Fasano, US
Alessio Fasano, West Friendship, MD US
Patent application number | Description | Published |
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20080269136 | METHOD OF USE OF PEPTIDE ANTAGONISTS OF ZONULIN TO PREVENT OR DELAY THE ONSET OF DIABETES - A method for preventing or delaying the onset of autoimmune diseases is disclosed. | 10-30-2008 |
20090082279 | PEPTIDE ANTAGONISTS OF ZONULIN AND METHODS FOR USE OF THE SAME - Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions. | 03-26-2009 |
20090176244 | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF CROHN'S DISEASE - The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The methods involve determining the presence, absence, or level of zonulin in a subject sample. In certain embodiments, the need for more laborious and/or invasive tests to monitor disease state is minimized or obviated. | 07-09-2009 |
20090297559 | USE OF TIGHT JUNCTION AGONISTS TO FACILITATE PULMONARY DELIVERY OF THERAPEUTIC AGENTS - The present invention provides materials and methods to facilitate the pulmonary delivery of therapeutic agents. In some embodiments, agonists of tight junctions (e.g., zonulin agonists) are used in compositions to facilitate the uptake of therapeutic agents from the pulmonary mucosa. | 12-03-2009 |
20100087380 | PHARMACEUTICAL COMPOSITIONS FOR INHIBITING INTESTINAL PERMEABILITY - A method for preventing or delaying the onset of autoimmune diseases is disclosed. | 04-08-2010 |
20110105385 | Antibacterial lactobacillus GG peptides and methods of use - The present invention provides antibacterial peptides isolated from | 05-05-2011 |
20110183923 | PEPTIDE ANTAGONISTS OF ZONULIN AND METHODS FOR USE OF THE SAME - Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions. | 07-28-2011 |
20110201543 | USE OF TIGHT JUNCTION ANTAGONISTS IN THE TREATMENT OF ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS - The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof. | 08-18-2011 |
20120076861 | MATERIALS AND METHODS FOR THE TREATMENT OF CELIAC DISEASE - The present invention provides materials and methods for the treatment of celiac disease. In addition, the present invention provides materials and methods of monitoring the treatment of a subject having celiac disease. | 03-29-2012 |
20120107329 | EGFR and PAR2 Regulation of Intestinal Permeability - The present invention provides methods for diagnosing and treating an immune-mediated disease, e.g., an autoimmune disease, an allergy or an inflammatory disease. Diagnosis is made by detecting a heterozygous or homozygous genotype of haptoglobin 2 or by detecting and quantifying pre-haptoglobin 2 mRNA or protein. After diagnosis, the disease may be treated by decreasing cell permeability leading to increased transepithelial electrical resistance, for example, by administering an antibody directed against single chain zonulin thereby inhibiting epidermal growth factor receptor and inhibiting proteinase-activated receptor 2 (PAR | 05-03-2012 |
20120196275 | MULTICELLULAR ORGANOTYPIC MODEL OF HUMAN INTESTINAL MUCOSA - Disclosed are methods of preparing multi-cellular three-dimensional tissue constructs, that include fibroblasts, endothelial cells, lymphocytes and epithelial cells. The present methods may include embedding fibroblasts and endothelial cells in a matrix enriched with gut basement membrane proteins to form a cell containing matrix that is then added to a bioreactor and exposed to epithelial cells and activated lymphocytes as the cell cultures. Also provided are the tissue constructs formed from such methods, a matrix enriched with gut basement membrane proteins and kits that include the same. Further provided are methods of measuring toxicity of a pathogen or commensal organisms, chemosensitivity of tissues to a toxic material and inflammatory conditions, which use the present multi-cellular three-dimensional tissue constructs. | 08-02-2012 |
20130157943 | METHOD AND USE OF PEPTIDE ANTAGONISTS OF ZONOLIN TO PREVENT OR DELAY THE ONSET OF DIABETES - A method for preventing or delaying the onset of autoimmune diseases is disclosed. | 06-20-2013 |
20130190247 | PEPTIDE ANTAGONISTS OF ZONULIN AND METHODS FOR USE OF THE SAME - Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions. | 07-25-2013 |
20130295594 | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF CROHN'S DISEASE - The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The methods involve determining the presence, absence, or level of zonulin in a subject sample. In certain embodiments, the need for more laborious and/or invasive tests to monitor disease state is minimized or obviated. | 11-07-2013 |
