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| 20080306053 | MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH - The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands. | 12-11-2008 |
| 20080306076 | MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH - The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands. | 12-11-2008 |
| 20080306093 | MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH - The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands. | 12-11-2008 |
| 20100304402 | CHIMERIC HUMAN SWEET-UMAMI AND UMAMI-SWEET TASTE RECEPTORS - This invention relates to chimeric taste receptors comprising the extracellular portion of one T | 12-02-2010 |
| 20110223618 | ASSAYS USING CHIMERIC T1R POLYPEPTIDE - This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation. | 09-15-2011 |
| 20110224155 | MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH - The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands. | 09-15-2011 |
| 20110230502 | MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH - The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands. | 09-22-2011 |
| 20110245353 | SWEET FLAVOR MODIFIER - The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds. | 10-06-2011 |
| 20130041046 | SWEET FLAVOR MODIFIER - The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions. | 02-14-2013 |
| 20140128481 | SWEET FLAVOR MODIFIER - The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds. | 05-08-2014 |
| 20140235623 | MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH - The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands. | 08-21-2014 |
| 20150141527 | SWEET FLAVOR MODIFIER - The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions. | 05-21-2015 |
| 20150265711 | SWEET FLAVOR MODIFIER - The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds. | 09-24-2015 |
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| 20090036708 | Novel Process for the Preparation of Nonracemic Long Chain alpha-Amino Acid Derivatives - The present invention provides a process for the preparation of a nonracemic a-amino acid derivative from an optically active N-acyl lactam using an organometallic reagent to effect the opening of the ring followed by reduction of the ketone carbonyl to an alcohol or a methylene, or by a reductive amination to an amine, or by a ketalization reaction. | 02-05-2009 |
| 20120263961 | WATER-BASED COATING SYSTEM WITH IMPROVED MOISTURE AND HEAT RESISTANCE - The present invention provides a water-based coating system that can be used to form durable, abrasion resistant, corrosion resistant, protective barriers on a wide range of substrates. The coating system is particularly effective for protecting metal-containing substrates, such as intermodal cargo containers, against corrosion. As an overview, the present invention provides water-based primer compositions suitable to form primer coats and topcoats on substrates. Desirably, the primer incorporates one or more chlorinated resins for excellent corrosion protection. These polymers not only provide excellent corrosion protection and but also show excellent adhesion to a wide range of substrate materials. The system also includes topcoat compositions enhance compatibility and adhesion to the primer and to provide enhanced application. | 10-18-2012 |
| 20130056167 | METHOD FOR CONTROLLING EXTREMELY LOW TI IN EXTRA LOW CARBON ALSI-KILLED STEEL - The present invention provides a method for controlling extremely low Ti in extra low carbon AlSi-killed steel, the weight percentage of the chemical composition of the extra low carbon AlSi-killed steel comprising: C≦0.005%, Si: 0.1-3.4%, Mn: 0.1-0.5%, P≦0.2%, S≦0.002%, Al: 0-1.2%, N≦0.005%, Ti≦0.0015 and a balance substantially being Fe and inevitable impurities; the liquid steel having said chemical composition is obtained by hot metal preprocessing, smelting, retained RH smelting and ingoting, wherein the top ladle slag is modified, and calcium-aluminum based modifier of 0.6-1.7 kg/t steel are added, so as to ensure a controlling demand that when refined RH decarburization is over, the content of T.Fe in top ladle slag composition ≧5%, the content of Al | 03-07-2013 |
| 20130105472 | WATER-BASED COATING SYSTEM WITH IMPROVED MOISTURE AND HEAT RESISTANCE | 05-02-2013 |
| 20130105473 | WATER-BASED COATING COMPOSITIONS AND SYSTEMS WITH IMPROVED SAG RESISTANCE AND RELATED METHODS | 05-02-2013 |
| 20130224064 | NON-ORIENTED ELECTRICAL STEEL PLATE WITHOUT CORRUGATED FAULT AND PRODUCTION METHOD THEREOF - A non-oriented electrical steel sheet without corrugated defect and a manufacturing method thereof is provided, the weight percentage of the chemical composition of the non-oriented electrical steel sheet is that C is no more than 0.005%, Si is 1.2-2.2%, Mn is 0.2-0.4%, P is no more than 0.2%, S is no more than 0.005%, Al is 0.2-0.6%, N is no more than 0.005%, O is no more than 0.005%, and a balance substantially being Fe, a slab can be obtained by hot metal preprocessing, smelting with converter, RH refining, and continuous casting and pouring, wherein a secondary cooling water amount is controlled, the water flowrate of cooling water is controlled to 100-190 l/min, the average superheat of liquid steel in the continuous casting process is controlled to 10-45° C., the slab is heated and hot rolled; wherein the furnace tap temperature of the slab is 1050-1150 ° C., the temperature difference between random two points in the length direction when the slab is heated, is lower than 25° C., the hot rolling process includes a rough rolling process and a planishing process, the entry temperature in the planishing process is no lower than 970° C.; the finished non-oriented electrical steel sheet is obtained by acid pickling, cold rolling, annealing and coating. No corrugated defect can be accomplished by controlling the cooling speed of the slab in continuous casting and pouring process, the temperature difference in the length direction of the slab in the heating furnace, and by controlling the temperature drop before planishing the slab. | 08-29-2013 |
