Patent application number | Description | Published |
20080292732 | Plant and Plant Storage Organ Having Glp-1 Derivative Accumulated Therein and Method of Producing the Same - The present invention is to provide a plant and a plant storage organ thereof in which GLP-1 derivatives are accumulated, and a method of producing them in order to develop a method for ingesting orally GLP-1 derivatives at a low cost and to make use of it in diabetic treatment. A transgenic plant or a plant storage organ thereof in which GLP-1 derivatives are accumulated cleavable with a digestive enzyme is produced by a method comprising: integrating into a vector a linked GLP-1s-DNA which comprises tandem repeated ānā DNAs (ānā being an integer of 3 or more) encoding a GLP-1 derivative consisting of GLP-1 (7-36) or of an amino acid sequence of GLP-1 (7-36) in which one or a few amino acids are deleted, substituted and/or added, and C-terminal consists of Arg or Lys, and having GLP-1 activity; introducing the vector into a plant cell; and redifferentiating the obtained transformant. The transgenic plant and the plant storage organ are useful as a pharmaceutical composition or a food or drink for treating or preventing diabetes. | 11-27-2008 |
20090320164 | METHOD FOR PRODUCTION OF PLANT CELL HAVING CHROMOSOME LOSS - The present invention provides a simple aneuploid production process, applicable to all species, without producing unexpected damage to chromosomes other than a chromosome which is to be disappeared. A vector comprising two site-specific recognition sequences oriented in the opposite direction, or one site-specific recombinase recognition sequence comprising a point-symmetric nucleotide sequence, and a recombinase gene is introduced into a plant cells or a vector comprising two site-specific recognition sequences oriented in the opposite directions or one site-specific recombinase recognition sequence comprising a point-symmetric nucleotide sequence is introduced into a plant cell; a recombinase is allowed to act transiently in the cell during at least growth of the cell; and the cell is cultured and grown; and a cell in which a predetermined chromosome is disappeared is selected. | 12-24-2009 |
20110203016 | PROCESS FOR PRODUCING PLANT STORAGE ORGAN WITH HIGH PRODUCTION OF RECOMBINANT PROTEIN AND NOVEL RECOMBINANT PROTEIN - The present invention provides a method for highly producing a recombinant protein in a plant storage organ and a GLP-1 derivative. The plant storage organ in which the recombinant protein is highly produced is obtained by transformation with the use of a vector which comprises a recombinant protein gene, a cytokinin-related gene, a drug-resistant gene and a removable DNA element, in which the cytokinin-related gene and the drug-resistant gene exist in the positions so that they can behave together with the DNA element, while the recombinant protein to be expressed in the plant storage organ exists in the position so that it would not behave together with the DNA element. The GLP-1 is produced by using the method, and a derivative having been stabilized against enzymatic digestion is further provided. | 08-18-2011 |
Patent application number | Description | Published |
20080233605 | Method of Assaying Glycated Protein - The present invention provides a convenient, efficient method for assaying glycated protein, fructosyl peptide, or fructosyl amino acid which can be performed with reduced effect of fructosyl lysine compounds. The invention also provides a reagent for the assay. | 09-25-2008 |
20100330600 | HIGH-MOLECULAR-WEIGHT ADIPONECTIN MEASUREMENT METHOD - Provided is a method of separating and measuring highly active HMW adiponectin in adiponectin multimers. A method of measuring high-molecular-weight adiponectin in a sample, wherein adiponectin multimers are separated by use of a protease and measured immunologically, the method comprising reacting a sample containing adiponectin multimers with chymotrypsin. | 12-30-2010 |
20110091993 | METHOD FOR QUANTIFICATION OF SOLUBLE LR11 - Provided is a method for quantifying soluble LR11 in a biological sample such as serum by an immunological means conveniently and accurately without the need of carrying out any complicated separation manipulation. An immunological quantification method for soluble LR11 in a sample derived from a mammal, including a step of treating the sample with at least one surfactant selected from a group consisting of a polyoxyalkylene alkyl ether, a polyoxyalkylene alkyl phenyl ether, an alkyl glycoside, an alkylthio glycoside, an acyl-N-methylglucamide and a salt of cholic acid. | 04-21-2011 |
20110177610 | NOVEL MARKER FOR ARTERIOSCLEROTIC DISEASE - Disclosed is a novel marker for an arteriosclerotic disease. Also disclosed is a method for evaluating the presence or level of an arteriosclerotic disease in a mammal, or a method for evaluating the prophylactic or therapeutic effect on an arteriosclerotic disease in a mammal, which is characterized by detecting a soluble LR11 in a sample collected from the mammal. | 07-21-2011 |
