Patent application number | Description | Published |
20090099405 | MONOPHASIC MULTI-COIL ARRAYS FOR TRANCRANIAL MAGNETIC STIMULATION - Efficient use of multi-coil arrays for magnetic nerve stimulation depends upon coordinating the coil polarity, the pulse phase and the pulse timing. Monophasic magnetic nerve stimulators produce more precise and predictable results in the stimulation of nerves than biphasic and polyphasic machines, but are less electrically efficient, and consequently limited in terms of pulse train speed. The present invention concerns the coordination of pulse polarity, phase, timing, and strength between multiple magnetic stimulation coils. The goal is to optimize the manner in which multiple coils may be used synergistically to control the activity of underlying neural tissue. | 04-16-2009 |
20090156884 | TRANSCRANIAL MAGNET STIMULATION OF DEEP BRAIN TARGETS - The treatment of specific neurological and psychiatric illnesses using Transcranial Magnetic Stimulation (TMS) requires that specific neuroanatomical structures are targeted using specific pulse parameters. Described herein are methods of positioning and powering TMS electromagnets to selectively stimulate a deep brain target region while minimizing the impact on non-target regions between the TMS electromagnet and the target. Use of these configurations may involve a combination of physical, spatial and/or temporal summation. Specific approaches to achieving temporal summation are detailed. | 06-18-2009 |
20090234243 | ROBOTIC APPARATUS FOR TARGETING AND PRODUCING DEEP, FOCUSED TRANSCRANIAL MAGNETIC STIMULATION - Techniques for applying electromagnetic energy to deep, targeted areas without overwhelming other areas are provided. One or more coils are moved relative to a target area and magnetic fields are applied to the target from multiple coil locations. As a result, the aggregate electromagetic energy applied to the target over time is greater than surrounding areas. Additionally, a model for testing and treatment planning is provided. | 09-17-2009 |
20100184198 | Systems and Methods of Urea Processing to Reduce Sorbent Load - The present invention provides novel methods for removal and disposal of ammonia from spent dialysate in a dialysis system. Ammonium ions present in spent dialysate are converted into gaseous ammonia by raising the pH of the spent dialysate solution in a first reactor. Gaseous ammonia diffuses through a semi-permeable hydrophobic membrane at the outlet of the first reactor and into a second reactor via a gas channel. The second reactor converts gaseous ammonia into an ammonium compound for easy disposal. | 07-22-2010 |
20100185042 | CONTROL AND COORDINATION OF TRANSCRANIAL MAGNETIC STIMULATION ELECTROMAGNETS FOR MODULATION OF DEEP BRAIN TARGETS - Described herein are devices and method for control and coordination of TMS electromagnets for modulation of deep brain targets. For example, described herein are methods and devices for stimulating neural structures within the brain using multi-coil arrays. Also described herein are devices and methods that relate generally to the focusing of magnetic fields generated by electromagnets used for Transcranial Magnetic Stimulation. Devices and methods relating generally to the focusing of magnetic fields generated by electromagnets used for Transcranial Magnetic Stimulation are also described, as well as devices and methods that relate generally to moving and positioning electromagnets generating magnetic fields used for Transcranial Magnetic Stimulation. Finally, also described are devices and methods that relate generally to control of moving, positioning, and activating electromagnets generating magnetic fields used for Transcranial Magnetic Stimulation. | 07-22-2010 |
20100190229 | SYSTEM FOR OPTICAL STIMULATION OF TARGET CELLS - Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo. Other aspects and embodiments are directed to systems and methods for screening chemicals based screening chemicals to identify their effects on cell membrane ion channels and pumps, and to systems and methods for controlling an action potential of neuron (e.g., in vivo and in vitro environments). | 07-29-2010 |
20100286468 | TRANSCRANIAL MAGNETIC STIMULATION WITH PROTECTION OF MAGNET-ADJACENT STRUCTURES - System and methods for Transcranial Magnetic Stimulation (TMS) are described in which regions adjacent (e.g., to the sides and behind the TMS electromagnet) are protected from the high magnetic fields emitted by the TMS electromagnet. Thus, adjacent muscle or neural structures are protected and undesirable side effects are avoid or minimized, allowing stimulation from previously unavailable sites such as the mouth and pharynx. | 11-11-2010 |
