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| 20080213772 | USE OF MICROPHTHALMIA FOR DIAGNOSIS, PROGNOSIS AND/OR TREATMENT OF MELANOMA - Microphthalmia (Mi) while present in melanocytes, a cells and osteoclast, is not normally present in other cells. We have found that Mi is present in the nucleus of melanoma cells. Melanoma can be diagnosed by contacting a malignant cell with a probe for Mi. If the probe identities Mi in the nucleus of the cell, the cell is a melanoma. | 09-04-2008 |
| 20090176726 | METHODS FOR TREATING MITF-RELATED DISORDERS - Methods for treating melanoma and other MITF-related disorders by administering a compound that causes an increase in HIF-1 level or activity (e.g., by increasing the level of HIF-1I in a cell) within cells. Such methods include administration of a compound that is a hydroxylase inhibitor, e.g., a prolyl hydroxylase inhibitor that reduces hydroxylation of HIF-1I thereby causing an increase in HIF-1I in the cell. Such treatment can lead to a decrease in MITF activity or expression. | 07-09-2009 |
| 20120149724 | MODULATING ENDOGENOUS BETA-ENDORPHIN LEVELS - Systemic beta-endorphin can be elevated in response to cutaneous irradiation, including ultraviolet and ionizing radiation. Increases in systemic beta-endorphin levels associated with cutaneous irradiation can be modulated with opiate receptor antagonists, particularly compounds that antagonize opioid receptor binding by beta endorphin. | 06-14-2012 |
| 20140296223 | METHOD FOR REGULATING SKIN PIGMENTATION - This invention relates to a method for regulating skin pigmentation of a subject, comprising the step of administering the agent for inhibiting the expression or activation of Microphthalmia Transcription Factor (MITF) to the subject who is in need of regulation of skin pigmentation. | 10-02-2014 |
| 20150245596 | MELANOCORTIN RECEPTOR MUTANT MOUSE AND USES THEREOF - Embodiments disclosed are transgenic mice having mutations in a MC1R and a BRAF gene. Such transgenic mice have high incidences of invasive melanomas. These transgenic mice are useful animal systems and tools for screening test candidates for the treatment of melanoma involving MC1R and BRAF mutations. | 09-03-2015 |
| 20160130222 | INHIBITORS OF THE MITF MOLECULAR PATHWAY - Provided herein are compounds of the formula (IV) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful as MITF inhibitors, MITF pathway inhibitors and for the treatment of cancer. | 05-12-2016 |
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| 20120305192 | PARALLEL SINGLE SUBSTRATE PROCESSING FLUID JET MODULE - A system for fluid processing one or more substrate surfaces arrayed in a fluid. The system has a process module with a frame and a plurality of fluid jet elements to inject a fluid at the substrate surfaces without contacting the substrate surfaces. A substrate holder assembly has a holder frame and a number of substrate holders, each of which is coupled to the holder frame and configured to hold a substrate so that a different substrate is held by each substrate holder of the substrate holder assembly for transport therewith as a unit to and from the process module. The substrate holder assembly and each substrate holder of the substrate holder assembly are removably coupled to the process module frame and, when coupled to the process module frame, each substrate holder is independently moveable and positionable relative to the other substrate holders of the substrate holder assembly. | 12-06-2012 |
| 20120305193 | PARALLEL SINGLE SUBSTRATE PROCESSING AGITATION MODULE - A system for fluid processing one or more substrate surfaces arrayed in a fluid. The system has a process module with a frame and a plurality of agitation members to fluid process the substrate surfaces without contacting the substrate surfaces. A substrate holder assembly has a holder frame and a number of substrate holders, each of which is coupled to the holder frame and configured to hold a substrate so that a different substrate is held by each substrate holder of the substrate holder assembly for transport therewith as a unit to and from the process module. The substrate holder assembly and each substrate holder of the substrate holder assembly are removably coupled to the process module frame and, when coupled to the process module frame, each substrate holder is independently moveable and positionable relative to the other substrate holders of the substrate holder assembly. | 12-06-2012 |
| 20120306137 | PARALLEL SINGLE SUBSTRATE PROCESSING SYSTEM - A system for fluid processing substrate surfaces arrayed in a fluid having a process section with a frame having a plurality of process elements to process the substrate surfaces without contacting the substrate surfaces. A substrate holder assembly having a holder frame and a number of substrate holders, each of which is coupled to the holder frame and is configured for holding a substrate so that each substrate holder holds a different substrate for transport as a unit with the substrate holder assembly to and from the process section. The substrate holder assembly and each substrate holder are removably coupled to the process section frame, and the substrate holders of the substrate holder assembly are movable relative to the holder frame and positionable in repeatable alignment with respect to a predetermined feature of the process section and independent of positioning of the holder frame with respect to the process section. | 12-06-2012 |
