De Lange, NL
Albert Maas De Lange, Gorreduk NL
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20150040403 | ROTARY SHAVING UNIT - A shaving unit ( | 02-12-2015 |
Ben De Lange, Munstergeleen NL
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20090012300 | Process for the Preparation of an (Hetero) Arylamine - The present invention relates to a process for the preparation of an (hetero)arylamine, wherein an optionally substituted (hetero)aromatic bromide compound is contacted with a nucleophilic organic nitrogen-containing compound in the presence of a base, and a catalyst comprising a copper atom or ion and at least one ligand, said ligand comprising at least one coordinating oxygen atom, and if said oxygen atom is part of an OH group, then said OH group is attached to an aliphatic spa carbon atom or to a vinylic carbon atom. | 01-08-2009 |
20090043112 | Process for the Preparation of Enantiomerically Enriched Indoline-2-Carboxylic Acid - The present invention relates to a process for the preparation of an enantiomerically enriched optionally substituted indoline-2-carboxylic acid or a salt thereof, wherein an enantiomerically enriched chiral ortho-X-substituted phenylalanine compound, wherein X is a leaving group, is subjected to cyclisation, preferably at a temperature of below about 140° C., upon formation of the enantiomerically enriched indoline-2-carboxylic acid compound. | 02-12-2009 |
20100143981 | WHOLE-CELL CATALYTIC SYSTEM COMPRISING A HYDANTOINASE, A RACEMASE AND A CARBAMOYLASE - The present invention relates to a whole cell catalytic system for the preparation of an enantiomerically enriched α-amino acid from a corresponding hydantoin wherein hydantoinase, L-carbamoylase and hydantoin racemase are coexpressed in a recombinant micro-organism wherein the genes coding for these three enzymes are located on a single replicon. The present invention further relates to the use of such a whole cell catalytic system according in the preparation of an enantiomerically enriched L-α-amino acid from a corresponding hydantoin. | 06-10-2010 |
20100174092 | NOVEL 5 SUBSTITUTED HYDANTOINS - The present invention relates to 5-substituted hydantoins, a process for the preparation of 5-substituted hydantoins and the use of 5-substituted hydantoins in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel 5-substituted hydantoins. | 07-08-2010 |
20100221796 | NOVEL CARBAMOYLGLYCINE DERIVATIVES - The present invention relates to carbamoylglycine derivatives, a process for the preparation of carbamoylglycine derivatives and the use of carbamoylglycine derivatives in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel carbamoylglycine derivatives. | 09-02-2010 |
20100324304 | IMPROVED RAMIPRIL SYNTHESIS - The present invention relates to the preparation of ramipril (formula [1]) from unprotected (2S,3S,6S)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid and to a method for preparing unprotected (2S,3S,6S)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid. | 12-23-2010 |
20110008852 | CONVERGENT SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES USEFUL THEREIN - Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R | 01-13-2011 |
20110263871 | METHOD FOR THE SYNTHESIS OF A RAMIPRIL INTERMEDIATE - The present invention relates to a process for the preparation of octahydrocyclopenta[b]pyrrole-2-carboxylic acid and esters thereof of general formula (1) in the presence of a cobalt and/or nickel comprising catalyst and to the use of compounds of general formula (1) in the synthesis of ramipril. | 10-27-2011 |
20130041162 | PRODUCTION OF ATORVASTATIN LOW IN ETHER IMPURITIES - The present invention relates to a method for the production of atorvastatin having decreased levels of impurities of general formulae (3) and (4) by means of a concentrating step. | 02-14-2013 |
20130041163 | PRODUCTION OF ATORVASTATIN LOW IN LACTONE IMPURITIES - The present invention relates to a method for the production of atorvastatin having decreased levels of impurity (3) by means of a pH-controlling step. | 02-14-2013 |
20130310577 | CONVERGENT SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES USEFUL THEREIN - Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). | 11-21-2013 |
Ben De Lange, Echt NL
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20130178636 | ESTERS OF HEXANOIC ACIDS AS INTERMEDIATES FOR THE PREPARATION OF ATORVASTATIN - The invention relates to compounds of general formula (3) wherein R | 07-11-2013 |
