Francine
Francine Behar-Cohen, Paris Cedex 06 FR
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20130131024 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF FLUID ACCUMULATION IN AND/ OR UNDER THE RETINA - The present invention provides methods and compositions for the treatment of fluid accumulation in and/or under the retina. | 05-23-2013 |
20150216879 | Methods and Compositions for the Treatment of Fluid Accumulation in and/or Under the Retina - The present invention provides methods and compositions for the treatment of fluid accumulation in and/or under the retina. | 08-06-2015 |
Francine Behar-Cohen, Paris FR
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20090088721 | Enhanced retinal delivery of a nucleic acid through iontophoresis - The present invention provides a device and a method for the enhanced retinal delivery of nucleic acid therapeutics utilizing iontophoresis to evoke a transient elongation of the Müller Cells of a mammalian eye. The enhanced retinal deposition can be achieved by either a topical application, subconjunctival, or an intravitreal injection of the nucleic acid composition followed by, preceded by, or administered simultaneously with the iontophoretic application. The present invention thus provides a particularly advantageous method for the treatment of ocular diseases comprising the in vivo administration of a nucleic acid capable of alleviating the symptoms of a disease, the delivery of the nucleic acid being enhanced by using iontophoresis. This method can be applied particularly to the diseases of the retina resulting from an alteration of a gene expression and/or the over-expression of particular growth factors. The diseases include, but are not limited to, human ocular retinopathies including, neovascular diseases (Age-Related Macular Edema, Diabetic Retinopathies, Diabetic Macular Edema, etc.) and inherited retinopathies such as retinitis pigmentosa. | 04-02-2009 |
20110098632 | DEVICE DELIVERING MEDICINES BY TRANSPALPEBRAL ELECTROPHORESIS - The invention concerns a device for ocular application of an active principle ( | 04-28-2011 |
20110152749 | EYE INJECTION DEVICE - An injection device for injecting a product into an eye, said device comprising an injection needle and a support on which the injection needle is fixed, said device being characterized in that it comprises a locating mark disposed in such a way that the latter can be placed in contact with a defined bearing region of the surface of the eye, before any contact of the injection needle with said surface, and can then be kept in contact with said bearing region during a stage of penetration of said injection needle through said surface of the eye. | 06-23-2011 |
20120225947 | RETINAL NEUROPROTECTION BY ION CHANNEL BLOCKERS REGULATED BY THE SUR SUBUNIT - The present invention relates to the use of blockers of ion channels regulated by the SUR subunit, for the treatment and/or prevention of eye diseases associated with ischemia and/or retinal excitotoxicity. | 09-06-2012 |
20130012573 | METHODS FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS - A method for intracellular delivery of isolated naked nucleic acids into a biological tissue or organ, that includes (a) contacting the tissue or organ with an efficient amount of at least one active corticosteroid, and (b) contacting the tissue or organ treated in step b with an efficient amount of isolated naked nucleic acids, wherein step (a) is carried out for a period of time ranging from at least five minutes to at most two hours and being immediately followed by step (b). | 01-10-2013 |
20130143850 | METHODS AND COMPOSITIONS FOR STIMULATING REEPITHELIALISATION DURING WOUND HEALING - The present invention relates to methods and compositions for stimulating reepithelialisation during wound healing. More particularly, the present invention relates to a mmeralocorticoid receptor antagonist or an inhibitor of mineralocorticoid receptor gene expression for use in a method for stimulating reepithelialisation of the skin or of the cornea during wound healing. | 06-06-2013 |
20130150304 | TREATMENT OF A DISEASE ASSOCIATED WITH RETINAL DEGENERATIVE DISORDER - Treatment of a disease associated with retinal degenerative disorder. The present invention relates to human Transferrin or an active fragment thereof for use in the treatment of a disease associated with retinal degenerative disorder. | 06-13-2013 |
20130261535 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF AN OCULAR DISEASE IN A SUBJECT - A method of treating an ocular disease in a subject includes delivering a pharmaceutical composition into a ciliary muscle of the subject and inducing transfection of the therapeutic nucleic acid into the ciliary muscle by exposing the pharmaceutical composition to ultrasound. The pharmaceutical composition comprises echo-contrast agent microbubbles and a therapeutic nucleic acid. | 10-03-2013 |
20140024627 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF OCULAR INFLAMMATORY DISEASES - The current invention provides a new and original method for treatment of ocular inflammatory diseases. More particularly, the present invention relates a mineralocorticoid receptor agonist for use in the treatment of an ocular inflammatory disease. | 01-23-2014 |
