Feldman, MA
Adam S. Feldman, Brookline, MA US
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20090239245 | METHOD FOR DIAGNOSIS AND PROGNOSIS OF EPITHELIAL CANCERS - The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy. | 09-24-2009 |
20140106378 | METHODS FOR DIAGNOSIS AND PROGNOSIS OF EPITHELIAL CANCERS - The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy. | 04-17-2014 |
20150093767 | METHODS FOR DIAGNOSIS AND PROGNOSIS OF EPITHELIAL CANCERS - The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy. | 04-02-2015 |
Andrew S. Feldman, Duxbury, MA US
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20120234057 | Anti-Theft Ring Assembly And Method Of Using the Same - An anti-theft assembly for deterring theft of a ring is provided. The anti-theft assembly includes a base that can be used to support an electronic article surveillance marker; a product engagement member including a support member that supports the ring during use and a locking member that secures the support member to the base; and an attachment member for securing the ring to the support member. In one embodiment, the support member and the locking member are a single, unitary member. In another embodiment, the support member and the locking member are separate members. Once assembled, upon applying a twisting force to the ring the engagement member rotates within the opening so that the attachment member is not broken. | 09-20-2012 |
20140075725 | ANTI-THEFT RING ASSEMBLY AND METHOD OF USING THE SAME - An anti-theft assembly for deterring theft of a ring is provided. The anti-theft assembly includes a base that can be used to support an electronic article surveillance marker; a product engagement member including a support member that supports the ring during use and a locking member that secures the support member to the base; and an attachment member for securing the ring to the support member. In one embodiment, the support member and the locking member are a single, unitary member. In another embodiment, the support member and the locking member are separate members. Once assembled, upon applying a twisting force to the ring the engagement member rotates within the opening so that the attachment member is not broken. | 03-20-2014 |
Bart Feldman, Lexington, MA US
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20140095295 | METHOD AND SYSTEM FOR IMPLEMENTING CALENDAR OPTIMIZATION - Disclosed is an improved approach to implement and handle promotion optimization by an enterprise software application. Promotion optimization functionality is provided to permit customer controlled rules to be processed for the promotions. The promotion optimization functionality in some embodiments include adding exclusions sets, improving the buy-down calculation, increased flexibility when entering event costs, better support for different causal types, and/or new parameters that provide greater flexibility. | 04-03-2014 |
20140278713 | ASSET FORECASTING IN ASSET INTENSIVE ENTERPRISES - A method, system, and computer program product for asset service and maintenance lifecycle management and supply chain planning. Some embodiments commence upon receiving a database record corresponding to an individually identified asset to be individually tracked through a corresponding asset lifecycle. Each individually identified asset has an asset-specific scheduled maintenance plan. During the performance of activities pertaining to the asset-specific scheduled maintenance plan, observations are made and events are recorded to generate a series of observations that are in turn collected into a learning model. The learning model and a predictor based on the learning model is used to predict a future demand or a forecast for items in quantities that are not given in the asset-specific scheduled maintenance plan. In exemplary cases, the forecast comprises items and/or quantities that are not given in the scheduled maintenance plan. | 09-18-2014 |
Bart C. Feldman, Lexington, MA US
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20100169167 | Computer Implemented System for Determining a Distribution Policy for a Single Period Inventory System, Optimization Application Therefor, and Method Therefor, and Decision Support Tool for Facilitating User Determination of a Distribution Policy for a Single Period Inventory System - Computer implemented system for determining a distribution policy for a single period inventory system on the basis of the relative merit of allocating a draw unit of one of a multitude of different consumer items to one of a multitude of different locations in accordance with an allocation decision criterion subject to one or more constraints, an optimization application therefor, and method therefor, and including a Decision Support Tool for facilitating user determination of a distribution policy for a single period inventory system. | 07-01-2010 |
Brian P. Feldman, Northborough, MA US
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20150343663 | HOT PRESS AND METHOD OF USING - Embodiments of the present disclosure relate to a hot press and methods of using the hot press. In an embodiment, the hot press can include a pressing element including a flared body. In another embodiment, the hot press can include a compression surface. The compression surface can include a first layer including a monocrystalline material and a second layer including a polycrystalline material, wherein the monocrystalline material and the polycrystalline material include a same primary compound. In a further embodiment, a sample including more than one layer of ceramic oxide material can be hot pressed without a die. | 12-03-2015 |
