Davis, MA
April D. Davis, Sterling, MA US
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20110313782 | INTEGRATED CLINICAL TRIAL WORKFLOW SYSTEM - A computer-based system configured to present a user interface that enables a user to access multiple clinical trial systems via a common secure web-based interface. Data integration and reconciliation achieved using an integration platform, in which multiple clinical trial systems are connected to a central messaging hub, provides an integrated clinical trial workflow system that reduces the redundancy in data entry and functionality present in conventional clinical trial workflow systems that employ standalone systems for various aspects of clinical trial management. Aggregation of data using the integration platform provides clinical trial directors with consolidated useful information for making management decisions and the user interface may be dynamically configured based, at least in part, on user access credentials resulting in a more efficient workflow for administrators of a clinical trial. | 12-22-2011 |
Beth Shelley Davis, Acton, MA US
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20100297986 | PRESENCE LITE - A service is provided to cell phone subscribers to improve reachability. A home location register node maintains state information on a subscriber's cell phone status. Cell phone status information includes: off; on, registered and available to receive calls; on, registered but busy participating in an ongoing call; on, registered but temporarily unavailable; and on, registered but unattended. Temporarily unavailable is further qualified: poor reception location, high interference, cell throughput saturation, intentional user disposition. Long term unavailability may also be inferred and indicated depending on the device and/or system status. When a call to a subscriber's cell phone cannot be completed or is not answered, the service annunciates the reason to the calling party. The calling party can then make a more informed decision as to when to reattempt the call and is more likely to reattempt the call. The service is provided in conjunction with call forwarding to landlines phones and/or voicemail. | 11-25-2010 |
Brandi Davis, Brighton, MA US
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20110152352 | SMAD PROTEINS CONTROL DROSHA-MEDIATED MIRNA MATURATION - The invention, in some aspects, relates to compositions and methods useful for modulating expression of miRNAs that are regulated by the TGF-β/BMP signaling pathway. In some aspects, the invention relates, to oligonucleotides comprising a CAGRN-motif that modulate expression of miRNAs that are regulated by TGF-β/BMP signaling pathway. The invention, in some aspects, relates to composition and methods useful for inhibiting microRNA processing. In some aspects, the invention relates to composition and methods for treating TGF-Beta/BMP mediated disorders. | 06-23-2011 |
Brian Davis, Medford, MA US
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20110320575 | STORING AND SYNCHRONIZING MEDIA DEVICE INFORMATION - Systems, devices, and methods for storing and synchronizing data using Extensible Messaging and Presence Protocol (XMPP), Session Initiation Protocol (SIP) or any other protocol that provides for authentication, presence and messaging. One such method is performed in a digital media device, such as a set top. Device and user-configured settings associated with a digital media device may be saved to a network. The settings may be synchronized with other devices of a user, or used to configure a newly provisioned replacement digital media device. The settings may include pointers to network resources where content is stored such that content need not be transferred from an old or failed digital media device to the newly provisioned digital media device. | 12-29-2011 |
20110320585 | PROVIDING STATE INFORMATION AND REMOTE COMMAND EXECUTION IN A MANAGED MEDIA DEVICE - Systems and methods for providing state information and remote command execution using Extensible Messaging and Presence Protocol (XMPP), Session Initiation Protocol (SIP) or any other protocol that provides for authentication, presence and messaging. A device may exist within a managed or unmanaged network and sign on to a managed network and provide presence information augmented with state information to provide near real-time state information to the managed network. The network may also discover remote command support in endpoint devices to command and control the devices remotely, while traversing unmanaged networks and components. | 12-29-2011 |
20110321062 | CAPTURING EVENTS FROM AND PROVIDING TARGETED MESSAGES TO A DIGITAL MEDIA DEVICE - Systems and methods for collecting events and providing messages using Extensible Messaging and Presence Protocol (XMPP), Session Initiation Protocol (SIP) or any other protocol that provides for authentication, presence and messaging. One such method is performed in a digital media device, such as a set top. A digital media device may collect events associated with usage and behavior and publish the information to a node. The node may communicate data to an aggregator and a harvester to reformat the data to make it available to analytics systems. In addition, the digital media device may subscribe to a node to receive notifications of messages having geographic or other relevance based on an identifier associated with the digital media device. | 12-29-2011 |
David Davis, East Freetown, MA US
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20090139513 | Bivalent water heating system - A bivalent water-heating system includes a water-storage tank having at least one wall defining an interior storage cavity configured for storing water to be heated. The storage cavity includes an upper-cavity and lower-cavity portions. A non-solar heating unit is situated at least partially in the upper-cavity portion and includes a combustion chamber defined by at least one wall through which heat produced by the combustion of fuel is transferred to stored water located within the upper-cavity portion. Water stored in the lower-cavity portion is heated by a solar heating subsystem that circulates a heat-transferring fluid between a solar collector that converts solar radiation to heat energy and a heat exchanger situated within the lower-cavity portion such that heat-transferring fluid (i) absorbs heat at the solar collector, (ii) is routed to the heat exchanger where the heat-transferring fluid transfers heat to water stored in the lower-cavity portion, and (iii) is returned from the heat exchanger to the solar collector to absorb additional heat. | 06-04-2009 |
David B. Davis, Lunenberg, MA US
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20110259322 | METHOD AND SYSTEM FOR CONTROLLING EFFICIENCY OF HEATING SYSTEM - A method and system is provided for controlling efficiency of a heating system which is a combination hot water and space heating system that can modulate energy transfer. The heating system includes a heat exchanger for transferring and modulating heat between a primary fluid system having a hot water supply and a secondary fluid system for space heating. The primary fluid system includes a storage container, temperature sensors, a heating element connected to the heating assembly within the storage container for increasing the temperature of the storage fluid therein, a heating assembly, and a storage pump for delivering storage fluid from the storage container to the heat exchanger. The secondary fluid system includes a heating supply structure for containing a heating supply fluid, temperature sensors, and a heating supply pump in connection with the heating supply structure for circulating the heating supply fluid. | 10-27-2011 |
Donald T. Davis, Somerville, MA US
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20080244711 | System and Method for Specifying Access to Resources in a Mobile Code System - Mobile code, such as an applet, is permitted to create a network connection with a content server on a network, without restricting the applet only to connections from the computer from which it was downloaded. This is achieved in accordance with the principles of the present invention by using network restriction software in the execution engine or runtime system under which the applet executes. When the applet attempts to create a network connection to a content server, the network restriction software checks a name file on the content server for the presence of an entry whose name corresponds to the name of the computer from which the applet was downloaded. If such an entry is present, then the network restriction software permits the network connection between the applet and the content server to be created. If not, the applet may not create a network connection with the content server. | 10-02-2008 |
D. Westervelt Davis, Wellesley, MA US
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20110101214 | COUPLING DIFFERENTIAL MOBILITY BASED AMBIENT PRESSURE ION PREFILTERING AND ION FOCUSING AT LOW FLOW RATES FOR A PORTABLE MASS SPECTROMETER - A sample analysis apparatus and system including an ion inlet, an ion detector and an ion focusing assembly for converging a plurality of ion streams from the ion inlet into at least one focused ion stream. | 05-05-2011 |
Franklin Davis, Newton, MA US
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20090210514 | METHODS, APPARATUSES, COMPUTER PROGRAM PRODUCTS, AND SYSTEMS FOR MOBILE WEB BROWSING - An apparatus for delivering web content to a mobile device may include a processor. The processor may be configured to determine whether a web page may be adapted or should be viewed in its original form, transcode the original web page to generate a transcoded version of the web page if it is determined that the web page may be adapted, and to send data comprising either the original web page of the transcoded version to a remote device. Users may request a different version than the processor's initial determination, and an aggregation of such user preferences may be used to make a better determination of what version to send by default to all users. Corresponding methods, computer program products, and systems are also provided. | 08-20-2009 |
Franklin Arthur Davis, Newton, MA US
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20100161754 | METHOD, APPARATUS AND COMPUTER PROGRAM PRODUCT FOR PROVIDING UNRESTRICTED CONTENT ON A USER TERMINAL - An apparatus for providing unrestricted content on a user terminal may include a processor. The processor may be configured to invoke a substitute function expansion application to request access to content associated with an object, in response to receiving an indication of an unknown function expansion application required to access the content associated with the object. The processor may further be configured to communicate information associated with the object to a network entity via the substitute function expansion application. The processor may also be configured to process the content associated with the object received from the remote network entity via the function expansion application, in response to the network entity accessing the content at a location associated with the network entity, and provide the received content associated with the object. | 06-24-2010 |
Heather Davis, Haverhill, MA US
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20100113446 | HYDANTOIN COMPOUNDS - The invention relates to the use of hydantoin compounds useful for treating or preventing autoimmune disorders. The present invention also provides compositions and uses thereof. | 05-06-2010 |
Heather A. Davis, Haverhill, MA US
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20110105427 | DEAZAPURINES AND USES THEREOF - The present invention provides compounds having formula (I): | 05-05-2011 |
Heather M. Davis, Oxford, MA US
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20090270402 | Novel triazolopyridazines - The present invention is directed to novel compounds of formula (I) | 10-29-2009 |
20100069371 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS - Compounds having the formula | 03-18-2010 |
Jack Davis, Boston, MA US
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20110086705 | MUSIC GAME SYSTEM AND METHOD OF PROVIDING SAME - A music game method includes retrieving song data having note information from a storage medium coupled to a computer system. The method also includes determining from the song data at least two note indicators to be presented sequentially and determining from the song data a leader between first and second note indicators. The leader provides information related to the second note indicator. A music game system includes a song manager module configured to retrieve song data having note information from a storage medium, and a user interface module configured to determine from the song data at least two note indicators to be presented sequentially and to determine from the song data a leader between first and second note indicators. Each note indicator is related to corresponding note information. The first and second note indicators are adjacent to one another. | 04-14-2011 |
Jack Daniel Davis, Boston, MA US