20140309613 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF AN OCULAR DISEASE IN A SUBJECT - The present invention relates to a method for treating an ocular disease in a subject comprising the steps consisting of i) delivering a pharmaceutical composition formulated with a therapeutic nucleic acid of interest into the suprachoroidal space of the diseased eye and ii) exposing the region where the pharmaceutical composition was delivered to an electrical field. | 10-16-2014 |
20140316326 | DEVICE FOR THE TREATMENT OF AN OCULAR DISEASE - The present invention relates to an injection device comprising: —a first support ( | 10-23-2014 |
20140316372 | DEVICE FOR THE TREATMENT OF AN OCULAR DISEASE - An electrode device having an insertion part ( | 10-23-2014 |
20140323947 | DEVICE FOR DELIVERING MEDICINES BY TRANSPALPEBRAL ELECTROPHORESIS - The invention concerns a device for ocular application of an active principle ( | 10-30-2014 |
20150238356 | EYE INJECTION DEVICE - An injection device for injecting a product into an eye, said device comprising an injection needle and a support on which the injection needle is fixed, said device being characterized in that it comprises a locating mark disposed in such a way that the latter can be placed in contact with a defined bearing region of the surface of the eye, before any contact of the injection needle with said surface, and can then be kept in contact with said bearing region during a stage of penetration of said injection needle through said surface of the eye. | 08-27-2015 |
Francine Bernard, Hartsdale, NY US
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20150245594 | Multi-leash handle - A multi-leash handle, capable of securing more than one dog's leash. The handle forms an enclosure, opening to attach or remove the leashes easily, and features a flexible, ergonomic handgrip. In the first exemplary embodiment, the front bar of the handle features a hinged member, which closes with a latch. The front bar is cylindrical, with a smooth surface, and is used to retain the rings at the ends of the leashes. At the other end of each leash is a clip, to be secured to the dog's collar. The handgrip is provided on the rear of the handle. One leash is provided with the handle. Additional leashes in assorted sizes and colors are available separately. | 09-03-2015 |
Francine Cand, Saint Martin D'Heres FR
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20100120171 | CIRCULATING VE-CADHERIN AS A PREDICTIVE MARKER OF SENSITIVITY OR RESISTANCE TO ANTI-TUMORAL TREATMENT AND IMPROVED METHOD FOR THE DETECTION OF SOLUBLE PROTEINS - The application relates to improved means for the detection of soluble protein(s), such as soluble angiogenesis-related protein(s), more particularly circulating VE-cadherin. These means notably comprise the dilution of the fluid sample (e.g., serum or plasma sample), before submitting it to protein detection. Said dilution is advantageously diluted in a surfactant-containing solution. The improved means of the invention enabled to determine that circulating VE-cadherin is a reliable prognostic marker of the sensitivity or resistance to anti-tumoral treatment. It is believed that prior art sVE-cadherin detection means did not enable such determination. | 05-13-2010 |
Francine Connan, Deuil La Barre FR
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20080248044 | POLYEPITOPIC PROTEIN FRAGMENTS OF THE E6 AND E7 PROTEINS OF HPV, THEIR PRODUCTION AND THEIR USE PARTICULARLY IN VACCINATION - Polyepitopic peptides of E6 and E7 proteins of Human Papillomavirus, their production, and methods of treating pathologies in which a polyepitopic peptide of the E6 and E7 protein of Human Papillomavirus is recognized by the cellular immune system. | 10-09-2008 |
Francine Denizeau, Montreal CA
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20080254439 | Plant Extract and Use Thereof as a Cryoprotective Agent - A cryopreservation medium comprising a protein-containing plant extract is disclosed. Methods, compositions, uses and kits for cryopreservation of biological material, such as a molecule, organelle, cell, embryo, tissue or organ, are also disclosed. | 10-16-2008 |
Francine Farouz, Mercer Island, WA US
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20100216820 | THIENOPYRIMIDIONES FOR TREATMENT OF INFLAMMATORY DISORDERS AND CANCERS - The current invention provides compounds of formula (1): wherein: one of Q | 08-26-2010 |
20110021541 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA - Compounds that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3Kδ plays a role in leukocyte function, using the compounds also are disclosed. | 01-27-2011 |
Francine Gemperle, Pittsburgh, PA US
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20130267789 | WEARABLE HUMAN PHYSIOLOGICAL AND ENVIRONMENTAL DATA SENSORS AND REPORTING SYSTEM THEREFOR - A method and apparatus is provided to detect the physiological and environmental status of an individual. The apparatus comprises a pod which is worn within a proximity zone of the body such that the mobility and flexibility of the body are not deleteriously affected by the presence of the apparatus. The system permits the dynamic monitoring of human physiological and environmental status data without substantial interference in human motion and flexibility. Sensors and processors are mounted within said pod. | 10-10-2013 |