20140128321 | METHOD AND USE OF PEPTIDE ANTAGONISTS OF ZONULIN TO PREVENT OR DELAY THE ONSET OF DIABETES - A method for preventing or delaying the onset of autoimmune diseases is disclosed. | 05-08-2014 |
20140128328 | PEPTIDE ANTAGONISTS OF ZONULIN AND METHODS FOR USE OF THE SAME - Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the | 05-08-2014 |
Alessio Fasano, Baltimore, MD US
Patent application number | Description | Published |
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20130288950 | USE OF TIGHT JUNCTION ANTAGONISTS IN THE TREATMENT OF ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS - The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof. | 10-31-2013 |
Alessio Fasano, Charlestown, MA US
Patent application number | Description | Published |
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20140363818 | EGFR and PAR2 Regulation of Intestinal Permeability - The present invention provides methods for diagnosing an immune-mediated disease, e.g., an autoimmune disease, an allergy or an inflammatory disease. Diagnosis is made by detecting a heterozygous or homozygous genotype of haptoglobin 2 or by detecting and quantifying pre-haptoglobin 2 mRNA or protein. After diagnosis, the disease may be treated by decreasing cell permeability leading to increased transepithelial electrical resistance, for example, by administering an antibody directed against single chain zonulin thereby inhibiting epidermal growth factor receptor and inhibiting proteinase-activated receptor 2 (PAR | 12-11-2014 |
David M. Fasano, Maple Glen, PA US
Patent application number | Description | Published |
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20120258249 | LOW/ZERO VOC GLYCOL ETHER-ESTERS AS COALESCENTS FOR AQUEOUS POLYMERIC DISPERSIONS - Certain ether-esters compounds and certain ether ester coalescents are provided. Also provided are an aqueous coating composition including an aqueous polymeric dispersion and from 0.1% to 40% by weight, based on the weight of the aqueous polymeric dispersion solids, of the glycol ether-ester coalescents and a method for forming a coating from the aqueous coating composition. | 10-11-2012 |
David Michael Fasano, Maple Glenn, PA US
Patent application number | Description | Published |
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20090162558 | Core-shell polymers suitable for use in organic media - A composition including a core-shell polymeric particle, the core including, when dry, at least one void and the shell including, as polymerized units, from 18% to 50%, by weight based on the weight of the shell, monomer selected from the group consisting of acrylonitrile, methacrylonitrile, acrylamide, methacrylamide, and mixtures thereof. is provided. Also provided is a composition including an organic medium and a core-shell polymeric particle, the core including, when dry, at least one void and the shell having a calculated shell-organic medium interaction parameter, X | 06-25-2009 |
David Michael Fasano, Maple Glen, PA US
Patent application number | Description | Published |
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20100166967 | High gloss extended alkyd emulsion paints - This invention is an aqueous paint composition comprising an alkyd emulsion; a dispersion of organic extender particles, which particles comprise, when dry, one or more void; and one or more pigment. The aqueous paint composition provides high gloss decorative and protective coatings for various substrates, which coatings are extended with lower cost-in-use opaque polymer while still providing the high gloss performance of unextended alkyd emulsion paints. Also provided is a method for providing the high gloss coating. | 07-01-2010 |
20130085222 | COATING COMPOSITION WITH HIGH PIGMENT VOLUME CONTENT OPAQUE POLYMER - The present invention relates to a latex composition comprising a) an opaque polymer having a pigment volume concentration of from 18 to 28; b) fully or partially polymer encapsulated TiO | 04-04-2013 |
Dianne Fasano, Lake Geneva, WI US
Patent application number | Description | Published |
