Engelhardt, US
Ashley E. Engelhardt, Greenwood, IN US
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20100051502 | CARRIER HAVING INTEGRAL DETECTION AND MEASUREMENT OF ENVIRONMENTAL PARAMETERS - A carrier includes an enclosure for storing articles sensitive to electrostatic discharge (ESD) and a replacement component that is affixed to the enclosure as an integral component of the carrier. The replacement component includes a housing that provides an enclosure for a device having a sensor for sensing one or more environmental parameters. At least one of the sensed environmental parameters is an ESD parameter. | 03-04-2010 |
Barbara Engelhardt, San Francisco, CA US
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20110060736 | Query Revision Using Known Highly-Ranked Queries - An information retrieval system includes a query revision architecture providing one or more query revisers, each of which implements a query revision strategy. A query rank reviser suggests known highly-ranked queries as revisions to a first query by initially assigning a rank to all queries, and identifying a set of known highly-ranked queries (KHRQ). Queries with a strong probability of being revised to a KHRQ are identified as nearby queries (NQ). Alternative queries that are KHRQs are provided as candidate revisions for a given query. For alternative queries that are NQs, the corresponding known highly-ranked queries are provided as candidate revisions. | 03-10-2011 |
Brian S. Engelhardt, San Diego, CA US
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20140212936 | Solventless Extraction Process - The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing water soluble compound and/or materials by washing the lysed cell mixtures with aqueous washing solutions until a substantially non-emulsified lipid is obtained. | 07-31-2014 |
David G. Engelhardt, Canton, CT US
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20130001435 | Combination Electronic Device Dock and Dissinfector - Disclosed is a disinfecting docking station for at least one portable electronic device, such as a medical technician's tablet computer, that has at least one recharging connector. An enclosure is adapted to receive the at least one portable electronic device therein through an openable side that includes a selectively closable door. Each electronic device is exposed to a disinfecting wavelength of light, such as UV light, to disinfect the surface of the device. The enclosure includes supports that minimally contact each device so that the device will be substantially exposed to the UV light. A control circuit monitors the exposure time and level, and is programmable to activate the UV light based on pre-set criteria. The enclosures may be stacked and provide power and network connectivity to each device while docked therein. | 01-03-2013 |
20140248179 | COMBINATION ELECTRONIC DEVICE DOCK AND DISSINFECTOR - Disclosed is a disinfecting docking station for at least one portable electronic device, such as a medical technician's tablet computer, that has at least one recharging connector. An enclosure is adapted to receive the at least one portable electronic device therein through an openable side that includes a selectively closable door. Each electronic device is exposed to a disinfecting wavelength of light, such as UV light, to disinfect the surface of the device. The enclosure includes supports that minimally contact each device so that the device will be substantially exposed to the UV light. A control circuit monitors the exposure time and level, and is programmable to activate the UV light based on pre-set criteria. The enclosures may be stacked and provide power and network connectivity to each device while docked therein. | 09-04-2014 |
20150182648 | COMBINATION ELECTRONIC DEVICE DOCK AND DISSINFECTOR - Disclosed is a disinfecting station for at least one portable electronic device. An enclosure is adapted to receive the at least one portable electronic device therein through an openable side that includes a selectively closable door. Each electronic device is exposed to a disinfecting wavelength of light, such as UV light, to disinfect the surface of the device. The enclosure can include supports that minimally contact each device so that the device will be substantially exposed to the UV light. A control circuit can monitor the exposure time and level, and is programmable to activate the UV light based on pre-set criteria. The enclosures may be stacked and provide power and network connectivity to each device while docked therein. | 07-02-2015 |
Dean Engelhardt, New York, NY US
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20100273145 | ASSAY METHOD UTILIZING POLYNUCLEOTIDE SEQUENCES - A method of detecting in a sample an analyte (A) having a molecularly recognizable portion thereon, which comprises: providing (B) a molecular bridging entity having thereon: (i) a portion capable of recognizing the molecularly recognizable portion on the analyte; and (ii) a portion comprising a polynucleotide sequence; and (C) a signalling entity having thereon: (i) a polynucleotide portion capable of annealing to the polynucleotide portion of the bridging entity, thereby to form a stable polynucleotide hybrid, and (ii) a signal generating portion; forming a complex comprising: (1) the analyte (A) complexed through its molecularly recognizable portion to (2) the recognizing portion of the entity (B); the entity (B) being complexed through the polynucleotide portion thereon to (3) the polynucleotide portion of the signalling entity; and detecting a signal by means of the signal generating portion present in the complex. | 10-28-2010 |
Dean L. Engelhardt, New York, NY US
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20080248564 | NOVEL PROPERTY EFFECTING AND/OR PROPERTY EXHIBITING COMPOSITIONS FOR THERAPEUTIC AND DIAGNOSTIC USES - The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits. | 10-09-2008 |
