Epstein, MA
Adam Epstein, Chicopee, MA US
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20130085315 | UNIVERSAL BALLOON FOR BRACHYTHERAPY APPLICATOR - A toroidal brachytherapy balloon is provided that fits over any brachytherapy applicator and reproducibly positions the applicator on every use. | 04-04-2013 |
Adam S. Epstein, Wellesley, MA US
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20090133802 | Welded Materials and Method For Making The Same - A method of welding materials includes obtaining a first material having a first thermoplastic layer formed thereon; obtaining a second thermoplastic layer; positioning the first material and the second thermoplastic layer such that the first thermoplastic layer faces the second thermoplastic layer; applying energy to the first thermoplastic layer and the second thermoplastic layer at a first location to establish a first weld; applying energy to the first thermoplastic layer and the second thermoplastic layer at a second location, the second location being offset from the first location, a portion of the second location overlapping a portion of the first location. | 05-28-2009 |
Alan Epstein, Lexington, MA US
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20100122519 | ULTRA-LOW SULFUR FUEL AND METHOD FOR REDUCED CONTRAIL FORMATION - A method of managing contrail formation of a gas turbine engine includes delivering an ultra-low sulfur fuel to a combustor of a gas turbine engine to limit an amount of sulfur byproduct produced in an exhaust of the gas turbine engine. | 05-20-2010 |
20110056208 | REVERSED-FLOW CORE FOR A TURBOFAN WITH A FAN DRIVE GEAR SYSTEM - A gas turbine engine comprises a fan drive gear system, a low spool connected to the fan drive gear system, and a high spool disposed aft of the low spool. The low spool comprises a rearward-flow low pressure compressor disposed aft of the fan drive gear system, and a forward-flow low pressure turbine disposed aft of the low pressure compressor. The high spool comprises a forward-flow high pressure turbine disposed aft of the low pressure turbine, a combustor disposed aft of the high pressure turbine, and a forward-flow high pressure compressor disposed aft of the combustor. | 03-10-2011 |
Alan H. Epstein, Lexington, MA US
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20130220004 | DEBRIS DETECTION IN TURBOMACHINERY AND GAS TURBINE ENGINES - An exemplary debris detection method according to one example embodiment of the present disclosure includes, among other things, monitoring turbomachine performance, and initiating a debris warning when an actual rate of change in turbomachine performance varies from a predicted rate of change in the performance. | 08-29-2013 |
20130223991 | GAS TURBINE ENGINE DRIVING MULTIPLE FANS - A gas turbine engine includes a core engine with a compressor section, a combustor and a turbine. The turbine drives an output shaft, and the output shaft drives at least four gears. Each of the at least four gears extends through a drive shaft to drive an associated fan rotor. | 08-29-2013 |
20140119903 | Gas Turbine Engine With Inlet Particle Separator and Thermal Management - A gas turbine engine includes a nose cone at an inlet end, and spaced radially inwardly of a nacelle. A compressor is downstream of the nose cone. A core inlet delivers air downstream of the nose cone into the compressor. An inlet particle separator includes a manifold for delivering air radially outwardly of the core inlet. Air delivered by the inlet particle separator passes over a heat exchanger before passing to an outlet. | 05-01-2014 |
20150226117 | GAS TURBINE ENGINE WITH DISTRIBUTED FANS - A gas generator has at least one compressor rotor, at least one gas generator turbine rotor and a combustion section. A fan drive turbine is positioned downstream of a path of the products of combustion having passed over the at least one gas generator turbine rotor. The fan drive turbine drives a shaft and the shaft engages gears to drive at least three fan rotors. | 08-13-2015 |
20150300265 | GAS TURBINE ENGINE WITH COOLING SCHEME FOR DRIVE GEAR SYSTEM AND PITCH CONTROL - A gas turbine engine comprises an outer nacelle. A nose cone is spaced radially inward of the outer nacelle. The nose cone defines a particle separator for directing an outer air flow and an inner airflow. The inner airflow is directed through a core inlet to a compressor. The engine further comprises a drive gear system for driving at least one propeller. A variable pitch control system may alter a pitch angle of the at least one propeller. Some of the outer air flow is directed to at least one of the drive gear system and the pitch control system. | 10-22-2015 |
Alexander Epstein, Reading, MA US