20100286470 | TRANSCRANIAL MAGNETIC STIMULATION FIELD SHAPING - Described herein are Transcranial Magnetic Simulation (TMS) systems and methods of using them for emitting focused, or shaped, magnetic fields for TMS. In particular, described herein are arrays of TMS electromagnets comprising at least one primary (e.g., central) TMS electromagnet and a plurality of secondary (e.g., lateral or surrounding) TMS electromagnets. The secondary TMS electromagnets are arranged around the primary TMS electromagnet(s), and are typically configured to be synchronously fired with the primary TMS electromagnets. Secondary TMS electromagnets may be fired at a fraction of the power used to energize the primary TMS electromagnet to shape the resulting magnetic field. The secondary TMS electromagnets may be stimulated at opposite polarity to the primary TMS electromagnet(s). Focusing in this manner may prevent or reduce stimulation of adjacent non-target brain regions. | 11-11-2010 |
20100292527 | DEVICE AND METHOD FOR HYPERTENSION TREATMENT BY NON-INVASIVE STIMULATION TO VASCULAR BARORECEPTORS - The treatment of hypertension may be accomplished by stimulation of the carotid baroreceptors. In the present application the inventors disclose methods in which non-invasively-delivered mechanical perturbations caused by sound, ultrasound, or electrical perturbations caused by magnetic, or direct current stimulation may be used to stimulate the carotid baroreceptors, triggering physiological responses that treat medical disorders including hypertension. | 11-18-2010 |
20100298623 | INTRA-SESSION CONTROL OF TRANSCRANIAL MAGNETIC STIMULATION - Described herein are methods for controlling Transcranial Magnetic Stimulation during or within a session, where direct immediate patient reported feedback is utilized to assess the effect and optimize the treatment in real time. These methods may be applicable to superficial repetitive Transcranial Magnet Stimulation (rTMS) or deep-brain stereotactic Transcranial Magnetic Stimulation (sTMS). Examples of therapies that may benefit from these methods include TMS treatment of: acute pain (e.g., during dental procedures or bunionectomies), depression, or Parkinson's Disease, to name only a few. TMS systems and devices including or more patient inputs that may be used to perform these methods are also described. | 11-25-2010 |
20110004450 | DISPLAY OF MODELED MAGNETIC FIELDS - Methods and systems for modeling and displaying magnetic field intensities during Transcranial Magnetic Stimulation (TMS) are described, particularly methods and system for modeling and displaying TMS using overlapping magnetic fields to stimulate deep brain regions. | 01-06-2011 |
20110054344 | USE OF IMPEDANCE TECHNIQUES IN BREAST-MASS DETECTION - A device is described for measuring electrical characteristics of biological tissues with plurality of electrodes and a processor controlling the stimulation and measurement in order to detect the presence of abnormal tissue masses in the breast and determine probability of tumors containing malignant cancer cells being present in a breast. The device has the capability of providing the location of the abnormality, at least to the quadrant. The method for measuring electrical characteristics includes placing electrodes and applying a voltage waveform in conjunction with a current detector. A mathematical analysis method is then applied to the collected data, which computes spectrum of frequencies and correlates magnitudes and phases with given algebraic conditions to determine mass presence and type. | 03-03-2011 |
20110082326 | TREATMENT OF CLINICAL APPLICATIONS WITH NEUROMODULATION - Described herein are systems and methods for Transcranial Magnetic Stimulation (TMS) including one or more TMS electromagnets for stimulation of target deep brain regions to stimulate, enhance and/or inhibit neural activity. | 04-07-2011 |
20110098779 | SUB-MOTOR-THRESHOLD STIMULATION OF DEEP BRAIN TARGETS USING TRANSCRANIAL MAGNETIC STIMULATION - Systems and methods for modulating deep brain target regions using an array of TMS electromagnets, wherein each TMS electromagnet stimulates the target at a level that is below motor threshold (MT). Neurological disorders (or disorders having neurological effects) may be treated by sub-MT stimulation of deep-brain targets from an array of TMS electromagnets. | 04-28-2011 |
20110130615 | MULTI-MODALITY NEUROMODULATION OF BRAIN TARGETS - Disclosed are methods and systems and methods for deep or superficial deep-brain stimulation using multiple therapeutic modalities. These impact multiple points in a neural circuit or one or multiple points in multiple neural circuits to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. Modality examples are implanted deep-brain stimulators (DBS), Transcranial Magnetic Stimulation (TMS), transcranial Direct Current Stimulation (tDCS), implanted optical stimulation, focused ultrasound, RF stimulation, vagus nerve stimulation, other-implant stimulation, functional stimulation, and drugs. Some targets may be up-regulated and others down-regulated. Coordinated control is provided, as applicable, for control of the direction of the energy emission, intensity, session duration, frequency, pulse-train duration, phase, and numbers of sessions, if and as applicable, for neurormodulation of neural targets. Use of ancillary monitoring or imaging to provide feedback may be applied. | 06-02-2011 |
