Patent application number | Description | Published |
20130341996 | Self-Propelled Construction Machine - A self-propelling construction machine has a machine frame, an operating drum and a drum housing enclosing the operating drum. The drum housing is closed off by a front and/or rear sealing element and/or lateral sealing element. The construction machine has a mechanism for raising and lowering the at least one sealing element. A measuring unit is configured so that the measuring unit measures the forces acting on the sealing element when the sealing element encounters an obstacle. A control unit generates a control signal for raising the sealing element when the force measured by the measuring unit is larger than a predetermined limit value, so that the sealing element is raised. | 12-26-2013 |
20130341997 | Road Milling Machine - The invention relates to a road milling machine, with a milling drum housing partially surrounding a milling drum, wherein the opening between the milling drum housing and the surface of the material to be milled can be closed off by a hold-down device. The distance between the axis of rotation and the hold-down device increases in the specified direction of rotation of the milling drum at least over a section of the gap between the milling drum and the hold-down device. The particular configuration of the hold-down device leads to an improvement in transport of the milled material to the transport arrangement. The gap width increasing in the direction of rotation of the milling drum improves material flow with a relatively small power requirement and relatively low wear of the milling drum. | 12-26-2013 |
20140049093 | Self-Propelled Building Machine And Method For Operating A Building Machine - A self-propelled building machine, especially a road cutting machine or a surface miner, has a machine frame and a chassis, comprising running gears resting on the ground. In addition, the present invention relates to a method for operating such a building machine. In an operating mode for adjusting the working depth of the working device the imposed weight applied by the building machine on the running gear is measured, whereby depending on the imposed weight either a controlled or an uncontrolled lowering of the building machine is indicated. A measuring device comprises a sensor for measuring the weight imposed by the building machine on at least one of the running gears. Depending on the measured imposed weight, a signal is generated indicating an uncontrolled lowering of the building machine, if the imposed weight falls short of a predetermined value and/or a signal indicating a controlled lowering of the building machine is generated if the imposed weight reaches or exceeds a predetermined threshold value. | 02-20-2014 |
20140110990 | Self-Propelled Building Machine - A road cutting machine has a machine frame and at least one left-hand running gear and at least one right-hand running gear. A device is provided for raising or lowering the running gears resting on the ground, in relation to the machine frame, and also a control unit is provided for activating the device for raising and lowering the running gears, so that the height of the running gears can be adjusted to the machine frame. The control unit comprises sensors for detecting changes in the height of the ground to be covered by the running gears in relation to the machine frame, whereby the control unit contains a control mode for initiating actions in the control system for adjusting the height of the running gears. The control unit is configured in such a way in the control mode that if a change is detected in the height of the ground, the respective running gear or the respective running gears are raised or lowered so as to compensate any lateral tilting due to a change in the height of the ground. | 04-24-2014 |
20140333117 | Road Milling Machine, In Particular Small Milling Machine, For Working Road Surfaces - In a road milling machine, in particular small milling machine, for working road surfaces, with a machine frame, with a milling drum supported at the machine frame in a drum casing, with a milling drum drive comprising a drum gearbox mounted at the drum casing, where the drum gearbox comprises a gearbox housing with a connecting flange for mounting at the drum casing, as well as a reduction gearbox and an output shaft for driving the milling drum, it is provided for the following features to be achieved: that the gearbox housing comprises, on the underside between the reduction gearbox and the connecting flange, a cut-out dividing the gearbox housing and extending radially inwards in such a fashion that the reduction gearbox is arranged in a first housing part arranged outside of the drum casing, and the output shaft is arranged in a second housing part protruding into the drum casing. | 11-13-2014 |
Patent application number | Description | Published |
20130224108 | Methods for the Treatment of Head and Neck Squamous Cell Carcinoma - This invention relates to the staging, diagnosis, and treatment of cancerous diseases, particularly to the use of monoclonal antibodies, antigen binding fragments thereof, and/or cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more CDMAB, chemotherapeutic agents, and conjugates thereof, as a means for initiating a cytotoxic response to human head and neck squamous cell carcinomas. The invention further relates to binding assays, which utilize the monoclonal antibodies, antigen binding fragments thereof, and/or CDMAB of the instant invention. The cancerous disease modifying antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells. In particular aspects, the CDMAB used in the methods of the invention is an anti-CD44 antibody, which may be the antibody produced by the hybridoma deposited with the ATCC having accession number PTA-4621 and/or a chimeric or humanized version thereof. | 08-29-2013 |
Patent application number | Description | Published |
20120135992 | CYCLIC TRIAZO SODIUM CHANNEL BLOCKERS - The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The compounds are of formula (I): in which z is a single bond or an optionally substituted linking group, R1 is a halo-alkyl group; and A is an optionally substituted aromatic heterocyclic or carbocyclic ring system; or a salt thereof. | 05-31-2012 |
20120135993 | CYCLIC TRIAZO SODIUM CHANNEL BLOCKERS - The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The triazine compounds are of formula (I) wherein: R1 is hydrogen or a substituent group; R2 is amino or a substituent group; N* is amino when R1 is hydrogen or ═NH when R1 is a substituent group; R3 and R4 are both carbocyclic, heterocyclic or alkyl groups and may be same or different; and R5 is hydrogen, alkyl or a cyclic aryl group, with the proviso that: when R3 and R4 are both alkyl they are linked to form a cycloalkyl group, and R5 is a cyclic aromatic group; and when R3 and R4 are both carbocyclic or heterocyclic groups, R5 is hydrogen or an alkyl group; or a salt thereof. | 05-31-2012 |
20140243343 | CYCLIC TRIAZO SODIUM CHANNEL BLOCKERS - The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The compounds are of formula I: | 08-28-2014 |
Patent application number | Description | Published |
20110009413 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS - Compounds of general structure in which X and Y are each N or C with at least one of X and Y being N; Z is a single bond or an optionally substituted linking group R1 is hydrogen or a substituent group; R2 is amino or a substituent group; N* is amino when RI is hydrogen or ═NH when R1 is a substituent group; or N* is a group NRaRb where Ra and Rb are independently H or an alkyl group; or N* is an optionally substituted piperazinyl ring; and A is an optionally substituted heterocyclic or carbocyclic ring system which may be linked to the triazo/diazo ring through R2 to form a fused multicyclic ring; are indicated as suitable for treatment of disorders in mammals that are susceptible to sodium channel blockers and antifolates, and particularly disorders such epilepsy, multiple sclerosis, glaucoma and uevitis, cerebral traumas and cerebral ischaemias, stroke, head injury, spinal cord injury, surgical trauma, neurodegenerative disorders, motorneurone disease, Alzheimer's disease, Parkinson's disease, chronic inflammatory pain, neuropathic pain, migraine, bipolar disorder, mood, anxiety and cognitive disorders, schizophrenia and trigeminal autonomic cephalalgias; for treatment of mammalian cancers; and for treatment of malaria. | 01-13-2011 |