one column with data elements in another column. In a preferred embodiment, the first column of data is generated from contacts located on the user's mobile computing device, such as a smart phone. Data in other columns is pulled from remotely located databases. A primary use for such a matchmaking system would be for job referrals by users connecting the unique contacts stored locally on their mobile devices to job openings stored with a remotely located database. | 02-18-2016 |
Luke Fryer, Seattle, WA US
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20110251489 | ULTRASOUND MONITORING SYSTEMS, METHODS AND COMPONENTS - Ultrasound monitoring systems and components used in ultrasound monitoring systems, such as Transcranial Dopper (TCD) systems, are disclosed. Components include framework systems for mounting, locating and maintaining one or more ultrasound probes in contact with an anatomical surface, adjustable probe mounting systems, and probe interface components providing an acoustically transmissive interface between a probe mounting system and the emissive face of the ultrasound probe. | 10-13-2011 |
Nate Fryer, Broomfield, CO US
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20100009818 | Multi Axes Exercise Apparatus - An apparatus and method for an exercise apparatus is disclosed that includes a base structure, a multiple axes pivotal mechanism disposed adjacent to the base structure, and an arm. The arm further includes a distal end portion and a proximal end portion with a longitudinal axis spanning therebetween. The distal and proximal end portions are each adapted to provide independent resistive force to muscle exertion, with the proximal end portion being adjacent to the mechanism such that operationally at least two independent axes of movement occur in the arm relative to the structure. Also included in the exercise apparatus is an assemblage for creating selectable variable resistance forces to the movement of the arm relative to the structure, such that each axis of movement has an independent selectable variable resistance force to the arm movement. | 01-14-2010 |
Richard D. Fryer, Chatfield, MN US
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20160100976 | Male External Catheter with Absorbent and Adhesive - The invention relates generally to external urinary catheters for males. More specifically, the invention relates to an external urinary catheter that includes an absorbent material to absorb urinary discharge. The absorbent material can be located in either a distal end of a tubular sheath, or in a receptacle that attached to the distal end of the tubular sheath. The tubular sheath of the external urinary catheter can include a tubular sheath of silicone rubber, wherein the sheath has an inner surface and an outer surface, and a layer of adhesive material directly and non-releasably bonded to the inner surface. | 04-14-2016 |
Samuel M. Fryer, Fairport, NY US
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20090030952 | GLOBAL ASSET MANAGEMENT - A system and a method for managing data among devices, servers and systems by providing a logically unified and aggregated view of a user's digital assets including metadata from any system node or device. This invention describes a method supporting the aggregated view by using manifests. A manifest is a file/database that includes data about all media assets within a user's virtual collection. | 01-29-2009 |
20090094518 | METHOD FOR IMAGE ANIMATION USING IMAGE VALUE RULES - A method for image presentation are provided, in which at least one theme for image presentation is obtained; at least one set of images is acquired for presentation in association with each theme; and a presentation area image is generated for presentation on a display with a plurality of separate presentation objects in the presentation area image; an image value for each of the acquired images is determined; an emphasis score is determined for each of the acquired images. The presentation area image is presented with one of the acquired images in each of the presentation objects; and the presentation objects are animated by moving the presentation objects relative to each other in a manner that attracts more attention to presentation objects that are used to present images having a higher emphasis score than presentation objects that are used to simultaneously present images having a lower emphasis score. | 04-09-2009 |
20100245625 | IDENTIFYING COLLECTION IMAGES WITH SPECIAL EVENTS - A method for associating event times or time periods with digital images in a collection for determining if a digital image is of interest, includes storing a collection of digital images each having an associated capture time; comparing the associated capture time in the collection with a special event time to determine if a digital image in the collection is of interest, wherein the comparing step includes calculation of a special event time associated with a special event based on the calendar time associated with the special event and using such information to perform the comparison step; and associating digital images of interest with the special event. | 09-30-2010 |
20110099478 | IDENTIFYING COLLECTION IMAGES WITH SPECIAL EVENTS - A method for associating event times or time periods with digital images in a collection for determining if a digital image is of interest, includes storing a collection of digital images each having an associated capture time; comparing the associated capture time in the collection with a special event time to determine if a digital image in the collection is of interest, wherein the comparing step includes calculation of a special event time associated with a special event based on the calendar time associated with the special event and using such information to perform the comparison step; and associating digital images of interest with the special event. | 04-28-2011 |
