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| 20110011961 | GRANULES COMPRISING A BETA-LACTAM ANTIBIOTIC - The present invention relates to granules comprising a β-lactam antibiotic, wherein C | 01-20-2011 |
| 20110086803 | PEPTIDES CONTAINING TRYPTOPHAN - The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45. | 04-14-2011 |
| 20130231278 | Peptides containing tryptophan - The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45. | 09-05-2013 |
| 20160082070 | METHODS OF TREATMENT USING WATER-SOLUBLE TRYPTOPHAN-CONTAINING PEPTIDES OBTAINED BY THE HYDROLYSIS OF HENS EGGS LYSOZYME - The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45. | 03-24-2016 |
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| 20100021448 | I-CREI MEGANUCLEASE VARIANTS WITH MODIFIED SPECIFICITY, METHOD OF PREPARATION AND USES THEREOF - Method of preparing 1-CreI meganuclease variants having a modified cleavage specificity, variants obtainable by said method and their applications either for cleaving new DNA target or for genetic engineering and genome engineering for non-therapeutic purposes. Nucleic acids encoding said variants, expression cassettes comprising said nucleic acids, vectors comprising said expression cassettes, cells or organisms, plants or animals except humans, transformed by said vectors. | 01-28-2010 |
| 20110072527 | I-CREI MEGANUCLEASE VARIANTS WITH MODIFIED SPECIFICITY, METHOD OF PREPARATION AND USES THEREOF - Method of preparing I-CreI meganuclease variants having a modified cleavage specificity, variants obtainable by said method and their applications either for cleaving new DNA target or for genetic engineering and genome engineering for non-therapeutic purposes. Nucleic acids encoding said variants, expression cassettes comprising said nucleic acids, vectors comprising said expression cassettes, cells or organisms, plants or animals except humans, transformed by said vectors. | 03-24-2011 |
| 20110158974 | Heterodimeric Meganucleases and Use Thereof - Heterodimeric meganuclease comprising two domains of different meganucleases which are in two separate polypeptides, said heterodimeric meganuclease being able to cleave a chimeric DNA target sequence comprising one different half of each parent meganuclease DNA target sequence. | 06-30-2011 |
| 20120258537 | I-CREI MEGANUCLEASE VARIANTS WITH MODIFIED SPECIFICITY, METHOD OF PREPARATION AND USES THEREOF - Method of preparing I-CreI meganuclease variants having a modified cleavage specificity, variants obtainable by said method and their applications either for cleaving new DNA target or for genetic engineering and genome engineering for non-therapeutic purposes. Nucleic acids encoding said variants, expression cassettes comprising said nucleic acids, vectors comprising said expression cassettes, cells or organisms, plants or animals except humans, transformed by said vectors. | 10-11-2012 |
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| 20100144012 | USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF - A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y and a second variant of I-CreI variant having the amino acid sequence of accession number pdb 1g9y in a single polypeptide. | 06-10-2010 |
| 20110287513 | USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF - A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y and a second variant of I-CreI variant having the amino acid sequence of accession number pdb 1g9y in a single polypeptide. | 11-24-2011 |
| 20120159659 | CUSTOM-MADE MEGANUCLEASE AND USE THEREOF - New rare-cutting endonucleases, also called custom-made meganucleases, which recognize and cleave a specific nucleotide sequence, derived polynucleotide sequences, recombinant vector cell, animal, or plant comprising said polynucleotide sequences, process for producing said rare-cutting endonucleases and any use thereof, more particularly, for genetic engineering, antiviral therapy and gene therapy. | 06-21-2012 |
| 20120288942 | USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF - Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and to its application for genome engineering and gene therapy. | 11-15-2012 |
| 20120288943 | USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF - Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and to its application for genome engineering and gene therapy. | 11-15-2012 |
| 20130203840 | USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF - A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y and a second variant of I-CreI variant having the amino acid sequence of accession number pdb 1g9y in a single polypeptide. | 08-08-2013 |
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| 20110173710 | CHIMERIC MEGANUCLEASE ENZYMES AND USES THEREOF - The current invention relates to polypeptides encoding mutant I-DmoI derivatives with enhanced cleavage activity and altered sequence specificity and uses of these polypeptides. These polypeptides comprise at least the first I-DmoI domain, and the peptide sequence comprises the substitution of at least one of residues 15, 19 and/or 20 as well as at least one of the residues in positions 27, 29, 33, 35, 37, 75, 76, 77, 81 of the first I-DmoI domain. | 07-14-2011 |