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20090188371 | METHODS AND APPARATUS FOR STRINGED CONTROLLERS AND/OR INSTRUMENTS - Stringed instruments, game controllers, and related structures and methods are described. A game controller having one or more strings is described for a computer gaming application. Output signals may be sent from the controller to the gaming application indicative of fingering of the game controller and the time at which the strings of the game controller are struck. Multi-mode apparatus are also described. A stringed apparatus may be used as both a game controller and an instrument. Bracing structures and methods are also described for bracing stringed apparatus, such as stringed game controllers and instruments. | 07-30-2009 |
20090191932 | METHODS AND APPARATUS FOR STRINGED CONTROLLERS AND/OR INSTRUMENTS - Stringed instruments, game controllers, and related structures and methods are described. A game controller having one or more strings is described for a computer gaming application. Output signals may be sent from the controller to the gaming application indicative of fingering of the game controller and the time at which the strings of the game controller are struck. Multi-mode apparatus are also described. A stringed apparatus may be used as both a game controller and an instrument. Bracing structures and methods are also described for bracing stringed apparatus, such as stringed game controllers and instruments. | 07-30-2009 |
20100279772 | METHODS AND APPARATUS FOR STRINGED CONTROLLERS AND/OR INSTRUMENTS - Stringed instruments, game controllers, and related structures and methods are described. A game controller having one or more strings is described for a computer gaming application. Output signals may be sent from the controller to the gaming application indicative of fingering of the game controller and the time at which the strings of the game controller are struck. Multi-mode apparatus are also described. A stringed apparatus may be used as both a game controller and an instrument. Bracing structures and methods are also described for bracing stringed apparatus, such as stringed game controllers and instruments. | 11-04-2010 |
20110086704 | MUSIC GAME SYSTEM AND METHOD OF PROVIDING SAME - A method of providing a music game using a computer system includes the act of retrieving, from a storage medium coupled to the computer system, note information including timing information. The computer system includes a music game controller. The method also includes displaying, on a graphical user interface, a note indicator based on the note information. The method further includes receiving, by the computer system, an input from a music game controller, the input being indicative of a user playing a note in response to the note indicator. | 04-14-2011 |
James C. Davis, Kingston, MA US
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20090043087 | DNA purification and recovery from high particulate and solids samples - This invention relates to methods for rapid nucleic acid purification from sources heavily contaminated with high particulate material, such as cellular debris, and solids, including suspended solids. In particular, this invention provides methods for rapid, quantifiable recovery and purification of nucleic acids from a variety of sources heavily contaminated with solids, such as small organisms, tissue samples, samples of blood found on soil, or samples of washing from foods, which are frequently difficult sources for nucleic acid isolation due to their propensity to clog filters and columns. A device and kit are also provided. | 02-12-2009 |
James C. Davis, Plymouth, MA US
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20100075858 | BIOLOGICAL BAR CODE - The invention provides coding compositions comprising mixtures of coding oligonucleotides and methods of using such compositions to code samples. The compositions and methods are useful for identifying, verifying, or authenticating any type of sample, whether the sample is biological or non-biological. | 03-25-2010 |
20100173392 | ROOM TEMPERATURE ELUTION OF NUCLEIC ACIDS - The present invention provides compositions and methods for efficient recovery of nucleic acids, in particular DNA, from storage media. The present invention provides a method for using an alkaline elution buffer and mechanical agitation to elute nucleic acids from dried samples on storage media at room temperature. In particular, the present invention provides a method for room temperature recovery of DNA, including double stranded DNA (dsDNA) and single stranded (ssDNA), from storage media. The eluted DNA is suitable for numerous downstream applications | 07-08-2010 |
20100178210 | STABLE PROTEIN STORAGE AND STABLE NUCLEIC ACID STORAGE IN RECOVERABLE FORM - The invention provides compositions and methods for storage of biomolecules. The biomolecules are stored via absorption to a substrate. Absorbed biomolecules can be eluted or recovered from the substrate at a future time, and optionally be subjected to a subsequent analysis or application. Biomolecules absorbed to a substrate for storage may also optionally be preserved, i.e., the absorbed biomolecule is resistant to or resists degradation. | 07-15-2010 |
20140065689 | Stable Protein Storage and Stable Nucleic Acid Storage in Recoverable Form - The invention provides compositions and methods for storage of biomolecules. The biomolecules are stored via absorption to a substrate. Absorbed biomolecules can be eluted or recovered from the substrate at a future time, and optionally be subjected to a subsequent analysis or application. Biomolecules absorbed to a substrate for storage may also optionally be preserved, i.e., the absorbed biomolecule is resistant to or resists degradation. | 03-06-2014 |
Jason Davis, Bellingham, MA US
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20120155768 | METHOD FOR PARTITIONING A PATTERN INTO OPTIMIZED SUB-PATTERNS - A method is provided for dividing a pattern into a plurality of sub-patterns, each sub-pattern being adapted for use with an image search method that can provide a plurality of sub-pattern search results. The method represents the pattern as a plurality of feature points, generates candidate partitions of the plurality of feature points, and then scores the candidate partitions by examining characteristics of each potential sub-pattern of each candidate partition. The highest-scoring partition is selected, and then it is applied to the plurality of feature points, creating one or more sub-pluralities of features. The invention advantageously provides a plurality of sub-patterns where each sub-pattern contains enough information to be located with a feature-based search method, where that information has been pre-evaluated as being useful and particularly adapted for running feature-based searches. | 06-21-2012 |
Jason Davis, Franklin, MA US
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20130188870 | METHODS FOR FINDING AND CHARACTERIZING A DEFORMED PATTERN IN AN IMAGE - A method is disclosed for finding a deformed pattern in an image using a plurality of sub-patterns. By advantageously restricting sub-pattern search ranges, search speed is improved, and the incidence of spurious matches is reduced. The method also quickly decides which sub-pattern result, of several potential candidates, is most likely to be the correct match for a deformed sub-pattern. Also, a method is provided for characterizing a deformed pattern in an image by using results from feature-based search tools to create a mapping that models the deformation of the pattern. A transform, selectable by a user, is fit to the results from the search tools to create a global deformation mapping. This transformation is fit only to feature points derived from matches resulting from successful sub-pattern search, without including data from areas of the pattern that were blank, not matched, or otherwise didn't contain information about the pattern's distorted location. | 07-25-2013 |
Jason Adam Davis, Franklin, MA US
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20100049341 | METHOD OF CONFIGURING A MACHINE VISION APPLICATION PROGRAM FOR EXECUTION ON A MULTI-PROCESSOR COMPUTER - A machine vision system includes a computer with one or more processors and software that has a plurality of tool routines each performing a different image analysis function. A machine vision application program is created by selecting certain ones of the plurality of tool routines to analyze the image. A maximum number of processors on the computer is designated as available for executing a machine vision application, wherein the maximum number may be less than the total number of processors on the computer. When the machine vision application program operates execution of each tool routine is limited to using simultaneously no more than the maximum number of processors. | 02-25-2010 |
Jody Davis, Ipswich, MA US
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20130291886 | Magnetic Headband - Methods and devices are provided for various headbands and one or more decorative features configured to be magnetically attached to the headbands. In certain embodiments, a decorative feature can magnetically attach to any part of a headband via a magnetic element seated within a magnetic element pocket of the decorative feature. The magnetic element can be securely contained within the magnetic element pocket by a closure. In certain embodiments the decorative feature can also optionally include a sleeve that can slide over the headband and more securely attach the decorative feature to the headband. | 11-07-2013 |
John E. Davis, Westfield, MA US
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20080201937 | Methods for Making Data Storage Media and the Resultant Media - Methods for forming data storage media and the media formed thereby are disclosed herein. In one embodiment, the method for forming a data storage media, comprises: injection molding a substrate comprising surface features, wherein said surface features have greater than about 90% of a surface feature replication of an original master; and disposing a data layer over at least one surface of said substrate; wherein said data storage media has an axial displacement peak of less than about 500μ under shock or vibration excitation when excited by a 1 G sinusoidal loading. | 08-28-2008 |
John Robert Davis, Cambridge, MA US
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20080281605 | Consultants - instrumentation loop logic diagrams - The intent of the Process Loop Sheet is to convey information regarding how various pieces of equipment interact with a variable process design. For Instance, all Water and Wastewater Plants are designed to accommodate influent flow rates that are not consistent from one hour to the next. These flow rates are generally expressed as low flow rate, average daily flow rate, and maximum flow rate. In both types of plants there are generally pump stations, screenings and grit removal, clarifiers, filters, odor control, various types of chemical injections, and storage tanks. In addition there are typically local control panels communicating information about a particular process to a Central Control Room. Generally the major local control panels are provided with programmable logic controllers that interface through software with operator work stations that are located in the Central Control Room. | 11-13-2008 |
Jonathan Davis, Ludlow, MA US
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20100081523 | Adjustably weighted training device and method of manufacture - The present application is direct to an adjustably weighted baseball bat for use when striking a ball and includes a cylindrical contacting region having a transverse dimension of D | 04-01-2010 |
Jonathan Davis, Auburndale, MA US
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20130196871 | Fibronectin Binding Domains with Reduced Immunogenicity - Fibronectin type III ( | 08-01-2013 |
20130245238 | Fibronectin Binding Domains with Reduced Immunogenicity - Fibronectin type III ( | 09-19-2013 |
20140113370 | FC FUSION PROTEINS COMPRISING NOVEL LINKERS OR ARRANGEMENTS - The application provides Fc fusion proteins having novel arrangements. In one embodiment, the application provides Fc fusion proteins comprising a | 04-24-2014 |
20140288288 | ANTI-CD19 ANTIBODIES WITH REDUCED IMMUNOGENICITY - Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response. | 09-25-2014 |
20150051149 | FIBRONECTIN BINDING DOMAINS WITH REDUCED IMMUNOGENICITY - Fibronectin type III (10Fn3) binding domains having novel designs that are associated with reduced immunogenicity are provided. The application describes alternative 10Fn3 binding domains in which certain immunogenic regions are not modified when producing a binder in order to maintain recognition as a self antigen by the host organism. The application also describes 10Fn3 binding domains in which HLA anchor regions have been destroyed thereby reducing the immunogenic contribution of the adjoining region. Also provided are 10Fn3 domains having novel combinations of modified regions that can bind to a desired target with high affinity. | 02-19-2015 |
Jonathan H. Davis, Auburndale, MA US
