Patent application number | Description | Published |
20100075355 | ULTRA-SENSITIVE DETECTION OF ENZYMES BY CAPTURE-AND-RELEASE FOLLOWED BY QUANTIFICATION - The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample. | 03-25-2010 |
20100075407 | ULTRA-SENSITIVE DETECTION OF MOLECULES ON SINGLE MOLECULE ARRAYS - The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample. | 03-25-2010 |
20100075439 | ULTRA-SENSITIVE DETECTION OF MOLECULES BY CAPTURE-AND-RELEASE USING REDUCING AGENTS FOLLOWED BY QUANTIFICATION - The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample. | 03-25-2010 |
20100239833 | Elastomeric mask and use in fabrication of devices - An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain un-shielded, while other openings of the lower mask are shielded. A first deposition step, following by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique. | 09-23-2010 |
Patent application number | Description | Published |
20100075862 | HIGH SENSITIVITY DETERMINATION OF THE CONCENTRATION OF ANALYTE MOLECULES OR PARTICLES IN A FLUID SAMPLE - The present invention relates to methods, systems, and kits for detecting, quantifying and/or analyzing a fluid sample comprising molecules or particles at low concentration. In certain embodiments, the methods for detection and/or quantifying analyte molecules in a sample comprise capturing a plurality of analyte molecules on a substrate (e.g., an array comprising a plurality of reaction vessels). The substrate may then be exposed to additional reaction components such as at least one binding ligand. The substrate may additionally be exposed to a precursor labeling agent molecule, wherein the precursor labeling agent molecule, in some cases, is converted to a labeling agent molecule, which may be detected, either directly or indirectly, which determination may be related to the presence of and/or may be employed to quantify the analyte molecules. Although the various aspects of the present invention may use a number of different assay formats, in one embodiment, the assays are conducted in a plurality of reaction vessels defined, at least in part, by the distal ends of fiber optic strands. | 03-25-2010 |
20110212462 | ULTRA-SENSITIVE DETECTION OF MOLECULES USING DUAL DETECTION METHODS - Described herein are systems and methods for the detection of and/or determination of a measure of the concentration of analyte molecules or particles in a fluid sample. In some cases, the systems and methods employ techniques to reduce or limit the negative effects associated with non-specific binding events. Certain methods of the present invention involve associating the analyte molecules at least a first type of binding ligand and at least a second type of binding ligand, and spatially segregating the analyte molecules into a plurality of locations on a surface. The presence of an analyte molecule at or in a location may be determined by determining the presence of both the first type of binding ligand and the second type of binding ligand. | 09-01-2011 |
20110212537 | METHODS AND SYSTEMS FOR EXTENDING DYNAMIC RANGE IN ASSAYS FOR THE DETECTION OF MOLECULES OR PARTICLES - Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects. | 09-01-2011 |
20110212848 | ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES USING BEADS OR OTHER CAPTURE OBJECTS - The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components. | 09-01-2011 |
20110245097 | METHODS AND SYSTEMS FOR EXTENDING DYNAMIC RANGE IN ASSAYS FOR THE DETECTION OF MOLECULES OR PARTICLES - Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects. | 10-06-2011 |
20110277930 | OPTICAL MODULATOR/DETECTOR BASED ON RECONFIGURABLE DIFFRACTION GRATING - A system is provided for positioning separate portions of a sample in elongate, parallel channels of a sample chamber and for irradiating a sample in the chamber to create a diffraction pattern where the sample and chamber differ in refractive index. The system also can measure absorption of electromagnetic radiation by a sample in the chamber, and can measure the absorption simultaneously with measurement of diffraction by the sample. | 11-17-2011 |
20120196774 | SYSTEMS, DEVICES, AND METHODS FOR ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES - Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like. | 08-02-2012 |
20120277114 | ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES USING BEADS OR OTHER CAPTURE OBJECTS - The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components. | 11-01-2012 |
20120289428 | ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES USING BEADS OR OTHER CAPTURE OBJECTS - The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components. | 11-15-2012 |
20130165342 | METHODS AND SYSTEMS FOR EXTENDING DYNAMIC RANGE IN ASSAYS FOR THE DETECTION OF MOLECULES OR PARTICLES - Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects. | 06-27-2013 |
20140243223 | ULTRA-SENSITIVE DETECTION OF MOLECULES ON SINGLE MOLECULE ARRAYS - The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample. | 08-28-2014 |
20140378333 | DIGITAL BRIDGE PCR - The present disclosure, among other things, provides methodologies for quantifying targets of interest in samples by 1) capturing single target entities on individual solid phase particles in a manner that permits that those particles that contain captured targets to be optically distinguished from those that do not, and 2) optically analyzing the particles so that those with captured target entities are “counted”. In some embodiments, provided methods and compositions in the present application comprise a population of particles including one or more sub-populations distinguishable from one another. | 12-25-2014 |
Patent application number | Description | Published |
20090088445 | Deazapurines useful as inhibitors of Janus kinases - The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 04-02-2009 |
20100081645 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE - The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 04-01-2010 |
20110118255 | PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JAK2 INHIBITORS - The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. The invention also provides processes for preparing the compounds of the invention. | 05-19-2011 |