| 20110207199 | NOVEL METHOD TO GENERATE MEGANUCLEASES WITH ALTERED CHARACTERISTICS - Method to generate and select a meganuclease having at least two altered characteristics in comparison to a parent meganuclease, comprising the steps: a. constructing from a parent meganuclease, a first series of variants which differ from said parent meganuclease by at least one acid amino substitution; b. screening the variants from said first series of step a. and selecting those which have a first altered characteristic; c. constructing from the selected variants of step b. a second series of variants having a least one other amino acid substitution; d. screening the variants from said series of step b. and selecting those which have said first altered characteristic and a second altered characteristic. Polypeptide obtained from said method. | 08-25-2011 |
| 20120244131 | METHOD FOR MODULATING THE EFFICIENCY OF DOUBLE-STRAND BREAK-INDUCED MUTAGENESIS - A method for modulating double-strand break-induced mutagenesis at a genomic locus of interest in a cell, thereby giving new tools for genome engineering, including therapeutic applications and cell line engineering. A method for modulating double-strand break-induced mutagenesis, concerns the identification of effectors that modulate double-strand break-induced mutagenesis by use of interfering agents; these agents are capable of modulating double-strand break-induced mutagenesis through their respective direct or indirect actions on said effectors. Methods of using these effectors, interfering agents and derivatives, respectively, by introducing them into a cell in order to modulate and more particularly to increase double-strand break-induced mutagenesis. Specific derivatives of identified effectors and interfering agents, vectors encoding them, compositions and kits comprising such derivatives for modulating or increasing double-strand break-induced mutagenesis. | 09-27-2012 |
| 20130149786 | I-CREI VARIANTS WITH NEW SPECIFICITY AND METHODS OF THEIR GENERATION - The present invention relates to 1-Cre1 variants which can in particular recognise and cleave DNA targets which do not comprise the same nucleotides at positions ±6 and ±7 which are present in the wild type 1-Cre1 target. The present invention also relates to 1-Cre1 variants which can recognise and cleave targets which do not comprise the wild type nucleotides at positions ±4, ±5, ±6, ±7 and to 1-Cre1 variants with new specificity which can recognise and cleave targets which do not comprise the wild type nucleotides at positions ±4, ±5, ±6, ±7, ±8, ±9 and ±10. | 06-13-2013 |
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| 20130190385 | METHOD FOR MODULATING DOUBLE-STRAND BREAK-INDUCED HOMOLOGOUS RECOMBINATION - The present invention concerns a method for modulating double-strand break-induced homologous recombination through the identification of effectors that modulate said double-strand break-induced homologous recombination by uses of interfering agents; these agents are capable of modulating double-strand break-induced homologous recombination through their respective actions on said effectors. The present invention also concerns the uses of these effectors and interfering agents and derivatives, respectively, by introducing them in an eukaryotic cell in order to modulate and more particularly to increase double-strand break-induced homologous recombination and gene targeting efficiency. The present invention also relates to specific derivatives of identified effectors and interfering agents, vectors encoding them, compositions and kits comprising such derivatives in order to modulate and more particularly to increase double-strand break-induced homologous recombination and gene targeting efficiency. | 07-25-2013 |
| 20130196320 | METHOD FOR IMPROVING CLEAVAGE OF DNA BY ENDONUCLEASE SENSITIVE TO METHYLATION - The present invention concerns novel methods for improving cleavage of DNA by rare-cutting endonucleases, overcoming DNA modification constraints, particularly DNA methylation, thereby giving new tools for genome engineering, particularly to increase the integration efficiency of a transgene into a genome at a predetermined location, including therapeutic applications and cell line engineering. | 08-01-2013 |
| 20130337454 | METHOD FOR INCREASING THE EFFICIENCY OF DOUBLE-STRAND BREAK-INDUCED MUTAGENESIS - The present invention relates to a method for increasing double-strand break-induced mutagenesis at a genomic locus of interest in a cell, thereby giving new tools for genome engineering, including therapeutic applications and cell line engineering. More specifically, the present invention concerns a method for increasing double-strand break-induced mutagenesis at a genomic locus of interest, leading to a loss of genetic information and preventing any scarless re-ligation of said genomic locus of interest by NHEJ. The present invention also relates to engineered endonucleases, chimeric or not, vectors, compositions and kits used to implement this method. | 12-19-2013 |
| 20140115726 | NEW TALE-PROTEIN SCAFFOLDS AND USES THEREOF - The present invention relates to new Transcription Activator-Like Effector proteins and more particularly new Transcription Activator-Like Effector Nucleases (TALENs) that can efficiently target and process nucleic acids. The present invention also concerns methods to use these new Transcription Activator-Like Effector proteins. The present invention also relates to vectors, compositions and kits in which Transcription Activator-Like Effector proteins of the present invention are used. | 04-24-2014 |