20090068731 | Novel process, construct and conjugate for producing multiple nucleic acid copies - This invention provides inter alia an in vitro process for producing multiple specific nucleic acid copies in which the copies are produced under isostatic conditions, by degradation of primer sequences from extended primers, thereby allowing subsequent priming events on the same template. | 03-12-2009 |
20100021500 | Processes for treating subjects carrying viral infectious agent - This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or adminstering to a subject one or more antigens, or trained or adopted immune cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention. | 01-28-2010 |
20110097791 | Novel process, construct and conjugate for producing multiple nucleic acid copies - This invention provides inter alia an in vitro process for producing multiple specific nucleic acid copies in which the copies are produced under isostatic conditions, e.g., temperature, buffer and ionic strength, and independently of any requirement for introducing an intermediate structure for producing the copies. In other aspects, the invention provides in vitro processes for producing multiple specific nucleic acid copies in which the products are substantially free of any primer-coded sequences, such sequences having been substantially or all removed from the product to regenerate a primer binding site, thereby allowing new priming events to occur and multiple nucleic acid copies to be produced. This invention further provides a promoter-independent non-naturally occurring nucleic acid construct that produces a nucleic acid copy or copies without using or relying on any gene product that may be coded by the nucleic acid construct. Another aspect of this invention concerns a protein-nucleic acid construct in the form of a conjugate linked variously, e.g., covalent linkage, complementary nucleic acid base-pairing, nucleic acid binding proteins, or ligand receptor binding. Further disclosed in this invention is an in vivo process for producing a specific nucleic acid in which such a protein-nucleic acid construct conjugate is introduced into a cell. A still further aspect of the invention relates to a construct comprising a host promoter, second promoter and DNA sequence uniquely located on the construct. The host transcribes a sequence in the construct coding for a different RNA polymerase which after translation is capable of recognizing its cognate promoter and transcribing from a DNA sequence of interest in the construct with the cognate promoter oriented such that it does not promote transcription from the construct of the different RNA polymerase. | 04-28-2011 |
Gary Engelhardt, San Jose, CA US
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20150043208 | LED LIGHTING DEVICE - A light-emitting diode (“LED”) based lighting fixture is provided. The LED based lighting fixture includes at least one reflector having a reflective enhancing material to reflect light and at least one frame are attached on a top surface of at least one housing. Further, one or more LED module mounted on a top surface of the at least one frame to emit light, the at least one frame oriented at an angle in a range of 10° to 45° degrees or approximately 30° degrees extending from a plane perpendicular to a plane of the top surface of the at least one housing. Finally, at least one lens such as a frost lens or a translucent lens can be positioned approximate to a bottom surface of the at least one housing for reflective light to emit there through. | 02-12-2015 |
Jeffrey S. Engelhardt, Jacksonville, FL US
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20120030240 | ENTERPRISE CONTENT MANAGEMENT FEDERATION AND INTEGRATION SYSTEM - An enterprise content management federation and integration system integrates a plurality of applications and federates information seamlessly by receiving, by a composite system, a request from a client system. The system then translates, by a manager system, the request from the client system. The manager system performs one or more high level validations and retrieves information from a mapping stored by an ontology modeling system, a plurality of content types, repositories, actions and object types based at least in part on a plurality of attributes including one or more metadata models or attribute models. The manager system then invokes one or more composites based at least in part on the request from the client system and some or all the information retrieved from the mapping. | 02-02-2012 |
John Engelhardt, Greenwich, CT US
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20080297162 | Electrical Instrument Platform for Mounting on and Removal from an Energized High Voltage Power Conductor - An apparatus for monitoring and measuring the electrical, thermal and mechanical operating parameters of high voltage power conductors. A toroidal shaped housing, which can be mounted onto an energized conductor, contains all of the necessary electrical instruments to monitor the parameters associated with the conductor. Moreover, the housing includes the processing capability to analyze disturbance and fault events based on these parameters. | 12-04-2008 |
20090138229 | POWER LINE TEMPERATURE AND SAG MONITOR SYSTEM - The combination of a temperature sensor and an inclination sensor or the combination of a temperature sensor and a tension monitor properly positioned in conjunction with an energized electrical conductor produces outputs that are dependent on the conductor's average temperature in real time. A transmitter is used to communicate this information in real time to a central location such that up to optimal or maximum power transmission is feasible through the conductor while maintaining a safe clearance to the ground. This allows for close monitoring of thermal expansion resulting from increased load as well as varying environmental conditions. | 05-28-2009 |
John Engelhardt, Iowa City, IA US
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20090241203 | Transgenic animal models of disease - The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions. | 09-24-2009 |