| 20120306139 | PARALLEL SINGLE SUBSTRATE PROCESSING SYSTEM HOLDER - A substrate holder adapted to hold and retain a substrate during vertical fluid processing of a surface of the substrate. The wafer holder has a frame. A first leg is coupled to the frame by a first compliant flexure, the first leg having a first contact member configured to engage a first edge of the substrate. A second leg is coupled to the frame by a second compliant flexure, the second leg having a second contact member configured to engage a second edge of the substrate. Upon deflection of the first and second compliant flexures, the first and second legs are moveable in substantially opposite directions disengaging the first and second contact fingers from the first and second edges of the substrate respectively. | 12-06-2012 |
| 20120308345 | PARALLEL SINGLE SUBSTRATE PROCESSING SYSTEM - A system for processing surfaces of substrates having a process module having a process module frame and a plurality of process elements to process the substrate surfaces without contacting the substrate surfaces. A plurality of substrate holder assemblies, each having a number of substrate holders, each of which is removably coupled to the process module frame, each substrate holder configured to hold a substrate. The process module frame has alignment features aligning the substrate holders in the substrate holder assembly in repeatable alignment with respect to each of the process elements with each of the process elements located between the substrates. A loader module is configured to unload processed substrates from each of the substrate holder assemblies and load unprocessed substrates to each of the substrate holder assemblies. A transporter is configured to transport the substrate holder assemblies to and from the process module and the loader module. | 12-06-2012 |
| 20120308346 | PARALLEL SINGLE SUBSTRATE PROCESSING SYSTEM LOADER - A substrate unload and load apparatus adapted to unload and load a plurality of processed substrates from a plurality of arrayed substrate holders, the apparatus having a frame and a plurality of processed substrate supports coupled to the frame configured to support the processed substrates. A plurality of unprocessed substrate supports is coupled to the frame configured to support the unprocessed substrates, each of the unprocessed substrate supports alternating and interleaved with each of the processed substrate supports. A holder release is coupled to the frame and configured to engage the arrayed substrate holders having a first state where the arrayed substrate holders releases the processed substrates from the arrayed substrate holders, the holder release having a second state where the arrayed substrate holders captures the unprocessed substrates with arrayed substrate holders. | 12-06-2012 |
| 20130009415 | SUBSTRATE LOADER AND UNLOADER HAVING AN AIR BEARING SUPPORT - A substrate separation chuck adapted to separate a substrate from an adhering surface. The substrate separation chuck has a support adapted to support the adhering surface. An air bearing surface is adapted to support the substrate, the air bearing surface axially moveable relative to the support. The air bearing surface has a first position adjacent the substrate with the substrate coupled to the adhering surface. The air bearing surface is moveable from the first position to a second position separating the substrate from the adhering surface without contact between the substrate and the air bearing surface. | 01-10-2013 |
| 20130011222 | SUBSTRATE LOADER AND UNLOADER - A substrate loader adapted to load and unload a substrate to and from a moveable holder having a seal. The substrate loader has a base and a holder support frame coupled to the base, the holder support frame adapted to repeatably position the moveable holder relative to a predetermined datum. The substrate transport is coupled to the base and having a substrate chuck and adapted to move and transport the substrate relative to the holder. The substrate transport is deterministically positioned relative to the predetermined datum and is adapted to move the substrate from a first position, with the substrate captured by the moveable holder, to a second position with the substrate disengaged from the holder and the seal, the substrate transport movement of the substrate from the first to the second position effecting disengagement from the holder and the seal substantially without contacting the substrate. | 01-10-2013 |
