Davis, NJ
Anjul Davis, Newton, NJ US
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20140028997 | AGILE IMAGING SYSTEM - An agile optical imaging system for optical coherence tomography imaging using a tunable source comprising a wavelength tunable VCL laser is disclosed. The tunable source has long coherence length and is capable of high sweep repetition rate, as well as changing the sweep trajectory, sweep speed, sweep repetition rate, sweep linearity, and emission wavelength range on the fly to support multiple modes of OCT imaging. The imaging system also offers new enhanced dynamic range imaging capability for accommodating bright reflections. Multiscale imaging capability allows measurement over orders of magnitude dimensional scales. The imaging system and methods for generating the waveforms to drive the tunable laser in flexible and agile modes of operation are also described. | 01-30-2014 |
Anjul M. Davis, Little Falls, NJ US
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20090270738 | Methods for single-pass volumetric bidirectional blood flow imaging Spectral Domain Optical Coherence Tomography using a modified hilbert transform - The present subject matter relates to in vivo volumetric bidirectional blood flow imaging using single-pass flow imaging spectral domain optical coherence tomography. This technique uses a modified Hilbert transform algorithm to separate moving and non-moving scatterers within a depth. The resulting reconstructed image maps the components of moving scatterers flowing into and out of the imaging axis onto opposite image halfplanes, enabling volumetric bidirectional flow mapping without manual segmentation. | 10-29-2009 |
Anthony Davis, Jersey City, NJ US
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20150181974 | ATHLETIC SHOE TRAINER - An athletic shoe for simulating training in running spikes. The athletic shoe includes an outsole for engaging a horizontal supporting surface, a midsole having a wedge portion coupled to the outsole and an arch portion elevated at an angle of not less than 15° relative to the horizontal surface, and an upper that encloses the midsole. By incorporating a wedge that elevates the forefoot of the shoe and a molded plate, rigidity is provided to the arch of the foot to maintain the user on the balls of the user's feet. | 07-02-2015 |
Brian Davis, Milltown, NJ US
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20090232995 | Controlled degradability of organic materials - A chemical mixture for treating biodegradable materials which when subjected to anaerobic decomposition generate environmentally harmful gases such as methane and hydrogen sulfide. The chemical mixture includes chemicals for inhibiting the production of methane and hydrogen sulfide (H | 09-17-2009 |
20120227921 | METHOD OF PRODUCING PAPER WITH METHANE REDUCTION INGREDIENTS - Disclosed is a formulation and method for treating paper so that paper in landfills produces less methane than untreated paper. The method includes adding one or more nitrate salts to paper during the process of making paper, or after the paper is made. One effect of adding the nitrate salts is promoting the growth of certain bacteria which do not produce methane as they consume paper products. | 09-13-2012 |
Brooke Davis, Morristown, NJ US
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20110159142 | SUGAR FREE CONFECTIONERY; METHODS OF MAKING SAME; AND USE IN PREPARING MULTILAYERED CONFECTIONERY - Disclosed are sugar free confectionery products, methods of making, and multilayer structures prepared from the confectionery products and chewing gum. | 06-30-2011 |
20160073657 | SUGAR FREE CONFECTIONERY; METHODS OF MAKING SAME; AND USE IN PREPARING MULTILAYERED CONFECTIONERY - Disclosed are sugar free confectionery products, methods of making, and multilayer structures prepared from the confectionery products and chewing gum. | 03-17-2016 |
Brooke Davis, Whippany, NJ US
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20150201642 | BULK PACKAGED, UNCOATED CHEWING GUM - Disclosed herein are unwrapped and uncoated chewing gum products exhibiting excellent stability when bulk packaged as loose units. | 07-23-2015 |
Carrie Davis, Denville, NJ US
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20160071427 | SYSTEM AND METHOD FOR TEACHING HANDWRITING - The present teachings are directed towards a method of teaching handwriting to a student. The method can include playing a first audio cue from a plurality of different audio cues. Each audio cue can include at least one musical note and can correspond to a specific one of a plurality of letter formation strokes. The method can include instructing the student to perform a first movement in response to the student hearing the first audio cue. The first movement can correspond to a first one of the letter formation strokes. | 03-10-2016 |
Charronne Davis, Mahwah, NJ US
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20100081135 | Single nucleotide polymorphisms and use of same predicting male- specific prenatal loss - The present invention is directed to a panel of single nucleotide polymorphisms (SNPs) in specific genes that serve as biomarkers for sex-specific prenatal loss of a conceptus or embryo. There is provided herein methods and reagents for assessing the specific SNPs in those genes. The method useful in applying these SNPs in predicting an increased risk of prenatal loss is also disclosed. | 04-01-2010 |
20100092959 | Single nucleotide polymorphisms as genetic markers for childhood leukemia - The present invention is directed to a panel of single nucleotide polymorphisms (SNPs) in specific genes that serve as biomarkers for sex-specific childhood leukemia risk. There is provided herein methods and reagents for assessing the specific SNPs in those genes. The method useful in applying these SNPs in predicting an increased risk or a decreased risk for childhood leukemia for males and females is also disclosed. | 04-15-2010 |
20130316922 | QUANTITATION AND PROFILING OF VAGINAL MICROFLORA - Disclosed are methods of quantifying microflora in vaginal samples. Quantitative assessment of vaginal microflora by real-time PCR to create a profiling of | 11-28-2013 |
20140045710 | SINGLE NUCLEOTIDE POLYMORPHISMS AND USE OF SAME IN PREDICTING MALE-SPECIFIC PRENATAL LOSS - The present invention is directed to a panel of single nucleotide polymorphisms (SNPs) in specific genes that serve as biomarkers for sex-specific prenatal loss of a conceptus or embryo. There is provided herein methods and reagents for assessing the specific SNPs in those genes. The method useful in applying these SNPs in predicting an increased risk of prenatal loss is also disclosed. | 02-13-2014 |
Charronne Florence Davis, Ramapo, NJ US
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20160053333 | Novel Haplotype Tagging Single Nucleotide Polymorphisms and Use of Same to Predict Childhood Lymphoblastic Leukemia - The present invention is directed to novel haplotype tagging single nucleotide polymorphisms (SNPs) in specific regions outside the HFE gene that serve as a reliable biomarker for a decreased risk for childhood lymphoblastic leukemia (ALL) in a child. There is provided herein methods and reagents for assessing the haplotype tagging SNPs selected from the group consisting of rs807212, rs198853, rs9467664, rs2213284, rs2230655 and rs12346. The method useful in applying these SNPs in predicting a decreased risk of childhood lymphobastic leukemia (ALL) is also disclosed. | 02-25-2016 |
Dorinne S. Davis, Mt. Arlington, NJ US