20120180141 | Transgenic Animal Models of Disease - The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions. | 07-12-2012 |
John J. Engelhardt, Fremont, CA US
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20150322119 | ENHANCING ANTI-CANCER ACTIVITY OF IMMUNOMODULATORY FC FUSION PROTEINS - The present disclosure provides a method for enhancing the anti-tumor efficacy of an Fc fusion protein which binds specifically to a target, e.g., a co-inhibitory or co-stimulatory receptor of ligand, on a T cell in a subject afflicted with a cancer or a disease caused by an infectious agent and alters the activity of the immunomodulatory target, thereby potentiating an endogenous immune response against cells of the cancer or the infectious agent, wherein the method comprises selecting, designing or modifying the Fc region of the Fc fusion protein so as to enhance the binding of said Fc region to an activating Fc receptor (FcR). The disclosure also provides an Fc fusion protein produced by said method which has an enhanced ability to potentiate an endogenous immune response against cells of a cancer or an infectious agent in a subject. The disclosure further provides a method for treating a subject which comprises administering to the subject a therapeutically effective amount of an Fc fusion protein, wherein the Fc region of the Fc fusion protein has been selected, designed or modified so as to increase the binding of said Fc region to an activating FcR. | 11-12-2015 |
Johnnie Engelhardt, West Columbia, TX US
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20120108469 | APPARATUS FOR COMBINATORIAL SYNTHESIS - Apparatus and methods are described for split synthesis combinatorial chemistry that provides candidate libraries where an even distribution of theoretical products is obtainable through even mixing during the pooling step, followed by controlled redistribution of the mixed pooled products from the prior addition step into separate synthesis columns, one for each different specie of subunit to be added. | 05-03-2012 |
20140100120 | METHODS OF X-APTAMER GENERATION AND COMPOSITIONS THEREOF - Provided herein are methods for a novel bead-based next-generation “X-aptamer” selection scheme that extends aptamer technology to include X-modified bases, thus resulting in X-aptamers, at any position along the sequence because the aptamers are chemically synthesized via a split-pool scheme on individual beads. Also provides are application to a wide range of commonly used DNA modifications, including, but not limited to, monothioate and dithioate backbone substitutions. This new class of aptamer allows chemical modifications introduced to any of the bases in the aptamer sequence as well as the phosphate backbones and can be extended to other carbohydrate-based systems. | 04-10-2014 |
Michael Thomas Engelhardt, Sunnyvale, CA US
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20110037446 | SWITCH MODE POWER SUPPLY WITH DYNAMIC TOPOLOGY - A power supply system has an inductive device, a plurality of switching devices for providing connection of the inductive device to input and output nodes and a ground node, and a switch driver circuit for driving the switching devices so as to enable the power supply to operate in a boost mode to increase the input voltage, in a buck mode to decrease the input voltage, and in a solid-state flyback mode to transfer between the boost mode and the buck mode. In the solid-state flyback mode, the switching devices are controlled to provide switching of the inductive device between an input state in which the inductive device is connected between the input node and the ground node, and an output state in which the inductive device is connected between the ground node and the output node. | 02-17-2011 |
20130207629 | NEGATIVE SLOPE COMPENSATION FOR CURRENT MODE SWITCHING POWER SUPPLY - Generated are an error signal representative of a difference between a signal representative of the output voltage of a current mode switching power supply and a reference voltage, and a peak current threshold signal that is indicative of a peak current that should be reached in an inductor within the power supply during each cycle of a periodic clock signal and that has a level that is based on the error signal. A switch control signal regulates the voltage output of the power supply by closing and then opening a power switch during each cycle of the periodic clock signal. Timing of opening is based on the peak current threshold signal. Negative slope compensation causes the switch control circuit to delay opening the power switch during each cycle of the periodic clock signal in an amount that decreases with increasing duty cycles of the switch control signal. | 08-15-2013 |
Michel Engelhardt, Woodbury, NY US
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20110196540 | ENVIRONMENTAL CONTROL SYSTEM FOR PRECISION AIRBORNE PAYLOADS - Outside air enters a ram air scoop on an aircraft frame, and is ducted to a ram air control valve. The air control valve outputs a desired air mass flow to a cyclone air-water separator which removes moisture and produces a dry air flow. A heater assembly heats the dry air to a desired temperature and directs the heated air into an equipment bay enclosure on the aircraft. The relative humidity of the heated air is sensed by an air moisture sensor which produces a corresponding signal. Other sensors disposed near a payload in the bay enclosure produce corresponding air temperature and air pressure signals. All the sensor signals are input to a processor or controller configured to activate the air control valve and the heater assembly according to set points for temperature and humidity that are specified for the payload in the bay enclosure. | 08-11-2011 |
20140153193 | PHASE CHANGE HEAT SINK FOR TRANSIENT THERMAL MANAGEMENT - A heat dissipating assembly, for dissipating heat, having at least one heat producing component and a heat sink having phase change material conductively coupled to the at least one heat producing component. | 06-05-2014 |