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| 20110017206 | APPARATUS AND METHODS FOR DIRECT INHALATION OF SCENTS AND MEDICINES - An intranasal tab may provide temporary, controlled and direct inhalation of scents and/or medicine into the nose, thereby increasing the overall effectiveness and velocity of impact that scents and/or medicine may have on the mind and/or body. The tabs may provide increased convenience, speed, comfort and effectiveness of mobile aromatherapy and medicinal therapy. The tabs may be substantially flat, triangular, and designed from various types of absorbent materials. The center of the tab may be comprised of highly absorbent material compared to the perimeter and external surfaces of the tab which remain relatively dry to the touch. The tabs are adapted to be inserted separately into either nostril of the nose without falling out. | 01-27-2011 |
| 20120277696 | DELIVERING AND/OR RECEIVING FLUIDS - The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. | 11-01-2012 |
| 20130079666 | DELIVERING AND/OR RECEIVING FLUIDS - The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. | 03-28-2013 |
| 20130138058 | DELIVERING AND/OR RECEIVING FLUIDS - The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. | 05-30-2013 |
| 20130327328 | APPARATUS AND METHODS FOR DIRECT INHALATION OF SCENTS AND MEDICINES - A dissolvable intranasal tab may provide temporary, controlled and direct inhalation of scents and/or medicine into the nose, thereby increasing the impact and velocity scents and/or medicine may have on the mind and body. The tabs may provide increased mobility, convenience, speed, and effectiveness of aromatherapy and medicinal inhalation therapy. The tabs may be substantially flat, triangular, and designed to be inserted into the nose allowing air to flow over both sides of the tab. The tab may be comprised of material relative to alternative components of the tab such that scents and/or medicines are formed into the shape of the tab and the outside of the tab is relatively dry to the touch. The tabs are adapted to be inserted separately into either nostril and to dissolve over a period of time inside the nose during normal breathing. | 12-12-2013 |
| 20150038876 | DELIVERING AND/OR RECEIVING FLUIDS - The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. | 02-05-2015 |
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| 20090088845 | TITANIUM TANTALUM OXYGEN ALLOYS FOR IMPLANTABLE MEDICAL DEVICES - The present disclosure relates to alloys of titanium, tantalum, and oxygen that include from greater than 0 to about 60 weight % tantalum, from greater than or equal to about 0.10 weight % oxygen, and the balance titanium and other impurities. Also disclosed are methods of making such alloys. In addition, articles of manufacture including such alloys, such as biomedical implants, are disclosed. | 04-02-2009 |
| 20110233057 | HOMOGENEOUS TITANIUM TUNGSTEN ALLOYS PRODUCED BY POWDER METAL TECHNOLOGY - The present disclosure is related to homogeneous alloys comprising titanium and 9% to less than 20% by weight of tungsten, wherein the alloy has a yield strength of at least 120,000 psi and ductility of least 20% elongation; and with further alloying an ultimate tensile strength of at least 200,000 psi and useful ductility of at least 2% elongation; and with the addition of ceramic particulate reinforcements can exhibit an ultimate tensile strength of at least 180,000 psi. Products and metal matrix composites comprising such homogeneous alloys are also disclosed. The metal matrix composites further comprise a discontinuous reinforcement chosen from TiC, TiB | 09-29-2011 |
| 20140079583 | TITANIUM TUNGSTEN ALLOYS PRODUCED BY ADDITIONS OF TUNGSTEN NANOPOWDER - Disclosed herein are titanium-tungsten alloys and composites wherein the tungsten comprises 0.5% to 40% by weight of the alloy. Also disclosed is a method of making such alloys and composites using powders of tungsten less then 3 μm in size, such as 1 μm or less. Also disclosed is a method of making the titanium alloy by powder metallurgy, and products made from such alloys or billets that may be cast, forged, or extruded. These methods of production can be used to make titanium alloys comprising other slow-diffusing beta stabilizers, such as but not limited to V, Nb, Mo, and Ta. | 03-20-2014 |
| 20140373680 | HOMOGENEOUS TITANIUM TUNGSTEN ALLOYS PRODUCED BY POWDER METAL TECHNOLOGY - The present disclosure is related to homogeneous alloys comprising titanium and 9% to less than 20% by weight of tungsten, wherein the alloy has a yield strength of at least 120,000 psi and ductility of least 20% elongation; and with further alloying an ultimate tensile strength of at least 200,000 psi and useful ductility of at least 2% elongation; and with the addition of ceramic particulate reinforcements can exhibit an ultimate tensile strength of at least 180,000 psi. Products and metal matrix composites comprising such homogeneous alloys are also disclosed. The metal matrix composites further comprise a discontinuous reinforcement chosen from TiC, TiB | 12-25-2014 |
| 20140377119 | Oxygen-Enriched TI-6AI-4V Alloy and Process for Manufacture - A titanium alloy comprising an elevated level of oxygen is disclosed. The alloy may have 5.5 to 6.75 weight percent of aluminum, 3.5 to 4.5 weight percent of vanadium, 0.21 to 0.30 weight percent of oxygen, and up to 0.40% of weight percent of iron. The alloy may also have a minimum ultimate tensile strength of 130,000 psi, a minimum tensile yield strength of 120,000 psi, and a minimum ductility of 10% elongation. Also disclosed is a method for manufacturing components having the aforementioned alloy. | 12-25-2014 |