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20100293137 | METHOD AND SYSTEM FOR JOURNALING DATA UPDATES IN A DISTRIBUTED FILE SYSTEM - An exemplary embodiment of the present invention provides a method of processing a file system transaction in a distributed file system. The method includes receiving a transaction request from a computer, wherein the transaction request includes file data to be stored and a first segment identifier that determines a destination of the file data. The method also includes generating a first distributed journal record corresponding to the file data. The method also includes generating a first file operation request based, at least in part, on the transaction request. The method also includes sending the first file operation request to a first segment server corresponding to the first segment identifier, wherein the first segment server generates a second distributed journal record corresponding to the file data on a memory device associated with the first segment server. | 11-18-2010 |
Charles B. Epstein, Brookline, MA US
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20090215876 | Mitotic Progression Genes and Methods of Modulating Mitosis - The invention features methods of identifying candidate therapeutic compounds for the treatment of proliferative disorder. The invention also features methods for treating a proliferative disorder. | 08-27-2009 |
Charles D. Epstein, East Longmeadow, MA US
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20130138578 | Systems and Methods for Building Retirement Income - The present application is directed to systems and methods for building retirement income. A desirement mortgage may be determined which represents a maximum value of a user account. A supplemental funding source may be used for achieving the maximum value, and a compound interest source may also be used. Periodic inputs may be automatically inputted into the user account. A desirement date may be determined for achieving the maximum value. Periodically, a choice of account may be adjusted or changed based on achieving the maximum value at the desirement date. | 05-30-2013 |
Daniel Epstein, Somerville, MA US
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20110295725 | METHODS AND APPARATUS FOR AUTOMATED DEPOSIT RECONCILIATION - Methods and apparatus for reconciling bank transactions with stored deposit entries in a practice management system. A plurality of bank transactions received from a bank are processed to select bank deposits from the plurality of bank transactions. A plurality of matching rules are used to automatically match at least some of the selected bank deposits with the stored deposits in the practice management system. A user interface enables a user to review the results of the automatic matching process and to manually match bank deposits to stored deposit entries. The user interface also enables users to reconcile stored deposit entries in the practice management system to bank statements to facilitate the preparation of month-end financial statements. | 12-01-2011 |
20120233068 | METHODS AND APPARATUS FOR HEALTHCARE PAYMENT PROCESSING - Methods and apparatus for facilitating a payment collection process by enabling a patient to pre-authorize payment for future medical services not covered by the patient's healthcare payer. Rather than sending a statement to a patient instructing the payment to remit an outstanding balance, a practice management system automatically applies electronic funds for the patient's outstanding balance in accordance with terms of a contract executed between the patient and the medical practice at the time of service. By including contract terms such as a predefined maximum charge amount and limited contract duration, patients may feel that their electronic account information is safe and that they will be billed only for what they owe. Additionally, medical practices may have better assurance that remittance for medical services will be paid promptly by patients under the terms of the contract. | 09-13-2012 |
20130332186 | METHODS AND APPARATUS FOR HEALTHCARE PAYMENT PROCESSING - Methods and apparatus for facilitating a payment collection process by enabling a patient to pre-authorize payment for future medical services not covered by the patient's healthcare payer. Rather than sending a statement to a patient instructing the payment to remit an outstanding balance, a practice management system automatically applies electronic funds for the patient's outstanding balance in accordance with terms of a contract executed between the patient and the medical practice at the time of service. By including contract terms such as a predefined maximum charge amount and limited contract duration, patients may feel that their electronic account information is safe and that they will be billed only for what they owe. Additionally, medical practices may have better assurance that remittance for medical services will be paid promptly by patients under the terms of the contract. | 12-12-2013 |
Jacob H. Epstein, Medford, MA US
