Patent application number | Description | Published |
20100175153 | REGULATING THE ETHYLENE RESPONSE OF A PLANT BY MODULATION OF F-BOX PROTEINS - The relationship between F-box proteins and proteins involved in the ethylene response in plants is described. In particular, F-box proteins may bind to proteins involved in the ethylene response and target them for degradation by the ubiquitin/proteasome pathway. The transcription factor EIN3 is a key transcription factor mediating ethylene-regulated gene expression and morphological responses. EIN3 is degraded through a ubiquitin/proteasome pathway mediated by F-box proteins EBF1 and EBF2. The link between F-box proteins and the ethylene response is a key step in modulating or regulating the response of a plant to ethylene. Described herein are transgenic plants having an altered sensitivity to ethylene, and methods for making transgenic plant having an altered sensitivity to ethylene by modulating the level of activity of F-box proteins. Methods of altering the ethylene response in a plant by modulating the activity or expression of an F-box protein are described. Also described are methods of identifying compounds that modulate the ethylene response in plants by modulating the level of F-box protein expression or activity. | 07-08-2010 |
20100242135 | ETP1 AND ETP2 REGULATE PLANT ETHYLENE RESPONSE - ETP1 and ETP2 bind to EIN2 and modulate plant ethylene sensitivity. | 09-23-2010 |
20110131688 | REGULATING THE ETHYLENE RESPONSE OF A PLANT BY MODULATION OF F-BOX PROTEINS - The relationship between F-box proteins and proteins involved in the ethylene response in plants is described. In particular, F-box proteins may bind to proteins involved in the ethylene response and target them for degradation by the ubiquitin/proteasome pathway. The transcription factor EIN3 is a key transcription factor mediating ethylene-regulated gene expression and morphological responses. EIN3 is degraded through a ubiquitin/proteasome pathway mediated by F-box proteins EBF1 and EBF2. The link between F-box proteins and the ethylene response is a key step in modulating or regulating the response of a plant to ethylene. Described herein are transgenic plants having an altered sensitivity to ethylene, and methods for making transgenic plant having an altered sensitivity to ethylene by modulating the level of activity of F-box proteins. Methods of altering the ethylene response in a plant by modulating the activity or expression of an F-box protein are described. Also described are methods of identifying compounds that modulate the ethylene response in plants by modulating the level of F-box protein expression or activity. | 06-02-2011 |
20130295569 | EPIGENOMIC INDUCED PLURIPOTENT STEM CELL SIGNATURES - Provided herein are methods of characterizing the epigenetic signature of human induced pluripotent stem cells. The methods are useful in identifying human induced pluripotent stem cells (hiPSCs), diagnostic markers for incomplete hiPSCs reprogramming, and characterization of the efficacy of different reprogramming techniques. | 11-07-2013 |
20140196170 | ETHYLENE GAS SIGNALING IN PLANTS - Provided herein are, inter alia, transgenic plants with altered ethylene sensitivity. The transgenic plants provided herein express an EIN2 protein including an amino acid mutation at a position corresponding to position 645 of SEQ ID NO:1. Expression of the EIN2 protein carrying the mutation at position 645 will result in plants with modulated ethylene sensitivity. In some embodiments, the mutation at position 645 of the EIN2 protein will result in plants with increased ethylene sensitivity. Alternatively, in other embodiments, the mutation at position 645 of the EIN2 protein will result in plants with decreased ethylene sensitivity. | 07-10-2014 |
Patent application number | Description | Published |
20150261506 | METHODS AND SYSTEMS FOR DYNAMIC RUNTIME GENERATION OF CUSTOMIZED APPLICATIONS - A user equipment (UE) device for programmatic runtime generation of an application. The UE device receives a UI definition file that includes definitions indicating visual appearance attributes of portions of the application, a set of components that are UI building blocks to be presented within the application, and a set of behaviors that may be performed by the components, where the definitions include attribute-value pairs. The UE device receives a set of component definition files that include code for implementing components that includes the components indicated by the UI definition file and after a beginning of an execution of the application, the UE device parses the UI definition file to identify the visual appearance attributes, the set of components, and the set of behaviors; and dynamically instantiates the set of components based upon the parsed UI definition file and the set of component definition files to create the application. | 09-17-2015 |
20150264423 | METHODS AND SYSTEMS FOR DYNAMIC RUNTIME GENERATION OF CUSTOMIZED APPLICATIONS - In an embodiment, a method in a server end station for efficiently providing customized user interfaces for an application is provided. The method includes transforming augmented style rules into style generation code. The augmented style rules includes both style syntax and a set of one or more expressions including a set of variables. The augmented style rules are not valid according to a style standard of the style syntax, and the style generation code, when executed by invocations using input variables corresponding to the set of variables, generates a set of valid style rules according to the style standard. The style generation code is transmitted to a user equipment device of a user, which when executed, causes a customized user interface to be presented to the user. | 09-17-2015 |