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20110207991 | METHOD AND APPARATUS FOR PROVIDING THERAPY USING SPONTANEOUS OTOACOUSTIC EMISSION ANALYSIS - A method and apparatus for providing therapy using spontaneous otoacoustic emission (SOAE) analysis is described. In one embodiments, a method for utilizing the voice-ear-brain connection to achieve self-healing includes capturing audio emissions of at least one ear of a patient, determining a frequency spectrum of the audio emissions, identifying a peak frequency in the frequency spectrum, and producing at least one audio signal in response the peak frequency. | 08-25-2011 |
Graham Davis, Glendora, NJ US
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20100206894 | SHIPPING DEVICE AND RELATED METHODS - A containment assembly may be used with a shipping container and may include: a cargo net having a pair of sleeves; and, a pair of tethering members that are received within the sleeves and that have ends that extends out from the sleeves. The ends of the tethering members may be attachable to multiple attachment surfaces on the shipping container to change the orientation of the cargo net with respect to the shipping container. | 08-19-2010 |
Graham Davis, Princeton, NJ US
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20090065368 | APPARATUS AND METHODS FOR ANALYTE MEASUREMENT AND IMMUNOASSAY - The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments. | 03-12-2009 |
20090204513 | POINT-OF-CARE INVENTORY MANAGEMENT SYSTEM AND METHOD - A system and method are disclosed for controlling an inventory of point-of-care diagnostic devices. The inventory includes a main inventory and at least one subinventory. Each device has an ambient temperature shelf life. Data associated with the devices is entered, including: the current quantity and predetermined minimum quantity of devices in the main inventory; and the current quantity and predetermined minimum quantity of devices in the subinventory. A first timestamp is associated with each device when the device is transferred from the main inventory to the ambient temperature subinventory. The first timestamp is compared to a second timestamp prior to use of the device to determine whether the device's ambient temperature shelf life is exceeded. The current quantity of devices in the subinventory is updated in response to an event that causes a change in the current quantity of devices in the subinventory. | 08-13-2009 |
20110117580 | REDUCING LEUKOCYTE INTERFERENCE IN NON-COMPETITIVE IMMUNOASSAYS - The invention is directed to methods and devices for reducing interference from leukocytes in an analyte immunoassay, and in particular in non-competitive immunoassays. In one embodiment, the invention is to a method comprising the steps of (a) amending a biological sample such as a whole blood sample with sacrificial beads; and (b) performing a non-competitive immunoassay on the amended sample to determine the concentration of said analyte in said sample. Preferably, the sample is amended with IgG-coated sacrificial beads. | 05-19-2011 |
20110117581 | REDUCING LEUKOCYTE INTERFERENCE IN COMPETITIVE IMMUNOASSAYS - The invention is directed to methods and devices for reducing interference from leukocytes in an competitive analyte immunoassays. In one embodiment, the invention is to a method comprising the steps of (a) amending a biological sample such as a whole blood sample with sacrificial beads opsonized for leukocytes; and (b) performing a competitive immunoassay on the amended sample to determine the concentration of said analyte in said sample. Preferably, the sample is amended with IgG-coated sacrificial beads. | 05-19-2011 |
20110166427 | Point-of-Care Inventory Management System and Method - A system and method are disclosed for controlling an inventory of point-of-care diagnostic devices. The inventory includes a main inventory and at least one subinventory. Each device has an ambient temperature shelf life. Data associated with the devices is entered, including: the current quantity and predetermined minimum quantity of devices in the main inventory; and the current quantity and predetermined minimum quantity of devices in the subinventory. A first timestamp is associated with each device when the device is transferred from the main inventory to the ambient temperature subinventory. The first timestamp is compared to a second timestamp prior to use of the device to determine whether the device's ambient temperature shelf life is exceeded. The current quantity of devices in the subinventory is updated in response to an event that causes a change in the current quantity of devices in the subinventory. | 07-07-2011 |
20110256573 | METHOD AND APPARATUS FOR DETERMINING AT LEAST ONE HEMOGLOBIN RELATED PARAMETER OF A WHOLE BLOOD SAMPLE - A method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by an interior surface of a first panel, and an interior surface of a second panel, and the chamber has a height extending between the interior surfaces of the panels, wherein the chamber is configured to increase the oxygenation state of the sample to a substantially oxygenated state within a predetermined amount of time after entry into the chamber; b) imaging the at least one red blood cell contacting the interior surfaces, and producing image signals; c) determining an optical density of at least a portion of the imaged red blood cell contacting both interior surfaces; and d) determining the at least one hemoglobin related parameter of the red blood cell contacting the interior surfaces, using the determined optical density and a molar extinction coefficient for oxygenated hemoglobin. | 10-20-2011 |
20110269159 | REAGENTS FOR REDUCING LEUKOCYTE INTERFERENCE IN IMMUNOASSAYS - Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample such as a whole blood sample with one or more leukocidal reagents that reduce or eliminate the metabolic activity of leukocytes, and performing an immunoassay on the amended sample to determine the concentration of analyte in the sample. Preferably, the sample is amended with one or more enzymes and optionally one or more enzyme substrates and cofactors. | 11-03-2011 |
20110290669 | Apparatus and Methods for Analyte Measurement and Immunoassay - The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments. | 12-01-2011 |
20110306070 | MAGNETIC BEADS FOR REDUCING LEUKOCYTE INTERFERENCE IN IMMUNOASSAYS - Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample with magnetic sacrificial beads opsonized to leukocytes, binding leukocytes in the sample to the magnetic sacrificial beads, and magnetically retaining the beads out of contact from an immuno sensor. | 12-15-2011 |
20120142026 | Assay Devices with Integrated Sample Dilution and Dilution Verification and Methods of Using Same - The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided. | 06-07-2012 |
20120295290 | MAGNETIC BEADS FOR REDUCING LEUKOCYTE INTERFERENCE IN IMMUNOASSAYS - Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample with magnetic sacrificial beads opsonized to leukocytes, binding leukocytes in the sample to the magnetic sacrificial beads, and magnetically retaining the beads out of contact from an immunosensor. | 11-22-2012 |
20120305409 | Apparatus and Methods for Analyte Measurement and Immunoassay - The present invention relates to methods for measuring an amount of an analyte using an electrochemical assay in a conduit comprising a sensor, wherein said sensor comprises an electrode having a surface layer of immobilized antibody that binds said analyte, and a counter/reference electrode disposed within said conduit. A solution comprising a substrate for said enzyme and at least one air segment contacts the sensor to remove unbound analyte and labeled antibody from a region of the sensor. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments. | 12-06-2012 |
