Patent application number | Description | Published |
20100172943 | PEPTIDE NANOPARTICLES AND USES THEREFOR - The present invention provides nanoparticle compositions including one or more peptides. The present invention achieves transdermal delivery of such peptides without the need for peptide modification, or for use of chemical or mechanical abrasion or disruption of skin. | 07-08-2010 |
20110212157 | DERMAL DELIVERY - The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and/or actinic keratosis. Methods generally involve administering nanoemulsions (e.g., nanoparticle compositions) comprising at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared, e.g., by high pressure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm. | 09-01-2011 |
20110305734 | NUCLEIC ACID NANOPARTICLES AND USES THEREFOR - The present invention provides nanoparticle compositions including one or more nucleic acids. The present invention achieves delivery (particularly transdermal delivery) of such nucleic acids without the need for nucleic acid modification, or for use of chemical or mechanical abrasion or disruption of skin. | 12-15-2011 |
20120164182 | Botulinum nanoemulsions - The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision. | 06-28-2012 |
20120321571 | PARABEN COMPOSITIONS - The present invention provides paraben compositions and associated methods and reagents, particularly useful for the treatment of dermatologic conditions. In some embodiments, provided compositions are formulated for and achieve transdermal delivery, for example by topical administration. | 12-20-2012 |
20120321579 | SURFACTANT COMPOSITIONS - The present invention provides surfactant compositions and associated methods and reagents, particularly useful for the treatment of dermatologic conditions. In some embodiments, provided compositions are formulated for and achieve transdermal delivery, for example by topical administration. | 12-20-2012 |
20120328525 | NANOPARTICLE COMPOSITIONS AND COMPONENTS THEREOF - The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and/or actinic keratosis, among others. Methods generally involve administering provided compositions to the skin. | 12-27-2012 |
20120328549 | OIL COMPOSITIONS - The present invention provides oil compositions and associated methods and reagents, particularly useful for the treatment of dermatologic conditions. In some embodiments, provided compositions are formulated for and achieve transdermal delivery, for example by topical administration. | 12-27-2012 |
20120328701 | NANOPARTICLE COMPOSITIONS, FORMULATIONS THEREOF, AND USES THEREFOR - The present invention describes novel nanoparticle compositions, and systems and methods utilizing them for treating disorders and/or conditions. Methods generally involve administering nanoparticle compositions (e.g., nanoparticle compositions comprising at least one known therapeutic agent and/or independently active biologically active agent; and/or empty nanoparticle compositions) to a subject in need thereof. | 12-27-2012 |
20120328702 | NANOPARTICLE COMPOSITIONS - The present invention describes novel nanoparticle compositions, and systems and methods utilizing them for treating disorders and/or conditions associated with the epidermal and/or dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, actinic keratosis, facial wrinkles, muscle contracture, and headache. Methods generally involve administering nanoparticle compositions to the skin. | 12-27-2012 |
20140099342 | BOTULINUM NANOEMULSIONS - The embodiment described herein are related nanoemulsions comprising | 04-10-2014 |
20140234382 | PEPTIDE NANOPARTICLES AND USES THEREFOR - The present invention provides nanoparticle compositions including one or more peptides. The present invention achieves transdermal delivery of such peptides without the need for peptide modification, or for use of chemical or mechanical abrasion or disruption of skin. | 08-21-2014 |
20150196490 | NANOPARTICLE COMPOSITIONS - The present invention describes novel nanoparticle compositions, and systems and methods utilizing them for treating disorders and/or conditions associated with the epidermal and/or dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, actinic keratosis, facial wrinkles, muscle contracture, and headache. Methods generally involve administering nanoparticle compositions to the skin. | 07-16-2015 |
20150313536 | Demonstrable Efficacy Across or Within Patient Populations - The present invention provides methods for improving observed or determined efficacy by administration of agents to more severely diseased subjects, as contrasted with less severely diseased subjects. The present disclosure specifically demonstrates that, with respect to treatment of certain skin conditions, and particularly conditions associated with dysregulated and/or diseased skin cells, administration to more severely diseased subjects improves observed or determined efficacy. | 11-05-2015 |
20150313819 | Methods to Treat, Prevent, and Improve Skin Conditions - The present invention provides antagonists of acetylcholine receptors for the treatment of skin conditions. The present invention achieves treatment of skin conditions without causing the severe damage to the skin associated with antagonism of nicotinic acetylcholine receptors. | 11-05-2015 |
Patent application number | Description | Published |
