Patent application number | Description | Published |
20130165343 | IDENTIFICATION OF MULTIGENE BIOMARKERS - Methods for identifying multigene biomarkers for predicting sensitivity or resistance to an anti-cancer drug of interest, or multigene cancer prognostic biomarkers are disclosed. The disclosed methods are based on the classification of the mammalian genome into 51 transcription clusters, i.e., non-overlapping, functionally relevant groups of genes whose intra-group transcript levels are highly correlated. Also disclosed are specific multigene biomarkers for predicting sensitivity or resistance to tivozanib, or rapamycin, and a specific multigene biomarker for determining breast cancer prognosis, all of which were identified using the methods disclosed herein. | 06-27-2013 |
20140045715 | TIVOZANIB RESPONSE PREDICTION - A diagnostic method for predicting whether a human tumor will be sensitive or resistant to treatment with tivozanib (AV-951) is disclosed. The method is based on measurement of macrophage content in a tissue sample from a tumor. Measurement of macrophage content can be based on analysis of macrophage marker gene expression, e.g., by RNA analysis or immunohistochemistry. | 02-13-2014 |
20140242597 | PREDICTING TUMOR RESPONSE TO ANTI-ERBB3 ANTIBODIES - A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor. | 08-28-2014 |
Patent application number | Description | Published |
20120231478 | TIVOZANIB RESPONSE PREDICTION - A diagnostic method for predicting whether a human tumor will be sensitive or resistant to treatment with tivozanib (AV-951) is disclosed. The method is based on measurement of macrophage content in a tissue sample from a tumor. Measurement of macrophage content can be based on analysis of macrophage marker gene expression, e.g., by RNA analysis or immunohistochemistry. | 09-13-2012 |
20120302572 | USE OF EMT GENE SIGNATURES IN CANCER DRUG DISCOVERY, DIAGNOSTICS, AND TREATMENT - The present invention provides diagnostic methods for assessing the EMT status of tumor cells, and for predicting the effectiveness of treatment of a cancer patient with an EGFR or IGF-1R kinase inhibitor, utilizing an EMT gene signature index score. The present invention further provides methods for treating patients with cancer that incorporate these methods. | 11-29-2012 |
20130165337 | IDENTIFICATION OF MULTIGENE BIOMARKERS - Methods for identifying multigene biomarkers for predicting sensitivity or resistance to an anti-cancer drug of interest, or multigene cancer prognostic biomarkers are disclosed. The disclosed methods are based on the classification of the mammalian genome into 51 transcription clusters, i.e., non-overlapping, functionally relevant groups of genes whose intra-group transcript levels are highly correlated. Also disclosed are specific multigene biomarkers for predicting sensitivity or resistance to tivozanib, or rapamycin, and a specific multigene biomarker for determining breast cancer prognosis, all of which were identified using the methods disclosed herein. | 06-27-2013 |
Patent application number | Description | Published |
20130287980 | CURABLE ELASTOMER COMPOSITIONS WITH LOW TEMPERATURE SEALING CAPABILITY - Curable sealant compositions having low temperature sealing ability improved over convention curable sealing compositions. The composition is flowable and can be cured to a cross linked form to provide cured reaction products that exhibit elastomeric properties. The curable elastomeric sealant composition can include a cross linkable elastomeric oligomer; an initiator or cross-linking agent; a glassy monomer and/or a rubbery monomer; and optionally one or more additives. Cured reaction products of the composition have a single Tg and retain a higher sealing force at low temperatures (but above the cured product Tg) as compared to a curable composition made from the same cross linkable elastomeric oligomer but without the glassy and/or rubbery monomer. | 10-31-2013 |
20140275399 | PREPARATION OF NOVEL FLUOROCOMPOUNDS, METHODS OF PREPARATION ANDCOMPOSITIONS MADE THEREFROM - Novel fluorinated compounds, their method of preparation and use are disclosed, as well as the incorporation of new and old fluorinated compounds in controlled radical polymerization processes to efficiently produce polymer compositions with unique and enhanced properties. Various cure mechanisms and types of end-uses are disclosed. | 09-18-2014 |
20150210882 | CURABLE ELASTOMER COMPOSITIONS WITH LOW TEMPERATURE SEALING CAPABILITY - Curable sealant compositions having low temperature sealing ability improved over convention curable sealing compositions. The composition is flowable and can be cured to a cross linked form to provide cured reaction products that exhibit elastomeric properties. The curable elastomeric sealant composition can include a cross linkable elastomeric oligomer; an initiator or cross-linking agent; a glassy monomer and/or a rubbery monomer; and optionally one or more additives. Cured reaction products of the composition have a single Tg and retain a higher sealing force at low temperatures (but above the cured product Tg) as compared to a curable composition made from the same cross linkable elastomeric oligomer but without the glassy and/or rubbery monomer. | 07-30-2015 |
20150337067 | SYNTHESIS OF FUNCTIONAL POLYISOBUTYLENE-CONTAINING OLIGOMERS AND POLYMERS - Disclosed are single step and multi-step methods of making functional polyisobutylene (PIB)-containing oligomers and polymers and the materials made thereby. In the single step method a functional group containing PIB oligomer or polymer is made under cationic polymerization conditions in a direct, one step reaction. In the multi-step method a functional group containing PIB oligomer or polymer is made in a two-step process. The first step is performed under cationic polymerization conditions. The second step is performed under non-cationic polymerization conditions. | 11-26-2015 |