| 20130245183 | WATER-BASED COATING SYSTEM WITH IMPROVED ADHESION TO A WIDE RANGE OF COATED AND UNCOATED SUBSTRATES INCLUDING MUFFLER GRADE STAINLESS STEEL - The present invention provides a water-based coating system that can be used to form a durable, abrasion resistant, tough, protective coating on a wide range of substrates. The coating system advantageously has excellent adhesion properties and can be directly coated onto stainless steel surfaces without requiring an intervening primer layer. Primer layers or other types of coatings can be used in combination with the coating system of the present invention if desired, however. The coating system is particularly effective for protecting metal-containing substrates such as intermodal, refrigerated cargo containers. The resultant coatings are flexible and impact resistant. Being water-based, the coating compositions have lower VOC emissions and less residual odor than solvent-based compositions. | 09-19-2013 |
| 20140366602 | Method for Manufaturing Thin Strip Continuously Cast 700MPa-Grade High Strength Weather-Resistant Steel - A method for manufacturing thin strip continuously cast 700 Mpa grade high strength weather-resistant steel, the method comprising the following steps: 1) casting a 1-5 mm thick cast strip in a double roller continuous casting machine, the cast strip comprising the following chemical compositions by weight percent: C 0.03-0.1%, Si≦0.4%, Mn 0.75-2.0%, P 0.07-0.22%, S≦0.01%, N≦0.012%, and Cu 0.25-0.8%, further comprising more than one of Nb, V, Ti and Mo: Nb 0.01-0.1%, V 0.01-0.1%, Ti 0.01-0.1%, and Mo 0.1-0.5%, and the balance being Fe and unavoidable impurities; 2) cooling the cast strip at a rate greater than 20° C./s; 3) hot rolling the cast strip under a temperature of 1050-1250° C. at a reduction rate of 20-50% and a deformation rate greater than 20 s-1; then conducting austenite online recrystallization, the thickness of the hot rolled strip being 0.5-3.0 mm; 4) cooling at a rate of 10-80° C./s; and 5) rolling up under a temperature of 500-650° C. The obtained steel strip microstructure mainly consists of uniformly distributed bainites and needle-shaped ferrites. | 12-18-2014 |
| 20150013844 | Non-Oriented Silicon Steel and Manufacturing Process Thereof - The present invention provides a non-oriented silicon steel with excellent magnetic properties and a manufacturing process therefor. During the manufacturing process of the present invention, the temperature T of the molten steel of steel tapped from a converter during steelmaking and the carbon content [C] and the free oxygen content [O] comply with the following formula: 7.27×10 | 01-15-2015 |
| 20150034212 | Non-Oriented Electrical Steel Sheet with Fine Magnetic Performance, and Calcium Treatment Method Therefor - A non-oriented electrical steel sheet with fine magnetic performance, and a calcium treatment method therefor, including an RH (Ruhrstahl-Heraeus) refinement step. The RH refinement step sequentially comprises a decarbonization step, an aluminum deoxidation step, and a step of adding calcium alloy. In the step of adding calcium alloy, time when the calcium alloy is added satisfies the following condition: time interval between Al and Ca/total time after ΣAl=0.2-0.8. In this method, production cost is reduced, the production process is simple, a normal processing cycle of RH refinement is not affected, the device is convenient in operation and is controllable, and foreign substances are controllable in both shape and quantities. The non-oriented electrical steel sheet prepared according to the present invention has fine magnetic performance, and the method can be used for mass production of the non-oriented electrical steel sheet with fine magnetic performance. | 02-05-2015 |
| 20150267062 | Water-Based Coating System With Improved Adhesion To A Wide Range Of Coated And Uncoated Substrates Including Muffler Grade Stainless Steel - The present invention provides a water-based coating system that can be used to form a durable, abrasion resistant, tough, protective coating on a wide range of substrates. The coating system advantageously has excellent adhesion properties and can be directly coated onto stainless steel surfaces without requiring an intervening primer layer. Primer layers or other types of coatings can be used in combination with the coating system of the present invention if desired, however. The coating system is particularly effective for protecting metal-containing substrates such as intermodal, refrigerated cargo containers. The resultant coatings are flexible and impact resistant. Being water-based, the coating compositions have lower VOC emissions and less residual odor than solvent-based compositions. | 09-24-2015 |
| 20150277768 | RELOCATING DATA BETWEEN STORAGE ARRAYS - A method and apparatus for automatically relocating data in a plurality of storage arrays. The method may comprise obtaining feature information of a plurality of storage devices included in the plurality of storage arrays, wherein the plurality of storage devices are grouped into a plurality of storage tiers based on the feature information; obtaining location information of the plurality of storage devices, the location information including a storage tier and a storage array at which a respective storage device is located; monitoring an access status of data stored in the plurality of storage devices; and based on the access status, the feature information and the location information, automatically generating a data moving plan that indicates a target location to which the data is to be moved. Data may automatically move between different storage tiers and across different storage arrays, without being limited within a certain storage array. | 10-01-2015 |