20110178442 | PATIENT FEEDBACK FOR CONTROL OF ULTRASOUND DEEP-BRAIN NEUROMODULATION - Disclosed are methods and systems and methods for patient-feedback control of non-invasive deep brain or superficial neuromodulation using sound impacting one or multiple points in a neural circuit to produce acute effects and, with application in multiple sessions, Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. One or more of sonic transducer positioning, intensity, frequency, dynamic sweeps, phase/intensity relationships, and firing patterns are changed through feedback from the patient to optimize patient experience through up-regulation or down regulation. Examples are decreases in acute pain or tremor due to more effective impact on the neural targets. | 07-21-2011 |
20110190668 | ULTRASOUND NEUROMODULATION OF THE SPHENOPALATINE GANGLION - Disclosed are methods and systems for non-invasive neuromodulation of the Sphenopalatine Ganglion and associated neural structures vidian nerve and/or sphenopalatine nerve using an ultrasound transducer to treat migraine and cluster headaches as well as other indications such as neurologic and psychiatric conditions. Treatment may be unilateral or bilateral. | 08-04-2011 |
20110196267 | ULTRASOUND NEUROMODULATION OF THE OCCIPUT - Disclosed are methods and systems for non-invasive neuromodulation of the occipital nerves using ultrasound transducers to treat migraine and cluster headaches in their multiple variations as well other pain and tension conditions. Treatment may be unilateral or bilateral. | 08-11-2011 |
20110208094 | ULTRASOUND NEUROMODULATION OF THE RETICULAR ACTIVATING SYSTEM - Disclosed are methods and systems and methods for neuromodulation of the Reticular Activating System using ultrasound to produce acute effects or Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Included is control of direction of the energy emission, intensity, pulse duration, frequency, and phase/intensity relationships to targeting and accomplishing up-regulation and/or down-regulation. The invention can be applied for a variety of clinical purposes such as reversibly putting a patient to sleep or waking them up (for example, for the purpose of anesthesia) or reversibly putting a patient into a coma (for example for the purpose of protecting or rehabilitating the brain of the patient after a stroke or head injury). | 08-25-2011 |
20110270138 | ULTRASOUND MACRO-PULSE AND MICRO-PULSE SHAPES FOR NEUROMODULATION - Disclosed are methods and systems for non-invasive ultrasound stimulation of neural structures, whether the central nervous systems (such as the brain), nerve roots, or peripheral nerves using macro- and micro-pulse shaping. Which macro-pulse and micro-pulse shapes are most effect depends on the target. This can be assessed either by functional results (e.g., doing motor cortex stimulation and seeing which macro- and micro-pulse shape combination causes the greatest motor response) or by imaging (e.g., PET of fMRI) results. | 11-03-2011 |
20110273251 | SHAPED COILS FOR TRANSCRANIAL MAGNETIC STIMULATION - Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation. | 11-10-2011 |
20110315611 | Portable Dialysis Machine - The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface, a heater in thermal communication with the planar surface, and a sodium sensor in electromagnetic communication with the planar surface. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features. | 12-29-2011 |
20120016177 | TRAJECTORY-BASED DEEP-BRAIN STEREOTACTIC TRANSCRANIAL MAGNETIC STIMULATION - The present invention provides for Stereotactic Transcranial Magnetic Stimulation (sTMS) at predetermined locations with the brain or spinal cord and incorporates an array of electromagnets arranged in a specified configuration where selected coils in the array are pulsed simultaneously. Activation of foci demonstrated by functional MRI or other imaging techniques can be used to locate the neural region affected. Imaging techniques can also be utilized to determine the location of the designated targets. | 01-19-2012 |
20120065539 | USE OF IMPEDANCE TECHNIQUES IN BREAST-MASS DETECTION - A device is described for measuring electrical characteristics of biological tissues with one or a plurality of electrodes and a processor controlling the stimulation and measurement in order to detect the presence of abnormal tissue masses in the breast and determine probability of tumors containing malignant cancer cells being present in a breast. The device has the capability of providing the location of the abnormality, at least to the quadrant. Either single or multiple source electrodes can be used. Either palpable lumps can be evaluated or screening or breasts, whether with palpable masses or not, can be accomplished. The method for measuring electrical characteristics includes placing electrodes and applying a voltage waveform in conjunction with a current detector. A mathematical analysis method is then applied to the collected data, which computes spectrum of frequencies and correlates magnitudes and phases with given algebraic conditions to determine mass presence and type. | 03-15-2012 |