| 20140309145 | HIGH THROUGHPUT METHOD FOR ASSEMBLY AND CLONING POLYNUCLEOTIDES COMPRISING HIGHLY SIMILAR POLYNUCLEOTIDIC MODULES - The present invention relates to a method for the assembly and cloning of polynucleotides comprising highly similar polynucleotidic modules, that is highly versatile, does not require intermediate amplification step and can be easily automated for high throughput production of customized polynucleotidic modules. | 10-16-2014 |
| 20150037809 | METHOD TO OVERCOME DNA CHEMICAL MODIFICATIONS SENSITIVITY OF ENGINEERED TALE DNA BINDING DOMAINS - The present invention relates to polypeptides and more particularly to Transcription Activator-Like Effector derived proteins that allow to efficiently target and/or process nucleic acids. Particularly, the present invention reports the characterization of TALE derived proteins that can efficiently target methylated DNA. The present invention more specifically relates to TALE derived proteins that allow activation of methylated promoters responsible for gene silencing. | 02-05-2015 |
| 20150067900 | NEW REPEAT VARIABLE DIRESIDUES FOR TARGETING NUCLEOTIDES - The present invention relates to polypeptides and more particularly to Transcription Activator-Like Effector derived proteins that allow to efficiently target and/or process nucleic acids. The present invention also concerns methods to use these proteins. The present invention also relates to vectors, compositions and kits in which RVD domains and Transcription Activator-Like Effector (TALE) proteins of the present invention are used. | 03-05-2015 |
| 20150203871 | Transcription Activator-Like Effector (TALE) Fusion Protein - The present invention relates to Transcription Activator-Like Effector (TALE) derived proteins that allow to efficiently target and/or process double stranded nucleic acid sequences. The proteins of the invention are typically chimeric protein monomers composed of a core scaffold comprising Repeat Variable Dipeptide regions (RVDs) having binding specificity to a DNA target sequence, to which is fused a catalytic domain to its N-terminal. This later catalytic domain, which can be a monomer of a nuclease, is placed at this position to possibly interact with another catalytic domain fused to another TAL monomer, such that, when said monomers are binding to their respective target DNA sequences, both catalytic domains form a catalytic entity likely to process DNA in the proximity of these target sequences. This new TAL architecture makes it possible to target only one DNA strand, which is not the case, for instance, with classical TALEN architectures. The present invention also relates to vectors encoding such proteins and compositions or kits in which Transcription Activator-Like Effector (TALE) proteins of the present invention are used. | 07-23-2015 |
| 20150218230 | METHODS FOR MODULATING TAL SPECIFICITY - Methods for improving or modulating targeting specificity of TALE proteins by introducing alternative RVDs into their modular nucleic acid binding domains. Polynucleotides encoding TALE proteins having alternative targeting specificity towards a nucleic acid target sequence. TALE proteins having alternative targeting specificity towards a nucleic acid target sequence and methods of making and using them. | 08-06-2015 |
| 20150225465 | NEW MODULAR BASE-SPECIFIC NUCLEIC ACID BINDING DOMAINS FROM BURKHOLDERIA RHIZOXINICA PROTEINS - The present invention concerns new modular base-per-base specific nucleic acid binding domains (MBBBD) derived from newly identified proteins from the bacterial endosymbiont | 08-13-2015 |
| 20160102324 | NEW COMPACT SCAFFOLD OF CAS9 IN THE TYPE II CRISPR SYSTEM - The present invention is in the field of CRISPR-Cas system for genome targeting. The present invention relates to new engineered Cas9 scaffolds and uses thereof. More particularly, the present invention relates to methods for genome targeting, cell engineering and therapeutic application. The present invention also relates to vectors, compositions and kits in which the new Cas9 scaffolds of the present invention are used. | 04-14-2016 |
| 20160122774 | A METHOD FOR PRODUCING PRECISE DNA CLEAVAGE USING CAS9 NICKASE ACTIVITY - The present invention is in the field of a method for genome engineering based on the type II CRISPR system, particularly a method for improving specificity and reducing potential off-site. The method is based on the use of nickase architectures of Cas9 and single or multiple crRNA(s) harboring two different targets lowering the risk of producing off-site cleavage. The present invention also relates to polypeptides, polynucleotides, vectors, compositions, therapeutic applications related to the method described here. | 05-05-2016 |
