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De Kock

Andrew De Kock, Andover, MN US

Patent application numberDescriptionPublished
20100125320OVERMOLDED COMPONENTS FOR IMPLANTABLE MEDICAL LEADS AND RELATED METHODS - The various embodiments disclosed herein relate to medical electrical leads. More specifically, certain embodiments relate to leads having one or more drug-eluting components that are overmolded or otherwise positioned on the lead. Other embodiments relate to leads having one or more patterned surfaces, including some leads with one or more patterned surfaces over which one or more drug-eluting components are positioned. Further implementations relate to leads having one or more overmolded patterned surfaces, including some embodiments in which the overmolded surfaces contain at least one drug-eluting component.05-20-2010
20110156306IMPLANTABLE LEADS WITH A UNITARY SILICONE COMPONENT - A method of manufacturing a medical electrical lead includes molding a lead body pre-form, stringing an electrode onto the pre-form and overmolding the pre-form with a polymer to form a lead body portion. The pre-form has a proximal end, a distal end and at least one lumen extending between the proximal and distal ends. At least one asymmetric region of the pre-form has a transverse cross-section that has a non-circular outer dimension. The overmolding causes the asymmetric region to become substantially circular.06-30-2011
20110160819IMPLANTABLE LEADS WITH OPTIMIZED LEAD BODY CROSS-SECTION CONFIGURATION - The embodiments herein relate to medical lead body configurations that reduce conductor flexural fatigue. The various lead body embodiments include a support section and can also include other features such as a semi-straight portion of a lumen or semi-straight sides that optimize the reduction in conductor flexural fatigue.06-30-2011
20110160823IMPLANTABLE LEADS WITH A LOW COEFFICIENT OF FRICTION MATERIAL - A method of reducing a coefficient of friction between a medical electrical lead and a delivery system includes machining a mold for a lead, roughening at least a portion of the mold to an average surface roughness of at least about 7 micro-inches and injecting a polymer into the roughened mold to form a roughened portion of a lead body.06-30-2011
20110160825IMPLANTABLE LEADS WITH A CONDUCTOR COIL HAVING TWO OR MORE SECTIONS - Various coiled conductors having two or more sections and methods and devices for constructing such conductors are disclosed. The various embodiments of coiled conductors and related methods include two or more sections that can have different mechanical, structural, and/or electrical characteristics.06-30-2011
20110160828MRI CONDITIONALLY SAFE LEAD WITH LOW-PROFILE MULTI-LAYER CONDUCTOR FOR LONGITUDINAL EXPANSION - An implantable electrical lead having a flexible body and including a multi-layer coil conductor extending within the longitudinal body lumen from the connector assembly to at least the electrode, the multi-layer coil conductor including a first coil layer a second coil layer disposed about the first coil layer, wherein at least one parameter of the first and the second coil layer is configured such that the lead exhibits a predetermined axial stiffness or bending stiffness.06-30-2011
20110160830IMPLANTABLE LEADS WITH AN AXIAL REINFORCEMENT MEMBER - Implantable electrical leads including an axial reinforcement member are disclosed. In some embodiments, an implantable electrical lead can have a body, one or more electrodes, a cable conductor, a conductor coil, and a reinforcement member. A cable conductor can be disposed within the body and is configured to convey electrical signals between the proximal region and the distal region of the lead. The reinforcement member may be coupled to or integrally formed within the lead body and is configured to limit elongation of the lead body in response to a tensile force.06-30-2011
20110160831TAPERED DRUG-ELUTING COLLAR FOR A MEDICAL ELECTRICAL LEAD - A medical electrical lead includes a tapered distal tip having a tapered drug-eluting component incorporated therein. The drug-eluting component can be an overmolded drug-eluting collar or a pre-molded drug eluting collar. The drug-eluting collar is disposed in a recess formed in the tapered distal tip and maintains the overall tapered profile of the distal tip.06-30-2011
20160031530MARKER-BUOY DEPLOYMENT SYSTEM - Apparatus and associated methods relate to a marker-buoy deployment system having a launching module that becomes armed by inserting a marker buoy, then laterally launches a loaded marker buoy in response to a user command. In an illustrative embodiment, launching module may be spring operated. In some embodiments, the release device may be foot operated. In an exemplary embodiment, a safety device may prevent an accidental launch, for example, from a trailered boat. In some embodiments, a visual indicator may indicate whether the safety is on, or the buoy has been loaded or launched. In some embodiments, a deployed-buoy location system may record the location coordinates of one or more deployed marker buoys. In an exemplary embodiment, marker buoys may be loaded automatically from a magazine each time a marker buoy is deployed. In some embodiments, marker-buoys may advantageously be deployed by a boater whose hands are otherwise occupied.02-04-2016
20160067475IMPLANTABLE MEDICAL LEADS HAVING OSCILLATING CABLE CONDUCTOR LUMENS - An electrical implantable lead includes an elongated lead body having a plurality of lumens therein, including at least one linear lumen and at least one planar, non-linear lumen and a plurality of conductor cables disposed within the plurality of lumens. The electrical implantable lead further includes a terminal connector coupled to a proximal end of the lead body, the terminal connector being in electrical communication with at least one of the plurality of conductor cables. Further, the electrical implantable lead includes at least one electrode coupled to the lead body, the at least one electrode in electrical communication with at least one of the plurality of conductor cables. In accordance with various embodiments, the at least one non-linear lumen extends longitudinally along a portion of the lead body and includes a plurality or crests and a plurality of troughs.03-10-2016