Dan Feldman, Cambridge, MA US
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20130275400 | DATA CORESET COMPRESSION - An approach to compression of a large (n point or samples) data set has a combination of one or more desirable technical properties: for a desired level of accuracy (ε), the number of compressed points (a “coreset”) representing the original data is O(log n); the level of accuracy comprises a guaranteed bound expressed as multiple of error of an associated line simplification of the data set; for a desired level of accuracy and a complexity (e.g., number k of optimal line segments) of the associated line simplification, the computation time is O(n); and for a desired level of accuracy (c) and a complexity of the associated line simplification, the storage required for the computation is O(log n). | 10-17-2013 |
20140019450 | TEXT CHARACTERIZATION OF TRAJECTORIES - In one embodiment, processing location data collected with a mobile device having a positioning system includes accepting trajectory data representing successive geographic positions of the mobile device, where the positions are associated with corresponding times. A set of coordinate segments is determined to represent in the accepted trajectory data, such that the trajectory data represent repeated traversals of at least some of the coordinate segments. A textual characterization is associated with each segment of the determined set of coordinate segments, and then a representation of the trajectory data (for example, an electronic diary) is formed using the textual characterization of the coordinate segments and stored. In some examples, a text based query associated with the accepted trajectory data is accepted and a response is determined using the stored representation of the trajectory data. | 01-16-2014 |
Daniel J. Feldman, Brookline, MA US
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20150095299 | MERGING METADATA FOR DATABASE STORAGE REGIONS BASED ON OVERLAPPING RANGE VALUES - Metadata for a plurality of database storage regions within memory are merged, where the metadata for each storage region comprises an interval including first and second interval values indicating a value range for values within that storage region. The first and second interval values are examined to identify overlapping storage regions and produce a sum of overlapped storage regions. The sum of overlapped storage regions is compared to a threshold and the metadata of the overlapped storage regions are merged based on the comparison. | 04-02-2015 |
20150095379 | MERGING METADATA FOR DATABASE STORAGE REGIONS BASED ON OVERLAPPING RANGE VALUES - Metadata for a plurality of database storage regions within memory are merged, where the metadata for each storage region comprises an interval including first and second interval values indicating a value range for values within that storage region. The first and second interval values are examined to identify overlapping storage regions and produce a sum of overlapped storage regions. The sum of overlapped storage regions is compared to a threshold and the metadata of the overlapped storage regions are merged based on the comparison. | 04-02-2015 |
Henry Feldman, Newton, MA US
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20100105071 | METHODS FOR PREDICTING THE ONSET OF MENARCHE - Embodiments of the invention provide methods for predicting the onset of menarche, i.e. a females first menstrual period, through the measurement of salivary hormone levels (e.g. 17-β estradiol, testosterone, progesterone, and/or 17 hydroxy-progesterone (17-OHP)). In particular, the methods described herein enable a reliable determination that menarche will, or will not occur, within varied time intervals, e.g. 1 to 30 days, 1 to 45 days, 1 to 60 days and 1 to 90 days. Diagnostic kits and products of manufacture comprising the kits are also provided. | 04-29-2010 |
Jeffrey Feldman, Arlington, MA US
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20100158924 | Expression of the cysteine protease legumain in vascular and inflammatory diseases - The present invention provides isolated and purified polynucleotides, polypeptides, and antibodies related to mammalian (e.g., mouse and human) legumain and the novel legumain splice variant, ZB-1. The invention further relates to the use of these isolated and purified polynucleotides, polypeptides, and antibodies, as well as other legumain and ZB-1 agonists and antagonists, in modulating legumain and/or ZB-1 activity, expression, and/or secretion in a cell or cell population, e.g., monocytes, macrophages, foam cells, vascular endothelial cells, kidney proximal tubule cells, arterial endothelial cells, sites of inflammatory cell invasion into a vessel intima, and neointimal lesional areas of an artery. The invention also provides legumain and ZB-1 antagonists, e.g., antagonistic small molecules, antibodies and antibody fragments to legumain and ZB-1, legumain and ZB-1 inhibitory polypeptides, and legumain and ZB-1 inhibitory polynucleotides. The present invention is also directed to novel methods for diagnosing, prognosing, monitoring, treating, ameliorating and/or preventing vascular disorders/diseases and inflammatory disorders/diseases. | 06-24-2010 |
Jeffrey L. Feldman, Arlington, MA US
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20090017019 | METHODS AND COMPOSITIONS FOR MODULATING BMP-10 ACTIVITY - Methods and compositions for modulating cardiac, renal and vascular cell function and homeostasis using agonists and antagonists of BMP-10 are disclosed. In particular, methods for treating, preventing and/or diagnosing BMP-10-associated vascular, renal, fibrotic and cardiac conditions and/or disorders are disclosed. Screening methods for evaluating BMP-10 modulators, e.g., agonists and antagonists, are also disclosed. | 01-15-2009 |