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20130346170 | Customized Customer Loyalty Rewards Program Enhanced Rewards Distribution System and Method - A customer loyalty rewards program random enhanced reward distribution system and method may comprise a server ( | 12-26-2013 |
James Epstein, Sharon, MA US
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20130026978 | POWER SUPPLY FOR DOWNHOLE INSTRUMENTS - A power supply for a downhole instrument is provided. The power supply includes high temperature rechargeable energy storage, power generation capabilities and provides for operation in high temperature environments. A method of fabrication and use are provided. | 01-31-2013 |
20130029215 | Aluminum housing with a hermetic seal - A housing for an energy storage cell includes an interior which provides beneficial properties to fabricators of the cell. The cell may be hermetically sealed by conventional laser welding techniques. | 01-31-2013 |
20130143108 | MECHANICAL HERMETIC SEAL - In one embodiment, a cap for an energy storage cell is provided, the cap including: a body including a dome formed therein, the dome including a through-way; and, an electrode assembly including a hemispherically shaped electrical insulator surrounding an electrode; wherein the insulator is disposed in and hermetically seals the dome and the electrode is electrically separated from the body by the throughway. A method of manufacture and an energy storage cell are also disclosed. | 06-06-2013 |
20140265565 | MODULAR SIGNAL INTERFACE DEVICES AND RELATED DOWNHOLE POWER AND DATA SYSTEMS - A downhole power system is provided that includes an energy storage adapted to operate at high temperatures, and a modular signal interface device that serves to control the energy storage component as well as offer a means of data logging at high temperatures. The controller is fabricated from pre-assembled components that may be selected for various combinations to provide desired functionality. The energy storage may include at least one ultracapacitor. | 09-18-2014 |
20150287961 | Aluminum housing with a hermetic seal - A housing for an energy storage cell includes an interior which provides beneficial properties to fabricators of the cell. The cell may be hermetically sealed by conventional laser welding techniques. | 10-08-2015 |
Oleg Epstein, Belmont, MA US
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20100087429 | SPIRO-TRICYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I | 04-08-2010 |
20110251186 | Amino-Oxazines and Amino-Dihydrothiazine Compounds as Beta-Secretase Modulators and Methods of Use - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I | 10-13-2011 |
20110251190 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and other related conditions. In one embodiment, the compounds have a general Formula I | 10-13-2011 |
20130338177 | Spiro-Amino-Imidazolone and Spiro-Amino-Dihydro-Pyrimidinone Compounds as Beta-Secretase Modulators and Methods of Use - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I), wherein variables A | 12-19-2013 |
20140038954 | Spiro-Amino-Imidazo-Fused Heterocyclic Compounds as Beta-secretase Modulators and Methods of Use - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I, wherein variables A | 02-06-2014 |
20140045828 | AMINO-OXAZINES AND AMINO-DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I | 02-13-2014 |
20140107109 | AMINO-DIHYDROTHIAZINE AND AMINO-DIOXIDO DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 04-17-2014 |
20140213581 | FUSED MULTI-CYCLIC SULFONE COMPOUNDS AS INHIBITORS OF BETA-SECRETASE AND METHODS OF USE THEREOF - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 07-31-2014 |
20140296226 | Amino-Oxazine and Amino-Dihydrothiazine Compounds as Beta-Secretase Modulators and Methods of Use - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A | 10-02-2014 |
20150259308 | AMINO-DIHYDROTHIAZINE AND AMINO-DIOXIDO DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A | 09-17-2015 |
20150266824 | Pyrazole Amide Derivative - The present invention relates to a novel compound having a function of inhibiting RORĪ³ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases. | 09-24-2015 |
20150307521 | AMINO-OXAZINE AND AMINO-DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A | 10-29-2015 |
Samuel Epstein, Marlborough, MA US
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20110130715 | Device and Method for Delivering Micronized Therapeutic Agents in the Body - The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site. | 06-02-2011 |
Samuel Epstein, Boston, MA US
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20090216797 | Utilizing Reference/ID Linking in XML Wrapper Code Generation - Utilizing reference/identification (ID) linking in extensible markup language (XML) wrapper code generation in a data processing system. A code generator receives a type document and reference/ID constraints document and accesses the reference/ID constraints document to translate between XML structures and object structures. | 08-27-2009 |