20160083487 | Functional Polyisobutylene-Containing Oligomers and Polymers - A method of making functional polyisobutylene (PIB)-containing oligomers and polymers. By the disclosed method, the synthesis of functional PIB-containing polymers can be achieved directly under cationic polymerization conditions and does not include any post-polymerization reactions. The desired functionality is introduced by direct Electrophilic Aromatic Substitution (EAS) reaction using substituted phenyl ring carrying desirable functionalities that do not react with Lewis acid but have weak association with Lewis acid, which still allow living polymerization and EAS reaction under living cationic polymerization conditions. In the disclosed method functional polyisobutylene or isobutylene containing oligomers and polymers can be prepared using stoichiometric or near stoichiometric ratios of the capping or functionalization reagent to polymer end-chain. | 03-24-2016 |
Patent application number | Description | Published |
20110121867 | HIGH-SPEED COMPRESSION ARCHITECTURE FOR MEMORY - Memory design techniques are disclosed that provide a high compression ratio at no loss in speed. The techniques can be embodied, for instance, in heterojunction bipolar transistor (HBT) based ROMs. By embedding compression logic (e.g., XOR) functionality directly into the address decoders and sense amplifiers of the memory device, a high compression ratio is achieved at no loss in speed. For example, the logic-based compression functionality can be directly implemented into the buffers that form the address decoder as well as the sense amplifiers. | 05-26-2011 |
20110121881 | MULTIPLE INPUT / GAIN STAGE GILBERT CELL MIXERS - Multiple input and/or gain stage Gilbert cell mixer designs are disclosed. The designs allow one input to be turned on at a time, and are suitable, for example, for use in receiver and transmitter applications. In addition, the designs allow for the inputs of the multi-input Gilbert cell mixer to be connected together, thereby allowing for switching of gain states within the Gilbert cell mixer. The mixer design may include, for example, a Gilbert cell mixer stage, and a plurality of input/gain stages. Each input/gain stage has its output connected to the input of the mixer stage, and is configured for receiving an input signal and applying a gain factor to that input signal to provide a signal for mixing with the LO. Each input/gain stage is configured with stage select circuitry for enabling or disabling that stage, so that only one input/gain stage is active at a time. | 05-26-2011 |
Patent application number | Description | Published |
20110285807 | Voice Tracking Camera with Speaker Identification - A videoconferencing apparatus automatically tracks speakers in a room and dynamically switches between a controlled, people-view camera and a fixed, room-view camera. When no one is speaking, the apparatus shows the room view to the far-end. When there is a dominant speaker in the room, the apparatus directs the people-view camera at the dominant speaker and switches from the room-view camera to the people-view camera. When there is a new speaker in the room, the apparatus switches to the room-view camera first, directs the people-view camera at the new speaker, and then switches to the people-view camera directed at the new speaker. When there are two near-end speakers engaged in a conversation, the apparatus tracks and zooms-in the people-view camera so that both speakers are in view. | 11-24-2011 |
20110285808 | Videoconferencing Endpoint Having Multiple Voice-Tracking Cameras - A videoconferencing apparatus automatically tracks speakers in a room and dynamically switches between a controlled, people-view camera and a fixed, room-view camera. When no one is speaking, the apparatus shows the room view to the far-end. When there is a dominant speaker in the room, the apparatus directs the people-view camera at the dominant speaker and switches from the room-view camera to the people-view camera. When there is a new speaker in the room, the apparatus switches to the room-view camera first, directs the people-view camera at the new speaker, and then switches to the people-view camera directed at the new speaker. When there are two near-end speakers engaged in a conversation, the apparatus tracks and zooms-in the people-view camera so that both speakers are in view. | 11-24-2011 |
20110285809 | Automatic Camera Framing for Videoconferencing - A videoconferencing apparatus automatically tracks speakers in a room and dynamically switches between a controlled, people-view camera and a fixed, room-view camera. When no one is speaking, the apparatus shows the room view to the far-end. When there is a dominant speaker in the room, the apparatus directs the people-view camera at the dominant speaker and switches from the room-view camera to the people-view camera. When there is a new speaker in the room, the apparatus switches to the room-view camera first, directs the people-view camera at the new speaker, and then switches to the people-view camera directed at the new speaker. When there are two near-end speakers engaged in a conversation, the apparatus tracks and zooms-in the people-view camera so that both speakers are in view. | 11-24-2011 |
20120004918 | Full-Band Scalable Audio Codec - A scalable audio codec for a processing device determines first and second bit allocations for each frame of input audio. First bits are allocated for a first frequency band, and second bits are allocated for a second frequency band. The allocations are made on a frame-by-frame basis based on the energy ratio between the two bands. For each frame, the codec transform codes both frequency bands into two sets of transform coefficients, which are then packetized based on the bit allocations. The packets are then transmitted with the processing device. Additionally, the frequency regions of the transform coefficients can be arranged in order of importance determined by power levels and perceptual modeling. Should bit stripping occur, the decoder at a receiving device can produce audio of suitable quality given that bits have been allocated between the bands and the regions of transform coefficients have been ordered by importance. | 01-05-2012 |