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20100029499 | Artificial Protein Scaffolds - The present invention provides proteins having one or more similarities to the artificial protein Top7 or to a Top7 derivative. Proteins of the invention have one or more loops that are longer than the corresponding loops of Top7, and/or that bind to a preselected target molecule. The invention also provides nucleic acids and cells useful in producing the proteins and methods for their use. | 02-04-2010 |
20120094909 | FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO PCSK9 - The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein. | 04-19-2012 |
20130210703 | FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND PCSK9 - The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein. | 08-15-2013 |
Joseph H. Davis, Cambridge, MA US
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20120070870 | Methods and Molecules for Yield Improvement Involving Metabolic Engineering - The invention features methods and compositions relating to cells that have been engineered to reduce or eliminate proteins having enzymatic activity that interfere with the expression of a metabolic product. | 03-22-2012 |
Kelly J. Davis, Somerville, MA US
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20100254987 | ENGINEERED PROTEINS WITH HIGH AFFINITY FOR DOTA CHELATES - The present invention features, inter alia, compositions and methods for the treatment of cancer and infectious disease. The compositions include engineered proteins that specifically bind a metal chelate and may be bispecific. For example, the engineered proteins may bind (a) a target (e.g., a cellular protein) on a cancerous cell or a pathogen and (b) a metal chelate comprising DOTA, or an active variant thereof, and a metal ion such as a radionuclide. By virtue of the multiple binding sites, the engineered protein effectively delivers a metal chelate to a cell one wishes to destroy. | 10-07-2010 |
Linda Davis, Westfield, MA US
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20120226129 | ECG Lead Wire Organizer And Dispenser - An ECG lead set including an ECG electrode assembly and a lead set hub. ECG electrode includes at least one electrode configured to receive biopotential signals from a patient, a plug connector for connecting said ECG electrode assembly, a web, connected between the at least one electrode and the plug connector and configured to form an electrical connection therebetween. The lead set hub includes at least one receptacle configured to receive the plug connector of the ECG electrode assembly. | 09-06-2012 |
20120226131 | ECG Lead Wire Organizer And Dispenser - An ECG lead set including an ECG electrode assembly and a lead set hub. ECG electrode includes at least one electrode configured to receive biopotential signals from a patient, a plug connector for connecting said ECG electrode assembly, a web, connected between the at least one electrode and the plug connector and configured to form an electrical connection therebetween. The lead set hub includes at least one receptacle configured to receive the plug connector of the ECG electrode assembly. | 09-06-2012 |
20120226177 | ECG LEAD WIRE ORGANIZER AND DISPENSER - An ECG lead set including an ECG electrode assembly and a lead set hub. ECG electrode includes at least one electrode configured to receive biopotential signals from a patient, a plug connector for connecting said ECG electrode assembly, a web, connected between the at least one electrode and the plug connector and configured to form an electrical connection therebetween. The lead set hub includes at least one receptacle configured to receive the plug connector of the ECG electrode assembly. | 09-06-2012 |
Michael Andrew Davis, Burlington, MA US
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20140033085 | GOAL-ORIENTED USER INTERFACE - Methods and apparatus, including computer program products, are provided for user interfaces. In one aspect there is provided a method. The method may include receiving a first goal information representative of at least a first goal of a user; receiving a second goal information representative of at least another goal of at least one other user; storing the first goal information and the second goal information; generating, by a page generator, a page including a graphical element representative of a bloom, wherein the bloom corresponds to the first goal of the user; and providing the page to a user interface for presentation. Related systems, methods, and articles of manufacture are also disclosed. | 01-30-2014 |
Michael S. Davis, Ipswich, MA US
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20100181674 | ELECTRICAL CONTACTS FOR CMOS DEVICES AND III-V DEVICES FORMED ON A SILICON SUBSTRATE - A semiconductor structure having a substrate, a seed layer over the substrate; a silicon layer disposed on the seed layer; a transistor device in the silicon layer; a III-V device disposed on the seed layer; and a plurality of electrical contacts, each one of the electrical contacts having a layer of TiN or TaN and a layer of copper or aluminum on the layer of TaN or TiN, one of the electrical contacts being electrically connected to the transistor and another one of the electrical contacts being electrically connected to the III-V device. | 07-22-2010 |
Morgan C. Davis, Hinsdale, MA US
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20090178822 | Frame for a wall cut-out - For a wall cut-out ( | 07-16-2009 |
Nickolas G. Davis, Peabody, MA US
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20120310065 | ELECTROPHYSIOLOGY CATHETER FOR MAPPING AND/OR ABLATION - The present invention encompasses apparatus and methods for mapping electrical activity within the heart. The present invention also encompasses methods and apparatus for creating lesions in the heart tissue (ablating) to create a region of necrotic tissue which serves to disable the propagation of errant electrical impulses caused by an arrhythmia. | 12-06-2012 |
Paul Davis, Blackstone, MA US
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20090235557 | Article of Footwear Having an Adjustable Ride - An article of footwear has an upper and a sole. The sole has an upper sole member, a lower sole member, and at least one inflatable bladder disposed between the upper sole member and the lower sole member. The at least one inflatable bladder has an inflated state and a deflated state. A distance between the upper sole member and the lower sole member is greater in the inflated state than the deflated state. Varying the inflation of the inflatable bladder varies the amount of cushioning in the sole and the thickness of the sole so that the shoe can serve as a multipurpose shoe for activities requiring different amounts of cushioning. | 09-24-2009 |
20120210601 | Article of Footwear Having An Adjustable Ride - An article of footwear has an upper and a sole. The sole has an upper sole member, a lower sole member, and at least one inflatable bladder disposed between the upper sole member and the lower sole member. The at least one inflatable bladder has an inflated state and a deflated state. A distance between the upper sole member and the lower sole member is greater in the inflated state than the deflated state. Varying the inflation of the inflatable bladder varies the amount of cushioning in the sole and the thickness of the sole so that the shoe can serve as a multipurpose shoe for activities requiring different amounts of cushioning. | 08-23-2012 |
20130247425 | Articles Of Footwear - A sole for an article of footwear includes a fiber-reinforced polymer plate extending from a heel area of the article of footwear to a toe area of the article of footwear, wherein flexibility of the fiber-reinforced polymer plate varies as a function of location along a longitudinal axis of the fiber-reinforced polymer plate, and wherein the fiber-reinforced polymer plate includes a stiffening layer disposed at a midfoot area of the fiber-reinforced polymer plate. | 09-26-2013 |
20140026439 | Smooth Shoe Uppers And Methods For Producing Them - Shoe uppers having smooth seams and methods for producing them are disclosed. In one embodiment the upper uses thermoplastic seam tape which forms bonds between contiguous upper sections after being subjected to heat and/or pressure. In another embodiment, different parts of the shoe can be joined using hidden seams. Close seams can also be covered with a transfer material adapted to give the interior and/or exterior of the upper a smooth surface. In yet another embodiment, a method is disclosed which allows three-dimensional upper sections to be bonded on a last using thermoplastic seam tape. | 01-30-2014 |
20140082961 | Smooth Shoe Uppers And Methods For Producing Them - Shoe uppers having smooth seams and methods for producing them are disclosed. In one embodiment the upper uses thermoplastic seam tape which forms bonds between contiguous upper sections after being subjected to heat and/or pressure. In another embodiment, different parts of the shoe can be joined using hidden seams. Close seams can also be covered with a transfer material adapted to give the interior and/or exterior of the upper a smooth surface. In yet another embodiment, a method is disclosed which allows three-dimensional upper sections to be bonded on a last using thermoplastic seam tape. | 03-27-2014 |
20140115922 | Smooth Shoe Uppers And Methods For Producing Them - Shoe uppers having smooth seams and methods for producing them are disclosed. In one embodiment the upper uses thermoplastic seam tape which forms bonds between contiguous upper sections after being subjected to heat and/or pressure. In another embodiment, different parts of the shoe can be joined using hidden seams. Close seams can also be covered with a transfer material adapted to give the interior and/or exterior of the upper a smooth surface. In yet another embodiment, a method is disclosed which allows three-dimensional upper sections to be bonded on a last using thermoplastic seam tape. | 05-01-2014 |
20150040428 | Article Of Footwear With Extruded Components - The disclosed embodiments relate to portions of an article of footwear formed from an extruded member. In certain embodiments, a sole or portion of a sole can be formed from one or more extruded members. In certain embodiments, the extruded member can be a single, continuous piece of solid material. In certain embodiments, a sole for an article of footwear can be fashioned from an extruded member formed in a controlled geometric pattern. In certain embodiments, the sole can include one or more layers. | 02-12-2015 |
20150075029 | Article of Footwear Having an Adjustable Ride - An article of footwear has an upper and a sole. The sole has an upper sole member, a lower sole member, and at least one inflatable bladder disposed between the upper sole member and the lower sole member. The at least one inflatable bladder has an inflated state and a deflated state. A distance between the upper sole member and the lower sole member is greater in the inflated state than the deflated state. Varying the inflation of the inflatable bladder varies the amount of cushioning in the sole and the thickness of the sole so that the shoe can serve as a multipurpose shoe for activities requiring different amounts of cushioning. | 03-19-2015 |
Paul Davis, Canton, MA US
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20080250668 | Smooth Shoe Uppers and Methods for Producing Them - Shoe uppers having smooth seams and methods for producing them are disclosed. In one embodiment the upper uses thermoplastic seam tape which forms bonds between contiguous upper sections after being subjected to heat and/or pressure. In another embodiment, different parts of the shoe can be joined using hidden seams. Close seams can also be covered with a transfer material adapted to give the interior and/or exterior of the upper a smooth surface. In yet another embodiment, a method is disclosed which allows three-dimensional upper sections to be bonded on a last using thermoplastic seam tape. | 10-16-2008 |
Paul M. Davis, Blackstone, MA US
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20080276494 | Stable Footwear that Accommodates Shear Forces - A shoe sole is described that provides both cushioning and stability. The sole has a plurality of layers, including a transition layer which allows relative motion between the layers adjacent to the transition layer. The relative motion between the layers of the sole reduces the impact of horizontal shear stresses on the wearer's feet and ankles. One such transition layer includes pliable material and deformable holes within the pliable material. Another transition layer includes at least two rigid plates held together by less rigid grommets or sidewalls. The transition layer may be disposed beneath the entire shoe or only portions of the shoe, with either a more conventional sole structure or rigid support members completing the sole. | 11-13-2008 |