20140160315 | IDENTIFYING COLLECTION IMAGES WITH SPECIAL EVENTS - A method for associating event times or time periods with digital images in a collection for determining if a digital image is of interest, includes storing a collection of digital images each having an associated capture time; comparing the associated capture time in the collection with a special event time to determine if a digital image in the collection is of interest, wherein the comparing step includes calculation of a special event time associated with a special event based on the calendar time associated with the special event and using such information to perform the comparison step; and associating digital images of interest with the special event. | 06-12-2014 |
Thomas Michael Fryer, Lancaster, CA US
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20080289045 | Method and device for encoding software to prevent reverse engineering, tampering or modifying software code, and masking the logical function of software execution - This invention prevents software from being reverse engineered. The random nature and multiple uses of atoms prevent the analysis of key processes within the software. If an attempt is made to try and duplicate or bypass the program and/or key processes, then this invention will cause the failure of the execution of the software code thereby preventing unauthorized release and/or execution of the code. | 11-20-2008 |
20080289046 | Method and device for the prevention of piracy, copying and unauthorized execution of computer-readable media - Piracy is a growing concern for digital content and intellectual property holders. Prior art technology and Digital Rights Management (DRM) have failed to provide content holders with an effective solution. Too often, DRM is compromised within days of release offering little or no protection to content owners. This invention offers a unique process and/or method for protecting computer-readable media that is fast, efficient, and economical to implement, and can be implemented with all types of content. This invention provides the means to prevent piracy, copying, and unauthorized use of content on all computer-readable media (physical or memory-based). | 11-20-2008 |
Todd Fryer, Liberty, MO US
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20100023992 | Method and Apparatus for Managing Presentation of Media Content - A system that incorporates teachings of the present disclosure may include, for example, a set top box having a controller to monitor for a triggering event that is associated with viewing of media content, retrieve a screen saver from a remote server when the triggering event is detected, and apply the screen saver to a display device connected with the set top box. Other embodiments are disclosed. | 01-28-2010 |
20130142040 | POOLING AVAILABLE NETWORK BANDWIDTH FROM MULTIPLE DEVICES - Methods, apparatus and articles of manufacture for pooling available network bandwidth from multiple devices are disclosed. An example method disclosed herein comprises registering, at a router, availability of a first device, the first device to provide access to first wide area network bandwidth provided by a first wide area network, after registering the availability of the first device, including the first wide area network bandwidth in a network bandwidth pool accessible via the router when a pooling configuration parameter associated with the first device is determined to be valid, the network bandwidth pool including second wide area network bandwidth accessible via a second device registered with the router, the second device being different from the first device, and allocating at least a portion of the network bandwidth pool to route Internet protocol traffic associated with a third device. | 06-06-2013 |
Todd Andrew Fryer, Liberty, MO US
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20120293069 | Task-Lit Cabinet - Methods, apparatuses, and products passively generate electrical energy from waste heat. Electronic components in cabinets generate waste heat that is used to illuminate an interior of a cabinet. A thermovoltaic semiconductor detects a temperature differential between a pair of terminals installed in the cabinet. The thermovoltaic semiconductor generates a low voltage output in response to the temperature differential. A power supply receives the low voltage output and produces a higher voltage for low-wattage light sources installed in the cabinet. | 11-22-2012 |
20130128947 | SYSTEM AND METHOD FOR AUTOMATICALLY SELECTING ENCODING/DECODING FOR STREAMING MEDIA - Disclosed herein are systems, methods, and non-transitory computer-readable storage media for encoding media content based on network quality of service parameters. A system configured to practice the method determines quality of service parameters for a network between a media server and a media client. The system selects an encoder based on a list of decoders available at the media client and the quality of service parameters, and encodes at least a portion of the media via the encoder. The system can further determine settings for the encoder based on a media type, and encode the media via the encoder according to the settings. The system can detect when the media client moves to a new network, detect new quality of service parameters, and select a new encoder based on the list of decoders available at the media client, the media type, and the new quality of service parameters. | 05-23-2013 |
20150267912 | Task-Lit Cabinet - Methods, apparatuses, and products passively generate electrical energy from waste heat. Electronic components in cabinets generate waste heat that is used to illuminate an interior of a cabinet. A thermovoltaic semiconductor detects a temperature differential between a pair of terminals installed in the cabinet. The thermovoltaic semiconductor generates a low voltage output in response to the temperature differential. A power supply receives the low voltage output and produces a higher voltage for low-wattage light sources installed in the cabinet. | 09-24-2015 |