20160070813 | INTERACTIVE WEB APPLICATION EDITOR - Interactive editing of a web application at a user end station is described. The user end station dynamically loads into a running instance of the web application an interactive editor that allows editing of one or more user interface (UI) components of that running instance of the web application. A selection of a DOM element of the web application is received and a UI component that corresponds to the selected DOM element is determined. A set of parameters associated with the determined UI component is also determined. A value editor is displayed that is configured to display for at least one of the set of parameters a value and allows for that value to be modified. A modification of at least the value of the at least one of the set of parameters is received and the running instance of the web application is updated to reflect the modified value. | 03-10-2016 |
Patent application number | Description | Published |
20090118808 | Implantable Medical Lead - An implantable medical lead includes a device, such as a physiological sensor, that is coupled to one or more stimulation/sensing sensing conductors within the lead. When the implantable medical lead is coupled to an implantable medical device, the device carried by the lead both receives power from, and communicates with the implantable medical device via the one or more stimulation/sensing sensing conductors. Each of the one or more stimulation/sensing sensing conductors is also coupled to an electrode that is exposed to body tissue. | 05-07-2009 |
20090156912 | IMPLANTABLE OPTICAL SENSOR AND METHOD FOR MANUFACTURE - An implantable optical sensor and associated manufacturing method include a sensor housing having an inner surface and an outer surface and a window formed in the housing extending between the housing inner surface and the housing outer surface. An opto-electronic device enclosed within the housing and having a photonic surface is operatively positioned proximate the window for emitting light through the window or detecting light through the window. An optical coupling member is positioned between the opto-electronic device and the window for reducing light reflection at a surface within the implantable optical sensor. | 06-18-2009 |
20090270953 | Optical Device - A reflectance-type optical sensor includes one or more photodiodes formed in a semiconductor substrate. A well having sidewalls and a bottom is formed in the top surface of the substrate, and a reflective layer is formed on the sidewalls and bottom. A light-emitting diode (LED) is mounted in the well, so that light emitted laterally and rearwardly from the LED strikes the sidewalls or bottom and is redirected in a direction generally perpendicular to the top surface of the substrate. The optical sensor can be fabricated using microelectromechanical systems (MEMS) fabrication techniques. | 10-29-2009 |
20100185262 | CO-LOCATION OF EMITTERS AND DETECTORS AND METHOD OF OPERATION - An implantable medical device having an optical sensor selects the function of modular opto-electronic assemblies included in the optical sensor. Each assembly is provided with at least one light emitting device and at least one light detecting device. A device controller coupled to the optical sensor controls the function of each the assemblies. The controller executes a sensor performance test and selects at least one of the plurality of assemblies to operate as a light emitting assembly in response to a result of the performance test. The controller selects at least one other of the plurality of optical sensor assemblies to operate as a light detecting assembly in response to a result of the performance test | 07-22-2010 |
20110190850 | CLOCK SYNCHRONIZATION IN AN IMPLANTABLE MEDICAL DEVICE SYSTEM - This disclosure is directed to the synchronization of clocks of a secondary implantable medical device (IMD) to a clock of a primary IMD. The secondary IMD includes a communications clock. The communications clock may be synchronized based on at least one received communications pulse. The secondary IMD further includes a general purpose clock different than the communications clock. The general purpose clock may be synchronized based on at least one received power pulse. The communications clock may also be synchronized based on the at least one received power pulse. | 08-04-2011 |
20130138991 | CLOCK SYNCHRONIZATION IN AN IMPLANTABLE MEDICAL DEVICE SYSTEM - This disclosure is directed to the synchronization of clocks of a secondary implantable medical device (IMD) to a clock of a primary IMD. The secondary IMD includes a communications clock. The communications clock may be synchronized based on at least one received communications pulse. The secondary IMD further includes a general purpose clock different than the communications clock. The general purpose clock may be synchronized based on at least one received power pulse. The communications clock may also be synchronized based on the at least one received power pulse. | 05-30-2013 |