Patent applications by Andrew De Kock, Andover, MN US

Andrew L. De Kock, Andover, MN US

Patent application numberDescriptionPublished
20130138188IMPLANTABLE MEDICAL LEADS HAVING OSCILLATING CABLE CONDUCTOR LUMENS - An electrical implantable lead includes an elongated lead body having a plurality of lumens therein, including at least one linear lumen and at least one planar, non-linear lumen and a plurality of conductor cables disposed within the plurality of lumens. The electrical implantable lead further includes a terminal connector coupled to a proximal end of the lead body, the terminal connector being in electrical communication with at least one of the plurality of conductor cables. Further, the electrical implantable lead includes at least one electrode coupled to the lead body, the at least one electrode in electrical communication with at least one of the plurality of conductor cables. In accordance with various embodiments, the at least one non-linear lumen extends longitudinally along a portion of the lead body and includes a plurality or crests and a plurality of troughs.05-30-2013
20130158641MRI CONDITIONALLY SAFE LEAD WITH LOW-PROFILE MULTI-LAYER CONDUCTOR FOR LONGITUDINAL EXPANSION - An implantable electrical lead includes a lead body and a multi-layer coil conductor extending within the lead body. The multi-layer coil conductor includes a first coil layer and a second coil layer disposed about the first coil layer. The first and second coil layers are configured such that the multi-layer coil conductor has an axial stiffness substantially equal to an axial stiffness of the lead body adjacent to the multi-layer coil conductor.06-20-2013
20140052108MEDICAL DEVICE WITH TEXTURED SURFACE - Described is a guide catheter for guiding other medical devices into or through a body lumen, comprising: a polymeric, tubular inner liner having a textured inner surface; and, a polymeric jacket bonded to an exterior of the inner liner; wherein the texture of the inner surface of the inner liner reduces the coefficient of friction between the inner liner and the other medical devices.02-20-2014
20140075753IMPLANTABLE LEADS WITH A CONDUCTOR COIL HAVING TWO OR MORE SECTIONS - Various coiled conductors having two or more sections and methods and devices for constructing such conductors are disclosed. The various embodiments of coiled conductors and related methods include two or more sections that can have different mechanical, structural, and/or electrical characteristics.03-20-2014
20140135885IMPLANTABLE LEAD HAVING A LUMEN WITH A WEAR-RESISTANT LINER - An implantable lead includes a lead body having a proximal end portion and a distal end portion. The lead body includes an insulative member having a lumen extending longitudinally between the proximal end portion and the distal end portion. The lead body also includes a generally tubular liner disposed coaxially with the lumen within the insulative member. The implantable lead also includes an electrode disposed along the lead body in the distal end portion thereof, and a conductor disposed within the lumen and electrically coupled to the electrode. A terminal connector is coupled to the proximal end portion of the lead body and to the conductor.05-15-2014
20140155972MRI CONDITIONALLY SAFE LEAD WITH LOW-PROFILE CONDUCTOR FOR LONGITUDINAL EXPANSION - An implantable electrical lead includes a lead body and a multi-layer coil conductor extending within the lead body. The multi-layer coil conductor includes a first coil layer and a second coil layer disposed about the first coil layer. The first and second coil layers are configured such that the multi-layer coil conductor has an axial stiffness substantially equal to an axial stiffness of the lead body adjacent to the multi-layer coil conductor.06-05-2014
20150025611IMPLANTABLE MEDICAL LEADS HAVING OSCILLATING CABLE CONDUCTOR LUMENS - An electrical implantable lead includes an elongated lead body having a plurality of lumens therein, including at least one linear lumen and at least one planar, non-linear lumen and a plurality of conductor cables disposed within the plurality of lumens. The electrical implantable lead further includes a terminal connector coupled to a proximal end of the lead body, the terminal connector being in electrical communication with at least one of the plurality of conductor cables. Further, the electrical implantable lead includes at least one electrode coupled to the lead body, the at least one electrode in electrical communication with at least one of the plurality of conductor cables. In accordance with various embodiments, the at least one non-linear lumen extends longitudinally along a portion of the lead body and includes a plurality or crests and a plurality of troughs.01-22-2015