20130062466 | MOTOR AND GEARING SYSTEM FOR AIRCRAFT WHEEL - A compact in-wheel vehicle motor and gearing system designed to meet high power and torque requirements for driving a vehicle on the ground independently of other power sources is provided. The motor and gearing system includes a motor assembly with an outside rotor element mounted for rotation about an inside stator element and a gear assembly with a plurality of gear stages mounted inside the stator and drivingly connected to the motor assembly. The motor assembly and gear assembly are mounted interiorly of the wheel and completely within a space defined by the internal dimensions of the wheel. This motor and gearing system can be effectively installed in an existing aircraft wheel without changes to other components to produce a drive wheel with the torque and power required to move the aircraft independently on the ground. | 03-14-2013 |
20130088860 | SYSTEM AND METHOD FOR GENERATING ARTIFICIAL LIGHT - A system and method for generating artificial light for interior or exterior illumination are provided to illuminate interior and exterior underground, underwater, ground level, and above ground structures and spaces by employing various combinations of solar photovoltaic-generated power and conventional power to directly power LED or other light sources to provide interior or exterior illumination of a desired optimal intensity. One embodiment of this system provides a virtual skylight that illuminates interior structures and spaces with the benefits of illumination provided by a conventional skylight but without the disadvantages. A direct connection between a solar photovoltaic cell and the LED or other light-producing source eliminates complex and costly circuitry in both interior and exterior applications. The system is configured to provide, alternatively, solar PV power and/or conventional power as required to maintain artificial illumination at a desired optimum threshold intensify. | 04-11-2013 |
20150253773 | AIRCRAFT GROUND TRAVEL TRACTION CONTROL SYSTEM AND METHOD - A traction control system and method are provided for an aircraft equipped with a ground travel drive system with drive wheels powered by onboard wheel drive means that are capable of translating torque through the aircraft drive wheels and that are automatically controllable to control traction without reliance on the aircraft's brakes to keep the aircraft moving efficiently and autonomously on the ground under a range of environmental conditions. | 09-10-2015 |
20150336660 | ELECTRIC POWER CONNECTOR FOR AIRCRAFT DRIVE WHEEL DRIVE SYSTEM - An electric connector assembly is provided that is designed to provide a simple and reliable electric connection between a source of electric power on an aircraft and a plurality of electrical connections, such as those from stator windings, in an electric drive means powering an aircraft landing gear drive wheel. The plurality of drive means electrical connections are individually connected to power distribution elements designed to significantly reduce the number of connectors required to establish an electrical connection between the drive means and an aircraft power supply. The reduced number of connectors is directed out of the wheel and guided along a path by a path guide element to a connector element designed to connect directly with a wire harness or other connection with an aircraft source of electric power. This electric connector design facilitates disconnection and reconnection when removal and remounting of the drive wheel is required. | 11-26-2015 |
20160025152 | CLUTCH FOR NON-ENGINE POWERED VEHICLE DRIVE WHEEL - A clutch designed to effectively transfer torque between wheel drive system components in a vehicle drive wheel drive system to move the vehicle on a ground surface is provided. The wheel drive system components may include a non-engine drive means and a roller traction drive in torque transmission contact with the clutch and with the vehicle drive wheel. The clutch includes complementarily configured clutch components designed to mesh into engaging contact when activated by electromagnetic or other external engagement actuation means to transfer torque through an interface to a vehicle wheel. Drag and friction produced by activation of adjacent rotating patterned clutch elements amplifies axial forces to cause clutch elements to mesh into locking engagement to control transfer of torque between a non-engine drive means and a roller traction drive system to drive an aircraft landing gear wheel or other vehicle wheel. | 01-28-2016 |
Patent application number | Description | Published |
20110284685 | Wheel Structure for Integrating an Electric Drive Motor - A wheel design is provided for an aircraft landing gear wheel that is configured to maximize the space available within a landing gear wheel well to support a motor driver assembly that drives the aircraft wheel when the aircraft is on the ground. The wheel includes inboard and outboard support walls that are spaced apart a selected distance along the wheel axle so that the motor driver assembly components are substantially completely contained within the wheel space defined by the support walls. The preferred motor driver assembly includes an electric motor and a gear and clutch assembly operatively connected to the wheel to drive the wheel and move the aircraft on the ground. The wheel and motor driver assembly described herein may be retrofitted in an existing aircraft wheel without changing existing landing gear components, including tires, piston, and axle. | 11-24-2011 |
