Frijlink
Henderik Willem Frijlink, Groningen NL
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20140234409 | NICOTINAMIDE COMPOSITIONS AND THE THERAPEUTIC USE THEREOF - The present invention relates to compositions and methods for the prophylaxis or treatment of deficiencies in essential amino acid absorption and metabolism and/or of a pathology or symptom associated there with. In particular the invention concerns the treatment and/or prevention of ADHD, ADD and autism spectrum disorders. The present inventors have developed a method for prophylaxis or treatment of such symptoms and/or pathologies associated with a deficiency in essential amino acid absorption and/or metabolism, which method, stated generally, relies on the administration of nicotinamide, typically in a long-acting formulation so as to overcome the deficiencies of existing formulations, which have proven unsuitable for effective treatment. | 08-21-2014 |
20150056277 | DRUG DELIVERY SYSTEM - The invention relates to a time controlled, immediate release drug delivery system for oral administration of a first active ingredient to a subject in need thereof. The invention additionally relates to a dual drug delivery device, comprising the time controlled, immediate release drug delivery system according to the invention, further comprising a second coating comprising a second active ingredient. | 02-26-2015 |
20150202158 | GASTRO-RETENTIVE DRUG DELIVERY SYSTEM - The invention relates to floating drug delivery systems(FDDS) that provide solutions to the particular problems often encountered with floating drug delivery systems described in the art. On such generally recognized problem is the vulnerability of the systems, especially damage to the gas-filled compartment making it accessible to water so as to impair its buoyancy, ultimately resulting in insufficient gastric residence time. The invention, in an aspect, provides a self-repairing FDDS that maintains its floating capacity after damaging. The floating drug delivery systems of the invention, furthermore,allow for incorporation of high loads of active ingredients. The floating drug delivery systems can be designed in such a way that release of active ingredient from the system occurs entirely independent from the pH of the fluid surrounding the system. Furthermore, the procedure of manufacturing the floating drug delivery system of the invention is simple and straightforward, and therefore economically attractive. | 07-23-2015 |
Henderik Willem Frijlink, Eelde NL
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20090181089 | PH-Controlled Pulsatile Delivery System, Methods for Preparation and Use Thereof - The invention relates to delivery systems that allow for the pulsatile release of a substance, such as a drug, in response to a change in pH. More specifically, it relates to drug administration to the GI tract, in particular to site-specific intestinal drug delivery via the oral route. Provided is a pH-controlled pulsatile release system (PPRS) comprising a core surrounded by a coating layer, wherein said core comprises an active substance and wherein said coating layer comprises a pH-sensitive coating material wherein a swellable agent is embedded. Said swellable agent is capable of taking up at least 1.1 times, preferably at least 5 times, more preferably at least 10 times its weight in water. Also provided is a pharmaceutical composition comprising a PPRS, in particular a colon-specific PPRS. | 07-16-2009 |
20110237508 | Peptide Formulations and Uses Thereof - The present invention relates to the field of preventive and therapeutic medicine, in particular to peptide formulations. Provided is a pH-buffered aqueous formulation comprising oxytocin, vasopressin or an analogue thereof and at least one non-toxic source of divalent metal ions in a concentration of at least 2 mM, and the use of the formulation for the manufacture of a medicament for therapeutic and/or prophylactic treatments. Also provided is a method for treating or preventing haemorrhage in a subject in need thereof, comprising administering to said subject an effective dosage amount of an oxytocin formulation according to the invention. Further provided is a method for treating or preventing diabetes insipidus or vasodilatory shock in a subject in need thereof, comprising administering to said subject an effective dosage amount of a vasopressin formulation according to the invention. | 09-29-2011 |
Martijn Frijlink, Den Haag NL
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20150362610 | METHOD OF SUPPRESSING SPECTRAL ARTEFACTS OF WAVEFIELD DECOMPOSITION CAUSED BY IMPERFECT EXTRAPOLATION - Artefacts arising from imperfect extrapolation of a data set subjected to filtering operation are removed by forming a model of the extrapolated data, performing a filtering process on the model and the data set to form a filtered model and a filtered data set, and adaptively subtracting the filtered model from the filtered data set. The adaptive subtraction may employ a least-square error filter. | 12-17-2015 |
Martijn Frijlink, Gravenhage NL
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20130286777 | METHODS AND APPARATUS FOR GENERATING DEGHOSTED SEISMIC DATA - One embodiment relates to a method for deghosting seismic data from a marine seismic survey. The seismic data from the marine seismic survey is obtained, where the marine seismic survey was performed using multiple sub-sources towed at two or more different depths and fired at distinct time-delays. The seismic data is sorted into common receiver gathers, and the common receiver gathers are transformed from horizontal source coordinates to horizontal wavenumbers. For each selected frequency, a matrix operator is constructed, and an inversion procedure is applied to a system of equations based on the matrix operator to generate source-deghosted seismic data. Other embodiments, aspects and features are also disclosed. | 10-31-2013 |
Martijn O. Frijlink, The Hague NL
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20140022860 | WAVE FIELD SEPARATION BY MIXED DOMAIN INVERSION - Methods, devices, and computer-readable media are provided for accessing seismic data that describes seismic energy that propagated through media, including water and optionally surface or subsurface layers, to measurement locations in the water. The seismic data includes pressure data that describes time-variant pressures at measurement locations in the water. The seismic data may also include velocity data that describes time-variant velocities of particles at measurement locations in the water. The seismic data is processed using wavefield decomposition to reduce an effect of a portion of the seismic energy that reflects off of the surface of the water. The processing is performed in a discrete domain that includes or is the measurement locations. The discrete domain may exclude certain locations or ranges of locations. The processed seismic data may be used to generate a map of any surfaces of the media through which the seismic energy propagated. | 01-23-2014 |