20150352352FLEX SAFE SUTURE SLEEVE - A suture sleeve for securing an implantable lead with a suture includes an elongate, tubular body having a proximal end portion with a proximal face, a distal end portion with a distal face, and an exterior surface. The suture sleeve also includes a lumen within the tubular body extending from the proximal end portion to the distal end portion, wherein the lumen is sized to receive the implantable lead. The suture sleeve also includes a nonlinear, inner transition region extending from the lumen to at least one of the proximal face and the distal face of the tubular body, wherein the inner transition region is a curvilinear surface or a chamfered edge having an obtuse angle between adjacent surfaces thereof and is adapted to control the radius of curvature of the implantable lead that bends along the inner transition region.12-10-2015
20150366465BARORECEPTOR MAPPING SYSTEM - A system for mapping and marking baroreceptors of a patient. The system includes a mapping device, a marker, and a stimulator. The mapping device includes a plurality of electrodes to be situated on the patient. The marker is to be attached to the patient and mark a location of at least one of the plurality of electrodes based on an analysis of patient physiological responses to stimulation of the plurality of electrodes. The stimulator is to divide the plurality of electrodes into a first electrode zone and a second electrode zone and stimulate electrodes in the first electrode zone and the second electrode zone to obtain first patient physiological responses, where one of the first electrode zone and the second electrode zone is selected based on the first patient physiological responses.12-24-2015
20150366467BARORECEPTOR MAPPING SYSTEM - A system including a mapping device, a stimulator, and a marker. The mapping device includes a plurality of electrodes to be situated on a baroreceptor region of a patient to map baroreceptors in the baroreceptor region. The stimulator is to stimulate selected electrodes of the plurality of electrodes to obtain physiological responses from the patient in response to stimulation of the selected electrodes. The marker is to be attached to the patient to mark a location of at least one of the selected electrodes based on an analysis of the physiological responses from the patient, where the marker is to maintain its location on the patient as the mapping device is removed from the patient.12-24-2015
20160059005PADDLE LEADS CONFIGURED FOR SUTURE FIXATION - Various embodiments concern an implantable paddle lead. The paddle can be attached to a distal portion of an elongate lead body. The paddle can comprise a main panel and a ridge that peripherally surrounds the main panel. The main panel can comprise a first face and a second face opposite the first face. One or more electrodes can be exposed on the first face but not exposed on the second face. The paddles can be sutured to anatomical structures. The sutures can be threaded through the main panel but not through the ridge. The paddle can be thicker along the ridge than along the main panel.03-03-2016
20160074650PADDLE LEADS HAVING ASYMMETRIC ELECTRODE CONFIGURATIONS - Various embodiments concern an implantable lead. The lead can comprise a lead body. At least two conductors can extend within the lead body, such as in respective lumens of the lead body. The lead can comprise at least two electrodes. Each electrode can be connected to a respective one of the at least two conductors. A paddle body can be connected to the lead body. The paddle body can comprise a longitudinal axis that divides the paddle body into left and right sides. The at least two electrodes can be partially embedded within the paddle body. The at least two electrodes can be arrayed along the longitudinal axis. Each electrode can be asymmetric about the longitudinal axis.03-17-2016