20090095358 | Configurable Fluid Transfer Manifold for Inflatable Footwear - A configurable fluid transfer system for inflatable footwear includes a manifold. The manifold is part of an inflation system having an underfoot pump connected to one of the plurality of openings in the heel side of the manifold, an inflatable forefoot bladder connected to two of the plurality of openings in the bottom surface of the manifold and an inflatable heel bladder connected to one of the plurality of openings in the bottom surface of the manifold. Fluid flows from the underfoot pump to the inflatable forefoot bladder through a one-way valve and into a first channel in the manifold connected to a forefoot bladder. The fluid inflates the forefoot bladder and exits into a second channel in the manifold. Fluid flows from the inflatable forefoot bladder to the inflatable heel bladder through the second channel and inflates the heel bladder. A pressure regulator including a porous material may be in fluid communication with the fluid transfer system to control the rate of fluid exiting the system. | 04-16-2009 |
20100126661 | Method for Manufacturing Inflatable Footwear or Bladders for Use in Inflatable Articles - The present invention is a method for manufacturing inflatable articles, or bladders for inflatable articles, that is time-efficient, simple, inexpensive and permits the uninterrupted manufacture of numerous and even customized article or bladder configurations and sizes, without expensive configuration-specific, metal tooling. The method includes the steps of applying a barrier material to a side of a first film, providing a second film with the first film so that the barrier material is disposed between the first and second films, adhering the first film to the second film so that the films are sealed together in areas except where the barrier material has been applied to form at least one inflatable compartment and sealed peripheral edge, and cutting along the sealed peripheral edge to form an inflatable article or bladder for use in an article of manufacture. The barrier material may be a paint, ink, paper or surface treatment that effectively prevents the first film from adhering to the second. The inflatable article or bladder of the present invention may be used as or in athletic equipment, for example, including footwear. | 05-27-2010 |
20100192410 | Shoe Having an Inflatable Bladder - An article of footwear including a sole and an upper with an exterior and interior surface, and one or more bladders which comprises at least one of the exterior or interior surfaces of the upper. The bladder comprising sheets of polyurethane or polyester film attached together to form an airtight seal. The article of footwear also includes a inflation mechanism for selectively introducing air in the one or more bladders. The inflation mechanism is located under the foot of the wearer to be activated by the normal action of the wearer to inflate the one or more bladders. The article of footwear may also include an assembly for connecting several tubes to one under foot inflation mechanism. The article of footwear may also include inflatable laces that are inflated by an underfoot inflation mechanism. | 08-05-2010 |
20120084999 | Method for Manufacturing Inflatable Bladders for Use in Footwear and Other Articles of Manufacture - The present invention is a method for manufacturing inflatable bladders for use in articles of manufacture. The method includes the steps of providing a first polymer film, applying a curable release coating to the polymer film in a pattern that corresponds to the configuration of the inflatable bladder, curing the release coating to the first polymer film, providing a second polymer film with the first polymer film to form a layered element such that the release coating is disposed between the polymer films, positioning the layered element between two plies of material, applying heat and pressure to adhere the polymer films together except in the area where the release coating has been applied to form an inflatable compartment surrounded by a sealed perimeter, and removing the plies of material from the adhered first and second polymer films. | 04-12-2012 |
20120167413 | Shoe Having An Inflatable Bladder - An article of footwear including a sole and an upper with an exterior and interior surface, and one or more bladders which comprises at least one of the exterior or interior surfaces of the upper. The bladder comprising sheets of polyurethane or polyester film attached together to form an airtight seal. The article of footwear also includes a inflation mechanism for selectively introducing air in the one or more bladders. The inflation mechanism is located under the foot of the wearer to be activated by the normal action of the wearer to inflate the one or more bladders. The article of footwear may also include an assembly for connecting several tubes to one under foot inflation mechanism. The article of footwear may also include inflatable laces that are inflated by an underfoot inflation mechanism. | 07-05-2012 |
20130110415 | Body Mounted Monitoring System And Method | 05-02-2013 |
20130202467 | Pump and Valve Combination for an Article of Footwear Incorporating an Inflatable Bladder - An article of footwear having a pump and valve combination for inflating an inflatable bladder. In one embodiment the pump and valve combination has a pumping area formed between top and bottom polymeric films with a foam insert located therein and an air intake hole leading into the pumping area. A conduit leads from the pumping area to an inflatable bladder and a flow restrictor is located in a pathway of the conduit. In a second embodiment the pump and valve combination has a pumping area formed between top and bottom polymeric films and a grommet. An air intake is located in the pumping area. The grommet has an exhaust hole and a flexible band arranged around the grommet, including the exhaust hole. | 08-08-2013 |
20140053968 | METHOD FOR MANUFACTURING INFLATABLE FOOTWEAR OR BLADDERS FOR USE IN INFLATABLE ARTICLES - The present invention is a method for manufacturing inflatable articles, or bladders for inflatable articles, that is time-efficient, simple, inexpensive and permits the uninterrupted manufacture of numerous and even customized article or bladder configurations and sizes, without expensive configuration-specific, metal tooling. The method includes the steps of applying a barrier material to a side of a first film, providing a second film with the first film so that the barrier material is disposed between the first and second films, adhering the first film to the second film so that the films are sealed together in areas except where the barrier material has been applied to form at least one inflatable compartment and sealed peripheral edge, and cutting along the sealed peripheral edge to form an inflatable article or bladder for use in an article of manufacture. The barrier material may be a paint, ink, paper or surface treatment that effectively prevents the first film from adhering to the second. The inflatable article or bladder of the present invention may be used as or in athletic equipment, for example, including footwear. | 02-27-2014 |
20140059890 | METHOD FOR MANUFACTURING INFLATABLE BLADDERS FOR USE IN FOOTWEAR AND OTHER ARTICLES OF MANUFACTURE - The present invention is a method for manufacturing inflatable bladders for use in articles of manufacture. The method includes the steps of providing a first polymer film, applying a curable release coating to the polymer film in a pattern that corresponds to the configuration of the inflatable bladder, curing the release coating to the first polymer film, providing a second polymer film with the first polymer film to form a layered element such that the release coating is disposed between the polymer films, positioning the layered element between two plies of material, applying heat and pressure to adhere the polymer films together except in the area where the release coating has been applied to form an inflatable compartment surrounded by a sealed perimeter, and removing the plies of material from the adhered first and second polymer films. | 03-06-2014 |
Peter Davis, Wakefield, MA US
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20090031404 | Method and apparatus providing virtual private network access - A virtual private network device enables individual machines at a remote subnet to be visible and addressable from a central site by establishing a private address range for the remote machines, forming a virtual private network tunnel from the virtual private network device to the central site, and communicating the private address range to the central site to enable connections from the central site to individual machines on the remote subnet. | 01-29-2009 |
Randall Davis, Weston, MA US
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20080243033 | Method and apparatus for measuring representational motions in a medical context - Disclosed is an apparatus and corresponding method to capture individual representational motions made by a person while performing a neuropsychological test. A user of the apparatus and method may be allowed to view, edit, classify, and retrieve any captured and recorded motions made by the person. In one embodiment, a capture unit, such as a digitizer, captures the motions made by a person while performing a Clock Drawing Test, and the captured data may then be reported in a myriad of ways. The apparatus and method also provide a means to standardize administration and scoring of writing utensil and paper based neuropsychological testing administered to a person or control and test groups for domestic or international applications. By analyzing individual representational motions made by a person while performing a neuropsychological test, unexpectedly more information may be gleaned from the test than was available to physicians from only a completed drawing. | 10-02-2008 |
20120141032 | SKETCH RECOGNITION SYSTEM - Handwriting interpretation tools, such as optical character recognition (OCR), have improved over the years such that OCR is a common tool in business for interpreting typed text and sometimes handwritten text. OCR does not apply well to non-text-only diagrams, such as chemical structure diagrams. A method according to an embodiment of the present invention of interpreting a human-drawn sketch includes determining a local metric indicating whether a candidate symbol belongs to a certain classification based on a set of features. The set of features includes, as a feature, scores generated from feature images of the candidate symbol. Also included is determining a joint metric of multiple candidate symbols based on their respective classifications and interpreting the sketch as a function of the local and joint metrics. Sketches can be chemical composition, biological composition, electrical schematic, mechanical, or any other science- or engineering-based diagrams for which human-drawn symbols have well-known counterparts. | 06-07-2012 |
20140031724 | MEASURING REPRESENTATIONAL MOTIONS IN A MEDICAL CONTEXT - A method includes receiving data representing graphomotor motion during a succession of executions of graphomotor diagnostic tasks performed in a medical context by a subject, processing the received data using a computer, including determining a first set of quantitative features from a first execution of a task by the subject, and determining a second set of quantitative features from a second execution of a task by the subject, determining one or more metrics based on a comparison to the successive executions, including using at least the first set of quantitative features and the second set of quantitative features to determine said metrics, and providing a diagnostic report associated with neurocognitive mechanisms underlying the subject's execution of the tasks based on the determined metrics. | 01-30-2014 |
20140205188 | Sketch Recognition System - Handwriting interpretation tools, such as optical character recognition (OCR), have improved over the years such that OCR is a common tool in business for interpreting typed text and sometimes handwritten text. OCR does not apply well to non-text-only diagrams, such as chemical structure diagrams. A method according to an embodiment of the present invention of interpreting a human-drawn sketch includes determining a local metric indicating whether a candidate symbol belongs to a certain classification based on a set of features. The set of features includes, as a feature, scores generated from feature images of the candidate symbol. Also included is determining a joint metric of multiple candidate symbols based on their respective classifications and interpreting the sketch as a function of the local and joint metrics. Sketches can be chemical composition, biological composition, electrical schematic, mechanical, or any other science- or engineering-based diagrams for which human-drawn symbols have well-known counterparts. | 07-24-2014 |
Richard S. Davis, Salem, MA US
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20120243520 | LOCATION-BASED ASSOCIATION FOR COMMUNICATIONS NETWORKS - In one implementation, a region descriptor associated with a communications access point and a location descriptor are accessed at a client. The client determines that a location described by the location descriptor is included within a region described by the region descriptor. The client then requests association with the communications access point in response to the determining. | 09-27-2012 |