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20130149509 | Decorative and Protective Covering Process and System - A decorative and protective covering process and system can wrap, decorate and protect: a cabinet, countertop, table, furniture, backsplash, wall tile, shower surround, refrigerator, dishwasher, outdoor grill, air conditioner, elevator, door, wall, floor, ceiling, window sill, window frame, door frame. The wrapped product can be used in: a kitchen, bathroom, offices, garage, lobby, foyer, entryway, dining room, living room, family room, bedroom, bathroom, shower, bar, pantry, basement, utility room, garage, laundry room, den, movie theater, theater, stage, stage scenery, studio set, recreation room, clubhouse, conference room, office, store, motor home, pre-manufactured home, apartment, restaurant, house, hotel, motel, hospital, nursing home, mobile home, trailer, RV interior, boat interior, train interior, bus interior, rehabs, rental unit, condominium, home, townhome, gazebo, porch, outdoor bar, grilling area, etc. The wrapped product can provide a composite assembly with a multi-layer laminated protective decorative cover. | 06-13-2013 |
Julian B. Fasano, Troy, OH US
Patent application number | Description | Published |
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20100124147 | High Efficiency Mixer-Impeller - A mixer impeller having high efficiency blades. The impeller may include a central hub and a plurality of blades attached to and extending radially outwardly from the hub such that leading edges thereof are inclined upwardly from trailing edges thereof. Each of the blades may include a root attached to the hub, a tip, a first crease extending along substantially an entire length of the blade dividing the blade into a leading portion and a trailing portion, the leading and trailing portions meeting at the first crease such that the leading portion is angled downwardly from the trailing portion, and a second crease extending from a portion of the leading edge of the leading portion between the root and the tip diagonally along the leading portion to the tip, the second crease intersecting the tip at a point spaced from a point where the first crease intersects the tip, the second crease forming a tip portion of the leading portion that needs a remainder of the leading portion such that the tip portion is angled downwardly from the leading portion. | 05-20-2010 |
Michael Fasano, Watertown, CT US
Patent application number | Description | Published |
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20110141633 | CIRCUIT BREAKERS WITH GROUND FAULT AND OVERCURRENT TRIP - A circuit breaker apparatus may be used to interrupt overcurrent and ground fault in a circuit. The circuit breaker apparatus may include an overcurrent coil for tripping the circuit breaker apparatus, a voltage coil also for tripping the circuit breaker apparatus located proximate to the overcurrent coil, ground fault electronics connected to the voltage coil and structured to detect a ground fault in the circuit when the ground fault exceeds a threshold level, and a solid state switch. The ground fault electronics can be structured to send a trip signal to close the solid state switch when a ground fault is detected, the solid state switch is configured to force a current through the voltage coil when the solid state switch is closed, the current being of sufficient magnitude to trip the circuit breaker apparatus. | 06-16-2011 |
20120037598 | CIRCUIT INTERRUPTER WITH ENHANCED ARC QUENCHING CAPABILITIES - A circuit interrupter has a first contact, a second contact movable with respect to the first contact, an arcing chamber, and an arc splitter. The arc splitter is located on a first side of the first contact, as is an arc runner. An electrical conductor is connected to the arc runner having a first portion running from the first side of the first contact towards a second side of the first contact, the second side being opposite the first side with respect to the first contact. A second portion is connected to the first portion and the second contact; the second portion is located on the second side of the first contact. A current running through the arc runner and the electrical conductor generates a magnetic force on the arc moving the arc toward the arc splitter. | 02-16-2012 |
20120168295 | Ultra Low Profile Rocker Design - A rocker switch having a housing and a rocker extending from the housing. The rocker has a first side with a first end and a second end, a second side adjacent to the first side, and a channel. The channel is disposed on the second side of the rocker and has a first end and a second end. A pivot point is disposed on a crank. A pin, disposed on the crank, is located in a first side of the channel. The depression of the first end of the rocker causes a rotational movement of the channel in a curvilinear path around the pivot point, causing a rotational movement of the crank, moving the pin from the first end of the channel toward the second end of the channel. | 07-05-2012 |