| 20150277769 | SCALE-OUT STORAGE IN A VIRTUALIZED STORAGE SYSTEM - Embodiments of the present disclosure disclose a method and apparatus for storage scale-out in a virtualized storage system where in responsive to at least one new virtual storage control device being added, configuring at least a part of a virtual logic unit number configured in at least one existing virtual control device into the at least one new virtual storage control device; and responsive to the configuring, updating an access path for the at least part of the virtual logic unit number, the access path indicating all virtual storage control devices configured with the at least a part of the virtual logic unit number, and load of at least one virtual storage control device may be distributed onto more virtual storage control devices, such that data may be accessed through more virtual storage control devices, thereby preventing a single virtual storage control device from becoming a bottleneck for system performance. | 10-01-2015 |
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| 20120190197 | MASK PLATE, PATTENING METHOD AND METHOD FOR MANUFACTURING ARRAY SUBSTRATE - An embodiment of the disclosed technology provides a mask plate for photolithography process comprising a first pattern region, a second pattern region having a different exposure level from that of the first pattern region, and a redundant pattern provided between the first pattern region and the second pattern region, wherein the redundant pattern is configured for forming a redundant photoresist pattern so as to prevent developer diffusion at different concentrations across the photoresist redundant pattern. | 07-26-2012 |
| 20120247762 | Anti-Channeling Pack-Off Particles Used in a Production Section of an Oil-Gas Well, and Completion Method and Production Method Using Such Particles - Anti-channeling pack-off particles used in a production section of an oil-gas well, a completion method, and a production method are provided. The anti-channeling pack-off particles are macromolecule polymer particles having an average particle diameter of 0.05-1.0 mm and a real density of 0.8-1.4 g/cm | 10-04-2012 |
| 20120273789 | LIQUID CRYSTAL DISPLAY AND ARRAY SUBSTRATE - An embodiment of the disclosed technology discloses an array substrate comprising: a base substrate; a first layer transparent common electrode formed on the base substrate; a gate metal common electrode formed on the first layer transparent common electrode; an insulation layer formed on the gate metal common electrode, with via holes being formed in the insulation layer; and a second layer transparent common electrode formed on the insulation layer. A side portion of via holes is in contact with the gate metal common electrode, another side portion is in contact with the first layer transparent common electrode, such that the second layer transparent common electrode is connected electrically with the first layer transparent common electrode and the gate metal common electrode in the via holes. | 11-01-2012 |
| 20120287506 | COLOR FILTER SUBSTRATE CAPABLE OF POLARIZING AND MANUFACTURING METHOD THEREOF - The present disclosure relates to a field of liquid crystal display. A color filter substrate capable of polarizing and a manufacturing method thereof are disclosed. The manufacturing method of a color filter substrate comprises: step 1, forming an intermediate layer containing conductor on a substrate; step 2, forming a photoresist layer on the intermediate layer; step 3, forming the photoresist layer into a photoresist pattern with a grating pattern of nanometer size; and step 4, using this photoresist pattern with a grating pattern of nanometer size to etch the underlying intermediate layer to form the intermediate layer into a black matrix and a polarizing structure having grating patterns. | 11-15-2012 |
| 20120307171 | PIXEL STRUCTURE, LCD PANEL, AND MANUFACTURING METHOD THEREOF - An embodiment of the disclosed technology provides a pixel structure, comprising a TFT, a reflective region and a transmissive region, wherein the reflective region comprises a reflective region insulation layer, a reflection layer on the reflective region insulation layer and a reflective region pixel electrode on the reflection layer, and the transmissive region comprises a transmissive region pixel electrode, wherein the reflective region pixel electrode and the transmissive region pixel electrode form an integral structure, and the integral structure of the pixel electrodes is connected with the drain electrode of the TFT, wherein the organic layer in the reflective region is formed on an array substrate prior to a gate electrode of the TFT, and the reflection layer in the reflective region and the gate electrode of the TFT are formed in a same patterning process by using a same metal layer. | 12-06-2012 |
| 20130141775 | ELECTROWETTING DISPLAY PANEL AND THE MANUFACTURING METHOD THEREOF - Embodiments of the present disclosure provide an electrowetting display panel and the manufacturing method thereof The electrowetting display panel comprises: a first glass substrate; a second glass substrate provided opposite to the first glass substrate; a cavity provided between the first glass substrate and the second glass substrate; a colored conductive liquid filled into the cavity; and a reflecting conductive element provided on the surface of the first glass substrate facing away from the second glass substrate, and corresponding to the cavity, wherein the reflecting conductive element is used for controlling the light transmissivity of the colored conductive liquid within the cavity according to the voltage applied to the reflecting conductive element and reflecting the light passing through the colored conductive liquid toward the second glass substrate. | 06-06-2013 |