20130161190 | Integrated Test Device for Optical and Electrochemical Assays - This invention relates generally to test devices and methods for performing optical and electrochemical assays and, more particularly, to test devices having the ability to perform optical and electrochemical assays on a sample and to methods of performing optical and electrochemical assays using such test devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care. | 06-27-2013 |
20130162981 | Reader Devices for Optical and Electrochemical Test Devices - This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to devices having optical and electrochemical detectors and to methods of performing optical and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care. | 06-27-2013 |
20130184188 | Integrated Test Device for Optical Detection of Microarrays - This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to testing devices having an optically readable microspot array and/or an electrochemical detector and to methods of performing microspot arrays and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care. | 07-18-2013 |
20130189794 | Optical Assay Device with Pneumatic Sample Actuation - This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to test devices, e.g., cartridges, methods and systems, wherein the test devices have an entry port configured to receive a test sample into a holding chamber; a first conduit having at least one lateral flow test strip; and a displacement device, such as a pneumatic pump, configured to move a portion of said test sample from said holding chamber into said first conduit. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care. | 07-25-2013 |
20130224775 | Apparatus and Methods for Analyte Measurement Immunoassay - The present invention relates to methods for measuring an amount of an analyte using an electrochemical assay in a conduit comprising a sensor, wherein said sensor comprises an electrode having a surface layer of immobilized antibody that binds said analyte, and a counter/reference electrode disposed within said conduit. A solution comprising a substrate for said enzyme and at least one air segment contacts the sensor to remove unbound analyte and labeled antibody from a region of the sensor. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments. | 08-29-2013 |
20130273576 | REAGENTS FOR REDUCING LEUKOCYTE INTERFERENCE IN IMMUNOASSAYS - Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample such as a whole blood sample with one or more leukocidal reagents that reduce or eliminate the metabolic activity of leukocytes, and performing an immunoassay on the amended sample to determine the concentration of analyte in the sample. Preferably, the sample is amended with one or more enzymes and optionally one or more enzyme substrates and cofactors. | 10-17-2013 |
20140004554 | METHOD AND APPARATUS FOR DETERMINING AT LEAST ONE HEMOGLOBIN RELATED PARAMETER OF A WHOLE BLOOD SAMPLE | 01-02-2014 |
20140170672 | Portable Clinical Analysis System for Immunometric Measurement - The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. | 06-19-2014 |
20140170694 | Spatial Orientation Determination In Portable Clinical Analysis Systems - The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. | 06-19-2014 |
20140172315 | Operation and Verification of A Portable Clinical Analysis System - The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. | 06-19-2014 |
20140172316 | Portable Clinical Analysis System for Hematocrit Measurement - The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. | 06-19-2014 |
20140172341 | Self Correction for Spatial Orientation and Motion of Portable Clinical Analyzers - The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. | 06-19-2014 |
20140238859 | NUCLEIC ACID SEQUENCING BY ELECTROCHEMICAL DETECTION - Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to devices, methods, and systems for sequencing-by-synthesis using changes in pH to monitor base addition. In some embodiments the electrochemical hydrogen ion sensor is a microfabricated mixed metal oxide electrode and in some embodiments the electrochemical hydrogen ion sensor is a membrane electrode. Moreover, in some embodiments the device further comprises a reference electrode. Performing the sequencing reaction involves moving solutions and other fluids (e.g., samples, nucleotide solutions, wash solutions) into and out of the reaction vessel. Thus, in some embodiments, the device further comprises a tube or other transport mechanism or pathway attached to the reaction vessel. | 08-28-2014 |
20140348204 | Point-of-Care Inventory Management System and Method - A system and method are disclosed for controlling an inventory of point-of-care diagnostic devices. The inventory includes a main inventory and at least one subinventory. Each device has an ambient temperature shelf life. Data associated with the devices is entered, including: the current quantity and predetermined minimum quantity of devices in the main inventory; and the current quantity and predetermined minimum quantity of devices in the subinventory. A first timestamp is associated with each device when the device is transferred from the main inventory to the ambient temperature subinventory. The first timestamp is compared to a second timestamp prior to use of the device to determine whether the device's ambient temperature shelf life is exceeded. The current quantity of devices in the subinventory is updated in response to an event that causes a change in the current quantity of devices in the subinventory. | 11-27-2014 |
20150233862 | Assay Devices with Integrated Sample Dilution and Dilution Verification and Methods of Using Same - The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided. | 08-20-2015 |
20150233909 | Assay Devices with Integrated Sample Dilution and Dilution Verification and Methods of Using Same - The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided. | 08-20-2015 |
20150233910 | Assay Devices with Integrated Sample Dilution and Dilution Verification and Methods of Using Same - The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided. | 08-20-2015 |
20150233911 | Assay Devices with Integrated Sample Dilution and Dilution Verification and Methods of Using Same - The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided. | 08-20-2015 |
20150233952 | Assay Devices with Integrated Sample Dilution and Dilution Verification and Methods of Using Same - The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided. | 08-20-2015 |
20150276732 | Reagents for Reducing Leukocyte Interference In Immunoassays - Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample such as a whole blood sample with one or more leukocidal reagents that reduce or eliminate the metabolic activity of leukocytes, and performing an immunoassay on the amended sample to determine the concentration of analyte in the sample. Preferably, the sample is amended with one or more enzymes and optionally one or more enzyme substrates and cofactors. | 10-01-2015 |
20160041104 | Reader Devices for Optical and Electrochemical Test Devices - This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to devices having optical and electrochemical detectors and to methods of performing optical and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care. | 02-11-2016 |
Harry R. Davis, Kenilworth, NJ US
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20150320724 | METHODS OF TREATING DIABETES BY ADMINISTERING A GLUCAGON RECEPTOR ANTAGONIST IN COMBINATION WITH A CHOLESTEROL ABSORPTION INHIBITOR - Use of a glucagon receptor antagonist in combination with a cholesterol absorption inhibitor for the treatment of diabetes and related conditions is disclosed. | 11-12-2015 |
Harry R. Davis, Berkeley Heights, NJ US