20120261382 | Arc Runner With Integrated Current Path That Develops A Magnetic Field To Boost Arc Movement Towards Splitter Plates - A circuit interrupter for cooling and quenching an electrical arc having a housing with a first contact and a second contact movable with respect to the first contact. An arc splitter is located in an arcing chamber, and an arc runner is located near the second contact. The arc runner has an arc strap facing toward the first contact, a first wall shaped as a rectangular spiral perpendicularly extending from the arc strap, a second wall shaped as a rectangular spiral perpendicularly extending from to the arc strap and opposite the first wall. The arc runner generates a magnetic force on the arc forcing the arc toward the arc splitter. | 10-18-2012 |
20120262255 | Magnetic Circuit Interrupter With Current Limiting Capability - A circuit interrupter has a first contact, a second contact, and a trip arm which moves the second contact between a closed position where the second contact is touching the first contact and an open position in which the second contact is spaced apart from the first contact. A first trip mechanism has a first solenoid, a first overcurrent sensor, and a first arm. A second trip mechanism has a second solenoid, a second overcurrent sensor, and a second arm. The first trip mechanism activates the first arm after a first threshold amount of time which actuates the trip arm when the first overcurrent sensor detects a first threshold level. The second trip mechanism activates the second arm after a second threshold amount of time which actuates the trip arm when the second overcurrent sensor detects a second threshold level, the second threshold level being different than the first. | 10-18-2012 |
20130180956 | Low-Profile Circuit Breaker - A circuit interrupter having a compact design. According to some implementations, the circuit interrupter includes a conductor from a terminal to a contact having a portion that is angled with respect to the housing sides. This allows a fastener sleeve used to secure the device housing to be positioned closer to the center of mass of the housing, reducing the area of the housing. In some implementations, an arc splitter is provided which includes conductive plates that are angled with respect to the housing sides, allowing the area of the housing to be reduced. In some implementations, a terminal is designed to accommodate a connection without being doubled back, reducing the clearance required for the terminal and the overall area of the circuit interrupter. | 07-18-2013 |
20140062623 | REMOTE OPERATED CIRCUIT BREAKER - A circuit breaker having a movable contact arm for opening and closing the circuit which is controlled separately by a circuit breaker mechanism for circuit protection and by a switch lever mechanism which does not require actuation of the circuit breaker mechanism to function. The switch lever may be activated by a solenoid or other suitable means, and various interlocking mechanical states exist among the elements that provide added safety features. | 03-06-2014 |
20140076700 | Circuit Breaker With Arc Shield - A circuit breaker which includes a shielding component. The shielding component includes an external portion which defines a space external to the circuit breaker housing. The external portion prevents insertion of the circuit breaker into a breaker box closer than the distances defining the space. This can have the advantage of preventing arcing from the breaker contacts to the breaker box. The external portion may also prevent insertion of the circuit breaker into a breaker box such that a vent in the circuit breaker housing is blocked. In some implementations, the shielding component contains an internal portion which extends into the circuit breaker housing and is disposed to impede debris generated by contact arcing, or other debris, from entering the mechanism of the circuit breaker. | 03-20-2014 |
20140251959 | Arc Shield - A circuit breaker includes a shielding component having an external portion which defines a space external to the circuit breaker housing and covers a vent in the circuit breaker housing to direct gasses and debris from the vent to an outlet. The external portion also prevents insertion of the circuit breaker into a breaker box closer than the distances defining the space. This can have the advantage of preventing arcing from the breaker contacts to the breaker box. The external portion may also prevent insertion of the circuit breaker into a breaker box such that a vent in the circuit breaker housing is blocked. In some implementations, the shielding component contains an internal portion which extends into the circuit breaker housing and is disposed to impede debris generated by contact arcing, or other debris, from entering the mechanism of the circuit breaker. | 09-11-2014 |