| 20130149463 | METHOD OF MANUFACTURING PATTERNED GRAPHENE FILM - Embodiments of the invention provide a method of manufacturing a patterned graphene film. The method comprises the following steps: Step 1: a photoresist layer/electron-beam resist layer is coated on a substrate and patterned, the photoresist layer/electron-beam resist layer in a region for forming the patterned graphene film is removed; Step 2: a solution of oxidized graphene is coated on the substrate formed with the photoresist layer/electro-beam resist layer patterned in Step 1, so that a film of oxidized graphene is formed; Step 3: the substrate obtained in Step 2 is placed in a hydrazine steam, so that the film of oxidized graphene formed in Step 2 is reduced and a graphene film is obtained; and Step 4: the photoresist layer/electron-beam resist layer and the graphene film on the photoresist layer/electrone-beam resist layer are removed, so that the patterned graphene film is obtained. | 06-13-2013 |
| 20130153911 | ARRAY SUBSTRATE, MANUFACTURING METHOD THEREOF AND DISPLAY DEVICE - Embodiments of the present invention provide a method of manufacturing an array substrate, comprising: a step of forming a pixel electrode and a step of forming a common electrode, wherein at least one of the pixel electrode and the common electrode is formed of graphene. The embodiments of the present invention also provide an array substrate manufactured by the above method and a display device comprising the array substrate. | 06-20-2013 |
| 20130231724 | SYSTEM OF FUNCTIONAL ELECTRICAL STIMULATION - The present invention discloses a functional electrical stimulation system comprising a primary power, a boost module, an energy storage section, an output control relay, an automatic discharge circuit, a foot/hand controlled switch, a current detection chip and a current limiting fuse. The boost module comprises n DC chopper circuits connected in series, and outputs a high voltage of 100-200V. According to an enable signal and a current detection signal, the output control relay disables/enables the DC boost module. The automatic discharge circuit discharges capacitance of the energy storage section automatically when the relay turns off the power input. The Foot/hand controlled switch, the current detection chip and the current limiting fuse form a triple accident protection circuit. The functional electrical stimulation system maximizes the intensity of electrical stimulation within the range that the human body can withstand. Meanwhile, it provides multiple security protection mechanisms and enhanced reliability to avoid danger during the use. | 09-05-2013 |
| 20140054581 | ARRAY SUBSTRATE, MANUFACTURING METHOD THEREOF, AND DISPLAY DEVICE - Embodiments of the invention relate to an array substrate, a manufacturing method thereof and a display device comprising the array substrate. The array substrate comprises a gate line and a data line which define a pixel region, the pixel region comprises a thin film transistor region and an electrode pattern region, a gate electrode, a gate insulation layer, an active layer, a source electrode, a drain electrode and a passivation layer are formed in the thin film transistor region, the gate insulation layer, a pixel electrode, the passivation layer and a common electrode are formed in the electrode pattern region, and the common electrode and the pixel electrode form a multi-dimensional electric field. A color resin layer is formed between the gate insulation layer and the pixel electrode. | 02-27-2014 |
| 20140054586 | MANUFACTURING METHOD OF ARRAY SUBSTRATE, ARRAY SUBSTRATE AND DISPLAY - Embodiments of the present invention disclose a manufacturing method of an array substrate, an array substrate and a display. The manufacturing method comprises: forming a gate electrode of a TFT on a substrate; forming a metal oxide semiconductor thin film and a top metal thin film, and performing a mask process to the metal oxide semiconductor thin film and the top metal thin film, in order to form an active layer opposing the gate electrode and a source electrode and a drain electrode of the TFT respectively; and forming a passivation layer overlying the source electrode and the drain electrode, wherein during the mask process to the top metal thin film, a hydrogen peroxide-based etchant with a pH value between 6 and 8 is used to etch the top metal thin film. | 02-27-2014 |
| 20140070206 | Array Substrate, Method For Manufacturing The Same And Display Device - A manufacturing method of an array substrate, comprising the following steps: S1: forming a pattern comprising a semiconductor layer ( | 03-13-2014 |
| 20140070220 | ARRAY SUBSTRATE, METHOD FOR MANUFACTURING THE SAME AND DISPLAY DEVICE - Embodiments of the invention provide an array substrate, a method for manufacturing the same and a display device. The array substrate comprises a thin film transistor and a pixel electrode electrically connected to a drain electrode of the thin film transistor. The pixel electrode is formed of graphene, or a source electrode and the drain electrode of the thin film transistor are formed of graphene, or the pixel electrode, the source and drain electrodes of the thin film transistor are all formed of graphene. | 03-13-2014 |