20140286321 | METHOD OF ASSOCIATING A CLIENT WITH AN ACCESS POINT IN A WIRELESS LOCAL AREA NETWORK - A method of associating a client with an access point in a wireless local area network. The access point broadcasts a beacon announcing the existence of the access point. The beacon comprises a field which has a list of client identifiers of acceptable clients from which the access point will accept an association request. | 09-25-2014 |
20150016375 | Control of Frequency Channel Between Wireless Access Points According to Sequence - Embodiments herein relate to transferring control of a frequency channel between wireless access points (WAP) according to a sequence where the frequency channel is part of an industrial, scientific and medical (ISM) radio band. Each of the WAPs transfers control of the same frequency channel according to a sequence. The transfer of control in the sequence occurs between adjacent WAPs, and the first and last WAPs in the sequence are adjacent to each other. | 01-15-2015 |
Robert J. Davis, Waltham, MA US
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20110298679 | COMPACT ULTRA-WIDE BANDWIDTH ANTENNA WITH POLARIZATION DIVERSITY - Described are methods and apparatus, including a method of manufacture, for a compact antenna. Two biconical dipole antennas and a monocone monopole antenna are displaced in an adjacent and orthogonal configuration. The two biconical dipole antennas are each shunted to the monocone monopole antenna. | 12-08-2011 |
Robert S. Davis, Boston, MA US
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20120283341 | System and Method for Converting Biomass to Ethanol via Syngas - A method and apparatus for synthesizing ethanol using synthetic routes via synthesis gas are disclosed. A method and apparatus for gasifying biomass, such as biomass, in a steam gasifier that employs a fluidized bed and heating using hot flue gases from the combustion of synthesis gas is described. Methods and apparatus for converting synthesis gas into ethanol are also disclosed, using stepwise catalytic reactions to convert the carbon monoxide and hydrogen into ethanol using catalysts including iridium acetate. | 11-08-2012 |
20140256993 | System and Method for Converting Biomass to Ethanol via Syngas - A method and apparatus for synthesizing ethanol using synthetic routes via synthesis gas are disclosed. A method and apparatus for gasifying biomass, such as biomass, in a steam gasifier that employs a fluidized bed and heating using hot flue gases from the combustion of synthesis gas is described. Methods and apparatus for converting synthesis gas into ethanol are also disclosed, using stepwise catalytic reactions to convert the carbon monoxide and hydrogen into ethanol using catalysts including iridium acetate. | 09-11-2014 |
Roger J. Davis, Princeton, MA US
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20090053231 | Optical Disc Apparatus - Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor-2 (ATF2) and c-Jun. The pathways are activated by a number of factors, including cytokines and environmental stress. Methods are provided for identifying reagents that modulate MKK function or activity and for the use of such reagents in the treatment of MKK-mediated disorders. | 02-26-2009 |
20100183633 | INTERLEUKIN 6 AND TUMOR NECROSIS FACTOR ALPHA AS BIOMARKERS OF JNK INHIBITION - Biomarkers for JNK inhibition are described that can be used for monitoring effectiveness of JNK inhibitors and monitoring treatment with JNK inhibitors. | 07-22-2010 |
20100215665 | MIXED LINEAGE KINASES AND METABOLIC DISORDERS - Methods of treating metabolic stress disorders are disclosed that include administering to a subject a therapeutically effective amount of a composition that specifically inhibits the expression or activity of a mixed lineage kinase (MLK). Also disclosed are methods of identifying candidate compounds for treatment of metabolic stress disorders and methods of diagnosing metabolic stress disorders. | 08-26-2010 |
20120208846 | Therapeutic Methods For Type I Diabetes - The invention relates to the treatment and prevention of type I diabetes. More specifically, the invention relates to compounds that treat or prevent the body's immune system from destroying β-cells (i.e., insulin-producing cells in the pancreatic islets of Langerhans) by inhibition of JNK2, selective inhibition of JNK2, or inhibition of the expression of the MAPK9 gene or gene product. In one embodiment, the present invention contemplates the diagnosis, identification, production, and use of compounds which modulate MAPK9 gene expression or the activity of the MAPK9 gene product including but not limited to, JNK2, the nucleic acid encoding MAPK9 and homologues, analogues, and deletions thereof, as well as antisense, ribozyme, triple helix, antibody, and polypeptide molecules as well as small inorganic molecules. The present invention contemplates a variety of pharmaceutical formulations and routes of administration for such compounds. | 08-16-2012 |
20120240247 | JNK3 MODULATORS AND METHODS OF USE - The c-Jun NH | 09-20-2012 |
20140107123 | Therapeutic Methods For Type I Diabetes - The invention relates to the treatment and prevention of type I diabetes. More specifically, the invention relates to compounds that treat or prevent the body's immune system from destroying β-cells (i.e., insulin-producing cells in the pancreatic islets of Langerhans) by inhibition of JNK2, selective inhibition of JNK2, or inhibition of the expression of the MAPK9 gene or gene product. In one embodiment, the present invention contemplates the diagnosis, identification, production, and use of compounds which modulate MAPK9 gene expression or the activity of the MAPK9 gene product including but not limited to, JNK2, the nucleic acid encoding MAPK9 and homologues, analogues, and deletions thereof, as well as antisense, ribozyme, triple helix, antibody, and polypeptide molecules as well as small inorganic molecules. The present invention contemplates a variety of pharmaceutical formulations and routes of administration for such compounds. | 04-17-2014 |
Scott Davis, Great Barrington, MA US
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20090011210 | Lightweight glass fiber reinforced thermoplastic material - A glass fiber reinforced thermoplastic sheet material is provided in which certain properties, or combinations of properties, are improved relative to similar comparative sheet materials. The sheet material generally comprises a glass mat or glass fabric fiber reinforced thermoplastic resin in which the thermoplastic resin at least partially impregnates the glass mat or fabric. The thermoplastic sheet material contains about 15 wt. % to about 65 wt. % of the glass mat or fabric based on the weight of the thermoplastic sheet material and has a thickness in the range of about 0.4 mm to about 3.0 mm. By including glass mat or fabric and maintaining the sheet thickness in the aforementioned range, the present invention thermoplastic sheet material exhibits improved flexural and/or tensile strength and modulus properties at reduced basis weight compared to a comparative thermoplastic sheet materials. A method of providing the glass fiber reinforced thermoplastic sheet material having an improved combination of flexural strength and modulus and/or tensile strength and modulus properties is also described, in which a first layer of a first thermoplastic resin, a second layer of a second thermoplastic resin, and a layer of glass mat or glass fabric are provided; the first thermoplastic resin layer, the second thermoplastic resin layer and the glass mat or glass fabric layer are arranged such that the glass mat or glass fabric layer is interposed between the first and second thermoplastic resin layers; and heat and pressure are applied to substantially melt and compress the first thermoplastic resin and/or the second thermoplastic resin and to at least partially impregnate the glass mat or glass fabric layer with the molten first thermoplastic resin and/or the molten second thermoplastic resin. | 01-08-2009 |
Scott Davis, Pittsfield, MA US
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20120246873 | HOLLOW ARTICLES COMPRISING FIBER-FILLED POLYESTER COMPOSITIONS, METHODS OF MANUFACTURE, AND USES THEREOF - A hollow molded article is obtained by molding a thermoplastic polyester composition comprising a blend of reinforcing fiber glass, polybutylene terephthalate with a melting point of 210 to 230° C. and polyethylene terephthalate with a melting point of 240 to 260° C., wherein at least 10% of the outer surface of the article has a continuous glossy region with a gloss of at least 75 gloss units, as measured at 60 degrees in accordance with ASTM D523 and wherein the gloss varies from the average less than 10 gloss units in the glossy region. A gas-assisted injection molding process is also disclosed for making such hollow molded articles, which articles can have various uses, including handles for appliances or the like. | 10-04-2012 |
Scott A. Davis, Southboro, MA US
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20130012924 | Dual Durometer Soft/Flexible Enhanced Bond Strength Guiding Tip - A catheter having a distal tip comprising two sections of different hardness, and a method of making the same, is herein disclosed. The first section of the two sections is distal to the second section of the two sections and the second section is comprised of a material that is harder than the material of the first section. Additionally, the distal tip is bonded to a catheter shaft and the material of the catheter shaft is harder than the material of the first and second sections. The material of the catheter shaft, first section, and second section can comprise polyether block amide, with each section and the catheter shaft having different properties. | 01-10-2013 |
Scott H. Davis, Groton, MA US
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20080256090 | DYNAMIC DIRECTORY SERVICE - In a network of computer nodes, a directory service provides both the physical location of directory information around the network and the directory information itself in a single data structure. This single data structure is distributed throughout the network, and continuously redistributed, so as to create a directory service that is both more flexible, and more robust, than prior art directory services. | 10-16-2008 |
Scott Howard Davis, Needham, MA US
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20110265083 | FILE SYSTEM INDEPENDENT CONTENT AWARE CACHE - A server supporting the implementation of virtual machines includes a local memory used for caching, such as a solid state device drive. During I/O intensive processes, such as a boot storm, a “content aware” cache filter component of the hypervisor of the server first accesses a cache structure in a content cache device to determine whether data blocks have been stored in the cache structure prior to requesting the data blocks from a networked disk array via a standard I/O stack of the hypervisor. The content aware cache filter component is implemented in an I/O virtualization layer of the standard I/O stack that sits above a file system layer of the standard I/O stack, such that any file system protocol may be implemented in the file system layer. | 10-27-2011 |
20130018939 | NATIVE VIEWER USE FOR SERVICE RESULTS FROM A REMOTE DESKTOP - In one embodiment, a method includes establishing a session to a remote desktop determined for a user of a client device. The session allows the client device to remotely access the remote desktop to have one or more services performed for the user of the client device using resources of the remote desktop. The client device sends a request for a service in the one or more services to be performed on the remote desktop in the session and receives a result set determined from the service being performed by the remote desktop. A native viewer for the client device is determined based on a type of the result set. The native viewer is then invoked to display the result set. | 01-17-2013 |
20130167155 | FILE SYSTEM INDEPENDENT CONTENT AWARE CACHE - A server supporting the implementation of virtual machines includes a local memory used for caching, such as a solid state device drive. During I/O intensive processes, such as a boot storm, a “content aware” cache filter component of the server first accesses a cache structure in a content cache device to determine whether data blocks have been stored in the cache structure prior to requesting the data blocks from a networked disk array via a standard I/O stack of the hypervisor. | 06-27-2013 |
20140006346 | PRESERVING USER PROFILES ACROSS REMOTE DESKTOP SESSIONS | 01-02-2014 |
20150058286 | OPENING UNSUPPORTED FILE TYPES THROUGH REMOTING SESSIONS - Viewing and editing operations on a file having an unsupported file type are enabled through a method of opening the file through a remoting session. The method includes the steps of issuing a request to open the file and metadata of the file, programmatically transmitting credentials of the user to a connection server to log the user into a virtual machine, and establishing a remoting session with the virtual machine to access the file for viewing and editing, the virtual machine opening the file based on the request to open the file and the metadata of the file. | 02-26-2015 |