20110297786 | Integrated Electric Motor and Gear in an Aircraft Wheel - A wheel design is provided for an aircraft landing gear wheel that is configured to maximize the space available within a landing gear wheel well to support a geared motor assembly that drives the aircraft wheel when the aircraft is on the ground. The wheel includes inboard and outboard support walls that are spaced apart a selected distance along the wheel axle so that the geared motor assembly components are substantially completely contained within the wheel space defined by the support walls. The preferred motor driver assembly includes an electric motor and a gear and clutch assembly operatively connected to the wheel to drive the wheel and move the aircraft on the ground. The wheel and motor driver assembly described herein may be retrofitted in an existing aircraft wheel without changing existing landing gear components, including tires, piston, and axle. | 12-08-2011 |
20120001018 | Electric Motor Integrated with a Wheel - An integral motor and wheel assembly for aircraft landing gear is provided that includes an electric motor packaged within at least one gear wheel and configured to fit completely within the space provided in an existing aircraft for the landing gear components. The motor is positioned within the wheel to minimize the spin-up weight and to maximize the space within a given volume allocated for the motor. Installation of this motor and gear wheel assembly in an existing aircraft landing gear is designed to permit the continued use of existing landing gear components, including tires, axles, and pistons, so that the assembly can be easily retrofitted into existing aircraft. | 01-05-2012 |
20150204397 | SPRAG CLUTCH ASSEMBLY FOR AIRCRAFT DRIVE WHEEL DRIVE SYSTEM - A sprag clutch assembly for an aircraft drive wheel drive system capable of moving an aircraft autonomously on the ground in both forward and reverse directions is provided. The clutch is mounted within an aircraft drive wheel to be operatively engaged to control drive means braking torque when the aircraft is driven in a forward or reverse direction. The clutch assembly includes a plurality of pivoted sprag elements activatable to transmit torque and configured so that ratcheting occurs only when the aircraft drive wheel is driven in a forward direction and a braking torque is applied when the aircraft drive wheel is driven in reverse when the relative speed of the drive system is slower than the drive wheel speed, thereby permitting the drive system drive motor to function as a brake when the clutch assembly is engaged and the aircraft is reversing. | 07-23-2015 |
Patent application number | Description | Published |
20090207061 | Sigma-delta conversion circuit suitable for photocurrent measurement applications - A sigma-delta converter suitable for measuring a photocurrent comprises an input node adapted to receive a current to be measured (I | 08-20-2009 |
20100097257 | SIGMA-DELTA CONVERSION CIRCUIT SUITABLE FOR PHOTOCURRENT MEASUREMENT APPLICATIONS - A sigma-delta converter suitable for measuring a photocurrent comprises an input node adapted to receive a current to be measured (I | 04-22-2010 |
20110049986 | ADAPTIVE PHASE OFFSET CONTROLLER FOR MULTI-CHANNEL SWITCHING POWER CONVERTER - An adaptive phase offset controller for use with a switching power converter having first and second channels. The controller includes a discriminator which detects a ‘critical condition’ in which a switching signal for the first channel transitions during a critical time interval so as to give rise to crosstalk that can corrupt the operation of the second channel's control circuit. When the discriminator detects a critical condition, a phase offset circuit offsets the phase of the first channel's switching signals, such that subsequent transitions occur outside of the critical time interval. A second discriminator and phase offset circuit are preferably employed to detect critical conditions which can give rise to crosstalk that can corrupt the operation of the first channel's control circuit. | 03-03-2011 |
20150028924 | OSCILLATOR CIRCUIT WITH OUTPUT SLOPE PROPORTIONAL TO SUPPLY VOLTAGE - A voltage-controlled oscillator (VCO) comprises a supply voltage node, configured to receive a supply voltage, a VCO output capacitor, configured to provide an oscillating output voltage across the capacitor, a discharge switch configured to discharge the capacitor according to an oscillation frequency of the oscillating output voltage, and a comparator circuit configured to provide, to a control terminal of the discharge switch, a control signal that is determined based on a comparison of the output voltage and a specified threshold voltage. The oscillating output voltage includes a pulse having a ramp slope that is determined as a function of a magnitude of the supply voltage, and is capable of being adjusted independently of the oscillation frequency. | 01-29-2015 |
20150200666 | FOUR-STATE INPUT DETECTION CIRCUITRY - A circuit to detect states of a signal is provided. The circuit comprises an input node to receive an input signal. A state detection circuit detects a state of the input signal and generates a detection signal. The state corresponds to at least one of three states. Furthermore, the detection signal generated by the state detection circuit has a level based on the detected state of the input signal. A logic discriminator circuit generates first and second state signals based at least partly on the level of the detection signal. A clock detection circuit generates a clock signal based at least partly on a sequence of logic transitions of the first and second state signals. | 07-16-2015 |
Patent application number | Description | Published |