20150075754 | SINGLE-PASS COLD PLATE ASSEMBLY - A single-pass cold plate assembly having a base and a cover arranged in confronting relationship to define a cold plate with a spiral channel and a manifold with the manifold having a manifold inlet and a manifold outlet and where coolant may be introduced into the manifold inlet and may complete a single pass through the cold plate assembly. | 03-19-2015 |
Michel Engelhardt, Bohemia, NY US
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20150068703 | THERMAL MANAGEMENT SYSTEM AND METHOD OF ASSEMBLING THE SAME - A thermal management system for cooling a heat source onboard an aircraft that has a frame and a skin coupled to the frame such that the skin has a first segment and a second segment includes a first network of heat pipes coupled in conductive heat transfer with the heat source and the first segment of skin. The first network of heat pipes is configured to heat the first segment of skin using heat from the heat source. The thermal management system further includes a second network of heat pipes coupled in conductive heat transfer with the heat source and the second segment of skin. The second network of heat pipes is configured to heat the second segment of skin using heat from the heat source. The thermal management system is configured to selectively deactivate the first network of heat pipes and the second network of heat pipes. | 03-12-2015 |
Thomas Engelhardt, Chapel Hill, NC US
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20150321733 | Article of manufacture for improving safety on floating docks - An article of manufacture for improving the safety on floating docks alongside fixed landing decks or piers with a barrier affixed to the edge of the landing deck, fastening mechanism to mount the barrier to the landing deck, weights affixed to, or embedded into, the bottom part of barrier to ensure contact with the floating dock, and a guiding mechanism such as ropes affixed to landing deck and floating dock to ensure that barrier will always reconnect with the floating dock in case of separation. | 11-12-2015 |
Timothy P. Engelhardt, Avon, IN US
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20140066735 | DIABETES MANAGER FOR GLUCOSE TESTING AND CONTINUOUS GLUCOSE MONITORING - A handheld diabetes management device for managing blood glucose test data and continuous glucose monitoring data includes a port configured to receive a test strip, a wireless transceiver, a communications processor, and a user interface processor. The communications processor communicates with the wireless transceiver to periodically collect glucose measurement data from a continuous glucose monitoring device and to store the glucose measurement data in a first data storage module. The communications processor is operable to consume electrical power at a first rate. The user interface processor communicates with the communication processor to receive the glucose measurement data and operable to display the glucose measurement data on the device. The communications processor operates asynchronously from operation of the user interface processor to collect the glucose measurement data and the user interface processor operates to consume electrical power at a second rate that is higher than the first rate. | 03-06-2014 |
Timothy Peter Engelhardt, Avon, IN US
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20120165639 | STORAGE OF CALIBRATION DATA AT A CONTINUOUS GLUCOSE MONITOR - A method for storing data at a continuous glucose monitor is presented. The method includes measuring the blood glucose level of the patient. The method also includes receiving a plurality of physical attributes related to the glucose level of the patient. The method further includes determining calibration data based on the measured blood glucose level and at least one of the plurality of physical attribute samples, the calibration data configured to allow the handheld diabetes managing device to determine the estimated glucose level of the patient based on the plurality of physical attribute samples. Finally, the method includes transmitting the calibration data from the handheld diabetes managing device to the continuous glucose monitor for storage at the continuous glucose monitor. The calibration data and plurality of physical attribute samples can be retrieved by a separate device to determine an estimated glucose level of the patient. | 06-28-2012 |
20120166126 | CALIBRATION OF A HANDHELD DIABETES MANAGING DEVICE THAT RECEIVES DATA FROM A CONTINUOUS GLUCOSE MONITOR - A method for calibrating a handheld diabetes managing device based on data generated by a continuous glucose monitor. The method can include sampling a current of the continuous glucose monitor at a sampling interval over a time period to generate a plurality of current samples for the time period. The method can also include determining a mean, median and standard deviation of the plurality of current samples. The blood glucose level of the patient can be measured at a first time and a calibration equation that associates the plurality of current samples with the estimated glucose level of the patient based on the measured blood glucose level and the plurality of current samples can be determined when the standard deviation is less than a first threshold and an absolute value of a difference between the mean and median is less than a second threshold. | 06-28-2012 |
William E. Engelhardt, Morning View, KY US
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20150107959 | Product Transfer System And Related Methods - System and methods for providing a transfer of products with the ability to match speed and position, and to change the incoming products from a narrow-edge-leading orientation to broad-edge-leading orientation, and to convey the products to a location to be grouped and transferred. | 04-23-2015 |