20130198531 | PACEMAKER EVENT QUEUE TO CONTROL DEVICE PROCESSOR OPERATING POWER - In the present disclosure, conservation of an implantable medical device power supply of is facilitated by controlling the power consumption of the device's processing component. The power supplied to the processing component is controlled to enable processing of received events as a function of predetermined criteria rather than the actual occurrence of the events which is frequent, but irregular. Accordingly, the need for the processing component to start and stop (and thereby be fully powered on each start) with receipt of each event is obviated thereby maintaining the power consumption of the processing component and increasing longevity of the device. Event data associated with received events is stored in an event queue and subsequently retrieved and transmitted for processing based on predetermined criteria. The power supplied during an idle state of the processing component may be reduced in relation to the power supplied during a wake up state. | 08-01-2013 |
20130234692 | VOLTAGE SUPPLY AND METHOD WITH TWO REFERENCES HAVING DIFFERING ACCURACY AND POWER CONSUMPTION - Voltage supply and method having a first reference and a second reference. The first reference has an operation mode configured to supply a first reference voltage at a first accuracy and consume an operation power and a standby mode configured to consume standby power less than the operation power. The second reference is configured to supply a second reference having a second accuracy less than the first accuracy of the first reference and which consumes a second reference power less than the operation power of the first reference, the second reference voltage being trimmable based, at least in part, on a comparison of the first reference voltage to the second reference voltage. | 09-12-2013 |
20140100634 | PACEMAKER EVENT QUEUE TO CONTROL DEVICE PROCESSOR OPERATING POWER - In the present disclosure, conservation of an implantable medical device power supply of is facilitated by controlling the power consumption of the device's processing component. The power supplied to the processing component is controlled to enable processing of received events as a function of predetermined criteria rather than the actual occurrence of the events which is frequent, but irregular. Accordingly, the need for the processing component to start and stop (and thereby be fully powered on each start) with receipt of each event is obviated thereby maintaining the power consumption of the processing component and increasing longevity of the device. Event data associated with received events is stored in an event queue and subsequently retrieved and transmitted for processing based on predetermined criteria. The power supplied during an idle state of the processing component may be reduced in relation to the power supplied during a wake up state. | 04-10-2014 |
20140112408 | TELEMETRY POLLING CIRCUIT WITH NOISE DISCRIMINATION AND SELECTABLE TUNING - A medical device communication system includes a receiver adapted to receive radio frequency (RF) signals and configured to operate in a first mode to poll for an RF signal for a first time interval to detect an element of a valid input signal during the first time interval. In response to detecting the element of a valid input signal in the first time interval, the receiver operates in a second mode to poll for the RF signal for a second time interval to analyze the RF signal over the second time interval to detect a valid modulation of the RF signal. In response to detecting a valid modulation of the RF signal during the second time interval, the receiver is enabled to establish a communication session with a transmitting device. | 04-24-2014 |
Patent application number | Description | Published |
20100105997 | CLOSED LOOP PARAMETER ADJUSTMENT FOR SENSOR MODULES OF AN IMPLANTABLE MEDICAL DEVICE - In general, the invention is directed toward an implantable medical device that includes a controller and a plurality of sensor modules. The controller may control the sensor modules to perform one or more sensor actions in order to facilitate a measurement. The sensor modules may store one or more operational parameters that control various aspects of the sensor actions performed by the sensor modules. The controller may automatically adjust one or more of the operational parameters based on results received from previous measurements in order to provide closed loop parameter adjustment of the operational parameters associated with the sensor modules. The controller may communicate with the sensor modules via a common bus. Example measurements include tissue perfusion measurements, blood oxygen sensing measurements, sonomicrometry measurements, and pressure measurements. | 04-29-2010 |
20100106220 | TIMING COORDINATION OF IMPLANTABLE MEDICAL SENSOR MODULES - In general, the disclosure is directed toward an implantable medical device that includes a plurality of sensor modules that are implanted within a patient. The sensor modules may cooperate with each other to coordinate the timing for performance of one or more sensor actions across the modules when making a measurement. Example measurements include tissue perfusion measurements, oxygen sensing measurements, sonomicrometry measurements, and pressure measurements. The coordination of the sensor modules may be controlled by a signal that is transmitted from a host controller to the sensor modules via a bus. In some examples, the bus may have two wires that transmit both timing information and data information to the sensor modules. The signal may be a signal that is substantially periodic, such as a pulsed signal. In additional examples, the signal may supply operating power and timing information to the sensor modules. | 04-29-2010 |
20120232354 | OPTICAL SENSOR SYSTEM AND MEASUREMENT METHOD - A medical device including an optical sensor is configured to measure an optical signal by integrating a current induced on a light detector of the optical sensor to obtain a voltage signal. The voltage signal is compared to a threshold. Responsive to the voltage signal reaching the threshold, an optical sensor control parameter is adjusted. The optical sensor is operated to produce the voltage signal using the adjusted control parameter. | 09-13-2012 |