Patent applications by Andrew L. De Kock, Andover, MN US

Filip De Kock, Canford Cliffs GB

Patent application numberDescriptionPublished
20140104048ANTI-THEFT SYSTEM FOR AN AUTOMOTIVE EXHAUST COMPONENT - An anti-theft system for protecting a vehicle exhaust component (04-17-2014

Herman De Kock, Arendonk BE

Patent application numberDescriptionPublished
20090118339LYSINE RELATED DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS - The present invention concerns lysine related derivatives, their use as protease inhibitors, in particular as HIV aspartyl protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. The present invention also concerns combinations of the present lysine related derivatives with another anti retroviral agent. It further relates to their use in assays as reference compounds or as reagents.05-07-2009
200902095832-(SUBSTITUTED-AMINO)-BENZOTHIAZOLE SULFONAMIDE HIV PROTEASE INHIBITORS - The present invention relates to 2-(substituted-amino)-benzothiazole sulfonamide compounds and derivatives, their use as protease inhibitors, in particular as broad-spectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. The present invention also concerns combinations of the present 2-(substituted-amino)-benzothiazole sulfonamide compounds and derivatives with another anti-retroviral agent. It further relates to their use in assays as reference compounds or as reagents.08-20-2009
20110306634Amorphous Salt of a Macrocyclic Inhibitor of HCV - The amorphous form of the sodium salt of the macrocyclic inhibitor of HCV of formula:12-15-2011

Herman Augustinus De Kock, Arendock BE

Patent application numberDescriptionPublished
20130217725Macrocyclic Inhibitors Of Hepatitis C Virus - Inhibitors of HCV replication of formula (I)08-22-2013

Jan Abraham De Kock, Potchefstroom ZA

Patent application numberDescriptionPublished
20130176648POLE-SLIP PROTECTION SYSTEM AND METHOD FOR SYNCHRONOUS MACHINES - A method of protecting a synchronous machine (07-11-2013

Joel A. De Kock, New Richmond, WI US

Patent application numberDescriptionPublished
20110062128Multiple laser beam focusing head - An apparatus that divides a single laser beam into two or more beams that can be directed at an object, such as a work piece, to perform laser heat treatment is disclosed. An adapter stage is in optical communication with a light source, such as a laser source, and arranged to receive a light beam from the light source. A focus stage in optical communication with the adapter stage is arranged to receive the light beam from the adapter stage and to focus the light beam. A beam splitting stage in optical communication with the focus stage is arranged to receive the focused light beam and to split the focused light beam into a multiple light beams. A redirection stage in optical communication with the beam splitting stage is arranged to receive the multiple light beams and to direct them toward a plurality of target locations on the object.03-17-2011

Joery De Kock, Willebroek BE

Patent application numberDescriptionPublished
20100278782DIFFERENTIATION OF RAT LIVER EPITHELIAL CELLS INTO HEPATOCYTE-LIKE CELLS - Methods for differentiation of cells of a rat liver epithelial (RLEC) cell line to hepatocyte-like cells are disclosed. In particular, methods involve sequential exposure of the RLEC to two or more differentiation agents. Cells obtained by the method are described as well as their uses in various pharmacological, toxicological, therapeutic, diagnostic and research applications.11-04-2010

Lambert Hendrik De Kock, Takapuna Auckland NZ

Patent application numberDescriptionPublished
20140103618Trailer Coupling - A trailer coupling for a motor vehicle includes a base holder which can be or is securely mounted on the vehicle and further includes a coupling arm at the free end of which a coupling element is arranged for coupling a trailer and which protrudes towards the rear from the motor vehicle in a position of use, wherein the coupling arm can be releasably secured to the base holder or is mounted movably between the position of use and a position of non-use in which it is moved towards the motor vehicle. In the trailer coupling, it is provided that, for connection to the base holder, the coupling arm includes a holder part which can be secured to the base holder by means of a base holder fixing device and a coupling part on which the coupling element is located.04-17-2014