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20080261942 | COMBINATIONS OF BILE ACID SEQUESTRANT(S) AND STEROL ABSORPTION INHIBITOR(S) AND TREATMENTS FOR VASCULAR INDICATIONS - The present invention provides compositions, therapeutic combinations and methods including: (a) at least one bile acid sequestrant; and (b) at least one substituted azetidinone or substituted β-lactam sterol absorption inhibitor which can be useful for treating vascular conditions, diabetes, obesity and lowering plasma levels of sterols. | 10-23-2008 |
20150320724 | METHODS OF TREATING DIABETES BY ADMINISTERING A GLUCAGON RECEPTOR ANTAGONIST IN COMBINATION WITH A CHOLESTEROL ABSORPTION INHIBITOR - Use of a glucagon receptor antagonist in combination with a cholesterol absorption inhibitor for the treatment of diabetes and related conditions is disclosed. | 11-12-2015 |
Henry T. Davis, Kinnelon, NJ US
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20090248315 | System and Method for Determining Clinical Equivalence of Test Methods - A system, method and computer readable medium of instructions are provided which are useful for determining whether an evaluation testing method or device is clinically equivalent to a reference testing method or device. The report can include a modified mean difference plot, a variability chart, confidence intervals for bias and a plot of the intervals. A graphical user interface is provided to allow data associated with the reference and evaluation methods or devices to be identified. A level of variance in the reference method is determined. An observed bias between the evaluation methods or devices and the reference methods or devices is calculated. A confidence interval for the bias is calculated. The biases between the evaluation methods or devices and reference method or device is compared relative to the level of variance in the reference method, and a report is generated including a conclusion about whether the evaluation methods or devices are clinically equivalent to the reference method or device. | 10-01-2009 |
Janet Davis, Skillman, NJ US
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20090325293 | TREATMENT OF PLURIPOTENT CELLS - The present invention is directed to methods to treat pluripotent cells, whereby the pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of GSK-3B enzyme activity. | 12-31-2009 |
20100015711 | Differentiation of Pluripotent Stem Cells - The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. | 01-21-2010 |
20110091971 | Differentiation of Pluripotent Stem Cells - The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. The present invention also provides methods to generate and purify agents capable of differentiating pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. | 04-21-2011 |
20110151561 | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS - The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to increase the expression of NGN3 and NKX6.1 in populations of cells expressing markers characteristic of the pancreatic endocrine lineage. | 06-23-2011 |
20120190111 | Differentiation of Pluripotent Stem Cells - The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. | 07-26-2012 |
20120190112 | Differentiation of Pluripotent Stem Cells - The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. | 07-26-2012 |
20120196365 | Differentiation of Pluripotent Stem Cells - The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. | 08-02-2012 |
Janet Davis, Raritan, NJ US
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20130337564 | Treatment of Pluripotent Cells - The present invention is directed to methods to treat pluripotent cells, whereby the pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of GSK-3B enzyme activity. | 12-19-2013 |
20140080210 | Treatment of Pluripotent Cells - The present invention is directed to methods to treat pluripotent cells, whereby the pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of GSK-3B enzyme activity. | 03-20-2014 |
Jason Davis, Tinton Falls, NJ US
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20130338958 | HYBRID LOCATION TEST SYSTEM AND METHOD - The technology disclosed relates to testing hybrid positioning systems, including systems that rely on MEMS sensors. In particular, it relates to methods and devices for configuring and running tests of hybrid positioning systems. | 12-19-2013 |
Jason Davis, Eatontown, NJ US
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20140253372 | SYSTEM AND METHOD FOR TESTING REAL WORLD A-GNSS PERFORMANCE OF A DEVICE - The technology disclosed relates to implementing a novel-testing framework that combines playback of captured GNSS signals with real-time emulation of assisted global navigation satellite system telemetry (abbreviated A-GNSS) in a test session with a mobile device. In particular, it can be used for testing A-GNSS performance of communication devices, navigation systems, telematics and tracking applications. | 09-11-2014 |
Jay Davis, Hillsdale, NJ US
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20140049594 | Conference Server Communication Techniques - A method for updating at least one data element in a conference is disclosed. The conference can include a first node having at least a first server but no endpoints; a second node coupled to the first node, the second node having at least a second server but no endpoints; a first endpoint coupled to the first server; and a second endpoint coupled to the second server. The first and second nodes can form a free tree topology. In such a conference, an exemplary method includes sending an initial update from either (a) the first server belonging to the first node, or (b) the first endpoint, to the second server belonging to the second node; receiving the initial update by the second server; and sending, by the second server, the content of the initial update as an update to at least one of a third server or the second endpoint. | 02-20-2014 |
Jesse H. Davis, Demarest, NJ US
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20140244412 | PASSENGER INFORMATION MODULE - A method and system utilizes an interface for the blind and low vision passengers in a touch screen passenger information module (PIM). The PIM is enabled to operate in at least two modes. A low vision mode provides different user input framework on the touch screen as well as appropriate audio prompting. The interface enables a blind or low vision person to interact with the PIM easily, including using the PIM to pay for the fare. The low vision mode can be initiated by the passenger. | 08-28-2014 |
20140330724 | CREDIT CARD PROCESSING FOR A VEHICLE FLEET - Credit card transactions are processed and managed for a fleet of motor vehicles for hire. A plurality of simultaneous wireless communication connections is maintained between a respective plurality of vehicles in the fleet and a central control center. A plurality of messages is received at the central control center, each one of said messages including credit card transaction information. For each vehicle, the messages and said credit card transaction information are stored in the central control center in real-time or near real-time. A credit card transaction reconciliation report can be produced at any time, in response to a user request, for a motor vehicle identified in the user request. The credit card transaction reconciliation report utilizes the messages and credit card transaction information collected and stored in the central control center. | 11-06-2014 |
20150120416 | SYSTEM AND METHOD FOR INTERACTING BETWEEN PASSENGER AND IN-VEHICLE EQUIPMENT - A system for interacting with a passenger within a vehicle is provided. The system includes, but is not limited to, in-vehicle equipment which communicates with a remote server, a wireless communication device which communicates information between the remote server outside of the vehicle and the in-vehicle equipment, and a mobile device having a display. The in-vehicle equipment retrieves content from the remote server. The mobile device receives passenger information from the passenger. The mobile device pairs with and provides passenger information to the in-vehicle equipment. The in-vehicle equipment provides content to display on the mobile device in response to the provided passenger information. | 04-30-2015 |