20130197243 | SALTS OF 7-AMINO-3,5-DIHYDROXYHEPTANOIC ACID ESTERS - The invention relates to salts of acids with 2-propyl esters of general formula (2) The invention also relates to a method for the preparation of salts of acids with compounds of general formula (2) and to the use thereof in the preparation of atorvastatin. | 08-01-2013 |
20130296561 | PROCESS FOR THE PREPARATION OF STATINS IN THE PRESENCE OF BASE - The present invention relates to a process for the preparation of statins by means of a Julia-Kocienski reaction between an aldehyde and a sulfone derivative in the presence of an alkaline metal alkoxy base. The resulting derivatives are suitable as building blocks for statin type compounds such as cerivastatin, fluvastatin, pitavastatin and rosuvastatin. | 11-07-2013 |
20130296563 | METHYLTETRAZOLE SULFIDES AND SULFONES - The present invention relates to a process for the preparation of a 1-methyl-1H-tetrazole-5-thio derivative comprising reaction of a halomethyl substrate with 1-methyl-H-tetrazole-5-thiol to obtain a thio-ether compound, and oxidizing the thio-ether compound to the corresponding sulfone. In case of a chiral halomethyl substrate, the resulting chiral diol sulfone derivative is suitable as a building block for statin type compounds. | 11-07-2013 |
20130303779 | PROCESS FOR THE PREPARATION OF DIOL SULFONES - The present invention relates to a process for the preparation of a diol sulfone derivative comprising reaction of a halomethyl substrate with a thio-aryl compound to obtain a thio-ether compound, and oxidizing the thio-ether compound to the corresponding sulfone. In case of a chiral halomethyl substrate, the resulting chiral diol sulfone derivative is suitable as a building block for statin type compounds. | 11-14-2013 |
20140343292 | PROCESS FOR THE PREPARATION OF A THIOPRECURSOR FOR STATINS - The present invention relates to a process for the preparation of a precursor for the synthesis of hexanoic acid derived statins and to the use of said precursor in the manufacture of a medicament. | 11-20-2014 |
20140357864 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR - The present invention relates to a process for the preparation of a precursor for the synthesis of hexanoic acid derived statins and to the use of said precursor in the manufacture of a medicament. | 12-04-2014 |
20150251998 | PROCESS TO PRODUCE ATORVASTATIN INTERMEDIATES - The invention provides a process for the production of a compound of formula (I), said process comprising reacting a compound of formula (II) with a compound of formula (III) wherein R1 and R2 may be the same or different and are selected from H; a C1-C6 alkyl which may be straight or branched, substituted or unsubstituted; or R1 and R2 together represent an alkylidene group of the formula CRaRb wherein Ra and Rb may be the same or different and are selected from an alkyl group having between 1 and 6 atoms, and wherein R3 represents a C1-C6 alkyl group, wherein the reaction is carried out at reduced pressure. This may advantageously allow for lower reaction temperatures and/or may result in a higher yield. Also, a phase separation step may be omitted. | 09-10-2015 |
20150259285 | PROCESS TO PRODUCE ATORVASTATIN INTERMEDIATES - The invention provides a process for the production of 1 a compound of formula (I), said process comprising reacting a compound of formula (II), with a compound of formula (III), wherein R1 and R2 may be the same or different and are selected from H; a C1-C6 alkyl which may be straight or branched, substituted or unsubstituted; or R1 and R2 together represent an alkylidene group of the formula CRaRb wherein Ra and Rb may be the same or different and are selected from an alkyl group having between 1 and 6 atoms, and wherein R3 represents a C1-C6 alkyl group, wherein the reaction is carried out in the presence of a base. Using a base may advantageously allow a lower temperature and/or may result in a higher yield. Also, a phase separation step may be omitted. | 09-17-2015 |
Brenda Johanna Maria De Lange, Venhuizen NL