Scott Michael Davis, Pittsfield, MA US
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20120308777 | STERILIZED POLYETHERIMIDE /POLYPHENYLENE ETHER SULFONE ARTICLES - A sterilized article comprising a hydrogen peroxide plasma or hydrogen peroxide vapor sterilized polymer composition, the polymer composition comprising from 20 to 80 weight % of a polyphenylene ether sulfone; and from 20 to 80 weight % of a polyetherimide. When sterilized with a hydrogen peroxide plasma, or hydrogen peroxide vapor, the articles have surprisingly improved resistance to changes in color and clarity as well as resistance to loss of mechanical properties. | 12-06-2012 |
20120308778 | STERILIZED POLYETHERIMIDE ARTICLES - A sterilized article comprising a sterilized or hydrogen peroxide vapor-sterilized polymer composition, the polymer composition comprising a polyetherimide, wherein after exposure to 100 cycles of the hydrogen peroxide plasma sterilization using a mixture of hydrogen peroxide vapor and hydrogen peroxide plasma for 30 minutes at 20 to 55° C., the color of the polymer composition of the article exhibits a color shift of delta E of 10 units or less relative to the color of the polymer composition color before the first hydrogen peroxide plasma sterilization cycle, wherein delta E is measured in accordance with ASTM D2244. | 12-06-2012 |
20130283710 | CONNECTOR ASSEMBLIES FOR CONNECTING PANELS, PANELS WITH CONNECTOR ASSEMBLIES - In one embodiment, a connector assembly comprises: a connector; and a pair of side collectors, each comprising a connector engagement region having a size and geometry to mate with the connector so as to hold ends of two adjacent panels together; and a panel engagement region comprising a receiving area and having a size to attach onto an edge of the panel; and a clip, wherein the clip has a base that can be attached to a support, an engagement, and a stem extending therebetween, wherein the engagement has an extension projecting from a side of the engagement, wherein the panel engagement region further comprises an opening in a joint wall on a side of the panel engagement region opposite the receiving area, wherein the opening is configured to receive the extension of the engagement. | 10-31-2013 |
20130287489 | CONNECTOR ASSEMBLIES FOR CONNECTING PANELS - In one embodiment, a connector assembly comprises: a connector; and a pair of side collectors, each comprising a connector engagement region having a size and geometry to mate with the connector so as to hold ends of two adjacent panels together; and a panel engagement region comprising a receiving area and having a size to attach onto an edge of the panel; and a clip, wherein the clip has a base that can be attached to a support, an engagement, and a stem extending therebetween, wherein the engagement has an extension projecting from a side of the engagement, wherein the panel engagement region further comprises an opening in a joint wall on a side of the panel engagement region opposite the receiving area, wherein the opening is configured to receive the extension of the engagement. | 10-31-2013 |
Shawn Davis, Boston, MA US
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20110066134 | Controlling Drug Transport and Current in Iontophoretic Onychomycosis Treatment - Pharmaceutical drugs and formulations suitable for iontophoresis thereof that provide enhanced iontophoretic delivery of an anti-fungal drug to at least one body surface, such as a nail, are described. Also described are pharmaceutical formulations suitable for iontophoresis comprising terbinafine and methods for administering terbinafine to a body surface via iontophoresis. When the drug source is introduced into the nail using a mask, terbinafine concentrations in peripheral areas of nail following iontophoretic treatment are less than drug concentrations directly under the mask. Further, differences in delivered drug concentrations is effectuated by creating drug delivery gradients. Drug can be delivered to dissimilar tissues based on different transfer efficiencies exhibited by the dissimilar tissues, resulting in higher percentage delivery in one tissue vs. another tissue. | 03-17-2011 |
20110105872 | SYSTEMS AND METHODS FOR APPLICATION TO SKIN AND CONTROL OF ACTUATION, DELIVERY, AND/OR PERCEPTION THEREOF - The present invention generally relates, in certain aspects, to systems and methods for application to the skin, and control of actuation, delivery, and/or perception thereof. For example, certain aspects of the invention are generally directed to devices for delivering to and/or withdrawing fluid or from subjects, e.g., to or from the skin and/or beneath the skin. In one aspect, the delivery and/or withdrawal of fluid is at least partially obscured. For example, the obscuration may be by time, and/or by sensory obscuration (e.g., by providing tactile, olfactory, auditory, and/or visual sensations). Certain aspects of the invention are generally directed to devices able to automatically deliver to and/or withdraw fluid from the skin and/or beneath the skin after activation, e.g., where the fluid is delivered and/or withdrawn without the need for any additional intervention. The devices may be activated by any suitable technique. In other aspects, a device may be contained in a package, and when removed from the package, the device may be constructed and arranged to be able to deliver and/or withdraw fluid when the device is applied to the skin, and in some cases, automatically and/or without any further intervention by the subject or another person. | 05-05-2011 |
20110105951 | SYSTEMS AND METHODS FOR TREATING, SANITIZING, AND/OR SHIELDING THE SKIN OR DEVICES APPLIED TO THE SKIN - The present invention generally relates, in certain aspects, to systems and methods for treating, sanitizing, and/or shielding blood on the surface of the skin or devices applied to the skin. In one set of embodiments, while blood is withdrawn from the skin of the subject, the blood is covered and/or shielded such that the blood is not seen by the subject. In another set of embodiments, any blood present on the skin may be altered or treated such that it no longer appears as blood, e.g., by exposing the blood to a chemical such as a peroxide that alters the color of the blood. In yet another set of embodiments, blood present on the skin is withdrawn or taken up by the device such that visible residual blood is not present in an amount visible to the unaided eye once the device is removed. In some cases, the same device may be used to sanitize the skin and deliver to and/or withdraw fluid from the skin and/or beneath the skin. The sanitization may be performed before, during, or after delivering to and/or withdrawing fluid from the skin and/or beneath the skin. Sanitization may be performed, for example, using a sanitizer such as hydrogen peroxide, ethyl alcohol, isopropyl alcohol, or the like. | 05-05-2011 |
20110105952 | RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF - The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject. In some embodiments, the device may be repeatedly applicable to the skin of the subject to deliver to and/or withdraw fluid from the skin and/or beneath the skin of a subject, e.g., at the same location, or at different locations on the skin of the subject. In some aspects, the devices may be self-contained and/or have a relatively small size, and in some cases, the device may be sized such that it is wearable and/or able to be carried by a subject. For example, the device may have a mass and/or dimensions that allow the device to be carried or worn by a subject for various periods of time, e.g., at least about an hour, at least about a day, at least about a week, etc., or no more than about an hour, no more than about 10 min, etc. | 05-05-2011 |
20110125058 | PATIENT-ENACTED SAMPLING TECHNIQUE - The present invention is generally directed to systems and methods for sampling fluids from subjects. The fluid may be any suitable bodily fluid, e.g., blood or interstitial fluid. In some cases, the subject is a patient. The subject may have a device that can be applied to the skin of the subject (e.g., by the subject, or another person), and the device is able to obtain a sample of fluid. The fluid may be stored within a reservoir in the device, and the fluid may be obtained from the subject at any convenient time, e.g., at home, away from a healthcare setting, etc. In some embodiments, the device, or a portion thereof, may be returned to a clinical and/or laboratory setting to analyze the fluid stored within the device. | 05-26-2011 |
20110172508 | SAMPLING DEVICE INTERFACES - The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. | 07-14-2011 |
20110172510 | RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS - The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. | 07-14-2011 |
20110251562 | RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS - The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. | 10-13-2011 |
20120010529 | SAMPLING DEVICES AND METHODS INVOLVING RELATIVELY LITTLE PAIN - The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., to the skin and/or from the skin. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, to for example, using pain scales such as the Wong-Baker FACES Pain Scale. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. | 01-12-2012 |
20120041338 | CLINICAL AND/OR CONSUMER TECHNIQUES AND DEVICES - The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject. | 02-16-2012 |
20120275955 | PLASMA OR SERUM PRODUCTION AND REMOVAL OF FLUIDS UNDER REDUCED PRESSURE - In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum. | 11-01-2012 |
20120277629 | SYSTEMS AND METHODS FOR COLLECTION AND/OR MANIPULATION OF BLOOD SPOTS OR OTHER BODILY FLUIDS - The present invention generally relates to systems and methods for receiving blood (or other bodily fluids) from a subject, e.g., from or beneath the skin of a subject. In some cases, the blood (or other bodily fluids) may be deposited on a membrane or other substrate. For example, blood may be absorbed in a substrate, and dried in some cases to produce a dried blood spot. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and directing the blood on a substrate, e.g., for absorbing blood. The substrate, in some embodiments, may comprise filter paper or cotton-based paper. After absorption of some blood onto the substrate, the substrate may be removed from the device and shipped or analyzed. | 11-01-2012 |
20120277696 | DELIVERING AND/OR RECEIVING FLUIDS - The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. | 11-01-2012 |
20120277697 | SYSTEMS AND METHODS FOR COLLECTING FLUID FROM A SUBJECT - Systems and methods for delivering to and/or receiving fluids or other materials, such as blood or interstitial fluid, from subjects, e.g., from the skin. Beading disruptors and/or capillaries may be used for facilitating the transport of fluids from a subject into a device. Beading disruptors may disrupt the “pooling” of bodily fluids such as blood on the surface of the skin and help influence flow in a desired way. A capillary may conduct flow of fluid in the device, e.g., to an inlet of a channel or other flow path that leads to a storage chamber. A vacuum (reduced pressure relative to ambient) may be used to receive fluid into the device, e.g., by using relatively low pressure to draw fluid into the inlet of a channel leading to a storage chamber. The vacuum source may be part of the device. | 11-01-2012 |
20130079666 | DELIVERING AND/OR RECEIVING FLUIDS - The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. | 03-28-2013 |
20130138058 | DELIVERING AND/OR RECEIVING FLUIDS - The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. | 05-30-2013 |
20130158468 | DELIVERING AND/OR RECEIVING MATERIAL WITH RESPECT TO A SUBJECT SURFACE - The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. The flow activator may be actuated in a deployment direction by a deployment actuator, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, an effector may enable fluid communication between the opening and the vacuum source and may do so in response to actuation of the flow activator. | 06-20-2013 |
20130158482 | RAPID DELIVERY AND/OR RECEIVING OF FLUIDS - The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for receiving or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. In another aspect, the present invention is generally directed to arrangements of skin insertion objects such as microneedles and methods of forming and arranging skin insertion objects. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. | 06-20-2013 |
20150038876 | DELIVERING AND/OR RECEIVING FLUIDS - The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. | 02-05-2015 |
20150057510 | PATIENT-ENACTED SAMPLING TECHNIQUE - The present invention is generally directed to systems and methods for sampling fluids from subjects. The fluid may be any suitable bodily fluid, e.g., blood or interstitial fluid. In some cases, the subject is a patient. The subject may have a device that can be applied to the skin of the subject (e.g., by the subject, or another person), and the device is able to obtain a sample of fluid. The fluid may be stored within a reservoir in the device, and the fluid may be obtained from the subject at any convenient time, e.g., at home, away from a healthcare setting, etc. In some embodiments, the device, or a portion thereof, may be returned to a clinical and/or laboratory setting to analyze the fluid stored within the device. | 02-26-2015 |