Maarten Johannes David De Kock, Voorhout NL

Patent application numberDescriptionPublished
20100041038METHOD FOR DISCRIMINATING SINGLE NUCLEOTIDE POLYMORPHISMS - A method for discriminating single nucleotide polymorphisms (SNPs) offers improved sensitivity and specificity. A test kit is also provided. The method may be for genotyping in typing assays applied to a biological sample. The method may include steps of performing a real-time amplification of the target, generating multiple copies of amplicons, in presence of at least two different labeled probes, each probe allowing real-time detection at the SNP position of both the wildtype and at least one possible mutation, assessing the discriminatory variable value(s) based on the signals of each combination of two detection probes, and discriminating between the genotypes. The methods may be for diagnostic, preventive and therapeutic applications.02-18-2010

Paul De Kock, Numansdorp NL

Patent application numberDescriptionPublished
20100000832LOW-NOISE SHOCK ABSORBER - Shock absorber provided with a piston having a number of constantly open connecting channels which connect the two sides of the piston, and having a number of connecting channels to be opened and closed by element of a valve. The valve includes a plate valve which under the influence of flow therethrough, i.e. the pressure difference over the piston, on the outward movement of the shock absorber can be closed to a greater or lesser extent. On the inward movement, unimpeded flow of fluid through the piston can occur. A flow-through path is bounded by the corresponding connecting channels and the valve together with the upper side of the piston. In the rest position there is a flow-through possibility for fluid when the shock absorber fixings move away from each other, and when the shock absorber fixings move away from each other more quickly the flow-through cross section gradually decreases until the valve closes completely.01-07-2010
20100193310YAW DAMPER WITH PUMP - Yaw damper for damping yaw motions between two vehicle parts. This includes in the customary manner a piston part and a cylinder part, wherein that piston part is provided with a piston which divides that cylinder part into two chambers. Between these two chambers, connecting lines are present. The embodiment of these connecting lines determines the damping characteristic which governs the motion between the piston and the cylinder part. Especially for vehicle parts which move at higher speeds and/or high frequencies, such as train sets, it is desirable to provide a damper which is as stiff as possible. For this purpose, the present invention proposes the installation of pumping elements which, as far as possible, increase the pressure in the chambers which are formed by the piston in the cylinder part. Preferably, this construction is realized such that this pressure automatically decreases at lower speeds and/or low frequencies.08-05-2010
20110180361STIFF DAMPER - Damper which is, in particular, stiff during the inward stroke thereof and can be used, for example, as a railway damper. The piston which divides the cylinder into two chambers is provided with non-return valves which operate in both directions and are configured as characteristic. A sleeve extends from the bottom of the cylinder which is displaceable in the interior of the piston/piston rod and one end of which is connected to a reservoir and the other end of which may be connected to one of the chambers. In addition, a bottom valve is present in the cylinder. The combination of sleeve/bottom valve is fitted in such a manner that when the piston moves inwards in the cylinder, the liquid volume which has to be displaced is moved by additional rod volume which enters the cylinder via the sleeve in the reservoir. During the outward movement, the liquid is replenished from the reservoir via the bottom valve.07-28-2011
20120181126ADJUSTABLE SHOCK ABSORBER - Shock absorber comprising a piston inside which a sleeve is present which can be operated separately from the piston. This sleeve is provided with through-flow conduits which can cooperate with apertures, which are fitted at a vertical distance, of a part of the piston in order to provide an auxiliary flow when the piston is displaced in the cylinder. Such auxiliary flow enters into a chamber which is delimited by one or more spring plates which act on a sleeve which loads the main valve against opening when it is pressed down by the spring plate. By filling the chamber with fluid, the load applied on the sleeve by the spring plate is reduced and the load on the main valve decreases, as a result of which the latter opens more readily.07-19-2012
20140238798FLUID-FILLED, FREQUENCY-DEPENDENT DAMPER - A fluid-filled, frequency-dependent damper includes a cylinder connected to a cylinder attachment portion; a piston connected to a piston attachment portion, the piston being displaceable in the cylinder; first and second main chambers; and a throttling member for allowing and influencing a fluid flow between the first and second main chambers within the damper when the cylinder attachment portion and the piston attachment portion move relative to each other.08-28-2014
20150323037SHOCK ABSORBER - A shock absorber includes a cylinder; a piston movable therein and dividing the cylinder in first and second cylinder chambers; a cylinder attachment for attachment to a first part of a vehicle and connected to the cylinder; and a piston attachment for attachment to a second part of a vehicle and connected to the piston. The piston attachment and cylinder attachment move towards one another on an inward movement and away from one another on an outward movement. The piston includes a first inward channel; a first inward valve to open the first inward channel on inward movement; a first outward channel; a first outward valve to open the first outward channel on outward movement; a second inward channel; a second inward valve to open the second inward channel on inward movement; a second outward channel; and a second outward valve to open the second outward channel on outward movement.11-12-2015
20150345586SHOCK ABSORBER - A shock absorber includes a cylinder and a piston movable within the cylinder along a cylinder wall, the piston dividing the cylinder in a first cylinder chamber and a second cylinder chamber, which are filled with fluid. The shock absorber also includes cylinder and piston attachments for attachment to parts of a vehicle, the piston attachment and cylinder attachment moving towards one another in an inward movement and away from one another in an outward movement. Primary and auxiliary flow and valve arrangements allow fluid flow in between the first and second cylinder chambers to provide primary and auxiliary damping behavior of the shock absorber, respectively. The auxiliary flow and valve arrangement includes a first auxiliary flow and valve arrangement providing on outward movement a damping behavior showing a frequency dependency, and a second auxiliary flow and valve arrangement providing on inward movement a damping behavior showing a linear dependency12-03-2015

