Patent application number | Description | Published |
20100292099 | TARGETING OF RNA WITH EXTERNAL GUIDE SEQUENCES - The present disclosure provides compositions and methods for modulating gene expression by using EGS to target miRNA. Another aspect of the present disclosure is the use of EGS to target mitochondrial RNA. MiRNA targets may include immature or mature forms of miRNA, such as miRNA overexpressed in diseases such as cancer. | 11-18-2010 |
20110196018 | Nuclease resistant external guide sequences for treating inflammatory and viral related respiratory diseases - External Guide Sequence (EGS) are described that target proteins required for generation and modification of the immunoglobulin and T-cell repertoire that are useful for treatment or prevention of inflammatory or related diseases. Formulations suitable for administration of an EGS for treatment of inflammatory or related disease are described. The formulations may be administered via inhalation, injection, or orally. The formulations may be in the form of an ointment, lotion, cream, gel, drop, suppository, spray, liquid, powder, granule, solution, suspension, capsule, or tablet. Methods of treating inflammatory or related diseases by administering an effective amount of an EGS in a pharmaceutically acceptable carrier are also described. In preferred embodiments, the disease is asthma, allergic rhinitis, food allergies, atopic skin disease such as eczema, IL-4 and/or IL-13 dependent malignancies, IL-4 and/or IL-13 dependent autoimmune diseases, atopic diseases, the flu, and diseases caused by IL-4 dependent replication of viruses. | 08-11-2011 |
20110235515 | USE OF T-LOOP IN TRANS-SPLICING POLYNUCLEOTIDES - A method of regulating data flow in a wireless communication network includes: collecting data regarding dynamic loading of sector-carrier pairs (pilots) in communication sectors of the wireless communication network; obtaining data rates for data flows of the pilots to access terminals within the wireless communication network; determining one or more pilots to use for conveying data in the wireless communication network based on the data rates and the dynamic loading; and altering data flow over the pilots by at least one of changing a data rate over at least one of the pilots or changing a combination of pilots used by the wireless communication network for conveying data to increase total data flow. | 09-29-2011 |
20140243348 | COMPOSITIONS AND METHODS FOR TREATING HERPES VIRUSES - Compositions and methods that are useful for the treatment of herpesvirus infection (including herpes simplex virii) are disclosed. Methods for identifying compounds useful for the treatment of herpesvirus infection are also disclosed. | 08-28-2014 |
Patent application number | Description | Published |
20090106370 | Processing Electronic Messages According to Sender Classification - A computer-implemented method of sorting electronic messages can include identifying at least one recipient of an electronic message and retrieving a classification scheme of the recipient. An identifier can be included within the electronic message. The identifier can specify a tag selected from the classification scheme of the recipient. The electronic message, including the identifier specifying the selected tag, can be sent. | 04-23-2009 |
20090254817 | Enhanced spell checking utilizing a social network - A computer-implemented method of enhancing spell check. The method can include receiving from each of a plurality of clients at least one custom term and at least one class identifier that is associated with the custom term. The custom terms and the associated class identifiers can be processed to provide an electronic dictionary that includes a plurality of shared terms. Each of the shared terms can be associated with at least one of the class identifiers to which the shared term corresponds. Each of the custom terms can correspond to at least one of the shared terms. At least one of the shared terms can be output to at least one of the plurality of clients. | 10-08-2009 |
20100125577 | Extending Distribution Lists - A method including determining a set of clusters of person records from a data source that includes the person records, where the person records include attributes and person identifiers that correspond to the attributes; determining memberships of the person records to the clusters based on a correlation of the attributes across the person records; searching the person identifiers of the person records in the memberships for matches to existing person identifiers in a distribution list; and for the memberships that include person identifiers that are matches to the existing person identifiers, suggesting other person identifiers from these memberships to be added to the existing person identifiers in the distribution list to extend the distribution list. | 05-20-2010 |
20100169426 | EXPERTISE REFERRALS USING A REAL-TIME COMMUNICATION SYSTEM - A computer-implemented method of providing expertise based referrals can include receiving, from a first user, a voucher specifying a second user seeking expertise and a third user as a potential subject matter expert. Responsive to execution of the voucher, an instant messaging session between the second user and the third user can be established and an input from the second user indicating whether a posed question from the second user is resolved can be received. When the posed question is resolved, a role of maven can be assigned to the first user and a role of subject matter expert can be assigned to the third user. A transcript of the instant messaging session between the second user and the third user, a reference to the first user with the assigned role, and a reference to the third user with the assigned role can be stored as part of a referral transaction. | 07-01-2010 |
20110161840 | PERFORMANCE OF TEMPLATE BASED JAVASCRIPT WIDGETS - Included are method, article of manufacture, and device that serve to embed a universal script object into programming code used for rendering a web page, convert the universal script object into JavaScript, and upon receiving a request for a web page, send the converted and embedded universal script object towards a requestor. The universal script object may be converted from HTML or some other language. | 06-30-2011 |
20120203783 | PROCESSING ELECTRONIC MESSAGES ACCORDING TO SENDER CLASSIFICATION - A computer-implemented method of sorting electronic messages can include identifying at least one recipient of an electronic message and retrieving a classification scheme of the recipient. An identifier can be included within the electronic message. The identifier can specify a tag selected from the classification scheme of the recipient. The electronic message, including the identifier specifying the selected tag, can be sent. | 08-09-2012 |