| 20140077160 | TFT ARRAY SUBSTRATE AND A METHOD FOR MANUFACTURING THE SAME AND DISPLAY DEVICE - Embodiments of the present invention provide a thin film transistor (TFT) array substrate and a method for manufacturing the same and a display device. The TFT array substrate improves a structure of a TFT array substrate and has a small thickness, and process flow is simplified. The method for manufacturing a thin film transistor (TFT) array substrate comprises: obtaining a gate line and a gate electrode through a first patterning process on a glass substrate; forming a gate insulating layer on the gate line and the gate electrode; forming a graphene layer on the gate insulating layer, and obtaining a semiconductor active layer over the gate electrode by a second patterning process and a hydrogenation treatment; obtaining a data line, a source electrode, a drain electrode and a pixel electrode which are located on the same layer by a third patterning process; and forming a protection layer on the data line, the source electrode, the semiconductor active layer, the drain electrode and the pixel electrode. | 03-20-2014 |
| 20140077207 | ARRAY SUBSTRATE AND MANUFACTURING METHOD THEREOF - Embodiments of the present invention relate to an array substrate and a manufacturing method thereof. The manufacturing method comprises: step 1: forming a gate line, a gate electrode, a first insulating layer, an active layer and ohmic contact layers on a base substrate by a first patterning process using a gray-tone or half-tone mask, in which the active layer between the ohmic contact layers corresponds to a channel region; step 2: forming a second insulating layer and a pixel electrode film on the base substrate obtained after the step 1 by a second patterning process using a gray-tone or half-tone mask; and step 3: forming a drain electrode, a source electrode, a data line and a passivation layer on the base substrate obtained after the step 2 by a third patterning process using a gray-tone or half-tone mask. | 03-20-2014 |
| 20140100638 | FUNCTIONAL ELECTRICAL STIMULATION SYSTEM - A functional electrical stimulation system having a boost module to raise an output voltage of a primary power to a first preset voltage, an energy storage module, connected to the boost module, configured to store electrical energy of the first preset voltage, a central control unit configured to generate data packets of electrical stimulation parameters, and an electrical stimulation output channel, connected to the energy storage module, configured to receive the data packets of electrical stimulation parameters, analyze the electrical stimulation parameters from the data packets, convert electrical energy stored in the energy storage module to an electrical stimulation pulse corresponding to the electrical stimulation parameters and apply the electrical stimulation pulse to a part of a user. The functional electrical stimulation system can enhance flexibility and autonomy of an electrical stimulation pulse so that the user can select a personalized electrical stimulation pulse type according to his/her actual conditions. | 04-10-2014 |
| 20140110665 | LIGHT EMITTING DIODE AND MANUFACTURING METHOD THEREOF - The embodiments of the present invention relate to a light emitting diode and manufacturing method thereof. The electroluminescent layer of the light-emitting diode is formed of graphene/compound semiconductor quantum dot composites. | 04-24-2014 |
| 20140144835 | SYSTEM AND METHOD FOR HARVESTING RAINWATER - A system for harvesting rainwater for use in a skirt building. The skirt building includes a main building and a podium supporting the main building. The system includes: a standpipe; a buffer channel; a filter channel; and a green roof. The green roof includes a vegetation region including a baffled diversion corridor, and a bottom filtering layer including a drainage pipe. The standpipe is arranged on the main building and is connected to the buffer channel where the energy of rainwater flowing out of the standpipe is dissipated. The buffer channel, the filter channel, and the green roof are arranged on the podium, and the buffer channel communicates with the filter channel. The filter channel is connected to the green roof. The filter channel is divided into a plurality of sections respectively filled with different matrix materials. | 05-29-2014 |
| 20140144850 | SYSTEM AND METHOD FOR PURIFYING RAINFALL RUNOFF - A system for purifying rainfall runoff including a bar screen; a collection and diversion device; a filter channel; a grass ditch; and a water storage tank. The bar screen is disposed around the collection and diversion device for preliminarily filtering the road rainfall runoff. The collection and diversion device collects the road rainfall runoff and diverts early rainfall runoff to the filter channel, after the filter channel is full, later rainfall runoff is directly diverted to the grass ditch through open channels. The grass ditch includes a percolation bed capable of filtering the early and later rainfall runoff. The water storage tank is connected to the grass ditch via a guiding pipe, to receive the rainfall runoff effusing out of the grass ditch. Part of the rainfall runoff received by the water storage is transported to the percolation bed by a return conduit. | 05-29-2014 |
| 20150185379 | METHOD FOR MANUFACTURING COLOR FILTER SUBSTRATE, COLOR FILTER SUBSTRATE AND TRANSFLECTIVE LIQUID CRYSTAL DISPLAY DEVICE - A method for manufacturing a color filter substrate, comprising: preparing a mask plate for black matrix, and providing light hole filling patterns ( | 07-02-2015 |
| 20150194467 | DOUBLE-SIDED DISPLAY APPARATUS AND METHOD OF MANUFACTURING THE SAME - A double-sided display apparatus and a method of manufacturing the same are provided. The double-sided display apparatus includes a first substrate and a second substrate arranged opposite to each other; a first transparent electrode and a second reflective electrode arranged on the first substrate; a first reflective electrode opposed to the first transparent electrode on the first substrate and a second transparent electrode opposed to the second reflective electrode on the first substrate arranged on the second substrate; and a quantum light-emitting layer arranged between the respectively corresponded transparent electrodes and reflective electrodes, the quantum light-emitting layer including charge transport particles and QD light-emitting material mixed therein. The provided double-sided display apparatus is lighter, thinner, more portable, and of low cost. | 07-09-2015 |