Patent application number | Description | Published |
20090291461 | METHOD OF SELECTIVELY ASSAYING ADIPONECTIN MULTIMERS - Kits and methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of adiponectin multimers and provide information that cannot be obtained through measurement of the total amount of adiponectin alone. A method for selectively assaying a target adiponectin multimer in a biological sample comprising distinguishing target adiponectin multimer from the other adiponectin multimers by using a protease and/or an antibody. | 11-26-2009 |
20120322094 | HIGH-MOLECULAR-WEIGHT ADIPONECTIN MEASUREMENT METHOD - Provided is a method of separating and measuring highly active HMW adiponectin in adiponectin multimers. A method of measuring high-molecular-weight adiponectin in a sample, wherein adiponectin multimers are separated by use of a protease and measured immunologically, the method comprising reacting a sample containing adiponectin multimers with chymotrypsin. | 12-20-2012 |
20130029363 | METHOD FOR DIAGNOSING MALIGNANT TUMOR - To provide a method and a diagnostic kit for determining the presence of a malignant tumor or the severity thereof, a method for selecting a therapeutic method therefor or evaluating the effect of the therapeutic method, or a method for estimating the risk of recurrence of the malignant tumor or determining the presence or absence of the recurrence. | 01-31-2013 |
20130115229 | METHOD FOR DETECTING MALIGNANT TUMOR CELLS - Provided is a detection method for a malignant tumor cell, including measuring a protein marker expressed on a malignant tumor cell surface. The detection method for a malignant tumor cell includes measuring LR11 on a cell surface in a sample to be tested. | 05-09-2013 |
20130302826 | METHOD FOR QUANTIFICATION OF SOLUBLE LR 11 - Provided is a method for quantifying soluble LR11 in a biological sample such as serum by an immunological means conveniently and accurately without the need of carrying out any complicated separation manipulation. An immunological quantification method for soluble LR11 in a sample derived from a mammal, including a step of treating the sample with at least one surfactant selected from a group consisting of a polyoxyalkylene alkyl ether, a polyoxyalkylene alkyl phenyl ether, an alkyl glycoside, an alkylthio glycoside, an acyl-N-methylglucamide and a salt of cholic acid. | 11-14-2013 |
20140038213 | HIGH-MOLECULAR-WEIGHT ADIPONECTIN MEASUREMENT METHOD - Provided is a method of separating and measuring highly active HMW adiponectin in adiponectin multimers. A method of measuring high-molecular-weight adiponectin in a sample, wherein adiponectin multimers are separated by use of a protease and measured immunologically, the method comprising reacting a sample containing adiponectin multimers with chymotrypsin. | 02-06-2014 |
20140080158 | METHOD FOR IMMUNOLOGICALLY MEASURING SOLUBLE LR11 - To provide a method for assaying soluble LR11 in a biological sample, which method realizes a simple and accurate assay of soluble LR11 present in the sample by immunological means without requiring isolation of soluble LR11 from the biological sample (e.g., a serum sample). | 03-20-2014 |
Patent application number | Description | Published |
20090096923 | SYNC SEPARATION CIRCUIT - A sync separation circuit separates a synchronizing signal from a video signal containing the synchronizing signal. A minimum level detecting section detects a minimum level of a video signal. A sync tip level detecting section detects a sync tip level in the video signal. A pedestal level detecting section detects a pedestal level in the video signal. Based on both the sync tip level detected by the sync tip level detecting section and the pedestal level control by the pedestal level detecting section, a slice level setting section sets a slice level corresponding to an intermediate value between the sync tip level and the pedestal level. The slice level control section sets the slice level based on the minimum level detected by the minimum level detecting section if the slice level set based on the sync tip level and the pedestal level is inappropriate. | 04-16-2009 |
20090096926 | AUTOMATIC GAIN CONTROL CIRCUIT IN VIDEO SIGNAL PROCESSING DEVICE - In an automatic gain control circuit comprising a black level detecting unit which detects a black level from a video signal, a white level detecting unit which detects a white level from the video signal, and an analog-to-digital converter which adjusts a dynamic range of the video signal based on a difference value between the black level and the white level, a video signal for adjustment including a black level which indicates a minimum brightness of a video image and a white level which indicates a maximum brightness of the video image is input and the dynamic range is adjusted. | 04-16-2009 |