20120290305 | Scalable Audio in a Multi-Point Environment - Use of a scalable audio codec to implement distributed mixing and/or sender bit rate regulation in a multipoint conference is disclosed. The scalable audio codec allows the audio signal from each endpoint to be split into one or more frequency bands and for the transform coefficients within such bands to be prioritized such that usable audio may be decoded from a subset of the entire signal. The subset may be created by omitting certain frequency bands and/or by omitting certain coefficients within the frequency bands. By providing various rules for each endpoint in a conference, the endpoint can determine the importance of its signal to the conference and can select an appropriate bit rate, thereby conserving bandwidth and/or processing power throughout the conference. | 11-15-2012 |
20120320143 | Automatic Camera Selection for Videoconferencing - In videoconference camera selection, audio inputs associated with cameras for a videoconference are each processed into first and second audio energies respectively for first and second frequency ranges. The selection then determines which of the audio inputs has a greatest ratio of the first audio energy to the second audio energy and selects the associated camera view for outputting video for the videoconference. The selection can also process video inputs from the cameras either alone or in combination with the audio processing. Either way, the selection processes each of the video inputs for at least one facial characteristic and determines which of the video inputs has a greatest likelihood of framing a human face. In the end, the selection selects the associated camera view for outputting video for the videoconference based at least in part on this video-based determination. | 12-20-2012 |
20130271559 | Videoconferencing Endpoint Having Multiple Voice-Tracking Cameras - A videoconferencing apparatus automatically tracks speakers in a room and dynamically switches between a controlled, people-view camera and a fixed, room-view camera. When no one is speaking, the apparatus shows the room view to the far-end. When there is a dominant speaker in the room, the apparatus directs the people-view camera at the dominant speaker and switches from the room-view camera to the people-view camera. When there is a new speaker in the room, the apparatus switches to the room-view camera first, directs the people-view camera at the new speaker, and then switches to the people-view camera directed at the new speaker. When there are two near-end speakers engaged in a conversation, the apparatus tracks and zooms-in the people-view camera so that both speakers are in view. | 10-17-2013 |
20130294612 | AUTOMATIC MICROPHONE MUTING OF UNDESIRED NOISES BY MICROPHONE ARRAYS - Methods and systems for cancelation of table noise in a speaker system used for video or audio conferencing are disclosed. Table noise is cancelled by using a vertical microphone array to distinguish the tilt angle of sound received by a microphone. If the sound is close to horizontal, the audio is muted. If the sound is above a given angle from horizontal, it is not muted, as this indicates a person speaking. This eliminates paper rustling, keyboard clicks and the like. | 11-07-2013 |
20140049595 | Videoconferencing System Having Adjunct Camera for Auto-Framing and Tracking - A videoconference apparatus and method coordinates a stationary view obtained with a stationary camera to an adjustable view obtained with an adjustable camera. The stationary camera can be a web camera, while the adjustable camera can be a pan-tilt-zoom camera. As the stationary camera obtains video, faces of participants are detected, and a boundary in the view is determined to contain the detected faces. Absence and presences of motion associated with the detected face is used to verify whether a face is reliable. To then capture and output video of the participants for the videoconference, the view of the adjustable camera is adjusted to a framed view based on the determined boundary. In the end, active video captured in the framed view with the adjustable camera can be sent to a far-end for the videoconference. | 02-20-2014 |
20140270302 | LOUDSPEAKER ARRANGEMENT WITH ON-SCREEN VOICE POSITIONING FOR TELEPRESENCE SYSTEM - A videoconferencing system has a plurality of displays arranged side-by-side. Top loudspeakers are arranged adjacent the tops of the displays, and bottom loudspeakers are arranged adjacent the bottoms of the displays. A control unit operatively coupled to the displays and the loudspeakers routes video to each of the displays and routes audio corresponding to each display to any of the top and bottom loudspeakers arranged adjacent the display. Thus, the top and bottom loudspeakers form a vertical pair of loudspeakers that output the corresponding audio for its respective display. In this way, the audio for the video of a given display is perceived by participants to originate from the center of the given display. If one of the loudspeakers is not provided, gain setting and mixing between adjacent sets of loudspeakers can produce a virtual loudspeaker for the one that is missing. | 09-18-2014 |
Patent application number | Description | Published |
20140271590 | METHODS FOR PRODUCTION OF PLATELETS FROM PLURIPOTENT STEM CELLS AND COMPOSITIONS THEREOF - Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells. | 09-18-2014 |
20150313944 | METHODS FOR PRODUCTION OF PLATELETS FROM PLURIPOTENT STEM CELLS AND COMPOSITIONS THEREOF - Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells. | 11-05-2015 |
20160022736 | METHODS FOR PRODUCTION OF PLATELETS FROM PLURIPOTENT STEM CELLS AND COMPOSITIONS THEREOF - Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells. | 01-28-2016 |