Kenneth W. Davis, Bernardsville, NJ US
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20110277382 | Adjustable stake assembly and method of use - An adjustable stake assembly has a stake support appointed to receive at least one stake segment to form a structure, such as a plant support, lattice, fence, plant holder, recreational or decorative structure. The adjustable stake assembly includes a universal stake support having a tip appointed to penetrate a surface, a body portion and a top plate having a protrusion with a stake aperture integrated therein. At least one stake segment having a central portion and a lateral and distal end is appointed to be removably snapped-onto the universal stake support. The stake segment includes a flange appointed to be received in the stake aperture of the universal stake support, and the distal end having a segment aperture integrated therein appointed for receiving another stake segment for vertically stacking a plurality of the stake segments. In another embodiment the stake segments include at least one lateral connector section appointed for receiving at least one lateral connector section of another stake segment for cross-connection of the stake segments in relation to one another. Advantageously, in this manner the stake segments can be interconnected to one another for horizontal cross-connection in forming lattices, fences, or other structures. | 11-17-2011 |
20120159844 | Adjustable stake assembly and method of use - An adjustable stake assembly forms a plant support, lattice, fence, plant holder, recreational or decorative structure. The stake assembly includes a universal stake support having a pointed angular tip that penetrates a surface, a body portion with a protrusion having a stake aperture, and a horizontal member extending perpendicularly from said body portion and said tip. At least one stake segment has a central portion. A lateral and distal end is appointed to be removably snapped-onto the universal stake support. A segment aperture is appointed to receive another stake segment for vertically stacking a plurality of the stake segments. In another embodiment, the stake segments include at least one lateral connector section. The stake segments can be interconnected to one another for horizontal cross-connection when forming plant supports, lattices, fences, or other structures. | 06-28-2012 |
Kiel Davis, South Orange, NJ US
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20110011982 | MODULAR CONTROL MOMENT GYROSCOPE (CMG) SYSTEM FOR SPACECRAFT ATTITUDE CONTROL - A modular control moment gyroscope (CMG) system for a spacecraft attitude control system (ACS) is formed by a plurality of CMG modules, wherein each CMG module has a modular enclosure design that is identical to that of the other CMG modules, such that the plurality of CMG modules are mountable in a spacecraft array bus structure in any desired one of multiple array configurations. | 01-20-2011 |
20120111587 | PERCUSSIVE SHOVEL FOR ROBOTIC APPLICATIONS - A percussive digging tool attachment for a small robotic platform employs a percussor module for applying percussive impulses of relatively low impact at relatively high frequency to an attached digging tool to dig into or break up soil and rocks. By using low-impact, high-frequency percussive forces, it reduces the reaction loads on the small robotic platform while providing increased capability. | 05-10-2012 |
Larry Davis, Bridgewater, NJ US
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20110312934 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF - The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives of the general formula (I) where: R | 12-22-2011 |
Lorna-Mae Davis, Maplewood, NJ US
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20160022099 | Ridable Toilet Training Device - A ridable toilet training device teaches young children to use a toilet. The device includes a frame having a top wall, a bottom wall, a front wall, a rear wall and a pair of lateral walls. Each of the front and rear walls and the pair of lateral walls is attached to and extends between the top and bottom walls. An interior of the frame defines a receptacle. A plurality of wheels is rotatably coupled to the bottom wall. The plurality of wheels includes a front wheel assembly positioned near the front wall and a rear wheel assembly positioned near the rear wall. A hole is positioned in the top wall and extends around the receptacle. A bowl is positionable in the receptacle. The bowl has a lower wall and a perimeter wall coupled to and extending upwardly from the lower wall wherein the bowl receives waste products therein. | 01-28-2016 |
Malcolm Evan Davis, Lambertville, NJ US
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20120143580 | PROTEIN-LIGAND NOE MATCHING FOR HIGH-THROUGHPUT STRUCTURE DETERMINATION - A method of enhancing the throughput and applicability of NMR-based structure determination of protein-ligand complexes is disclosed. The method circumvents the need for protein sequence-specific resonance assignments and combines NMR data analysis and ligand docking methods into an integrated process. In one embodiment, NMR data is used to filter docking results to identify the most consistent binding modes, thereby providing structural information in a high-throughput fashion without the need for assigning protein resonances. Trial assignments for protein-ligand nuclear Overhauser effect (NOE) interactions are also produced by the method. | 06-07-2012 |
Margaret A. Davis, Bernardsville, NJ US
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20090165206 | Blanket for placement upon an infant secured in a seat and method of use - A blanket for placement upon an infant in a seat and method having sleeves and an open back construction as well as stabilization means is provided that it can be readily donned upon an infant buckled within a seat without the need to adjust safety straps. The travel blanket includes a base section constructed with a base periphery integrated with base stabilization means therein for securing the base section of the blanket onto an outer, exterior bottom portion of the seat. Lateral sections of the travel blanket further include lateral perimeters appointed for aiding in securing the lateral sections over the infant, without wrapping the torso of the infant. Construction of the travel blanket ensures a significant amount of coverage over the entire body of the infant that does not lend to shifting, zero wrapping of the infant's body/torso, and minimal jostling of the infant when applied. | 07-02-2009 |
20100170039 | Blanket for placement upon an infant secured in a seat and method of use - A blanket is placed upon an infant in a car seat. The blanket has contoured sleeves and an open back construction of the blanket, as well as stabilization means for securing the base section of the blanket onto an outer, exterior bottom portion of the seat. With these features, the blanket can be readily donned upon an infant that is buckled within a car safety seat without the need to adjust safety straps. The travel blanket includes a base section constructed with a base periphery integrated with the base stabilization means. Lateral sections of the travel blanket further include lateral perimeters appointed for aiding in securing the lateral sections over the infant, without wrapping the torso of the infant. Contoured arm sleeves provide enhanced safety to infants. The sleeves snuggly fit over the infant's wrists and do not have loose flowing material about the arms and wrists, which could present a suffocation risk. Construction of the travel blanket ensures a significant amount of coverage over the entire body of the infant that does not contribute to shifting, zero wrapping of the infant's body/torso, and minimal jostling of the infant when applied. | 07-08-2010 |