Francine Jotereau, Carquefou FR
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20090081226 | Soluble HLA-E Molecules And Their Use For Diagnosing And Treating Pathologies - The present invention relates to a purified soluble HLA-E molecule, characterized in that: | 03-26-2009 |
20110195045 | Methods, agents and peptides for inducing an immune response to matrix metalloproteinase-2 expressing tumors - The present invention relates to enhancing, modulating or stimulating the immune response to MMP-2 expressing tumors, including melanoma, and to the modulation and application of immune modulators and MMP-2 peptides for melanoma or other MMP-2 expressing tumor vaccines. The invention provides methods and means to activate an effective response to MMP-2 expressing tumors and modulate the ability of MMP-2 to skew CD4+ T cell responses toward that of T | 08-11-2011 |
20140030216 | METHODS, AGENTS AND PEPTIDES FOR INDUCING AN IMMUNE RESPONSE TO MATRIX METALLOPROTEINASE-2 EXPRESSING TUMORS - The present invention relates to enhancing, modulating or stimulating the immune response to MMP-2 expressing tumors, including melanoma, and to the modulation and application of immune modulators and MMP-2 peptides for melanoma or other MMP-2 expressing tumor vaccines. The invention provides methods and means to activate an effective response to MMP-2 expressing tumors and modulate the ability of MMP-2 to skew CD4+ T cell responses toward that of T | 01-30-2014 |
Francine Lyle, London GB
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20110209261 | BABY TOY - An improved baby toy is described. The toy is a bib-shaped garment that may be adapted to be worn by a carer for a baby. The garment comprises a main portion that may cover the chest of the carer and neck portions that can be wrapped around the neck of the carer and detachably fastened at the back of the neck. The garment also includes one or more toy fixing structures that are integral to the main portion and that allow toys to be attached to the garment in a way that they can subsequently be removed, if required. There may also be a reflective element on the rear face of the main portion. In addition to being worn by the carer, the garment may alternatively be worn around the waist of the baby or be attached to an object such as a table, car window or cot rail. | 09-01-2011 |
Francine Mondou, Blainville CA
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20110256305 | Turbine Coating Apparatus And Spray Gun Assembly Therefor - The present invention generally relates to a turbine coating apparatus and a spray gun assembly therefor. More specifically, the present invention relates to a spray gun assembly comprising a gun support mountable to the turbine coating apparatus and at least one spray gun mounted to the gun support. The spray gun is adapted for providing a spray of a coating substance onto a cluster of solid forms to be coated in the apparatus, where the spray defines a spray angle of less than 90 degrees relative to the coating plane defined by the cluster of solid forms in movement. | 10-20-2011 |
Francine Rendu, Paris FR
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20100330605 | TEST DEVICE FOR PLATELET AGGREGATION DETECTION - The invention relates to the test device for platelet aggregation detection comprising:—an element ( | 12-30-2010 |
Francine Rendu, Paris Cedex 13 FR
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20130078608 | ZEODRATION METHOD FOR THE PRESERVATION OF BLOOD PLATELETS - The present invention relates to a new method for the preservation of blood platelets. In particular, the present invention provides a method which includes submitting the platelets to zeodration carried out at temperatures between 18° C. and 24° C. The dried platelets thus obtained can be preserved at room temperature for long period of time. The invention also provides kits and compositions for using the preserved platelets. | 03-28-2013 |
Francine Van Os-Bardiaux, Monte Carlo MC
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20130133667 | INTRA-UTERINE SYSTEM - Intra-uterine system for inserting an active substance in an uterus, wherein the system comprises two flexible arms that extend from a central part in essentially mutually opposed directions, and retention means for the active substance, wherein during use the system is entered into the uterus, wherein an elongated housing extends from the central part at essentially equal angles with the flexible arms, wherein the housing comprises a storage container as retention means for the active substance, an outlet opening, a pump system, a control unit for controlled pumping of the active substance from the storage container through the outlet opening into the uterus and a energy storage means for supplying energy to the pump system and to the control unit. | 05-30-2013 |