20150087944 | TECHNIQUES AND DEVICES ASSOCIATED WITH BLOOD SAMPLING - The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor. | 03-26-2015 |
Shawn P. Davis, Boston, MA US
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20080312580 | CURRENT CONCENTRATION SYSTEM AND METHOD FOR ELECTROKINETIC DELIVERY OF MEDICAMENTS - An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a flux concentrator including an active electrode and a counter electrode adapted to be applied to the surface of a toenail or fingernail of the user, and a medicament matrix adjacent the active electrode and arranged to be sandwiched between the active electrode and nail. | 12-18-2008 |
20080319371 | METHOD AND SYSTEM FOR TREATING OF ONYCHOMYCOSIS WITH AN APPLICATOR HAVING A GEL MEDICAMENT LAYER - A method to electrokinetically deliver a medicament to a nail of a mammalian user including: forming a cast of the nail of the user wherein the cast is a reverse impression of the nail; applying a medicament matrix to the nail; sandwiching the medicament matrix between the cast and the nail; pressing the medicament matrix to the nail using the cast; applying electrical current to an electrical current path extending through the medicament matrix and the nail, and delivering medicament from the matrix into the nail by electrokinetic transporting the medicament along the current path. | 12-25-2008 |
20110071491 | Current Concentration System and Method for Electrokinetic Delivery of Medicaments - An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a flux concentrator including an active electrode and a counter electrode adapted to be applied to the surface of a toenail or fingernail of the user, and a medicament matrix adjacent the active electrode and arranged to be sandwiched between the active electrode and nail. | 03-24-2011 |
Stacy E. Davis, Medway, MA US
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20090315801 | PORTAL STRUCTURE PROVIDING ELECTROMAGNETIC INTERFERENCE SHIELDING FEATURES - In one aspect, an antenna pedestal includes a body having an inner cavity. The antenna pedestal includes a portal structure to access the inner cavity of the antenna pedestal. The portal structure also includes a threaded structure disposed around a portal accessing the inner cavity and comprising threads and a cover comprising threads configured to engage the threads of the threaded structure to close the portal. | 12-24-2009 |
20090315805 | ROTARY CONNECTOR PROVIDING ELECTROMAGNETIC INTERFERENCE SHIELDING FEATURES - In one aspect, a rotary connector having a longitudinal axis includes a first metal portion including a groove about the longitudinal axis. The rotary connector also includes a second metal portion and a spring disposed in the groove and having metal contact with the first portion and the second portion. One of the first metal portion or the second metal portion is configured to rotate about the longitudinal axis and the other of the first metal portion or the second metal portion is configured to remain substantially rotationally fixed with respect to the longitudinal axis. The rotary connector may be used for electromagnetic interference (EMI) shielding with antenna pedestals. | 12-24-2009 |
Steve Davis, Brookline, MA US
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20080249803 | System and method for creating a marketing analysis model - A method of producing a marketing report, wherein the marketing report is based on at least one or more patient information data-sets and one or more purchasing information data-sets, can include the steps of receiving a first patient information data-set from a patient, transmitting a patient association request to a purchase tracking module, wherein the patient association request includes a portion of the first patient information data-set, and the purchase tracking module is configured to store purchasing information data-sets. The method can include receiving a patient association confirmation, wherein the patient association confirmation acknowledges the association of a portion of the first patient information data-set with a purchasing information data-set stored in the purchase tracking module, scheduling a time for transmission of a first educational information data-set to the patient and transmitting the first educational information data-set at the properly scheduled time to the patient. | 10-09-2008 |
20100191542 | System And Method For Creating A Marketing Analysis Model - A method of producing a marketing report, wherein the marketing report is based on at least one or more patient information data-sets and one or more purchasing information data-sets, can include the steps of receiving a first patient information data-set from a patient, transmitting a patient association request to a purchase tracking module, wherein the patient association request includes a portion of the first patient information data-set, and the purchase tracking module is configured to store purchasing information data-sets. The method can include receiving a patient association confirmation, wherein the patient association confirmation acknowledges the association of a portion of the first patient information data-set with a purchasing information data-set stored in the purchase tracking module, scheduling a time for transmission of a first educational information data-set to the patient and transmitting the first educational information data-set at the properly scheduled time to the patient. | 07-29-2010 |
Steven Davis, Brookline, MA US
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20140040308 | System and Method for Analyzing De-Identified Health Care Data - A system and method for creating a unique alias associated with an individual identified in a health care database such that health care data, and particularly pharmaceutical-related data, can be efficiently gathered and analyzed. The system has a first data store for storing at least one record where each record includes a plurality of identification fields which when concatenated uniquely identify an individual, and at least one health care field corresponding to health care data associated with the individual. The system also has a second data store, and a processor. The processor selects a record of the first data store, then selects a subset of the plurality of identification fields within the selected record, and concatenates the selected subset of identification fields. Then the processor stores the concatenated identification fields in a record in the second data store with the at least one health care field from the selected record of the first data store. | 02-06-2014 |
Stuart M. Davis, Norfolk, MA US
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20090249614 | Battery - Ozonated manganese dioxide is prepared by an ozonation process and utilized as a cathode active material. An ozone containing gas stream contacts manganese dioxide and produces ozonated manganese dioxide with high efficiency. After preparation, ozonated manganese dioxide is stored for a limited time at a low temperature and incorporated into a cathode active material for alkaline batteries. | 10-08-2009 |
20090258297 | Battery - Primary alkaline batteries include cathodes containing manganese dioxide and anodes including zinc. The weight ratio of the manganese dioxide to zinc is relatively low because the manganese dioxide has a relatively high oxygen content. | 10-15-2009 |
20100047640 | FUEL SOURCE FOR ELECTROCHEMICAL CELL - Embodiments of the invention relate to a fuel source including a chemical hydride and at least one reactive metal source selected from the group consisting of a reactive metal, a reactive metalloid and a combination thereof. | 02-25-2010 |
20100081046 | BATTERIES - A battery includes a housing, an anode and a cathode within the housing, the anode having a first portion and a second portion adjacent to each other, a current collector at least partially disposed in the anode, a separator between the anode and the cathode, and an anode portion separator at least partially disposed in the anode and between the first and second portions of the anode. | 04-01-2010 |
20100112421 | Battery - A battery includes a housing, a cathode and an anode within the housing, and a battery-life indicator including a fragrance that is released to indicate usage of the battery. | 05-06-2010 |
20110143182 | Battery Separator - A battery includes a separator with a trapping layer that traps dissolved metal ions. | 06-16-2011 |
20110197434 | CATHODES AND CATHODE MIXTURES INCLUDING OZONATED MANGANESE DIOXIDE - Ozonated manganese dioxide is prepared by an ozonation process and utilized as a cathode active material. An ozone containing gas stream contacts manganese dioxide and produces ozonated manganese dioxide with high efficiency. After preparation, ozonated manganese dioxide is stored for a limited time at a low temperature and incorporated into a cathode active material for alkaline batteries. | 08-18-2011 |
20120034508 | Battery Separator - A battery includes a separator with a trapping layer that traps dissolved metal ions. | 02-09-2012 |
20120256583 | Low Cost Fast Charger with Internal Accumulator and Method - Disclosed is a charger device configured to charge a rechargeable battery comprising at least one rechargeable electrochemical cell includes a lead-acid battery charge accumulator device of a high discharge rate, having a discharge rate that is capable of delivering charging current to the at least one rechargeable electrochemical cell to charge the at least one rechargeable electrochemical cell within a period of about 5 to 15 minutes, a low rate 200 ma charger coupled in shunt with the lead-acid battery high discharge rate charge accumulator device and with the charger configured to re-charge the high discharge rate charge accumulator at a low charge rate, in comparison to the discharge rate of high discharge rate charge accumulator and a series resistor coupled between the accumulator and an output of the charger device. | 10-11-2012 |
Stuart Michael Davis, Norfolk, MA US
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20120084984 | CARTRIDGES AND RAZORS WITH TRIMMING WING - A cartridge or razor, suitable for wet or dry shaving, comprising a housing in which the housing comprises a front, a rear, a first side, a second side opposite the first side, and a wing on at least one of the first side and the second side. The cartridge or razor also comprises one or more shaving blades disposed in the housing and at least one trimming blade disposed in the wing. | 04-12-2012 |
20140057160 | ALKALINE CELL HAVING INCREASED INTERFACIAL AREA - An alkaline cell comprising a housing having a bottom end and a top end, and an electrode assembly disposed within the housing. The electrode assembly comprises a single first electrode and a single second electrode, a separator therebetween, and an electrolyte. The first electrode comprises a hollow outer body and at least one inner body positioned inside the outer body, the outer body and the at least one inner body being joined together inside the housing to form a single substantially homogeneous structure having an essentially uniform electrode properties. The second electrode comprises an intermediate body at least partially disposed between the outer body and the at least one inner body and electrically isolated from the outer body and the at least one inner body. | 02-27-2014 |
Theodore B. Davis, Boxford, MA US
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20100129916 | Expression of Toxic Genes In Vivo in a Non-Natural Host - Compositions and methods are provided for expression of a toxic protein in a host cell preferably a bacterial host cell where at least one T7 RNA polymerase gene Is contained on the host cell chromosome and one or more genes encoding a T7 RNA polymerase inhibitor is located on an F′ plasmid or on the chromosome. | 05-27-2010 |
Timothy D. Davis, Tewksbury, MA US
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20090068441 | Thermal interface materials - The present invention relates to thermal interface materials comprising a filler dispersed in a polymer, wherein the filler has an average aggregate particle size of less than or equal to 1 micron. Preferably the filler is a synthetic alumina, such as fumed alumina. | 03-12-2009 |
20140190672 | Thermal Interface Materials - The present invention relates to thermal interface materials comprising a filler dispersed in a polymer, wherein the filler has an average aggregate particle size of less than or equal to 1 micron. Preferably the filler is a synthetic alumina, such as fumed alumina. | 07-10-2014 |
William Davis, Hingham, MA US
Patent application number | Description | Published |