Raphael Davis, Pt. Jefferson, NJ US
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20130123647 | Methods Useful in Optimizing the Treatment of Neuropathies and Targeting Tissues with Cosmetic Botulinum Injections - The present invention pertains to methods of determining where, on the skin, a diagnostic, therapeutic, or cosmetic agent is likely to be most effectively applied (e.g., injected), and to methods for monitoring a patient after such an agent has been administered. The monitoring can produce information useful in determining whether a diagnostic, therapeutic (e.g., surgical), or cosmetic regime should be initiated, continued, continued in a modified fashion, or terminated (e.g., for a brief or prolonged period of time). The methods can be repeated periodically and use a non-invasive, in vivo form of digital image speckle correlation (DISC) to track deformation of the skin. | 05-16-2013 |
Richard Alan Davis, Morristown, NJ US
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20140332917 | MAGNETIC-FIELD SENSING DEVICE - Apparatus and associated methods may relate to Magneto-Resistive Sensing Devices (MRSDs). In accordance with an exemplary embodiment, an MRSD comprises an underlying semiconductor device and a magneto-resistive sensor. In some exemplary embodiments, the semiconductor device is processed through most of a standard process flow. After the standard process flow, in various embodiments, a planarization step may be performed to create a more planar top surface. In some embodiments, the magneto-resistive material, which may be made from a Nickel-Iron alloy, called Permalloy, is deposited on the planar surface. A layer of interconnect metallization also may reside in this top region. The magneto-resistive material may contact the topmost layer of metallization of the semiconductor device via contact openings in the planarized surface. In some embodiments, the magneto-resistive material may similarly contact the topmost layer of metallization through these contact openings. The magneto-resistive material resides directly above the underlying circuitry. | 11-13-2014 |
20160033588 | Magnetic-Field Sensing Device - Apparatus and associated methods may relate to Magneto-Resistive Sensing Devices (MRSDs). In accordance with an exemplary embodiment, an MRSD comprises an underlying semiconductor device and a magneto-resistive sensor. In some exemplary embodiments, the semiconductor device is processed through most of a standard process flow. After the standard process flow, in various embodiments, a planarization step may be performed to create a more planar top surface. In some embodiments, the magneto-resistive material, which may be made from a Nickel-Iron alloy, called Permalloy, is deposited on the planar surface. A layer of interconnect metallization also may reside in this top region. The magneto-resistive material may contact the topmost layer of metallization of the semiconductor device via contact openings in the planarized surface. In some embodiments, the magneto-resistive material may similarly contact the topmost layer of metallization through these contact openings. The magneto-resistive material resides directly above the underlying circuitry. | 02-04-2016 |
Roger B. Davis, Clinton, NJ US
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20140161513 | BATTERY PACK RELEASE WITH TACTILE FEEDBACK FOR CORDLESS POWER TOOLS - Battery packs include a battery pack housing, at least one battery release member held by the battery housing, a (blind) latch held by the battery pack housing in communication with the battery release member that releaseably locks the battery pack to a device, and a tactile feedback mechanism that is held by the battery pack housing and is in communication with the battery release member. The tactile feedback mechanism generates a tactile feedback that reduces or increases an application force required by a user to manually actuate the at least one release member. The tactile feedback transmitted through the at least one battery release member. The tactile feedback is generated when the at least one release member has been manually actuated by the user a sufficient distance to allow the user to easily remove the battery pack from the device. | 06-12-2014 |
20150140384 | Cordless Power Tool Batteries - In at least one illustrative embodiment, a cordless power tool battery may comprise a housing, a power storage unit, a first release button, and a second release button. The housing may have a first side wall and a second side wall spaced apart from the first side wall. The first release button may be coupled to the housing and extend along more than half of the first side wall of the housing. The second release button may be coupled to the housing and extend along more than half the second side wall of the housing. | 05-21-2015 |
Ross Davis, Palmyra, NJ US
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20140349821 | EXERCISE SYSTEM AND KIT - An exercise system or kit that includes separate components that can be used together during a workout. In one embodiment, the exercise system includes a cylindrical body, an elongated bar, and one or more resistance bands. The elongated bar may be a one-piece bar or a multi-piece bar. The cylindrical body extends along a longitudinal axis and has an annular groove formed into its outer surface that surrounds the longitudinal axis and a bore extending through the cylindrical body in the direction of the longitudinal axis. The dimensions of the bar, the groove, and the bore are such that the bar can be inserted into and through the bore and the bar can be positioned within the annular groove to achieve different types of exercise. Furthermore, the resistance bands can be coupled to the elongated bar. | 11-27-2014 |
Thomas Davis, Delran, NJ US
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20080244436 | METHOD AND APPARATUS FOR RAPID SURVEYING OF STATIC STRUCTURES - An apparatus to facilitate field assessment of static structure sites to provide data in a predetermined format acceptable to a taxing authority, including a personal computing device having a graphic display screen, a user interface, and application software. The user interface is arranged to accept alphanumeric data provided by a user of the apparatus and also accept graphic input from the user representative of structural features of the static structure. The application software is arranged to provide a real-time display on the graphic display screen of dimensional data associated with the graphic inputs as they are entered by the user. The application software is also arranged to compute dimensional attributes of enclosed polygons resulting from the graphic input by the user. | 10-02-2008 |
Thomas W. Davis, South Orange, NJ US
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20090209521 | Inhibition of VEGF Translation - In accordance with the present invention, methods for inhibiting the translation of VEGF and methods for decreasing VEGF level by inhibiting VEGF translation are provided. In another aspect of the invention, compounds that inhibit the 5′-UTR-dependent translation of VEGF and methods for identifying such compounds are provided. | 08-20-2009 |
20120157400 | METHODS FOR TREATING KAPOSI SARCOMA - Methods for treating Kaposi's sarcoma involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as a single-agent therapy or in combination with one or more additional therapies to a human in need of such treatment. | 06-21-2012 |