| 20150236055 | ARRAY SUBSTRATE AND METHOD OF MANUFACTURING THE SAME, AND DISPLAY APPARATUS - Embodiments of the present invention provide an array substrate and a method of manufacturing the same, and a display apparatus. The array substrate includes: a substrate; thin film transistors, data lines, gate lines disposed on the substrate; an interlayer insulating layer, disposed below the pixel electrodes, and provided with insulating raised strips protruding in a thickness direction of the substrate towards a space between adjacent pixel electrodes, wherein a projection of each raised strip on the substrate is not overlapped with those of pixel electrodes adjacent thereto in the thickness direction. When the array substrate is applied to a display apparatus, an interference of electric field between the adjacent pixel electrodes can be reduced, thereby avoiding phenomena such as color mixing and light leakage between two adjacent pixel units, and improving display effect of the display apparatus. | 08-20-2015 |
| 20150236056 | Array Substrate and Method for Fabricating the Same, and Display Device - The present invention discloses an array substrate and a manufacturing method for the same, and a display device. By adopting the manufacturing method for the array substrate provided by the embodiments of the present invention, via holes with relatively small hole sizes in a color resin layer are realized, so that the aperture ratio of pixels is improved. The manufacturing method for the array substrate includes: forming thin film transistors on a substrate; forming a color resin layer on the substrate on which the thin film transistors are formed; forming a first light-blocking layer with a light-shielding effect on the color resin layer, the photolithographic resolution of the first light-blocking layer being greater than that of the color resin layer; and performing a patterning process on the first light-blocking layer and the color resin layer to form via holes in the color resin layer. | 08-20-2015 |
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| 20120270273 | TRANSCRIPTION ACTIVATOR-LIKE EFFECTORS - Provided herein are compositions, kits and methods useful in the construction of designer transcription activator-like effector (dTALE) polypeptides. | 10-25-2012 |
| 20130019325 | Light-Sensitive Ion-Passing Molecules - Disclosed are polynucleotides and methods for expressing light activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The disclosure also provides animal cells and non-human animals comprising cells expressing the light-activated proteins. | 01-17-2013 |
| 20130089503 | Light-Sensitive Ion-Passing Molecules - The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The invention also provides animal cells and non-human animals comprising cells expressing the light-activated proteins. | 04-11-2013 |
| 20130090454 | Light-Sensitive Ion-Passing Molecules - The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The invention also provides animal cells and non-human animals comprising cells expressing the light-activated proteins. | 04-11-2013 |
| 20130137160 | Nucleotide-Specific Recognition Sequences For Designer TAL Effectors - The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (DNA) binding polypeptide having a N-terminal capping region, a DNA binding domain comprising at least five or more Transcription activator-like effector (TALE) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a C-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the DNA of the genomic locus. | 05-30-2013 |
| 20130137161 | Nucleotide-Specific Recognition Sequences For Designer TAL Effectors - The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (DNA) binding polypeptide having a N-terminal capping region, a DNA binding domain comprising at least five or more Transcription activator-like effector (TALE) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a C-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the DNA of the genomic locus. | 05-30-2013 |
| 20130137173 | NUCLEOTIDE-SPECIFIC RECOGNITION SEQUENCES FOR DESIGNER TAL EFFECTORS - The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (DNA) binding polypeptide having a N-terminal capping region, a DNA binding domain comprising at least five or more Transcription activator-like effector (TALE) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a C-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the DNA of the genomic locus. | 05-30-2013 |
| 20130137174 | NUCLEOTIDE-SPECIFIC RECOGNITION SEQUENCES FOR DESIGNER TAL EFFECTORS - The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (DNA) binding polypeptide having a N-terminal capping region, a DNA binding domain comprising at least five or more Transcription activator-like effector (TALE) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a C-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the DNA of the genomic locus. | 05-30-2013 |
| 20130149780 | Nucleotide-Specific Recognition Sequences For Designer TAL Effectors - The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (DNA) binding polypeptide having a N-terminal capping region, a DNA binding domain comprising at least five or more Transcription activator-like effector (TALE) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a C-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the DNA of the genomic locus. | 06-13-2013 |
