Dongling
Dongling Gao, Zhengzhou CN
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20130345295 | TARGETED ONCOLYTIC ADENOVIRUS FOR TREATMENT OF HUMAN TUMORS, CONSTRCUTION METHOD AND APPLICATION THEREOF - An oncolytic adenovirus vector and its potential application in cancer treatment and vaccination. The inventive vector (named Ad-TD-hIL12) is derived from the human adenovirus group C type 5, more particularly including deletion of three adenovirus genes E1A-CR2, E1B19K and E3gp-19K, and a fused cDNA sequence of p35 and p40 subunit of human IL12 placed under the control of the E3gp-19K promoter. The invention also includes a method to construct the triple gene-deleted vector (Ad-TD). The Ad-TD-hIL12 and Ad-TD-shIL12 (with a short p40 sequence of human IL 12) vectors can be used as targeted, genetically engineered agents for treatment of various solid tumors, via not only intratumoral injection, and also in intraperitoneal injection, without causing significant side effects, showing a superior antitumor efficacy and safety. | 12-26-2013 |
Dongling Sun, Beijing CN
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20160042704 | PIXEL UNIT, DISPLAY DEVICE AND DRIVING METHOD THEREOF - A pixel unit, a display device and a driving method thereof are provided. The display unit includes at least four sub-pixels, wherein three sub-pixels are polygonal, while the other at least one sub-pixel is disposed in a gap enclosed by the three polygonal sub-pixels. Thus, the display device according to an embodiment of the present invention can improve light utilization, while reducing structural complexity and driving difficulty | 02-11-2016 |
Dongling Yang, Beijing CN
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20150037817 | BIFUNCTIONAL TUMOR DIAGNOSIS REAGENT AND METHOD FOR TUMOR DIAGNOSIS - The invention relates to a bifunctional tumor diagnostic reagent and a method for tumor diagnosis. The reagent consists of a protein shell specifically recognizing a cancer tissue and/or a cancer cell and an inorganic nano-core having the catalytic activity of a peroxidase. The bifunctional tumor diagnostic reagent has two functions, i.e., tumor specific identification and color development, and enables the tumor specific identification and the color development to be completed in one step, and the operation of the process is simple and convenient. | 02-05-2015 |