20120157401 | METHODS FOR TREATING NEUROFIBROMATOSIS - Methods for treating neurofibromatosis involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as a single-agent therapy or in combination with one or more additional therapies to a human in need of such treatment. | 06-21-2012 |
20120157402 | METHODS FOR TREATING BRAIN TUMORS - Methods for treating brain tumors involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatment. | 06-21-2012 |
20120178707 | METHODS FOR TREATING PROSTRATE CONDITIONS - Methods for treating prostate cancer involving the administration of a compound that selectively inhibits pathological production of human vascular endothelial growth factor (VEGF) are described. Methods for treating benign prostatic hyperplasia involving the administration of a compound that selectively inhibits pathological production of human VEGF are also described. The compound may be administered as a single-agent therapy or in combination with one or more additional therapies to a human in need of such treatment. | 07-12-2012 |
20120202763 | METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS - Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments. | 08-09-2012 |
20120202801 | METHODS FOR TREATING BREAST CANCER - Methods for treating breast cancer involving the administration of a compound that selectively inhibits pathological production of human vascular endothelial growth factor (VEGF) are described. The compound can be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatment. | 08-09-2012 |
20150315182 | SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS - Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein. | 11-05-2015 |
Thomas Davis, South Orange, NJ US
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20100158858 | ADMINISTRATION OF CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES - In accordance with the present invention, compounds are provided which are useful in a method or in the manufacture of a medicament for post-transcriptionally inhibiting the expression of VEGF in a subject in need thereof comprising inhibiting VEGF mRNA translation by orally administering said medicament once, twice or thrice daily to the subject. | 06-24-2010 |
20100179132 | CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS - In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention. | 07-15-2010 |
20110160190 | CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS - In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention. | 06-30-2011 |
20110165581 | METHODS FOR SCREENING FOR COMPOUNDS FOR TREATING CANCER - The methods described herein provide nucleic acid constructs and screening methods for identifying and validating compounds for use in the treatment of cancer, wherein the compounds down-regulate the post-transcriptional expression of Bmi-1. | 07-07-2011 |
20110190239 | BMI-1 PROTEIN EXPRESSION MODULATORS - The compounds, pharmaceutical compositions, and methods of using such compounds or compositions thereof described herein are useful for treating a disease modulated by B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein expression. | 08-04-2011 |
20120129841 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES - In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and compositions, and methods for the administration and use of those compounds. provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing serum, plasma, and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention. | 05-24-2012 |
20130171103 | METHODS FOR TREATING VIRAL CONDITIONS - Compounds that selectively inhibit viral replication or the production of viral RNA or DNA, viral protein or virus induced cytopathic effects and compositions comprising such Compounds are described. Also described are methods of inhibiting viral replication or the production of viral RNA or DNA, viral protein or virus induced cytopathic effects using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments. | 07-04-2013 |
Timothy Davis, Columbus, NJ US
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20100026394 | SYSTEM AND METHOD FOR MODULATING PRESSURE IN AN ALKALI-VAPOR CELL - The present invention provides a system and method for achieving a calibration-free primary atomic clock standard operating at the 0-0 transition free-atom frequency, thus creating a primary frequency standard, with attributes that include scalable to chip-scale dimensions and power consumption. | 02-04-2010 |
Timothy J. Davis, Columbus, NJ US
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20150098629 | IRIS BIOMETRIC RECOGNITION MODULE AND ACCESS CONTROL ASSEMBLY - An iris biometric recognition module includes technology for capturing images of an iris of an eye of a person, whether the person is moving or stationary, and whether the person is located near the iris image capture device or at a distance from the iris image capture device. The iris biometric recognition technology can perform an iris matching procedure for, e.g., authentication or identity verification purposes. The iris biometric recognition module can be incorporated into, for example, a door lock assembly and other access controlled devices, mechanisms, and systems. | 04-09-2015 |
20150098630 | IRIS BIOMETRIC RECOGNITION MODULE AND ACCESS CONTROL ASSEMBLY - An iris biometric recognition module includes technology for capturing images of an iris of an eye of a person, whether the person is moving or stationary, and whether the person is located near the iris image capture device or at a distance from the iris image capture device. The iris biometric recognition technology can perform an iris matching procedure for, e.g., authentication or identity verification purposes. The iris biometric recognition module can be incorporated into, for example, a door lock assembly and other access controlled devices, mechanisms, and systems. | 04-09-2015 |
Timothy James Davis, Columbus, NJ US
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20090066430 | BATCH-FABRICATED, RF-INTERROGATED, END TRANSITION, CHIP-SCALE ATOMIC CLOCK - A chip scale atomic clock is disclosed that provides a low power atomic time/frequency reference that employs direct RF-interrogation on an end-state transition. The atomic time/frequency reference includes an alkali vapor cell containing alkali atoms, preferably cesium atoms, flex circuits for physically supporting, heating, and thermally isolating the alkali vapor cell, a laser source for pumping alkali atoms within the alkali vapor cell into an end resonance state by applying an optical signal along a first axis, a photodetector for detecting a second optical signal emanating from the alkali vapor cell along the first axis, a pair of RF excitation coils for applying an RF-interrogation signal to the alkali atoms along a second axis perpendicular to the first axis, a pair of bias coils for applying a uniform DC magnetic field along the first axis, and a pair of Zeeman coils for applying a Zeeman interrogation signal to the alkali atoms and oriented and configured to apply a time-varying magnetic field along the second axis through the alkali vapor cell. Another flex circuit is used for physically supporting the laser source, for heating the laser source, and for providing thermal isolation of the laser source. The laser source can be a vertical cavity surface emitting laser (VSCEL). The bias coils can be Helmholtz coils. | 03-12-2009 |
Wayne F. Davis, Ocean City, NJ US
