Down
Andrew Down, Dursley GB
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20140144155 | GAS TURBINE COMPRISING A HEAT SHIELD AND METHOD OF OPERATION - A turbine has a first and second inner wall, an inner casing and a shield element. The first and second inner walls are mounted to the inner casing such that an inner volume for working fluid is separated from an outer volume for cooling fluid. The first and second inner walls and inner casing are arranged to form a cavity in outer volume. The shield element is arranged inside cavity to separate cavity in an inner and outer region in a radially outer position to the inner region. A gap is formed between the first and second inner walls for working fluid between the inner volume and inner region. The shield element is arranged in cavity to form a fluid inlet for injecting cooling fluid from outer region to inner region for generating a predefined recirculation of working fluid and cooling fluid inside inner region. | 05-29-2014 |
Andrew Down, Fiskerton GB
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20090317242 | METHOD AND DEVICE FOR COOLING A COMPONENT OF A TURBINE - A method for cooling a component of a turbine is provided, wherein a fluid with a pressure below 1 bar is guided away from the component. Moreover, a turbine is described comprising a component, a conduit which is connected to the component so that a fluid can be guided away from the component, and a fluid discharge which is connected to the conduit. The fluid discharge is constructed so that it removes a fluid with a pressure below 1 bar. | 12-24-2009 |
Chris Down, Newcastle-Upon-Tyne GB
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20150377405 | INSPECTION SYSTEMS - There is provided a stabilisation system for an unmanned aerial vehicle (UAV) comprising positional stabilizer. A UAV provided with a stabilisation system, a method of stabilising a UAV and an inspection method are also provided. | 12-31-2015 |
Christopher David Down, Lowestoft GB
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20090020337 | Downhole drilling tool - A downhole drilling tool | 01-22-2009 |
David John Down, Burnham-On-Crouch GB
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20120156003 | METHOD AND APPARATUS FOR SUPPORTING A LOAD - A lifting block and a method of using it for supporting a load ( | 06-21-2012 |
James A. Down, Cary CA
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20130237960 | INTRADERMAL DELIVERY OF SUBSTANCES - The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient. Delivery devices which place the needle outlet at an appropriate depth in the intradermal space and control the volume and rate of fluid delivery provide accurate delivery of the substance to the desired location without leakage. | 09-12-2013 |
20130237961 | INTRADERMAL DELIVERY OF SUBSTANCES - The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to delver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient. Delivery devices which place the needle outlet at an appropriate depth in the intradermal space and control the volume and rate of fluid delivery provide accurate delivery of the substance to the desired location without leakage. | 09-12-2013 |
John Geoffrey Down, Melbourne AU
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20090197810 | ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES - This invention relates to novel α-conotoxin-like peptides comprising the following amino acid sequence (SEQ ID NO: | 08-06-2009 |
Kenneth David Down, Hertfordshire GB
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20110112070 | 4-CARBOXAMIDE INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF P13-KINASES - The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of P13-kinase activity. | 05-12-2011 |
20110118246 | Novel Compounds - The invention is directed to to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity. | 05-19-2011 |
20110178063 | BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES - The invention is directed to certain novel compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity. | 07-21-2011 |
Kenneth David Down, Stevenage, Hertfordshire, GB
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20110183973 | Novel Compounds - The invention is directed to certain novel compounds directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity. | 07-28-2011 |
Kenneth David Down, Stevenage GB
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20120238559 | NOVEL COMPOUNDS - The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): | 09-20-2012 |
20120245171 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF PI3 KINASES - The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): | 09-27-2012 |
20130165433 | Novel Use - The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection. | 06-27-2013 |
Kenneth David Down, Stevenag GB
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20120238571 | INDAZOLE DERIVATIVES AS PI 3-KINASE - The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): | 09-20-2012 |
Matthew Down, Birmingham GB
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20150016756 | PACKAGING AND METHOD OF PACKAGING - Packaging ( | 01-15-2015 |
Matthew Down, Bournville GB
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20130344203 | PACKAGING - A flow-wrapped package ( | 12-26-2013 |