20120316186 | DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES - The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 12-13-2012 |
20130090331 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE - The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 04-11-2013 |
20140171454 | Substituted Pyrrolo[2,3-d]pyrimidines as Inhibitors of Protein Kinases - The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 06-19-2014 |
20140315931 | DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES - The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 10-23-2014 |
Patent application number | Description | Published |
20100081657 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES - The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 04-01-2010 |
20120171245 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION - Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): | 07-05-2012 |
20130281431 | DNA-PK INHIBITORS - The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 10-24-2013 |
20130345218 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION - Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): | 12-26-2013 |
20140005192 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | 01-02-2014 |
20140045869 | DNA-PK INHIBITORS - The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 02-13-2014 |
20140142119 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION - Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): | 05-22-2014 |
20140206671 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE - The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 07-24-2014 |
20140296201 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION - Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): | 10-02-2014 |
20150111871 | DNA-PK INHIBITORS - The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 04-23-2015 |
20150191468 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION - Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): | 07-09-2015 |
Patent application number | Description | Published |
20120158921 | SYSTEMS AND METHODS FOR HANDLING A REGISTRATION STORM - Systems and methods for user device registration are disclosed. In certain embodiments, at least a first edge device in a group of edge devices enters a mass-restart mode. The first edge device receives a request for registration from a user device and determines whether the user device is currently registered through the first edge device. The first edge device generates a notification associated with the user device if the user device is not currently registered through the first edge device. A second edge device in the group of edge devices receives the notification and determines whether the user device is currently registered through the second edge device based on the notification. Registration information about the user device is deleted from the second edge device if the user device is currently registered through the second edge device. | 06-21-2012 |
20120166656 | Establishing Secure Communications Between Client Computing Devices Located Behind Network Security Devices - Methods and apparatuses, including computer program products, are described for establishing secure communications sessions between computing devices located behind network security devices. The method includes receiving, from a first client computing device, a request for a secure connection with a second client computing device, the request including a first transport protocol role and a first security protocol role associated with the first device. The method includes transmitting the request to the second device. The method includes receiving, from the second device, a response to the request including a second transport protocol role and a second security protocol role associated with the second device, transmitting the response to the first device, and establishing the secure connection between the first device and the second device, where the first and second security protocol roles are determined independently from the first and second transport protocol roles. | 06-28-2012 |
20140237089 | SYSTEMS AND METHODS FOR HANDLING A REGISTRATION STORM - Systems and methods for user device registration are disclosed. In certain embodiments, at least a first edge device in a group of edge devices enters a mass-restart mode. The first edge device receives a request for registration from a user device and determines whether the user device is currently registered through the first edge device. The first edge device generates a notification associated with the user device if the user device is not currently registered through the first edge device. A second edge device in the group of edge devices receives the notification and determines whether the user device is currently registered through the second edge device based on the notification. Registration information about the user device is deleted from the second edge device if the user device is currently registered through the second edge device. | 08-21-2014 |
Patent application number | Description | Published |
20090327211 | Virtualization management using a centralized server - Some embodiments of virtualization management using a centralized server have been presented. In one embodiment, a centralized server obtains metadata of an operating system and information on provisioning computing resources from a software vendor. The centralized server is deployed within an internal network of a customer of the software vendor, where the internal network further includes a set of at least one physical machine. The centralized server may further generate a graphical user interface to allow users of the centralized server to manage a set of virtual machines running on the set of at least one physical machine. The set of virtual machines may include at least one virtual host and at least one virtual guest. | 12-31-2009 |