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20100130989 | Tissue Repair Device - The present disclosure relates to a tissue repair device. The device includes a handle, a knob coupled to the handle, and a needle coupled to the handle. The needle includes a proximal end and a distal end, the distal end including a slot, wherein a first anchor is housed within the distal end and a second anchor is housed within the slot and located proximal to the first anchor. An actuator disposed within the needle and operatively coupled to the knob, wherein advancement of the knob allows for engagement of the actuator with the first anchor and subsequent advancement of the first anchor via the actuator. A method of tissue repair is also disclosed. | 05-27-2010 |
20130158555 | RETRODRILL SYSTEM - The present disclosure relates to a method of creating a bone tunnel during ligament reconstruction surgery. The method includes placing a guide wire through the femur, the guide wire having a first end portion including a pointed tip and a second end portion; placing a drill mechanism over the first end portion of the guide wire, the drill mechanism having a first end portion including a drill bit and a second end portion including an attachment portion; coupling an adaptor assembly to the attachment portion, the adaptor assembly including a shaft; coupling a drill to the shaft and operating the drill to create a tunnel in the femur; coupling a drill bit assembly to the second end portion of the guide wire and locating the assembly against the drill bit of the attachment portion; and operating the drill to create a counter bore within the tunnel. | 06-20-2013 |
20150018831 | RETRODRILL SYSTEM - The present disclosure relates to a method of creating a bone tunnel during ligament reconstruction surgery. The method includes placing a guide wire through the femur, the guide wire having a first end portion including a pointed tip and a second end portion; placing a drill mechanism over the first end portion of the guide wire, the drill mechanism having a first end portion including a drill bit and a second end portion including an attachment portion; coupling an adaptor assembly to the attachment portion, the adaptor assembly including a shaft; coupling a drill to the shaft and operating the drill to create a tunnel in the femur; coupling a drill bit assembly to the second end portion of the guide wire and locating the assembly against the drill bit of the attachment portion; and operating the drill to create a counter bore within the tunnel. | 01-15-2015 |
William H. Davis, Winchester, MA US
Patent application number | Description | Published |
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20080295405 | Method for controlling syngas production in a system with multiple feed materials - Two or more feed materials that possess differing syngas generation potentials are mixed in a mixer and fed as a composite feed stream into a gasifier to produce syngas. By controlling the feed rate of the mixture into the gasifier as well as the feed rates of one or more of the individual feed materials into the mixer, the syngas is produced at a target production rate, with target energy content (BTU). Potential feed materials include, but are not limited to, construction and demolition (C&D) debris, municipal solid waste (MSW), other sewage-related solids, waste tires, and other substances that contain varying levels of organic compounds capable of producing a syngas. | 12-04-2008 |
20090188844 | Construction & demolition debris (C&D) materials processing - A method of processing construction and demolition (C&D) debris at a location includes a set of processing steps. The method begins upon receipt of bulk C&D debris at the location. The bulk C&D debris is sorted into at least a first portion for further processing, and a second portion that is set aside. The first portion is then processed into a substantially homogenous wood waste material having particles of a given size by the unordered steps of shredding, screening, metals separation and flotation. The substantially homogenous wood waste material is then dried so that the particles have moisture content within a desired range. The wood waste material particles are then delivered into a molten metal bath at a submerged depth for gasification. Preferably, the process operates in a continuous or partially-continuous manner within a given facility, or within co-located facilities. | 07-30-2009 |
20100035193 | Method and system for fuel gas combustion, and burner for use therein - Power cycle generation equipment is operated in a more efficient and economical manner by using an uncooled (and potentially uncleaned) fuel gas supplied to the equipment directly from a gasification process, i.e., without first quenching or pressurizing the gas. In one embodiment, a burner used in conjunction with the power cycle generation equipment accepts such fuel gas directly from a syngas generator (or perhaps after particulate removal). The burner preferably operates with fuel gas and oxidizer inputs reversed as compared to existing configuration. | 02-11-2010 |
20110289845 | METHOD FOR CONTROLLING SYNGAS PRODUCTION IN A SYSTEM WITH MULTIPLE FEED MATERIALS USING A MOLTEN METAL BATH - Processes and apparatus for treating organic and inorganic materials in a metal bath contained in a high temperature reactor to produce synthesis gas are provided. Two or more feed materials that possess differing syngas generation potentials are mixed in a mixer and fed as a composite feed stream into a gasifier to produce syngas. The feed materials are prepared and analyzed for heat value prior to injection and the composition of materials in and exiting the reactor are monitored. By controlling the feed rate of the mixture into the gasifier as well as the feed rates of one or more of the individual feed materials into the mixer, the syngas is produced at a target production rate, with target energy content (BTU). Based upon the results of the analysis and monitoring, oxygen, steam, and/or other feed materials are also injected into the reactor, to control processing and synthesis gas quality. Potential feed materials include, but are not limited to, construction and demolition (C&D) debris, municipal solid waste (MSW), other sewage-related solids, waste tires, and other substances that contain varying levels of organic compounds capable of producing a syngas. | 12-01-2011 |
William R. Davis, Hingham, MA US
Patent application number | Description | Published |
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20090157124 | Anchoring System - The present disclosure relates to an anchor assembly. The anchor assembly includes an anchor defining a cavity and an opening to the cavity and an insertion member including a body having a proximal end portion and a flat distal end portion, and a head coupled to the proximal end portion of the body. The insertion member is configured for arrangement within the anchor cavity. A method of tissue repair and other anchor assemblies are also disclosed. | 06-18-2009 |
20130238026 | ANCHORING SYSTEM - The present disclosure relates to an anchor assembly. The anchor assembly includes an anchor defining a cavity and an opening to the cavity and an insertion member including a body having a proximal end portion and a flat distal end portion, and a head coupled to the proximal end portion of the body. The insertion member is configured for arrangement within the anchor cavity. A method of tissue repair and other anchor assemblies are also disclosed. | 09-12-2013 |
20130331851 | GRAFT CALIPER MARKING DEVICE - A graft caliper provides for a first member having a first pick at its distal end and its proximal end attached to a handle. A second member of the graft caliper is disposed above the first member and has a second pick at its distal end that extends beyond the first pick. The proximal end of the second member is attached to an adjuster which causes the second member to move from a first position to a second position in order to change a distance the second pick extends beyond the first pick. The graft caliper provides for an indication of at least one metric for describing the distance the second pick extends beyond the first pick and places an identifier on a surface of bone representing the location of a tunnel to be formed through a femur, tibia or any other anatomical structure. | 12-12-2013 |
20140214053 | TISSUE REPAIR DEVICE - The present disclosure relates to a tissue repair device. The device includes a handle, a knob coupled to the handle, and a needle coupled to the handle. The needle includes a proximal end and a distal end, the distal end including a slot, wherein a first anchor is housed within the distal end and a second anchor is housed within the slot and located proximal to the first anchor. An actuator disposed within the needle and operatively coupled to the knob, wherein advancement of the knob allows for engagement of the actuator with the first anchor and subsequent advancement of the first anchor via the actuator. A method of tissue repair is also disclosed. | 07-31-2014 |
20140243858 | TISSUE REPAIR DEVICE - The present disclosure relates to a tissue repair device. The device includes a handle, a knob coupled to the handle, and a needle coupled to the handle. The needle includes a proximal end and a distal end, the distal end including a slot, wherein a first anchor is housed within the distal end and a second anchor is housed within the slot and located proximal to the first anchor. An actuator disposed within the needle and operatively coupled to the knob, wherein advancement of the knob allows for engagement of the actuator with the first anchor and subsequent advancement of the first anchor via the actuator. A method of tissue repair is also disclosed. | 08-28-2014 |
20140309641 | TREPHINE - The present invention relates to medical apparatuses and procedures for reconstructing a ligament. There is provided a trephine ( | 10-16-2014 |
20140324077 | ANCHORING SYSTEM - The present disclosure relates to an anchor assembly. The anchor assembly includes an anchor defining a cavity and an opening to the cavity and an insertion member including a body having a proximal end portion and a flat distal end portion, and a head coupled to the proximal end portion of the body. The insertion member is configured for arrangement within the anchor cavity. A method of tissue repair and other anchor assemblies are also disclosed. | 10-30-2014 |
20150018882 | TISSUE REPAIR DEVICE - The present disclosure relates to a tissue repair device. The device includes a handle, a knob coupled to the handle, and a needle coupled to the handle. The needle includes a proximal end and a distal end, the distal end including a slot, wherein a first anchor is housed within the distal end and a second anchor is housed within the slot and located proximal to the first anchor. An actuator disposed within the needle and operatively coupled to the knob, wherein advancement of the knob allows for engagement of the actuator with the first anchor and subsequent advancement of the first anchor via the actuator. A method of tissue repair is also disclosed. | 01-15-2015 |
William Richard Davis, Hingham, MA US
Patent application number | Description | Published |
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20120109136 | OVAL TIBIA GUIDE - A guide apparatus having a body having a central axis defined therethrough and a first channel and a second channel formed therethrough, a handle coupled to the body, the handle having a locking mechanism configured to prevent movement of the body relative to the handle in a first direction along the central axis of the body, and an arm coupled to the handle, the arm configured to engage at least a portion of a bone. | 05-03-2012 |
20130090664 | GRAFT CALIPER MARKING DEVICE - A graft caliper provides for a first member having a first pick at its distal end and its proximal end attached to a handle. A second member of the graft caliper is disposed above the first member and has a second pick at its distal end that extends beyond the first pick. The proximal end of the second member is attached to an adjuster which causes the second member to move from a first position to a second position in order to change a distance the second pick extends beyond the first pick. The graft caliper provides for an indication of at least one metric for describing the distance the second pick extends beyond the first pick and places an identifier on a surface of bone representing the location of a tunnel to be formed through a femur, tibia or any other anatomical structure. | 04-11-2013 |
20140088606 | OVAL TIBIA GUIDE - A guide apparatus having a body having a central axis defined therethrough and a first channel and a second channel formed therethrough, a handle coupled to the body, the handle having a locking mechanism configured to prevent movement of the body relative to the handle in a first direction along the central axis of the body, and an arm coupled to the handle, the arm configured to engage at least a portion of a bone. | 03-27-2014 |
20140358153 | OVAL TIBIA GUIDE - A guide apparatus having a body having a central axis defined therethrough and a first channel and a second channel formed therethrough, a handle coupled to the body, the handle having a locking mechanism configured to prevent movement of the body relative to the handle in a first direction along the central axis of the body, and an arm coupled to the handle, the arm configured to engage at least a portion of a bone. | 12-04-2014 |