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20120192308 | Method for Providing Fertile Plants via Induction of BBM During Transformation - A method for providing a transgenic plant, including transforming a plant cell or plant material with a nucleotide sequence coding for a BBM protein, wherein activity of the BBM protein is induced during transformation and/or regeneration of the transformed plant cell or plant material, and wherein the plant cell or plant material originates from a recalcitrant plant is provided. In addition, a transgenic plant or material thereof having a BBM protein, wherein the transgenic plant is a recalcitrant plant is also provided. | 07-26-2012 |
Cornelius De Lange, Berkel En Rodenrijs NL
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20140004965 | PIN-SETTING APPARATUS FOR BOWLING OR SKITTLE LANES | 01-02-2014 |
Dirk-Jan Jeroen De Lange, Den Haag NL
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20100053333 | METHOD FOR DETECTING A MOVING OBJECT IN A SEQUENCE OF IMAGES CAPTURED BY A MOVING CAMERA, COMPUTER SYSTEM AND COMPUTER PROGRAM PRODUCT - The invention relates to a method for detecting a moving object in a sequence of images captured by a moving camera. The method comprises the step of constructing a multiple number of difference images by subtracting image values in corresponding pixels of multiple pairs of images being based on captured images. Further, the method comprises the step of retrieving a moving object by extracting spatial information of pixels in the multiple number of constructed difference images having relatively large image values. In addition, from a pair of images in the construction step an image is a representation of a high resolution image having a higher spatial resolution than original captured images on which the high resolution image is based. | 03-04-2010 |
Gerben Frank De Lange, Best NL
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20110216301 | LITHOGRAPHIC APPARATUS AND SCANNING METHOD - A lithographic apparatus includes a first support to support a first patterning device; a second support to support a second patterning device, each of the first and the second patterning device capable of imparting a radiation beam with a pattern in its cross-section to form a patterned radiation beam; a substrate table constructed to hold a substrate; a projection system to project the patterned radiation beam onto a target portion of the substrate; a controller to drive the first support and the second support and arranged to: drive the first support to perform a scanning movement; drive the second support to accelerate during at least part of the scanning movement of the first support; and drive the second support to perform a scanning movement upon completion of the scanning movement of the first support, so as to scan a die adjacent a die previously scanned during the scanning movement of the first support. | 09-08-2011 |
Gerrit Johannes De Lange, Zwolle NL
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20130211002 | LOW TEMPERATURE HEAT-CURABLE POWDER COATING COMPOSITION COMPRISING A CRYSTALLINE POLYESTER RESIN, AN AMORPHOUS RESIN AND A PEROXIDE - The invention relates to heat-curable powder coating composition comprising: i) at least one crystalline polyester resin present in an amount of at least 7.5 wt %; and ii) at least one amorphous polyester resin present in an amount of at most 92.5 wt %; and iii) at least one peroxide present in an amount of at least 0.65 parts of peroxide in hundred parts of i)+ii) (pph), wherein the at least one crystalline polyester resin has 2-butenedioic acid ethylenic unsaturations and/or the at least one amorphous polyester resin has 2-butenedioic acid ethylenic unsaturations; wherein if the at least one amorphous polyester resin has 2-butenedioic acid ethylenic unsaturations, then the theoretical weight per ethylenic unsaturation (WPU) of the at least one amorphous polyester resin is at most 850 g/mol; wherein the wt % is based on the total amount of i)+ii); wherein the peroxide is chosen from the group of peresters and monopercarbonates according to formula R | 08-15-2013 |
Hans De Lange, Rotterdam NL
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20150361717 | BLIND ASSEMBLY AND METHOD OF ATTACHING A SHADE MATERIAL TO A WINDING CORE OF A BLIND - Blind assembly comprising a shade material, a winding core and/or a bottom rail, and compensation means. The shade material is attached to the winding core and/or the bottom rail by attaching the compensation means to the shade material in a first condition in which the compensation means extend along a first line with a first shape. The compensation means can be attached to the winding core and/or the bottom rail in a second condition in which the first line has a second shape, different from the first shape. As a result, the shade material is loaded with compensation forces that can counteract any sagging forces exerted on the shade material by the sagging winding core and/or bottom rail. | 12-17-2015 |