20140354380 | Remote Operated Circuit Breaker - A circuit breaker having a movable contact arm for opening and closing the circuit which is controlled separately by a circuit breaker mechanism for circuit protection and by a switch lever mechanism which does not require actuation of the circuit breaker mechanism to function. The switch lever may be activated by a solenoid or other suitable means, and various interlocking mechanical states exist among the elements that provide added safety features. | 12-04-2014 |
20150070114 | Remote Operated Circuit Breaker With Manual Reset - A circuit breaker having a movable contact arm for opening and closing the circuit which is controlled separately by a circuit breaker mechanism for circuit protection and by a switch lever mechanism which does not require actuation of the circuit breaker mechanism to function. The switch lever may also be activated remotely by a remote actuator, for example, a solenoid. A manual reset mechanism is provided so that, actuation of which, when power has been lost to the remote actuator when the remote actuator is in the off position, moves the remote actuator to the on position, thereby resetting the circuit to the closed state. | 03-12-2015 |
Michael A. Fasano, Watertown, CT US
Patent application number | Description | Published |
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20080247100 | CIRCUIT BREAKERS WITH GROUND FAULT AND OVERCURRENT TRIP - A circuit breaker apparatus may be used to interrupt overcurrent and ground fault in a circuit. The circuit breaker apparatus may include an overcurrent coil for tripping the circuit breaker apparatus, a voltage coil also for tripping the circuit breaker apparatus located proximate to the overcurrent coil, and ground fault electronics connected to the voltage coil and structured to detect a ground fault in the circuit when the ground fault exceeds a threshold level. The ground fault electronics can be structured to send a trip signal to the voltage coil when a ground fault is detected, and the voltage coil can be structured to trip the circuit breaker apparatus when it receives the trip signal from the ground fault electronics. | 10-09-2008 |
Robert A. Fasano, Lake Geneva, WI US
Patent application number | Description | Published |
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20130149509 | Decorative and Protective Covering Process and System - A decorative and protective covering process and system can wrap, decorate and protect: a cabinet, countertop, table, furniture, backsplash, wall tile, shower surround, refrigerator, dishwasher, outdoor grill, air conditioner, elevator, door, wall, floor, ceiling, window sill, window frame, door frame. The wrapped product can be used in: a kitchen, bathroom, offices, garage, lobby, foyer, entryway, dining room, living room, family room, bedroom, bathroom, shower, bar, pantry, basement, utility room, garage, laundry room, den, movie theater, theater, stage, stage scenery, studio set, recreation room, clubhouse, conference room, office, store, motor home, pre-manufactured home, apartment, restaurant, house, hotel, motel, hospital, nursing home, mobile home, trailer, RV interior, boat interior, train interior, bus interior, rehabs, rental unit, condominium, home, townhome, gazebo, porch, outdoor bar, grilling area, etc. The wrapped product can provide a composite assembly with a multi-layer laminated protective decorative cover. | 06-13-2013 |
Steve Fasano, Chapel Hill, NC US
Patent application number | Description | Published |
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20090118367 | INSECTICIDAL COMPOSITIONS WITH DISINFECTANT - Insecticidal compositions having insecticide and disinfectant activity are provided. Preferably, the insecticidal composition contains both an insect control agent and a disinfectant. Particularly low levels (i.e., below 20%) of at least one hydrocarbon are introduced as a solvent. The insecticidal compositions further comprise an emulsifier, buffer and antifoaming agent. These insecticidal compositions are particularly suitable for delivery in a spray for non-industrial environments. In use, the present insecticidal compositions may be applied directly to or in or around any area where it is desired to control pestiferous insects and the fungi, bacteria, viruses and other contaminants associated with them. | 05-07-2009 |