20120179725 | UTILIZING REFERENCE/ID LINKING IN XML WRAPPER CODE GENERATION - Utilizing reference/identification (ID) linking in extensible markup language (XML) wrapper code generation in a data processing system. A code generator receives a type document and reference/ID constraints document and accesses the reference/ID constraints document to translate between XML structures and object structures. | 07-12-2012 |
Samuel J. Epstein, Marlborough, MA US
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20100145306 | Various Catheter Devices for Myocardial Injections or Other Uses - A catheter device comprising a proboscis shaft and a proboscis disposed within the proboscis shaft. In certain embodiments, the catheter device further comprises an elongate tubular member, wherein the proboscis shaft is disposed within the elongate tubular member. In certain embodiments, the catheter device comprises a tissue surface engagement structure, which has a first configuration and a second configuration. In the second configuration, the tissue surface engagement structure presents a larger transverse profile in comparison to the first configuration. The tissue surface engagement structure may have any of various designs, including an expandable assembly and a hinged assembly. In certain embodiments, a deformable cushion is positioned at the distal end of the proboscis shaft. The deformable cushion comprises a pocket that is filled with a reshapeable material. In certain embodiments, the proboscis shaft comprises a longitudinally compressible portion. | 06-10-2010 |
20130092079 | Coated Medical Device and Method for Manufacturing the Same - The medical device of the invention comprises a surface comprising at least one outermost portion and a plurality of depressions. The depressions occupy at least about 80% of the surface area of the surface. The depressions contain a coating material that preferably comprises a biologically active material and/or polymer, and the outermost portion is substantially free of any coating material. The invention is also directed to a method for manufacturing a medical device. The method comprises applying a coating material to the surface of the medical device by using at least one roller. | 04-18-2013 |
Samuel J. Epstein, Watertown, MA US
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20080215137 | THERAPEUTIC DRIVING LAYER FOR A MEDICAL DEVICE - The present invention regards the delivery of therapeutic at a target site. Systems that employ the present invention may employ a medical device sized to be inserted into a target site, a driving layer covering at least a portion of an accessible surface of the medical device, and a therapeutic interfaced with at least a portion of the driving layer. In this system, the driving layer may have a material characteristic that serves to release the therapeutic from the medical device when the medical device is at the target site. Other systems that employ the invention may also have properties that include having a driving layer with a higher solubility than the therapeutic at the target site, a medical device that is hydrophobic while the therapeutic is hydrophilic, and a coating covering at least a portion of the therapeutic. | 09-04-2008 |
20090143748 | Catheter Devices for Myocardial Injections or Other Uses - A catheter device includes an elongate tubular housing, a cannula, and a flexible proboscis. The cannula defines a cannula lumen which is in fluid communication with a cannula exit port located adjacent the distal end of the elongate housing. The distal tip of the cannula is disposed within the cannula lumen. The cannula defines a proboscis lumen and the cannula has a proboscis exit port in fluid communication with the proboscis lumen. The proboscis exit port is located at the distal tip of the cannula. The flexible proboscis has a distal tip and is disposed within the proboscis lumen. | 06-04-2009 |
Samuel R. Epstein, Boston, MA US
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20100042450 | SERVICE LEVEL MANAGEMENT IN A SERVICE ENVIRONMENT HAVING MULTIPLE MANAGEMENT PRODUCTS IMPLEMENTING PRODUCT LEVEL POLICIES - A change can be identified in service level for a Web service for an entity from a first service level to a second service level. Active policies associated with the first service can be retrieved. The active policies can be policies of a set of different management products of a service environment. For each management product, policies associated with the first service level can be deactivated. Policies associated with the second service level can be retrieved. For each management product, policies associated with the second service level can be activated. In one embodiment, the activation and deactivation of policies can occur automatically using a service level manager that programmatically handles service level specific adjustments across management products. | 02-18-2010 |