Martin Egbert Frijlink, Rotterdam NL
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20080200815 | Intravascular Ultrasound Techniques - Intravascular ultrasound techniques provide for intravascular imaging using contrast agents and nonlinear techniques. An ultrasound imaging device for detecting internal properties of a target body comprises an ultrasound transducer positioned at a distal end portion of a catheter, for transmitting excitation pulses and for receiving echo signals. A signal processor analyses echo signals at harmonics and/or subharmonics of the transmit frequency. The catheter may include a contrast agent delivery conduit extending along the catheter, the delivery conduit having an exit orifice proximal to the ultrasound transducer. The device may discriminate between echo signals respectively arising from interaction with tissue and from the interaction with contrast agent. The device may generate an image of the site of interest using non-linear components of the received ultrasound echo signals. | 08-21-2008 |
Naud Frijlink, Seattle, WA US
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20120089644 | AUTOMATIC CONTACT LINKING FROM MULTIPLE SOURCES - Linking data items describing a person into a single, unified contact entry without merging the data items. The data items include, for example, contact data, social network data, and other data describing the person. The contact entry is a single representation of the person that, in some embodiments, combines a plurality of personas of the person without merging the underlying data items. Metadata representing one or more contact entries is capable of being shared across a plurality of devices and applications such that a user is presented with a consistent contact list on different devices and from within different applications. In some embodiments, the user annotates one or more of the contact entries with notes or other data that is stored with the metadata. | 04-12-2012 |
20120260189 | INTEGRATED CONTACT CARD COMMUNICATION - Embodiments provide integrated reply functionality within the context of a contact card or panel. Contact information is provided for display in the contact card (e.g., a portion of a user interface of a computing device). The contact information is associated with a contact. The contact information identifies one or more transport modes for communication with the contact. In some embodiments, the computing device receives a request from a user to communicate with the contact via at least one selected transport mode. Based on the received request, the computing device provides an input field within the contact card. In other embodiments, the transport mode is automatically selected and the input field is displayed. Data from the user is received into the input field for communication to the contact. The computing device sends the data received into the input field to the contact via the selected transport mode. The integrated reply functionality is accessible from a conversation history displayed in the contact card. | 10-11-2012 |
20130111356 | INBOUND AND OUTBOUND COMMUNICATIONS AGGREGATED BY GROUP | 05-02-2013 |
20150310472 | MANAGEMENT OF ON-DEMAND CONTENT - Various embodiments relating to managing content sharing and consumption are disclosed. In one embodiment, a consumer may be issued a lifetime license for a content item. In response to issuing the lifetime license to the consumer one or more share credits may be issued to the consumer. A request to consume a requested content item on a temporary basis may be received from the consumer. A temporary digital authorization usable by the consumer to consume the requested content item on a temporary basis may be issued to the consumer in exchange for a share credit. | 10-29-2015 |
Wilhelm Klaas Frijlink, Zwolle NL
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20090124723 | PROCESS FOR THE MODIFICATION OF BIODEGRADABLE POLYMERS - Process for the modification of a polymer or copolymer having the following general structure for one or more of the repeating units: (1) wherein n is an integer, m is an integer in the range 0 to 6, and R is selected from hydrogen, substituted or unsubstituted C | 05-14-2009 |
20110104812 | PROCESS FOR TREATING POLYMERS CONTAINING RESIDUAL CATALYST - Process for thermally stabilizing a polymer containing residues of a Sn(II), Sb(III), Pb(II), Bi(III), Fe(II), Ti(II), Ti(III), Mn(II), Mn(III), or Ge(II)-containing catalyst by treating the polymer at a temperature above its melting temperature with a peroxide selected from the group consisting of ketone peroxides, hydroperoxides, peracids, hydrogen peroxide, and mixtures thereof, wherein said peroxide is used in an amount less than 0.2 wt % based on the weight of the polymer and wherein the molar ratio of peroxy functionalities from said peroxide (p) to metal (M) ranges from 1 to 100; said metal (M) being selected from the group consisting of Sn(II), Sb(III), Pb(II), Bi(III), Fe(II), Ti(II), Ti(III), Mn(II), Mn(III), and Ge(II). The invention further relates to a method for determining the metal residue content of a polymer. | 05-05-2011 |
20150291761 | Masterbatch Comprising A Cyclic Ketone Peroxide - Masterbatch comprising a dimeric and/or trimeric cyclic ketone peroxide dispersed in a polymeric matrix with a porosity, expressed as percentage of voids on the volume of the matrix, of 0.1-80 vol %, wherein said masterbatch comprises, per 100 g of polymeric matrix, 1-30 g dimeric and/or trimeric cyclic ketone peroxide and less than 0.20 g saturated hydrocarbons with 17-51 carbon atoms. | 10-15-2015 |
20150329682 | Peroxide masterbatch based on bioresin - Masterbatch comprising one or more organic peroxides in liquid form, dispersed in a polymeric matrix comprising at least 50 wt % of a bioresin, wherein the polymeric matrix has a porosity, expressed as percentage of voids on the volume of the matrix, of 2.5-70 vol % and the concentration of water in the masterbatch is kept to 2000 ppm or less, based on the total weight of the masterbatch. | 11-19-2015 |