20090328056 | Entitlement model - Some embodiments of an entitlement model have been presented. In one embodiment, a centralized server distributes copies of an operating system from a software vendor to a set of virtual guests of a virtual host running on a physical computing machine. The centralized server and the physical computing machine are coupled to each other within an internal network of a customer of the software vendor, whereas the centralized server has access to the software vendor external to the internal network of the customer. The centralized server may interact with a hypervisor of the physical computing machine to determine what type of license of the operating system the virtual host has and a number of copies of the operating system requested by the virtual guests. | 12-31-2009 |
20100042939 | ENHANCED EXPORTER TOOL - Some embodiments of an enhanced exporter tool have been presented. In one embodiment, a connected centralized server is synchronized with an external server of a software vendor over an external network. The connected centralized server may reside in an internal network of a customer of the software vendor. Content from the connected centralized server is exported to a disconnected centralized server of the customer according to a set of criteria. The disconnected centralized server may reside in a secured portion of the internal network of the customer. | 02-18-2010 |
20100058324 | MULTIPLE ORGANIZATION SUPPORT IN A NETWORKED SYSTEM - Some embodiments of multiple organization support in a networked system have been presented. In one embodiment, a centralized server manages a networked system, which includes the centralized server and a set of computing machines coupled to each other within an internal network of a customer. The centralized server segregates data within the networked system by grouping data into the concept of an organization created by the customer in order to isolate the organizations. | 03-04-2010 |
20100122173 | TRUSTED RELATIONSHIPS IN MULTIPLE ORGANIZATION SUPPORT IN A NETWORKED SYSTEM - Some embodiments of supporting trusted relationships between multiple organizations in a networked system have been presented. In one embodiment, a centralized server manages a networked system, which includes the centralized server and a set of computing machines coupled to each other within an internal network of a customer. The centralized server may segregate data and encapsulating resources within the networked system by a set of organizations created by the customer. Furthermore, a trusted relationship defined by a system administrator of the centralized server may be applied to a first one and a second one of the set of organizations. | 05-13-2010 |
20140026063 | FULL-SCREEN HETEROGENEOUS DESKTOP DISPLAY AND CONTROL - A system for full-screen heterogeneous desktop display and control is described. In one implementation, a method includes determining, by a processing device of a computing device, that a source is connecting with the computing device and is a candidate for assignment to a desktop graphical user interface (GUI) of the computing device, when the source is not assigned to an existing desktop GUI, generating, by a desktop manager of the computing device, a new desktop GUI on the computing device for the source, and assigning the new desktop GUI for the source to a scaled representation element in a desktop management interface provided by the desktop manager, the desktop management interface providing a plurality of scaled representation elements for a plurality of desktop GUIs on the computing device. | 01-23-2014 |
Patent application number | Description | Published |
20100050111 | Full-Screen Heterogeneous Desktop Display and Control - Described herein is a method and apparatus for generating and managing multiple desktops. The desktops can be tied to virtual software environments, remote desktops, separate user account desktops, shared desktops, full screen applications or similar sources. The desktops are managed through a desktop management interface that displays a scale image of each current desktop. The desktops can also be marked by type in the interface. The desktop management system queries a user during start-up for each program to determine whether a new desktop is to be generated for the program. The desktop management system also manages the switching between the available desktops. | 02-25-2010 |
20100174577 | Automated Task Delegation Based on Skills - The automated task delegation and project management system tracks user profiles and project profiles, which include information about the interests and skills each user in the system possess as well as the skills that are required by each project in the system and the characteristics of each project. This information can then be utilized to correlate user interests and skills with the available projects. Similarly, these user profiles can be utilized to identify mentors for new users in the system based on the skill sets and project involvement of other users and potential mentors in the system and the interests and skill sets of the new users. | 07-08-2010 |
20100174578 | Interface for Project and Task Submission for Automated Delegation - The automated task delegation and project management system tracks user profiles and project profiles, which include information about the interests and skills each user in the system possesses as well as the skills that are required by each project in the system and the characteristics of each project. This information can then be utilized to correlate user interests and skills with the available projects. Project data can be collected from the submitter to enable the automated matching. The user interface facilitates the collection and storage of the project profile data including tasks, files, resources, and tags. | 07-08-2010 |
20110249013 | PLUG-IN ARCHITECTURE FOR DYNAMIC FONT RENDERING ENABLEMENT - A computer system provides a plug-in architecture for creation of a dynamic font. The computer system can incorporate a new filter function into a filtering layer of a font program. The filtering layer includes pre-defined filter functions to transform a base font into a new font. The computer system applies one or more font rules in the filtering layer to the base font. The font rules are implemented by the new filter function and at least one of the pre-defined filter functions to randomize an appearance of each character in a character string. The character string rendered with the new font has a dynamic and randomized appearance. | 10-13-2011 |