Scott Epstein, Boston, MA US
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20090043301 | MONOPOLAR ENERGY DELIVERY DEVICES AND METHODS FOR CONTROLLING CURRENT DENSITY IN TISSUE - Devices, systems and methods for providing energy to treat large areas of tissue. Several embodiments of the devices control resistance or other parameters to provide substantially uniform current density along a length of tissue with reduced edge effects. | 02-12-2009 |
20110319902 | CATHETER DELIVERY SYSTEM - A method for delivering catheters, and stents composed of soft, compliant polymers through anatomical passages. These devices have a bulbous anchorage end with a diameter greater than the rest of the catheter. To facilitate implant and delivery a pusher catheter or sheath with an internal lumen larger than the outer diameter of the catheter but smaller than the outer diameter of the bulbous anchorage end. The distal end of pusher catheter or the sheath physically engages the proximal end of the bulbous anchorage end and applies an axial force to coaxially advance the catheter over a guidewire though anatomical passages. This method allows a physician to move the catheter to an anatomical site without the device exhibiting buckling due to axial force applied. Similarly, this delivery method will allow more force to be applied to the distal end of the catheter diminishing the likelihood of buckling. | 12-29-2011 |
Scott M. Epstein, Boston, MA US
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20120178874 | STRUCTURAL HYDROGEL POLYMER DEVICE - The present invention relates generally a manufacturing process which results in a completely hydrogel polymer device that maintains lumen patency which allows for numerous applications. Catheters and stents are particular examples, and their composition, mechanical characteristics, and the significantly unique ability to conduct and allow fluids to pass from one end to the other without physiological rejection, inflammation, or manifestation of complications due to implant or otherwise undesirable outcomes when used for ambulatory and or therapeutic interventions is the purpose of the invention. | 07-12-2012 |
20140343684 | CATHETER OR STENT DELIVERY SYSTEM - A method for delivering catheters, and stents composed of soft, compliant polymers through anatomical passages. These devices have a bulbous anchorage end with a diameter greater than the rest of the catheter. To facilitate implant and delivery a pusher catheter or sheath with an internal lumen larger than the outer diameter of the catheter but smaller than the outer diameter of the bulbous anchorage end. The distal end of pusher catheter or the sheath physically engages the proximal end of the bulbous anchorage end and applies an axial force to coaxially advance the catheter over a guidewire though anatomical passages. This method allows a physician to move the catheter to an anatomical site without the device exhibiting buckling due to axial force applied. Similarly, this delivery method will allow more force to be applied to the distal end of the catheter diminishing the likelihood of buckling. | 11-20-2014 |
Slava Epstein, Dedham, MA US
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20150313960 | NOVEL DEPSIPEPTIDE AND USES THEREOF - The present invention relates generally to novel depsipeptides, to methods for the preparation of these novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptides to treat or inhibit various disorders. | 11-05-2015 |
Slava S. Epstein, Dedham, MA US
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20120302613 | NOVEL ANTIBIOTICS - The invention relates generally to novel antibiotics and their analogs, to processes for the preparation of these novel antibiotics, to pharmaceutical compositions comprising the novel antibiotics; and to methods of using the novel antibiotics to treat or inhibit various disorders. | 11-29-2012 |
Todd Aaron Epstein, Salem, MA US
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20130180989 | CONTAINER - Disclosed is an improved container including a container body defining a container cavity, the improved container including a container top configured to create at least two container openings via at least at least partial depression of at least two container portions into the cavity defined by the container body. | 07-18-2013 |
20140144108 | CONTAINER - Disclosed is an improved container including a container body defining a container cavity, the improved container including a container top configured to create at least two container openings via at least at least partial depression of at least two container portions into the cavity defined by the container body. | 05-29-2014 |