Patent application number | Description | Published |
20080207694 | Hydroxamates as Histone Deacetylase Inhibitors and Pharmaceutical Formulations Containing Them - Compounds of structure (I) having histone deacetylase (HDAC) inhibitor activity are described. The compounds are chemically characterised by the presence of hydroxamic acid, with zinc as chelator, and an aromatic nucleus connected by a linker in which either a bicyclic aromatic system or a piperidino ring are present. | 08-28-2008 |
20120316351 | PROCESS FOR THE PREPARATION OF NEBIVOLOL - The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations. | 12-13-2012 |
20130274486 | PROCESS FOR THE PREPARATION OF NEBIVOLOL - The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations. | 10-17-2013 |
20130295622 | PROCESS FOR THE PREPARATION OF NEBIVOLOL - The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor. | 11-07-2013 |
Patent application number | Description | Published |
20120257920 | ORAL CARE SYSTEM, KIT AND METHOD - An oral care dispenser and oral care system incorporating the system that includes a resilient applicator that optimizes application of the subject fluid to the desired oral surfaces. In one embodiment, the invention is a dispenser comprising a housing having an internal reservoir containing the fluid. The resilient applicator is coupled to the housing and comprises a dispensing orifice. The resilient applicator comprises a working surface that is oriented at an oblique angle to a longitudinal axis of the housing and is defined by a polygonal perimeter edge, the polygonal perimeter edge comprising a plurality of apex portions and a plurality of side portions, wherein one of the plurality of side portions forms a distal most-portion of the resilient applicator. | 10-11-2012 |
20120272996 | ORAL CARE DISPENSER & ORAL CARE SYSTEM IMPLEMENTING THE SAME - An oral care dispenser and oral care system implementing the same. In one embodiment, the dispenser may comprise a collar having an axial passageway in which a drive component is rotatably coupled. The collar comprises a segmented neck portion and a non-segmented body portion that comprises a plurality of protuberances extending into the axial passageway. The drive component comprises at least one resilient arm that interacts with the plurality of protuberances to generate an audible signal during relative rotation. | 11-01-2012 |
20120301209 | ORAL CARE FLUID DELIVERY SYSTEM - An oral care implement having a fluid dispensing system for dispensing an oral care fluid. In one embodiment, the oral care implement may be a toothbrush including a handle, a neck and a head containing a plurality of tooth cleaning elements. Embodiments of the toothbrush further include a removable container or reservoir including a collapsible bladder that holds the oral care fluid. The bladder is in fluid communication with one or more fluid dispensing outlets disposed in the head. A manually actuated pump disposed in the handle provides the motive force for dispensing the fluid. | 11-29-2012 |
20130298341 | ORAL CARE DISPENSER & ORAL CARE SYSTEM IMPLEMENTING THE SAME - An oral care system comprising a toothbrush and a dispenser is disclosed. In one embodiment, the dispenser comprises a housing having a longitudinal axis and an internal reservoir containing an oral care material; a drive component rotatably disposed within the housing and comprising a drive screw, the drive component being axially retained relative to the housing through mechanical interference; and an elevator coupled to the drive screw so that rotation of the drive component in a first rotational direction causes the elevator to axially advance along the drive screw in a first axial direction to dispense the oral care material from a dispensing orifice. | 11-14-2013 |
20130316300 | Oral Care System, Kit and Method - An oral care dispenser and oral care system incorporating the system that includes a resilient applicator that optimizes application of the subject fluid to the desired oral surfaces. In one embodiment, the invention is a dispenser comprising a housing having an internal reservoir containing the fluid. The resilient applicator is coupled to the housing and comprises a dispensing orifice. The resilient applicator comprises a working surface that is oriented at an oblique angle to a longitudinal axis of the housing and is defined by a polygonal perimeter edge, the polygonal perimeter edge comprising a plurality of apex portions and a plurality of side portions, wherein one of the plurality of side portions forms a distal most-portion of the resilient applicator. | 11-28-2013 |