| 20130149781 | Nucleotide-Specific Recognition Sequences For Designer TAL Effectors - The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (DNA) binding polypeptide having a N-terminal capping region, a DNA binding domain comprising at least five or more Transcription activator-like effector (TALE) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a C-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the DNA of the genomic locus. | 06-13-2013 |
| 20130171124 | Compositions And Methods Of Treating Head And Neck Cancer - The present invention provides methods related to the treatment of head and neck squamous cell carcinoma (HNSCC) and its associated premalignant lesions. In particular, the invention features methods which may specifically target HNSCC-associated genes and alter gene expression to treat or alleviate a symptom of HNSCC, or its related premalignant lesions. These methods may involve decreasing the function of an HNSCC-associated gene with aberrant gain-of-function; or increasing the function of an HNSCC-associated gene with aberrant loss-of-function. | 07-04-2013 |
| 20130244323 | Systems, Methods and Compositions for Optical Stimulation of Target Cells - Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule. | 09-19-2013 |
| 20130288365 | Cell Line, System and Method for Optical-Based Screening of Ion-Channel Modulators - A variety of applications, systems, methods and constructs are implemented for use in connection with screening of ion-channel modulators. Consistent with one such system, drug candidates are screened to identify their effects on cell membrane ion channels and pumps. The system includes screening cells having light responsive membrane ion switches, voltage-gated ion switches and fluorescence producing voltage sensors. A chemical delivery device introduces the drug candidates to be screened. An optical delivery device activates the light responsive ion switches. An optical sensor monitors fluorescence produced by the voltage sensors. A processor processes data received from the optical sensor. A memory stores the data received from the optical sensor. | 10-31-2013 |
| 20130289669 | Optical Tissue Interface Method and Apparatus For Stimulating Cells - In one example, a system electrically stimulates target cells of a living animal using an elongated structure, a modulation circuit and a light pathway such as provided by an optical fiber arrangement. The elongated structure is for insertion into a narrow passageway in the animal such that an end of the elongated structure is sufficiently near the target cells to deliver stimulation thereto. The modulation circuit is for modulating the target cells while the elongated structure is in the narrow passageway, where the modulation circuit is adapted to deliver viral vectors through the elongated structure for expressing light responsive proteins in the target cells. The light pathway is used for stimulating the target cells by delivering light to the light-responsive proteins in the target cells. | 10-31-2013 |
| 20130295635 | System for Optical Stimulation of Target Cells - Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing a NpHR ion pump. The method includes the step of providing a sequence of stimuli to the cell. Each stimulus increases the probability of depolarization events occurring in the cell. Light is provided to the cell to activate the expressed NpHR ion pump, thereby decreasing the probability of depolarization events occurring in the cell. | 11-07-2013 |
| 20140113367 | Systems, Methods and Compositions for Optical Stimulation of Target Cells - Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated NpHR-based molecule comprising a nucleic acid sequence that codes for light-activated NpHR-based molecule and a promoter. Either a high expression of the molecule manifests a toxicity level that is less than about 75%, or the light-activated NpHR-based proteins are expressed using at least two NpHR-based molecular variants. Each of the variants characterized in being useful for expressing a light-activated NpHR-based molecule that responds to light by producing an inhibitory current to dissuade depolarization of the neuron. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion pumps or for controlling inhibitory currents in a cell (e.g., in in vivo and in vitro environments). | 04-24-2014 |
| 20140170753 | CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS - The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. | 06-19-2014 |
| 20140179006 | CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system. | 06-26-2014 |
| 20140179770 | DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS - The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition. | 06-26-2014 |
| 20140186843 | METHODS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF - Disclosed are locational or positional methods concerning CRISPR-Cas systems, and apparatus therefor. | 07-03-2014 |
| 20140186919 | ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme. | 07-03-2014 |
| 20140186958 | ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS - The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors with additional functional domains. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity. | 07-03-2014 |
| 20140189896 | CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system. | 07-03-2014 |
| 20140234972 | CRISPR-CAS Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system. | 08-21-2014 |
| 20140242664 | ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR-Cas system. | 08-28-2014 |
| 20140242699 | DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS - The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition. | 08-28-2014 |
| 20140242700 | ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme. | 08-28-2014 |