Patent applications by Paul De Kock, Numansdorp NL

Peter Antonius Maria Gerardus De Kock, Hilversum NL

Patent application numberDescriptionPublished
20160063085SYSTEM AND METHOD FOR ANTICIPATING CRIMINAL BEHAVIOUR - A system and method for anticipating criminal behaviour. The system includes or is connectable to a database including records, each record including data representative of a criminal incident. The system includes a pre-processing unit arranged for scanning each record for identifying data-items relating to a plurality of predetermined data types, wherein the plurality of predetermined data types includes all or a sub-set of: Arena, Time(frame), Context, Protagonist, Antagonist, Motivation, Primary Objective, Means, modus operandi, Resistance, Symbolism, and Red herring of the criminal incident. The system includes a classifying unit arranged for assigning to each identified data-item a category value of one of a plurality of predetermined category values associated with said predetermined data-type. The system includes a processing unit arranged for constructing a matrix containing a row for each record, and containing columns related to the predetermined data-types, the cells of the matrix containing the determined category values. The system includes an input unit, arranged for receiving user input, the user input including category values of a criminal incident for some, but not all, of the predetermined data types. The system includes a scenario generator arranged for estimating, on the basis of the user input and on the basis of the matrix, a category value for the predetermined data type(s) not included in the user input. The system includes an output unit arranged for outputting the estimated category value for the predetermined data type(s) not included in the user input.03-03-2016

Philip De Kock, Kapellen BE

Patent application numberDescriptionPublished
20080281130PROCESS FOR PRODUCING BISPHENOL A WITH AN EXTENDED SERVICE LIFE IN THE CRYSTALLISATION - The invention describes a process for producing bisphenol with a content of less than 15 wt. % of phenol, wherein a suspension crystallisation of a product mixture containing bisphenol A, minor components and phenol is performed in a crystalliser, the product mixture being pumped through a heat exchanger. Due to deposition (fouling, i.e. crystallisation and deposition on the surface of the heat exchangers) in the heat exchanger, the pressure difference increases from 0.5 to 3 bar across the heat exchanger. The resulting reduced flow rate, which would lead to increased fouling in the crystalliser, is offset by continuously increasing the speed of the pump, the pump speed being regulated in such a way that the current consumption of the pump is maintained such that it fluctuates by a maximum of 5%.11-13-2008
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