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| 20080234758 | INTRA-FACET FIXATION DEVICE AND METHOD OF USE - A implantable interference device configured for intra-facet placement within a facet joint is provided. The device includes a shank capable of engaging opposing faces of the facet joint. The shank can further include a head extending from a proximal end of the shank wherein the head is configured to engage and/or buttress opposing faces of the joint, and also configured for preventing over-insertion of the device. Optionally, at least a portion of the shank can include or be formed of a fusion-promoting bioactive material. Further, a method for providing fixation of a facet joint by intra-facet placement of an interference device within the facet joint is provided. | 09-25-2008 |
| 20080255618 | ARTICULATING FACET FUSION SCREW - A spinal implant is provided having an elongate member with a longitudinal axis and threads extending over at least a portion of the outer surface thereof. The implant includes a stabilization feature associated with the elongate member that is selectively configurable between a delivery configuration and a deployed configuration in which the stabilization feature is oriented at an angle with respect to the longitudinal axis of the elongate member. Also, at least a portion of the implant can include a fusion-promoting bioactive material. In another aspect, the invention includes methods for providing stabilization within a facet joint by delivery of an articulating intra-facet screw. | 10-16-2008 |
| 20080255622 | FACET FIXATION AND FUSION SCREW AND WASHER ASSEMBLY AND METHOD OF USE - A spinal implant including a stabilization member coupled to an elongate member is herein provided. The implant can be configured for placement within a facet joint in an intra-facet or trans-facet configuration. Also, the implant can include a fusion-promoting bioactive material thereby providing a single device capable of spinal stabilization and/or fusion. Furthermore, a method of placing such an implant within a facet joint in an intra-facet or trans-facet orientation is hereby provided. | 10-16-2008 |
| 20080255666 | FACET FIXATION AND FUSION WEDGE AND METHOD OF USE - A spinal implant including an at least one screw disposed within a wedge body is herein provided. The implant can be configured for placement with a facet joint in an intra-facet delivery. Furthermore, the implant can include a fusion-promoting bioactive material thereby providing a single device capable of spinal stabilization and/or fusion. Furthermore, a method of placing such an implant within a facet joint in an intra-facet orientation is hereby provided. | 10-16-2008 |
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| 20130196948 | POLYMERS FOR BIOMATERIALS AND THERAPEUTICS - Described herein are inventive compositions and methods relating to polymer conjugates and, in particular, to polymer conjugates having pendant side groups comprising ring moieties. In one aspect, embodiments are generally related to compositions that mimic naturally-occurring polyphenol compounds. The compositions comprise, in some embodiments, a polymer backbone having a plurality of hydroxyaromatic pendant side groups or derivatives thereof. For example, in some cases, a pendant side group may be a phenol or a substituted derivative thereof. In some cases, the pendant side group may be an oxidized hydroxyaromatic group, such as a quinone. In some embodiments, self-assembled structures comprising one or more of the polymer conjugates are provided. For example, the polymer conjugates may be combined with a complexing agent to form a particle. In some cases, a polymer conjugate may form a hydrogel. In some embodiments, the self-assembled structures may contain an agent, such as a pharmaceutically active agent. Also provided are methods and kits for forming the compositions, methods of using the compositions, and the like. | 08-01-2013 |
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| 20090269250 | Apparatus and Methods For Nanoparticle Generation and Process Intensification of Transport and Reaction Systems - Apparatus, systems and methods are provided that utilize microreactor technology to achieve desired mixing and interaction at a micro and/or molecular level between and among feed stream constituents. Feed streams are fed to an intensifier pump at individually controlled rates, e.g., based on operation of individually controlled feed pumps. The time during which first and second feed streams are combined/mixed prior to introduction to the microreactor is generally minimized, thereby avoiding potential reactions and other constituent interactions prior to micro- and/or nano-scale interactions within the microreactor. Various microreactor designs/geometries may be employed, e.g., “Z” type single or multi-slot geometries and “Y” type single or multi-slot geometries. Various applications benefit from the disclosure, including emulsion, crystallization, encapsulation and reaction processes. | 10-29-2009 |