| 20140248702 | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system. | 09-04-2014 |
| 20140256046 | ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS - The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors with additional functional domains. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity. | 09-11-2014 |
| 20140271602 | NUCLEOTIDE-SPECIFIC RECOGNITION SEQUENCES FOR DESIGNER TAL EFFECTORS - The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (DNA) binding polypeptide having a N-terminal capping region, a DNA binding domain comprising at least five or more Transcription activator-like effector (TALE) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a C-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the DNA of the genomic locus. | 09-18-2014 |
| 20140273231 | CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system. | 09-18-2014 |
| 20140273232 | ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR-Cas system. | 09-18-2014 |
| 20140273234 | ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme. | 09-18-2014 |
| 20140287938 | RECOMBINANT VIRUS AND PREPARATIONS THEREOF - The present invention generally relates to methods and compositions used delivery of gene editing compositions including transcriptional effectors with parvovirus and preferred methods for making same. | 09-25-2014 |
| 20140309705 | System for Optical Stimulation of Target Cells - Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing a NpHR ion pump. The method includes the step of providing a sequence of stimuli to the cell. Each stimulus increases the probability of depolarization events occurring in the cell. Light is provided to the cell to activate the expressed NpHR ion pump, thereby decreasing the probability of depolarization events occurring in the cell. | 10-16-2014 |
| 20140310830 | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system. | 10-16-2014 |
| 20140335620 | ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme. | 11-13-2014 |
| 20140357530 | FUNCTIONAL GENOMICS USING CRISPR-CAS SYSTEMS, COMPOSITIONS, METHODS, KNOCK OUT LIBRARIES AND APPLICATIONS THEREOF - The present invention generally relates to compositions, methods applications and screens used in functional genomics that focus on gene function in a cell and that may use vector systems and other aspects related to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas systems and components thereof. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. | 12-04-2014 |
| 20140358067 | Systems, Methods and Compositions for Optical Stimulation of Target Cells - Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule. | 12-04-2014 |
| 20150020223 | DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS - The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition. | 01-15-2015 |
| 20150031134 | CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system. | 01-29-2015 |
| 20150072394 | Opsin Polypeptides and Methods of Use Thereof - The present disclosure provides opsins, including variant opsins with increased activity and/or increased trafficking to the plasma membrane. The opsins are useful in therapeutic and screening applications, which are also provided. | 03-12-2015 |
| 20150079681 | CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system. | 03-19-2015 |
| 20150184139 | CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS - The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. | 07-02-2015 |
| 20150203872 | CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS - The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. | 07-23-2015 |
| 20150232882 | ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR-Cas system. | 08-20-2015 |
| 20150232883 | DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETING DISORDERS AND DISEASES USING PARTICLE DELIVERY COMPONENTS - The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery particle formulations and/or systems comprising one or more components of a CRISPR-Cas system, which are means for targeting sites for delivery. The delivery particle formulations of the invention are preferably nanoparticle delivery formulations and/or systems. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition. | 08-20-2015 |
| 20150247150 | ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR-Cas system. | 09-03-2015 |
| 20150259670 | SYSTEM FOR OPTICAL STIMULATION OF TARGET CELLS - Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing a NpHR ion pump. The method includes the step of providing a sequence of stimuli to the cell. Each stimulus increases the probability of depolarization events occurring in the cell. Light is provided to the cell to activate the expressed NpHR ion pump, thereby decreasing the probability of depolarization events occurring in the cell. | 09-17-2015 |
| 20150291965 | ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS - The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors with additional functional domains. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity. | 10-15-2015 |
| 20150291966 | INDUCIBLE DNA BINDING PROTEINS AND GENOME PERTURBATION TOOLS AND APPLICATIONS THEREOF - The present invention generally relates to methods and compositions used for the spatial and temporal control of gene expression that may use inducible transcriptional effectors. The invention particularly relates to inducible methods of altering or perturbing expression of a genomic locus of interest in a cell wherein the genomic locus may be contacted with a non-naturally occurring or engineered composition comprising a deoxyribonucleic acid (DNA) binding polypeptide. | 10-15-2015 |
| 20150297719 | SYSTEMS, METHODS AND COMPOSITIONS FOR OPTICAL STIMULATION OF TARGET CELLS - Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light- activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule. | 10-22-2015 |