20090216113 | Apparatus and Methods for Using an Electromagnetic Transponder in Orthopedic Procedures - Electromagnetic transponders as markers are used to localize and guide orthopedic procedures including: knee replacement, hip replacement, shoulder replacement, damaged bone reconstruction, and spine surgery, and more particularly, to guide orthopedic surgical navigation and alignment techniques and instruments. For example, the marker could further be used in any number of guides or templates that attach to the bony anatomy, such as a surgical guide, cutting guide, cutting jig, resection block and/or resurfacing guide. Further, the marker could be incorporated into an existing intramedullary guide rod for a femur and an extramedullary guide rod for a tibia in a knee replacement surgery; or into an external surgical guide system, or the marker could eliminate the need for an external template altogether. According to yet another anticipated use of the tracking system, the marker could be used in conjunction with or replace an optical alignment system. | 08-27-2009 |
20140303489 | APPARATUS AND METHODS FOR USING AN ELECTROMAGNETIC TRANSPONDER IN ORTHOPEDIC PROCEDURES - Electromagnetic transponders as markers are used to localize and guide orthopedic procedures including: knee replacement, hip replacement, shoulder replacement, damaged bone reconstruction, and spine surgery, and more particularly, to guide orthopedic surgical navigation and alignment techniques and instruments. For example, the marker could further be used in any number of guides or templates that attach to the bony anatomy; such as a surgical guide, cutting guide, cutting jig, resection block and/or resurfacing guide. Further, the marker could be incorporated into an existing intramedullary guide rod for a femur and an extramedullary guide rod for a tibia in a knee replacement surgery; or into an external surgical guide system, or the marker could eliminate the need for an external template altogether. According to yet another anticipated use of the tracking system, the marker could be used in conjunction with or replace an optical alignment system. | 10-09-2014 |
Patent application number | Description | Published |
20100183735 | METHOD FOR INDUCING SELECTIVELY SUPPRESSED IMMUNE RESPONSE TO TRANSPLANTED TISSUE OR CELLS - Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring induced anti-cancer immunity. In one embodiment, skin from the transplant donor is allografted to the transplant recipient to induce an immunological response to the transplanted skin. A quantity of blood is taken from the recipient and treated to render the T cells in the blood apoptotic and to induce differentiation of blood monocytes into dendritic cells. The treated blood is incubated and administered to the recipient to induce formation of suppressor T cell clones which reduce the number of T cells attacking the transplanted tissue or organ. This tolerogenic approach can be complemented by also feeding the immature dendritic cells apoptotic or necrotic cells from the organ donor. In a second embodiment, dendritic cells loaded with tumor antigens are injected intradermally to monitor the anti-cancer immunity induced by Transimmunization. | 07-22-2010 |
20100209409 | METHOD FOR SUPPRESSING IMMUNE SYSTEM RESPONSE TO TRANSPLANTED TISSUE OR CELLS - Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The maturation of the dendritic cells is truncated at a stage where the dendritic cells can inactivate T cell clones which would otherwise generate an undesired immune system response. The immature dendritic cells can be directly administered to the transplant recipient, or the dendritic cells can be co-incubated with the bone marrow or stem cell preparation, prior to transplantation, in order to suppress or eliminate anti-recipient donor T cells contaminating the bone marrow or stem cell preparation. The methods can be used to suppress graft versus host disease in recipients of transplanted bone marrow or stem cells, or to suppress rejection of transplanted organs or tissue. | 08-19-2010 |
20100267137 | METHODS FOR INDUCING THE DIFFERENTIATION OF BLOOD MONOCYTES INTO FUNCTIONAL DENDRITIC CELLS - Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood into a plasma component containing proteins, a platelet component and a buffy coat component. A plastic treatment device is provided having plastic channels that allow transmittance of light to the interior of the plastic device and a light source that produces light of a wave length selected to activate the photoactivatable agent. The plasma component containing proteins is first pumped through the plastic treatment device, followed by the platelet component and finally the buffy coat component. The resulting treated cells may be incubated or reinfused directly to the subject. | 10-21-2010 |
20130323710 | Methods for Inducing the Differentiation of Blood Monocytes into Functional Dendritic Cells - Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood into a plasma component containing proteins, a platelet component and a buffy coat component. A plastic treatment device is provided having plastic channels that allow transmittance of light to the interior of the plastic device and a light source that produces light of a wave length selected to activate the photoactivatable agent. The plasma component containing proteins is first pumped through the plastic treatment device, followed by the platelet component and finally the buffy coat component. The resulting treated cells may be incubated or reinfused directly to the subject. | 12-05-2013 |