20090096928 | COLOR KILLER CIRCUIT - There is provided a color killer circuit comprising a burst amplitude detection unit that detects an amplitude of a color burst; a delay unit that stores, delays, by a predetermined period of time, and outputs the detected amplitude; a subtractor that calculates a difference between an output from the burst amplitude detection unit and an output from the delay unit; a first comparator that compares the output from the burst amplitude detection unit with a first threshold value to determine whether or not the output from the burst amplitude detection unit is less than the first threshold value; and a second comparator that compares an output from the subtractor with a second threshold value to determine whether or not the output from the subtractor is greater than the second threshold value, wherein the color killer circuit masks the color component of the composite video signal when the first comparator determines that the output from the burst amplitude detection unit is less than the first threshold value, or when the second comparator determines that the output from the subtractor is greater than the second threshold value. | 04-16-2009 |
Patent application number | Description | Published |
20120104015 | PAPER SHEET RECEIVING/DISPENSING APPARATUS - A paper sheet receiving/dispensing apparatus includes strip films at least one of which is affixed, on at least one of front and back sides, with marks at intervals of a predetermined pattern in a predetermined shape and in a color different from a color of the strip films, a detection sensor for detecting the marks, and a storage device for storing a table that indicates an association between a roll outer diameter of the strip films wound around a winding drum and driving pulses of a stepping motor. The apparatus calculates the roll outer diameter based on the number of rotations of the winding drum, which is calculated based on detection pulses of the marks, and thicknesses of the strip films and a paper sheet, and controls rotations of the motor with driving pulses read from the table. | 05-03-2012 |
20130256091 | MONEY INPUT/OUTPUT APPARATUS, REPLENISHING/COLLECTING APPARATUS, AND METHOD OF RUNNING MONEY INPUT/OUTPUT APPARATUS - A money input/output apparatus includes a bill accommodation unit, a mount unit, a detection unit, a second storage unit, an instruction reception unit, a conveyance unit, and a control unit. The control unit reads the denomination of the bill from the first storage unit and determines whether or not the read denomination of the bill corresponds to the denomination stored in the second storage unit in association with the mount unit on which mounting of the bill accommodation unit has been detected when the detection unit has detected that the bill accommodation unit has been mounted on the mount unit, starts reception of an instruction to input or output to the bill from the instruction receiving unit and makes the conveyance unit convey the bill in accordance with the instruction when the denominations have been determined to correspond. Thereby, a bill accommodation unit can be used for all denominations. | 10-03-2013 |
Patent application number | Description | Published |
20110156335 | CONVEYING DIRECTION-SWITCHING DEVICE FOR PAPER LEAVES, CONVEYING DIRECTION CONTROL METHOD, AND PAPER LEAVES PROCESSOR - A conveying direction-switching device is formed by direction-changing drums each having the same hollow cylindrical shape having a length corresponding to a lateral width of paper money bills to be conveyed. The direction-changing drum has first to fourth openings arranged in the outer periphery thereof, in a manner spaced from each other by a rotational angle of 90 degrees, and the rotational angle position thereof is controlled to be a predetermined phase angle. Inside the direction-changing drum, the first opening and the fourth opening are connected by a paper money guide forming a first curved passage, the second opening and the fourth opening are connected by a paper money guide forming a straight passage, and the third opening and the fourth opening are connected by a paper money guide forming a second curved passage. | 06-30-2011 |
20150194003 | ERRONEOUS COIN INSERTION PREVENTIVE MECHANISM OF BANKNOTE HANDLING MACHINE - An erroneous coin insertion preventive mechanism of a banknote handling machine prevents a user from erroneously inserting a coin (or a token) through a banknote slot of the banknote handling machine. When a coin | 07-09-2015 |
20150279145 | BILL HANDLING APPARATUS - A bill handling apparatus includes a first squeezing unit that performs a first squeezing of a bill in receiving the bill, and a second squeezing unit that performs a second squeezing of the bill after the first squeezing, wherein the first squeezing unit comprises a pair of conveying belts that convey the bill in a predetermined conveying direction in receiving the bill, a distance between both the conveying belts being gradually reduced in a direction of thickness of the bill in the predetermined conveying direction, and the second squeezing unit comprises a pair of rollers disposed at an end part of the first squeezing unit in the predetermined conveying direction. | 10-01-2015 |