20140130274 | REFILL HEAD FOR AN ORAL CARE IMPLEMENT HANDLE - A refill head for an oral care implement, such as a toothbrush, wherein the refill head utilizes a specially designed structure for coupling the refill head to an oral care implement handle that ensures proper alignment and simplifies the loading and unloading of the refill head to the oral care implement handle. In one embodiment, the refill head comprises a tubular sleeve forming a cavity and first and second upper cam surfaces that form shoulders within the cavity. The first and second upper cam surfaces are separated by first and second axial slots of different configurations that prevent loading of the refill head onto the oral care implement handle in an improper rotational orientation through interaction with first and second bosses on the oral care implement handle. | 05-15-2014 |
20140137346 | REFILL HEAD FOR AN ORAL CARE IMPLEMENT HANDLE - A refill head, and an oral care implement including the same, wherein the refill head comprises a tubular sleeve having a cavity. First and second upper cam surfaces are provided in the cavity that form transverse shoulders within the cavity. The first and second upper cam surfaces are separated by first and second axial slots through which first and second bosses of a stem of a handle of the oral care implement can be passed. | 05-22-2014 |
20140143963 | REFILL HEAD FOR AN ORAL CARE IMPLEMENT HANDLE - A toothbrush handle, and toothbrush incorporating the same, wherein the handle comprises a stem to be slidably inserted into a refill head. An aperture in the stem defines a latch having a locking lug that operably mates with a locking lug of the refill head to axially retain the refill head to the handle. A resilient material seals the aperture to provide increased rigidity to the latch. | 05-29-2014 |
20140143964 | REFILL HEAD FOR AN ORAL CARE IMPLEMENT HANDLE - A refill head, and oral care implement incorporating the same, wherein the refill head can be uncoupled from a stem of a handle by compressing a portion of a tubular sleeve of the refill head radially inward, therby retracting a locking lug of the refill head radially outward | 05-29-2014 |
20140150190 | REFILL HEAD FOR AN ORAL CARE IMPLEMENT HANDLE - A refill head, and oral care implement incorporating the same, wherein the refill head comprises a tubular sleeve having a cavity for slidably receiving a stem of a handle of the oral care implement. An aperture in the tubular sleeve defines a latch having a locking lug that operably mates with a locking lug of the stem to axially retain the refill head to the handle. A resilient material seals the aperture to provide increased rigidity to the latch. | 06-05-2014 |
20140165312 | REFILL HEAD FOR POWERED ORAL CARE IMPLEMENT THAT PRODUCES VIBRATORY AND OSCILLATORY MOTION - A refill head, and a powered toothbrush including the same, wherein the refill head comprises a head portion including a movable tuft block that is rotated via operable coupling to a primary drive shaft of the handle. The head portion of the refill head is also receives vibrations from an eccentric that is operated by the primary drive shaft. | 06-19-2014 |
20140341636 | ORAL CARE IMPLEMENT AND REFILL HEAD THEREFOR - A refill head ( | 11-20-2014 |
20150209125 | ORAL CARE IMPLEMENT - An oral care implement, such as a toothbrush, which includes a handle and a replacement head utilizing a specially designed structure for coupling the replacement head to the handle of the oral care implement. The replacement head comprises a head and a tubular sleeve comprising a cavity for receiving a handle. A protuberance protrudes radially inward from an inner surface of the tubular sleeve for engaging a boss of a stem on the handle to impede rotation of the tubular sleeve about the stem in a first angular direction. A locking tab protrudes radially inward from the inner surface of the tubular sleeve for engaging an undercut surface of the boss to prevent axial disengagement of the tubular sleeve from the stem. The locking tab is circumferentially spaced from the protuberance so that an first axial channel exists therebetween for receiving a section of the boss. | 07-30-2015 |
20160000542 | Replacement Head for An Oral Care Implement, And Oral Care Implement And Method Of Utilizing The Same - A replacement head for an oral care implement, such as a powered toothbrush, wherein the replacement head utilizes a specially designed structure for coupling the replacement head to an oral care implement body. In one embodiment, the invention can be a replacement head comprising: a head having a plurality of tooth cleaning elements mounted thereto; a tubular sleeve comprising a cavity for receiving a stem of the body, a proximal edge defining an opening into the cavity, and a distal end to which the head is coupled, the tubular sleeve comprising a locking tab for engaging an undercut surface of a locking section of a boss. | 01-07-2016 |