Patent application number | Description | Published |
20130317751 | SYSTEM AND METHOD FOR PERFORMING GEOCHRONOLOGY - Systems and methods for determining geologic age are provided. A method includes separating a sample into species of interest; supplying the species of interest to a mass spectrometer; generating an intensity-versus-time data set for two or more elemental masses, identifying a set of intensity peaks having members from each of at least two of the intensity-versus-time data sets; and determining the geologic age of the sample using ratios of the members of the set of intensity peaks. A system includes a species generator for receiving a sample and generating species of interest; a mass spectrometer for receiving the species of interest and generating an intensity-versus-time data set for each of two or more elemental masses; and a processor configured to identify a set of intensity peaks, and to determine the geologic age of the sample using ratios of the members of the set of intensity peaks. | 11-28-2013 |
20140020456 | Method For Preparing Petroleum Based Samples For Analysis of Elemental and Isotopic Species - A method of separating petroleum samples containing a hydrocarbon-soluble elemental species of interest to facilitate analysis of an elemental and/or isotopic signature. A petroleum sample is mixed with a demulsifier and separated, for example by centrifuging, into one or more intermediate organic fractions. The intermediate organic fraction(s) are mixed with a solvent such as water and a second demulsifier, then separated into one or more prepared organic fractions and one or more solvent-based fractions. Some or all of the resulting fractions are then stored for possible further processing. Optionally, the petroleum sample may be spiked with one or more of an organic standard and an inorganic standard, and the solvent may likewise be spiked with an inorganic internal standard, to facilitate later analysis. | 01-23-2014 |
20140249053 | NANOPARTICLE PROBES, METHODS, AND SYSTEMS FOR USE THEREOF - Methods of identifying geological materials of interest comprising (i) providing a nanoprobe composition comprising one or more nanoprobes; wherein the nanoprobe includes (a) at least one tag; and (b) at least one signal generator; (ii) introducing the nanoprobes to a geological material; and (iii) detecting the presence of a signal generated by the signal generator on association of the tag with a target. Nanoprobe compositions identify geological materials, systems include such nanoprobe compositions, and methods use such nanoprobe compositions for the evaluation of geological materials. | 09-04-2014 |
20140250999 | METHOD AND SYSTEM FOR RESERVOIR SURVEILLANCE UTILIZING A CLUMPED ISOTOPE AND/OR NOBLE GAS DATA - A method is disclosed for producing hydrocarbons with the use of reservoir surveillance. The method includes interpreting a sample to determine noble gas signatures and clumped isotope signatures for the region of interest. Then, using the region of interest fingerprint to perform reservoir surveillance on produced fluids from the subsurface regions. | 09-11-2014 |
20140256055 | EXPLORATION METHOD AND SYSTEM FOR DETECTION OF HYDROCARBONS - A method for detecting hydrocarbons is described. The method includes performing a remote sensing survey of a survey location to identify a target location. Then, an underwater vehicle (UV) is deployed into a body of water and directed to the target location. The UV collects measurement data within the body of water at the target location, which is then analyzed to determine whether hydrocarbons are present at the target location. | 09-11-2014 |
20140284465 | EXPLORATION METHOD AND SYSTEM FOR DETECTION OF HYDROCARBONS WITH AN UNDERWATER VEHICLE - A method for detecting hydrocarbons with an underwater vehicle equipped with one or more measurement components is described. The method includes navigating the UV within the body of water; monitoring the body of water with measurement components associated with the UV to collect measurement data. The collected data from the UV is used to determine whether hydrocarbons are present and at the location. | 09-25-2014 |
20140288853 | METHOD FOR DETERMINING THE LOCATION, SIZE, AND FLUID COMPOSITION OF A SUBSURFACE HYDROCARBON ACCUMULATION - A method is disclosed for determining a presence, type, quality and/or volume of a subsurface hydrocarbon accumulation from a sample related thereto. The method may include obtaining sample data associated with a subsurface hydrocarbon accumulation, wherein the sample data includes a noble gas signature, a clumped isotope signature and/or a ecology signature. From the signatures, relationships between the noble gas signature; the clumped isotope signature and the ecology signature are identified and stored in memory. | 09-25-2014 |
20140303895 | METHOD FOR DETERMINING THE LOCATION, SIZE, AND FLUID COMPOSITION OF A SUBSURFACE HYDROCARBON ACCUMULATION - A method is disclosed for determining for determining a presence, type, quality and/or volume of a subsurface hydrocarbon accumulation from a sample related thereto. The method may include determining a noble gas signature of a sample and at least one or more of determining a clumped isotope signature of the sample and characterizing the ecology signature of the sample. Then, the method integrates signatures to determine information about the subsurface accumulation, such as the location, fluid type and quality, and volume of a subsurface hydrocarbon accumulation. | 10-09-2014 |
20150127313 | Method For Determining The Presence and Location of A Subsurface Hydrocarbon Accumulation and The Origin of The Associated Hydrocarbons - A method of determining a presence and location of a subsurface hydrocarbon accumulation from a sample of naturally occurring substance. An expected concentration of isotopologues of a hydrocarbon species is determined. An expected temperature dependence of isotopologues present in the sample is modeled using high-level ab initio calculations. A clumped isotopic signature of the isotopologues present in the sample is measured. The clumped isotopic signature is compared with the expected concentration of isotopologues. Using the comparison, it is determined whether hydrocarbons present in the sample originate directly from a source rock or whether the hydrocarbons present in the sample have escaped from a subsurface accumulation. The current equilibrium storage temperature of the hydrocarbon species in the subsurface accumulation prior to escape to the surface is determined. A location of the subsurface accumulation is determined. This information may be integrated with pre-drill basin burial history models to calibrate a basin model. | 05-07-2015 |