Patent application number | Description | Published |
20080200451 | Tetrahydroquinolines for Use as Modulators of the Mitotic Motor Protein Eg5 - Compounds of the formula (I), in which W, R, R | 08-21-2008 |
20080221118 | Tetrahydroquinoline Derivatives - Compounds of the formula I, in which s, k, I, W, R | 09-11-2008 |
20080234266 | Squaric Acid Derivatives II -
Compounds of the formula (I), in which R, X, X′ and R | 09-25-2008 |
20080312244 | Squaric Acid Derivatives as Protein Kinase Inhibitors - Compounds of the formula I, in which R, X, R | 12-18-2008 |
20090030028 | Tetrahydroquinolines - Disclosed are compounds of formula (I), wherein W, R, R | 01-29-2009 |
20090118267 | INDANES - Compounds of the formula (I), in which R | 05-07-2009 |
20090163556 | GLYCINAMIDE DERIVATIVES AS RAF-KINASE INHBITORS - The present invention relates to glycinamide derivatives of formula I, | 06-25-2009 |
20090253688 | Semicarbazide derivatives as kinase inhibitors - The present invention relates to semicarbazide derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. | 10-08-2009 |
20090298885 | METHYLENE UREA DERIVATIVES - The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. | 12-03-2009 |
20100022530 | TETRAHYDROBENZOISOXAZOLE AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN - Compounds of the formula (I) in which A | 01-28-2010 |
20100022579 | SUBSTITUTED TETRAHYDROQUINOLINES - Compounds of the formula (I), in which R | 01-28-2010 |
20100076012 | TETRAHYDROQUINOLINE DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF CANCER - Compounds of the formula (I), in which E, R | 03-25-2010 |
20100197757 | OXINDOLES AS KINASE INHIBITORS - The present invention relates to oxindoles of the formula I, their use as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases and their use for the manufacture of a pharmaceutical composition. | 08-05-2010 |
20110028472 | THIENOPYRIMIDINES - Novel thienopyrimidines of the formula (I), in which R | 02-03-2011 |
20110263561 | Novel pyrrolidone derivatives for use as MetAP-2 inhibitors - Compounds of the formula (I), in which R, X, Y, Z, R | 10-27-2011 |
20110275088 | USE OF EEF1A AS BIOMARKER AND A METHOD OF SCREENING METAP2 INHIBITORS - The invention relates to a method for screening compounds, which inhibit MetAP2 activity, by providing a cellular system or a sample thereof being capable of expressing MetAP2 and/or EEF1A, incubating at least a portion of the system with compounds to be screened, and detecting MetAP2 inhibition by determining EEF1A with N-terminal methionine residue (MetEEF1A). Another object of the invention concerns a method for monitoring physiological and/or pathological conditions, which are caused, mediated and/or propagated by MetAP2 activity, by administering an effective amount of at least a single compound to a mammal in need of such treatment and determining MetEEF1A in a biological sample withdrawn from the mammal. The invention also relates to the use of EEF1A as biomarker. | 11-10-2011 |
20110281859 | NOVEL HETEROCYCLIC COMPOUNDS AS METAP-2 INHIBITORS - Compounds of the formula I, in which D, X, Y, Z, R and R | 11-17-2011 |
20120101095 | ALKOXY-THIENOPYRIMIDINES AS TGF-BETA RECEPTOR KINASE MODULATORS - Novel alkoxy-thienopyrimidine derivatives of formula (I) | 04-26-2012 |
20120130147 | METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS - Compounds of the formula (I), in which R | 05-24-2012 |
20120225875 | HETEROARYLAMINOQUINOLINES AS TGF-BETA RECEPTOR KINASE INHIBITORS - Novel hetarylaminoquinoline derivatives of formula (I) | 09-06-2012 |
20120295902 | Hetaryl-[1,8]naphthyridine derivatives - Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) | 11-22-2012 |
20120316166 | HETARYLAMINONAPHTHYRIDINES - Novel hetarylaminonaphthyridine derivatives of formula (I) | 12-13-2012 |
20130012489 | Morpholinylquinazolines - The invention relates to compounds of the formulae (I), (II) and (III) | 01-10-2013 |
20130102603 | 2,4-DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER - The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors. | 04-25-2013 |
20130102608 | BIPYRIDYL DERIVATIVES - The present invention relates to novel bipyridyl derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors. | 04-25-2013 |
20130150359 | PYRAZOLOQUINOLINES - The invention relates to compounds of the formulae (I), (II) and (III), and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumours, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I) by reaction of compounds of the formula (II) or (III) and optionally conversion of a base or acid of the compounds of the formula (I) into one of its salts | 06-13-2013 |
20130158076 | Methylene Urea Derivatives - The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. | 06-20-2013 |
20130172337 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors - The invention relates to compounds of the formulae (I) and (II) in which R1, R2, R3, R4, R5, R8, X and m have the meaning indicated in the claims, and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumours, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I). | 07-04-2013 |
20130296274 | PYRROLIDINONES AS METAP-2 INHIBITORS - Compounds of the formula I in which R | 11-07-2013 |
20130345227 | PYRIDO [2, 3 - B] PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES - The present invention relates to novel pyrido[2,3-b]pyrazine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors. | 12-26-2013 |
20140038960 | Hetaryl-[1,8]naphthyridine derivatives - Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) | 02-06-2014 |
20140336201 | BIPYRIDYL DERIVATIVES - The present invention relates to novel bipyridyl derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors. | 11-13-2014 |
20150031670 | CYCLIC AMIDES AS METAP-2 INHIBITORS - Compounds of the formula (I), in which R | 01-29-2015 |