| 20120236680 | APPARATUS AND METHODS FOR NANOPARTICLE GENERATION AND PROCESS INTENSIFICATION OF TRANSPORT AND REACTION SYSTEMS - Apparatus, systems and methods are provided that utilize microreactor technology to achieve desired mixing and interaction at a micro and/or molecular level between and among feed stream constituents. Feed streams are fed to an intensifier pump at individually controlled rates, e.g., based on operation of individually controlled feed pumps. The time during which first and second feed streams are combined/mixed prior to introduction to the microreactor is generally minimized, thereby avoiding potential reactions and other constituent interactions prior to micro- and/or nano-scale interactions within the microreactor. Various microreactor designs/geometries may be employed, e.g., “Z” type single or multi-slot geometries and “Y” type single or multi-slot geometries. Various applications benefit from the disclosure, including emulsion, crystallization, encapsulation and reaction processes. | 09-20-2012 |
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| 20080300836 | Self-Perpetuation of a Stochastically Varying Resource Pool - A computer-readable medium has encoded thereon software for maintaining a steady-state worth of an inhomogenous renewable resource pool. The software includes instructions for causing a data-processing system to evaluate an indicator of a historical worth of the resource pool, to determine a draw amount at least in part on the basis of this indicator, and to output data representative of that draw amount. | 12-04-2008 |
| 20100179924 | Controlled Depletion of a Stochastically Varying Resource Pool - A method for controlling resource pool depletion includes, at a first time, determining a first remainder of a depletion interval; on the basis of the first remainder, determining a first depletion rate for urging the pool to reach a selected state at the end of the depletion interval; on the basis of the first depletion rate, partially depleting the pool; and at a second time following the first time, determining a second remainder of the depletion interval; receiving state information indicative of a difference between a state of the pool at the first time and a state of the resource pool at the second time; on the basis of the second remainder and the state information, determining a second depletion rate for urging the pool to reach a selected state at the end of the depletion interval; and on the basis of the second depletion rate, partially depleting the pool. | 07-15-2010 |
| 20140245320 | Self-Perpetuation of a Stochastically Varying Resource Pool - A computer-readable medium has encoded thereon software for maintaining a steady-state worth of an inhomogenous renewable resource pool. The software includes instructions for causing a data-processing system to evaluate an indicator of a historical worth of the resource pool, to determine a draw amount at least in part on the basis of this indicator, and to output data representative of that draw amount. | 08-28-2014 |
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| 20130110783 | VIRTUAL FULL BACKUPS | 05-02-2013 |
| 20130110969 | COOPERATIVE STORAGE MANAGEMENT | 05-02-2013 |
| 20150178169 | VIRTUAL FULL BACKUPS - According to embodiments described herein, a backup server maintains backup data for a set of data, which includes data for a first block and a second block. Backup data for the first and second block include backup data for a plurality of versions of the first and second block. A distinct watermark is stored for each version of the first block and each version of the second block. In response to a request to perform a restoration operation on the set of data, a particular version of the first block and a particular version of the second block are selected to use in the restoration operation by comparing a restoration target with the watermarks of the version of the first block and second block. The selected version of the first block has a different watermark than the selected version of the second block. | 06-25-2015 |
| 20150254141 | CENTRALIZED TAPE MANAGEMENT FOR DATABASES - A method, apparatus, and system for centralized tape management are provided for databases. A centralized availability machine or disk and tape backup server maintains working backup data for a plurality of database management systems (DBMSs) based on receiving, from each of the plurality of DBMSs, differential incremental updates. The updates may be at the database block level, with an index maintained to identify different versions of the blocks for snapshot recovery. The availability machine then determines a utilization schedule for distributing the working backup data to a plurality of tapes using a plurality of tape drives, and stores the working backup data as archived backup data on the plurality of tapes according to the utilization schedule. By placing each DBMS within a protection policy that indicates criteria to meet business goals with respect to tape backups, the utilization schedule can automatically schedule tape backup jobs with optimized hardware resource assignments. | 09-10-2015 |