Iise De Lange, Echt NL
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20140113338 | PREPARATION OF 5-FORMYL VALERIC ACID FROM ALPHA-KETOPIMELIC ACID - The invention relates to an alpha-ketopimelic acid decarboxylase enzyme that is a homologue of SEQ ID NO:2, comprising at least one mutation selected from a group of substitutions listed in the specification, to a method for preparing 5-formyl valeric acid (hereinafter also referred to as ‘5-FVA’), to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-ACA’), to a method for preparing ε-caprolactam (hereinafter referred to as ‘caprolactam’) from 6-ACA, to a method for the preparation of adipic acid, to a method for preparing diaminohexane. The invention further relates to a host cell which may be used in a method according to the invention and to a polynucleotide encoding an alpha-ketopimelic acid decarboxylase enzyme. | 04-24-2014 |
Ilse De Lange, Eindhoven NL
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20120190066 | HOST CELL FOR THE PRODUCTION OF A COMPOUND OF INTEREST - The present invention relates to a recombinant host cell for the production of a compound of interest. The invention further relates to a method for the production of such host cell. The invention further relates to the production of a compound of interest. The invention further relates to isolated polynucleotides and vectors and host cells comprising said polynucleotides. | 07-26-2012 |
Ilse De Lange, Echt NL
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20140099401 | ASPARAGINASE ENZYME VARIANTS AND USES THEREOF - The present invention relates to newly identified asparaginase polypeptide variants of SEQ ID NO: 3 and to polynucleotide sequences that encode such novel asparaginase variants. Furthermore the invention relates to the use of these novel asparaginase variants in industrial processes. | 04-10-2014 |
20140248662 | HOST CELL FOR THE PRODUCTION OF A COMPOUND OF INTEREST - The present invention relates to a recombinant host cell for the production of a compound of interest. The invention further relates to a method for the production of such host cell. The invention further relates to the production of a compound of interest. The invention further relates to isolated polynucleotides and vectors and host cells comprising said polynucleotides. | 09-04-2014 |
20150225728 | CELL MODIFICATION METHOD USING ESSENTIAL GENES AS MARKERS AND OPTIONALLY RECYCLING THESE - The invention relates to a method for modification of a host cell at a target locus, which method comprises: providing a host cell comprising, at a first locus, at least two site-specific recombination sites and a nucleic acid having an essential function or encoding a product having an essential function; introducing into the host cell, at the target locus, a further nucleic acid having the essential function or encoding for a product having the essential function; and carrying out recombination at the first locus via the at least two site-specific recombination sites, so that the nucleic acid having an essential function or encoding a product having an essential function is rendered non-functional, thereby to modify the host cell at the target locus. The invention also relates to a cell obtainable by a method of the invention. | 08-13-2015 |
Linda De Lange, Delfgauw NL
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20090004693 | Production of Polypeptides by Improved Secretion - The present invention relates to polypeptides that have an activity corresponding to at least one activity of the SEC61 polypeptide, polynucleotides encoding these polypeptides and the use thereof in the preparation of host cells suitable for production of a polypeptide of interest. Such host cells may have an increased capacity to secrete a polypeptide of interest. | 01-01-2009 |
Michel De Lange, Bk Enkhuizen NL
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20120117683 | PLANT RESISTANT TO A PATHOGEN - The present invention relates to novel | 05-10-2012 |