Patent application number | Description | Published |
20090124695 | PROSTAGLANDIN E1 AND E2 ANALOGS FOR THE TREATMENT OF VARIOUS MEDICAL CONDITIONS - A prostaglandin analog with selectivity to EP receptors and demonstrating EP agonist activity that may be used to expand hematopoietic stem cell populations or to treat or prevent influenza, bone fracture, bone disease, glaucoma, ocular hypertension, dysmenorrhoea, pre-term labor, immune disorders, osteoporosis, asthma, allergy, male sexual dysfunction, female sexual dysfunction, periodontal disease, gastric ulcer, renal disease, or other EP receptor-mediated conditions. | 05-14-2009 |
20090221654 | PROSTAGLANDIN E1 AND E2 ANALOGS FOR THE TREATMENT OF VARIOUS MEDICAL CONDITIONS - A prostaglandin analog with selectivity to EP receptors and demonstrating EP agonist activity that may be used to expand hematopoietic stem cell populations or to treat or prevent influenza, bone fracture, bone disease, glaucoma, ocular hypertension, dysmenorrhoea, pre-term labor, immune disorders, osteoporosis, asthma, allergy, male sexual dysfunction, female sexual dysfunction, periodontal disease, gastric ulcer, renal disease, or other EP receptor-mediated conditions. | 09-03-2009 |
20090286261 | METHOD FOR ASSAYING COMPOUNDS OR AGENTS FOR ABILITY TO DISPLACE POTENT LIGANDS OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE - An exemplary embodiment may be directed to a fluorescence polarization assay that screens compounds or agents for their affinity to hematopoietic prostaglandin D synthase (H-PGDS) based on their ability to displace a fluorophore-containing detection analyte bound to an enzyme comprising the primary amino acid sequence of H-PGDS. Another exemplary embodiment utilizes an enzyme having a maltose binding protein amino-acid sequence fused with an N-terminus of the enzyme. | 11-19-2009 |
20100075990 | MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES - Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D | 03-25-2010 |
20120041229 | METHODS FOR MANUFACTURING TETRANOR-PROSTAGLANDIN D, J, E, A AND F METABOLITES - The present invention generally relates to synthetic methods for preparing tetranor-prostaglandin D, J, E, A, and F metabolites. | 02-16-2012 |
20130079375 | MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES - Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D | 03-28-2013 |
Patent application number | Description | Published |
20080279644 | CUTTING TOOL INSERT HAVING INTERNAL MICRODUCT FOR COOLANT - A cutting tool insert includes: a body defining a rake face, a flank face, and a cutting edge at an intersection of the rake and flank faces; and a cooling microduct within the body. A portion of the microduct extends along the cutting edge not more than 0.5 millimeter from the rake face, and not more than 0.5 millimeter from the flank face. The microduct has a cross-sectional area of not more than 1.0 square millimeter. The microduct is adapted to permit the flow of a coolant therethrough to transfer heat away from the cutting edge and extend the useful life of the insert. Secondary conduits having cross-sectional area no larger than 0.004 square millimeter may communicate between the microduct and the rake and/or flank face to exhaust coolant behind the cutting edge and further enhance cooling. | 11-13-2008 |
20090175695 | ROTARY METAL-CUTTING INSERT AND MOUNTING CARTRIDGE THEREFOR - The flow of heat energy from the cutting edge rim of a self-propelled round annular rotary cutting element (“insert”) to axial-load and radial-load bearings in a cartridge which rotatably supports the insert on a machine tool body is reduced by defining heat flow paths from the insert rim to cartridge components which engages the bearings to have low thermal conductance relative to heat flow paths from the insert rim to other parts of the cartridge. Control over heat flow path thermal conductance is obtained by selection of materials used between the insert rim and the mentioned cartridge components, by reductions in the cross-sectional areas of the critical heat flow paths, and by combinations of those two techniques. Protection of the bearings from heat enables the insert and the cartridge to be reduced in size. Improved mountings of insert-supportive cartridges to tool bodies are disclosed. The insert and the cartridge preferably are shaped to enable the insert to be positioned on a tool body so that the insert's rake face can have a positive rake orientation relative to a workpiece. Arrangements for controlling cuttings chip formation and for handling cuttings chips also are disclosed. | 07-09-2009 |
20110002750 | CUTTING TOOL INSERT HAVING INTERNAL MICRODUCT FOR COOLANT - A cutting tool insert includes: a body defining a rake face, a flank face, and a cutting edge at an intersection of the rake and flank faces; and a cooling microduct within the body. The microduct has a cross-sectional area of not more than 1.0 square millimeter. The microduct is adapted to permit the flow of a coolant therethrough to transfer heat away from the cutting edge and extend the useful life of the insert. The microduct may have a portion with a cross-sectional area no larger than 0.004 square millimeter, and may communicate through at least one of the rake fact and the flank face to exhaust coolant near the cutting edge and further enhance cooling. | 01-06-2011 |
20120082518 | MICRO-JET COOLING OF CUTTING TOOLS - A cutting tool includes an insert defining a flank face, a rake face, and a cutting edge between the flank face and rake face. The cutting tool includes micro-nozzles formed in at least one of the tool body and the insert, and aimed at the cutting edge. Each micro-nozzle generates a micro jet of cutting fluid in close proximity to the cutting edge and adjacent to at least one of the flank face and the rake face. | 04-05-2012 |
20140294522 | ROUND WIPER TOOTH AND FACE MILL INCORPORATING THE SAME - A milling tool includes a body which is rotatable about a first axis. At least one cutting tooth mounted on the body having a cutting edge for cutting about the first axis. A wiper tooth extends from the mill body. The wiper tooth includes at least at a portion having a peripheral surface about the second axis and the peripheral surface intersects a face surface defining a cutting edge that is round about the second axis for cutting about the first axis. In some embodiments, the peripheral surface, the face surface and the cutting edge are formed on an insert that is mounted the mill body. | 10-02-2014 |