| 20160138047 | IMPROVED POLYNUCLEOTIDE SEQUENCES ENCODING TALE REPEATS - The present invention is in the field of the gene editing molecular tools. The present invention relates to rewritten nucleic acid sequences encoding repeated DNA recognition motifs of TALE (Transcription Activator-Like Effector) proteins. These nucleic acid sequences allow assembly and cloning of TALE repeats in any type of vectors, especially viral vectors. The invention thereby contributes to improving gene targeting in cells using TALE derived proteins, in particular for genetic regulation or modification. The present invention is particularly drawn to virus mediated transformation methods, by providing vectors, compositions and kits including said new nucleic acid sequences. | 05-19-2016 |
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| 20150376330 | PROCESS FOR PREPARING A COPOLYMER - A process for preparing a copolymer comprising subjecting a first cyclic ester having a ring size from 4 to 11 atoms and a second cyclic ester having a ring size from 12 to 40 atoms to ring-opening copolymerization using as catalyst a compound of formula I, wherein M is trivalent Al, Ti, V, Cr, Mn, Co, yttrium, Sc or lanthanides; X and X′ are both a heteroatom; Y and Y′ are O, N, S or P; Z is a substituent as described herein; L1 is an organic moiety linking X and Y; L2 is an organic moiety linking X′ and Y′; L3 is an organic moiety linking Y and Y′ and has a chain length between Y and Y′ of at least 2 atoms. The copolymer has a randomness of at least 0.5 and a number average molecular weight of at least 15000 g/mol. | 12-31-2015 |
| 20160083510 | BLOCK COPOLYMER AND PROCESS FOR PREPARING THE SAME - The invention relates to a block copolymer comprising a first block of general structure formula (II) and a second block of general structure formula (III) wherein Rx is an organic group having a chain length of from 1-9 atoms; R | 03-24-2016 |
| 20160096919 | METHOD FOR PREPARING A POLYESTER - The invention is directed to a method for preparing a polyester comprising providing a first cyclic ester having a ring size of from 12-40 atoms and subjecting the first cyclic ester to ring-opening polymerisation by contacting the first cyclic ester with a catalyst of formula I. | 04-07-2016 |
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| 20110034616 | POLYCARBONATE AND PROCESS FOR PRODUCING THE SAME - The invention relates to polycarbonate containing a dianhydrohexitol residue, obtainable from a polysaccharide, and a polyol residue, wherein the polycarbonate comprises between 0.2 and 5 mmol hydroxyl groups per gram polymer. The polycarbonate may be branched and comprises functional groups that can react with suitable crosslinkers. The polycarbonate can be used in for example coating compositions. | 02-10-2011 |
| 20130030135 | Vinyl-Terminated Macromonomer Oligomerization - Vinyl-terminated macromonomer oligomerization, namely, a process to produce polymacromonomers comprising contacting a vinyl-terminated macromonomer with a catalyst system capable of oligomerizing vinyl-terminated macromonomer, in the presence of an aluminum containing compound, a zinc containing compound, or a combination thereof, under polymerization conditions to produce a polymacromonomer, and polymacromonomers produced thereby. Also, polymacromonomers having a degree of polymerization greater than 10, a glass transition temperature Tg of less than 60° C., and an Mn of greater than or equal to about 5000 Da. | 01-31-2013 |
| 20160102172 | PE-LIKE POLYESTERS - A polyester having a saturated backbone, a method of preparing said polyester, an intermediate unsaturated polyester product, and a method for preparing said intermediate unsaturated polyester product, where the number of carbon backbone atoms between two neighbouring ester groups in the backbone is randomly distributed over the polyester, and the polyester has an M/E ratio of 14 or more, wherein M is the number of backbone carbon atoms in the polyester not including the ester carbons and E is the number of ester groups in the polyester. | 04-14-2016 |
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| 20100087929 | SHAPED PART OF AN ULTRA HIGH MOLECULAR WEIGHT POLYETHYLENE - Shaped parts of ultra high molecular weight polyethylene (UHMWPE) are made by a process comprising melt processing, wherein a) the UHMWPE has a weight average molecular weight (Mw) of at least 1*106 g/mol, b) during the shaping the storage plateau modulus of the UHMWPE (G*) is kept at a value of at most 1.5 MPa, c) whereafter, before the cooling, the G* is raised to its final value. The shaped parts may advantageously be used in medical applications, e.g., as an element of a hip or knee prosthesis. | 04-08-2010 |
| 20100160548 | PROCESS FOR THE PRODUCTION OF A DIANHYDROHEXITOL BASED POLYESTER - Process for the production of a polyester by the polycondensation of a mixture comprising isoidide, and a dicarboxylic acid or dicarboxylic acid anhydride, wherein the reaction is performed in the melt of the monomers and wherein these monomers are not activated. The polyesters based on one or more of the three isomers of dianhydrohexitol, being isosorbide, isomannide and isoidide, have properties which makes them suitable to be used in powder coatings, toner compositions as well as engineering plastics. The polyesters include a polyester according to the following formula, wherein n ranges from 3 to 300. | 06-24-2010 |
| 20120136134 | PROCESS FOR PREPARING A POLYESTER - Disclosed is a process for preparing a polyester or copolymer containing ester functionalities. The process can comprise:
| 05-31-2012 |