Patent application number | Description | Published |
20090278934 | System and method for predicting patient falls - A patient fall prediction system receives video image frames from a surveillance camera positioned in a patient's room and analyses the video image frames for movement that may be a precursor to a patient fall. In set up phase, the viewpoint of the camera is directed at a risk area associated with patient falls, beds, chairs, wheelchairs, etc. A risk area is defined graphically in the viewport. The patient fall prediction system generates a plurality of concurrent motion detection zones that are situated proximate to the graphic markings of the risk areas. These motion detection zones are monitored for changes between video image frames that indicate a movement. The pattern of detections is recorded and compared to a fall movement detection signature. One fall movement detection signature is a sequential detection order from the motion detection zone closest to the risk area in the frames associated with patient falls, to the motion detection zone farthest away from the risk area. The patient fall prediction system continually monitors the motion detection zones for changes between image frames and compiles detections lists that are compared to known movement detection signatures, such as a fall movement detection signature. Once a match is identified, the patient fall prediction system issues a fall warning to a healthcare provider. | 11-12-2009 |
20120026308 | System and method for using a video monitoring system to prevent and manage decubitus ulcers in patients - A video monitoring system captures image frames of a patient in various positions. The captured image frames are analyzed by the system for changes in a patient's position or movement, frames in which the system detects one or both of patient movement and repositioning are retained. The system analyzes an area of interest within each image frame that corresponds to an area in the camera's view field with the patient. Sequential image frames are compared for motion, only frames without motion, where the patient is still, are analyzed. Analysis techniques include selecting a plurality of vertical positions in the area of interest, each vertical position corresponding to a part of the patient body indicative of the patient's position, horizontally scanning values along the horizontal pixel row at each vertical position in the area of interest, finding an average value for each vertical position and identifying a patient interval of the horizontal pixel row having pixel values different from the average and a representative horizontal position of the patient interval for each vertical interval. Then, comparing those median horizontal positions from a current image frame to the representative horizontal positions from a previous image frame to determine a change in the patient's position. | 02-02-2012 |
20140247334 | SYSTEM AND METHOD FOR USING A VIDEO MONITORING SYSTEM TO PREVENT AND MANAGE DECUBITUS ULCERS IN PATIENTS - A video monitoring system captures image frames of a patient in various positions. The captured image frames are analyzed by the system for changes in a patient's position or movement, frames in which the system detects one or both of patient movement and repositioning are retained. The system analyzes an area of interest within each image frame that corresponds to an area in the camera's view field with the patient. Sequential image frames are compared for motion, only frames without motion, where the patient is still, are analyzed. | 09-04-2014 |
20140313340 | SYSTEM AND METHOD FOR PREDICTING PATIENT FALLS - A patient fall prediction system receives video image frames from a surveillance camera positioned in a patient's room and analyses the video image frames for movement that may be a precursor to a patient fall. In set up phase, the viewpoint of the camera is directed at a risk area associated with patient falls, beds, chairs, wheelchairs, etc. A risk area is defined graphically in the viewport. The patient fall prediction system generates a plurality of concurrent motion detection zones that are situated proximate to the graphic markings of the risk areas. These motion detection zones are monitored for changes between video image frames that indicate a movement. The pattern of detections is recorded and compared to a fall movement detection signature. | 10-23-2014 |
20150199892 | Noise Correcting Patient Fall Risk State System and Method for Predicting Patient Falls - A patient fall prediction system from noise corrected surveillance video by identifying patient fall risk states. A hierarchy of discrete patient fall risk states, from no risk, to intermediate risk to critical risk, describe a patient fall risk. The system transitions from state to state based on changes detected in corresponding areas between a current video frame and a background frame. A set of fall risk state transition rules govern the entry into new fall risk states. A video frame is subdivided into multiple predetermined areas, at least two contain images of the patient. The number of false alarms are reduced by accurately defining fall risk state transition rules and by reducing the opportunity for noise to impact the state transition results. Frames that contain new changes are excluded from fall risk state processing, i.e., the first video frame that might cause an erroneous elevated fall risk state is culled. | 07-16-2015 |