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20090164255 | METHODS AND SYSTEMS FOR MANAGING DISTRIBUTED DIGITAL MEDICAL DATA - A network for mediating the peer-to-peer transfer of digital patient medical data includes a plurality of distributed agents each associated with a health care provider and connected to a central system. Periodically the agents collect local information relating to patient medical files and/or data streams, for example diagnostic images and associated reports, and process that information into metadata files acting as pointers to the original files. The metadata files are transmitted to the central system where they are parsed and the attributes are stored on the central system in patient records with records from the same patient grouped together whenever possible. Registered users can search the central system, even in the absence of a unique identifier, to identify patient records pointing to the remote patient medical files. Upon finding a patient medical file, the invention provides a streamlined process for communicating access authorization from the patient to the hospital or facility storing the medical files. Once patient authorization is received, secure processes are provided for transferring the data in its entirety to or for viewing by the user in a peer-to-peer fashion. | 06-25-2009 |
20110112867 | METHODS AND SYSTEMS FOR MANAGING DISTRIBUTED DIGITAL MEDICAL DATA - A network for mediating the peer-to-peer transfer of digital patient medical data includes a plurality of distributed agents each associated with a health care provider and connected to a central system. Periodically the agents collect local information relating to patient medical files and/or data streams, for example diagnostic images and associated reports, and process that information into metadata files acting as pointers to the original files. The metadata files are transmitted to the central system where they are parsed and the attributes are stored on the central system in patient records with records from the same patient grouped together whenever possible. Registered users can search the central system, even in the absence of a unique identifier, to identify patient records pointing to the remote patient medical files. Upon finding a patient medical file, the invention provides a streamlined process for communicating access authorization from the patient to the hospital or facility storing the medical files. Once patient authorization is received, secure processes are provided for transferring the data in its entirety to or for viewing by the user in a peer-to-peer fashion. | 05-12-2011 |
20110112868 | METHODS AND SYSTEMS FOR MANAGING DISTRIBUTED DIGITAL MEDICAL DATA - A network for mediating the peer-to-peer transfer of digital patient medical data includes a plurality of distributed agents each associated with a health care provider and connected to a central system. Periodically the agents collect local information relating to patient medical files and/or data streams, for example diagnostic images and associated reports, and process that information into metadata files acting as pointers to the original files. The metadata files are transmitted to the central system where they are parsed and the attributes are stored on the central system in patient records with records from the same patient grouped together whenever possible. Registered users can search the central system, even in the absence of a unique identifier, to identify patient records pointing to the remote patient medical files. Upon finding a patient medical file, the invention provides a streamlined process for communicating access authorization from the patient to the hospital or facility storing the medical files. Once patient authorization is received, secure processes are provided for transferring the data in its entirety to or for viewing by the user in a peer-to-peer fashion. | 05-12-2011 |
20110131062 | METHODS AND SYSTEMS FOR MANAGING DISTRIBUTED DIGITAL MEDICAL DATA - A network for mediating the peer-to-peer transfer of digital patient medical data includes a plurality of distributed agents each associated with a health care provider and connected to a central system. Periodically the agents collect local information relating to patient medical files and/or data streams, for example diagnostic images and associated reports, and process that information into metadata files acting as pointers to the original files. The metadata files are transmitted to the central system where they are parsed and the attributes are stored on the central system in patient records with records from the same patient grouped together whenever possible. Registered users can search the central system, even in the absence of a unique identifier, to identify patient records pointing to the remote patient medical files. Upon finding a patient medical file, the invention provides a streamlined process for communicating access authorization from the patient to the hospital or facility storing the medical files. Once patient authorization is received, secure processes are provided for transferring the data in its entirety to or for viewing by the user in a peer-to-peer fashion. | 06-02-2011 |
20110166890 | METHODS AND SYSTEMS FOR MANAGING DISTRIBUTED DIGITAL MEDICAL DATA - A network for mediating the peer-to-peer transfer of digital patient medical data includes a plurality of distributed agents each associated with a health care provider and connected to a central system. Periodically the agents collect local information relating to patient medical files and/or data streams, for example diagnostic images and associated reports, and process that information into metadata files acting as pointers to the original files. The metadata files are transmitted to the central system where they are parsed and the attributes are stored on the central system in patient records with records from the same patient grouped together whenever possible. Registered users can search the central system, even in the absence of a unique identifier, to identify patient records pointing to the remote patient medical files. Upon finding a patient medical file, the invention provides a streamlined process for communicating access authorization from the patient to the hospital or facility storing the medical files. Once patient authorization is received, secure processes are provided for transferring the data in its entirety to or for viewing by the user in a peer-to-peer fashion. | 07-07-2011 |
William M. Davis, East Windsor, NJ US
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20100280980 | System and Method for Resolving Gamma Ray Spectra - A system for identifying radionuclide emissions is described. The system includes at least one processor for processing output signals from a radionuclide detecting device, at least one training algorithm run by the at least one processor for analyzing data derived from at least one set of known sample data from the output signals, at least one classification algorithm derived from the training algorithm for classifying unknown sample data, wherein the at least one training algorithm analyzes the at least one sample data set to derive at least one rule used by said classification algorithm for identifying at least one radionuclide emission detected by the detecting device. | 11-04-2010 |
20110258151 | System and Method for Resolving Gamma-Ray Spectra - A system for identifying radionuclide emissions is described. The system includes at least one processor for processing output signals from a radionuclide detecting device, at least one training algorithm run by the at least one processor for analyzing data derived from at least one set of known sample data from the output signals, at least one classification algorithm derived from the training algorithm for classifying unknown sample data, wherein the at least one training algorithm analyzes the at least one sample data set to derive at least one rule used by said classification algorithm for identifying at least one radionuclide emission detected by the detecting device. | 10-20-2011 |