20090202474 | EXPRESSION OF ORPHAN GPR64 IN INFLAMMATORY DISEASES - Methods of screening for agents for treating inflammatory diseases are provided. The methods involve screening for agents that modulate the activity or expression of GPR64, which has been discovered herein to play a role in inflammatory diseases. Methods for treating an inflammatory disease, as well as methods of modulating the activity or expression of GPR64, methods of screening for an inflammatory disease in a subject, pharmaceutical compositions, a nucleic acid variant, and antibodies are also provided. | 08-13-2009 |
Jeffrey Lawrence Feldman, Arlington, MA US
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20080247955 | Inflammation treatment, detection and monitoring via TREM-1 - The present invention provides methods of treating inflammatory diseases/disorders in a subject by inhibiting/antagonizing TREM-1 expression/activity/signal transduction and/or DAP12/TyroBP expression and/or activity. Methods of detecting the presence of inflammatory disease in a subject by detecting TREM-1 and/or DAP12/TyroBP expression and/or activity in the subject or a sample obtained therefrom, wherein increased expression or activity is indicative of the inflammatory disease are also included. The present invention further provides methods for assessing the efficacy of a TREM-1-modulating agent administered to a patient by detecting levels of secreted phosphoprotein 1 (SPP1) and/or one or more other biomarkers in the patient or in a sample from the patient. | 10-09-2008 |
Joel Feldman, Cambridge, MA US
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20140257039 | SURGICAL RETRACTOR WITH SMOKE EVACUATOR - Disclosed herein are systems, devices, and methods for retracting tissue and removing surgical smoke using a smoke evacuation conduit positioned on or within an internal surface of the retractor blade such that the conduit does not protrude onto the external surface of the blade, along with a smoke intake port on or flush with the exterior surface of the blade and set back from the tip to minimize tissue aspiration. The systems and devices allow for the channeling of surgical smoke away from the surgical site while avoiding occlusion of the surgeon's field of view and preserving the surgeon's freedom of motion. | 09-11-2014 |
Jon Feldman, Cambridge, MA US
Michael E. Feldman, Framingham, MA US
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20140172174 | SYSTEM AND METHOD FOR CONTROLLING ELECTRICALLY-POWERED TRASH COMPACTORS AND RECEPTACLES - Systems, methods, and computer-readable storage media for controlling electrically-powered trash compactors and receptacles. The system first receives data associated with a storage receptacle configured to communicate with the system via a network, wherein the data is received from a server storing information transmitted by the storage receptacle, the storage receptacle having an energy storage for powering operational functions performed by the storage receptacle. The system then identifies a parameter of the storage receptacle associated with an operational function of the storage receptacle, and transmits a signal to the storage receptacle for modifying the parameter based on the data associated with the storage receptacle to yield a modified operation of the storage receptacle. | 06-19-2014 |
Ryszard Feldman, Framingham, MA US
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20130148461 | Apparatus And Methods For Controlling The Composition Of Fluids In A Fluid Stream - Embodiments of the present invention are directed to a devices and methods for forming a desired miture of two or more fluids in a conduit. The devices and methods feature control means having error monitoring means and in response to an error event the control means organizes the packet-group of command signals to form at least one first error packet group. The error event occurs during the period of time in which the at least one error packet-group is received by a selectable value. The at least one error packet-group comprising an order or timing of first command signals and second commands signals to minimize deviation from the desired mixture in the flow of mixture-packets forming the desired mixture of two or more fluids in a conduit during the error event. | 06-13-2013 |
Solomon Feldman, Brookline, MA US
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20120304759 | SENSOR ASSEMBLY FOR USE WITH A FLUID TRANSPORT SYSTEM AND METHOD OF ASSEMBLING SAME - A sensor assembly for use with a fluid transport system is provided. The sensor assembly includes at least two sensors that are configured to measure a rate of flow of a fluid channeled through a pipeline of the fluid transport system. Moreover, the sensor assembly includes an annular collar that is coupled to the two sensors. The collar includes at least a first opening and at least a second opening defined therein. The first opening and the second opening are each sized to receive the two sensors therein such that the two sensors are substantially coaxially aligned with each other. A first sensor of the two sensors is positioned downstream from a second sensor of the two sensors. | 12-06-2012 |
20130219707 | SENSOR PORT INSERT APPARATUS - An insert apparatus for installing a transducer assembly in a sensor port of a flow cell is disclosed. The transducer assembly is installed in the cavity of the insert body without the use of glues or adhesives to bond the transducer assembly to the cavity. | 08-29-2013 |