20120083719 | ULTRASOUND-INTERSECTING BEAMS FOR DEEP-BRAIN NEUROMODULATION - Disclosed are methods and devices for ultrasound-mediated non-invasive deep brain neuromodulation impacting one or a plurality of points in a neural circuit using intersecting ultrasound beams. Depending on the application, this can produce short-term effects (as in the treatment of post-surgical pain) or long-term effects in terms of Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. Multiple beams intersect and summate at one or a plurality of targets. The ultrasound transducers are used with control of direction of the energy emission, intensity, frequency (carrier frequency and/or neuromodulation frequency), pulse duration, pulse pattern, and phase/intensity relationships to targeting and accomplishing up-regulation and/or down-regulation. | 04-05-2012 |
20120197163 | PATTERNED CONTROL OF ULTRASOUND FOR NEUROMODULATION - Disclosed are methods and devices for ultrasound-mediated non-invasive deep brain neuromodulation impacting one or a plurality of points in a neural circuit using patterned inputs. These are applicable whether the ultrasound beams intersect at the targets or not. Depending on the application, this can produce short-term effects (as in the treatment of post-surgical pain) or long-term effects in terms of Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. The ultrasound transducers are used with control of frequency, firing pattern, and intensity to produce up-regulation or down-regulation. | 08-02-2012 |
20120220812 | ULTRASOUND NEUROMODULATION FOR STROKE MITIGATION AND REHABILITATION - Disclosed are methods and systems and methods for neuromodulation of the Motor Cortex and other areas of the brain impacted by stroke. The neuromodulation can produce acute effects or result in Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Included is control of direction of the energy emission, intensity, pulse duration, frequency, firing pattern, and phase/intensity relationships to targeting and accomplishing up-regulation and/or down-regulation. The invention can be applied for mitigating the effects of stroke and/or in stroke rehabilitation. | 08-30-2012 |
20120226091 | ULTRASOUND NEUROMODULATION TREATMENT OF PAIN - Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat acute or chronic pain. The neuromodulation can produce acute effects or Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Included is control of direction of the energy emission, intensity, frequency, pulse duration, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 09-06-2012 |
20120232433 | ULTRASOUND NEUROMODULATION TREATMENT OF TINNITUS - Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat tinnitus. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) via training Included is control of direction of the energy emission, intensity, frequency, pulse duration, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 09-13-2012 |
20120245493 | ULTRASOUND NEUROMODULATION TREATMENT OF ADDICTION - Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat addiction. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 09-27-2012 |
20120283502 | ULTRASOUND NEUROMODULATION TREATMENT OF DEPRESSION AND BIPOLAR DISORDER - Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat depression, bipolar disorder, and other mood disorders. Also disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to affect the mood or emotional state of a subject or user. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Potentiation (LTP) or Long-Term Depression (LTD) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 11-08-2012 |
20120283604 | ULTRASOUND NEUROMODULATION TREATMENT OF MOVEMENT DISORDERS, INCLUDING MOTOR TREMOR, TOURETTE'S SYNDROME, AND EPILEPSY - Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat movement disorders (e.g., tremor disorders such as Parkinson's Disease and essential tremor, Tourette's Syndrome, and epilepsy). Also included are the Tourette's vocalizations. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training Included is control of direction of the energy emission, intensity, frequency, pulse duration, firing pattern, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 11-08-2012 |
20120296241 | ULTRASOUND NEUROMODULATION FOR TREATMENT OF AUTISM SPECTRUM DISORDER AND ALZHEIMERS DISEASE AND OTHER DEMENTIAS - Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound for the Treatment of Autism Spectrum Disorders and Alzheimer's Disease and other dementias. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, firing pattern, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 11-22-2012 |
20120310035 | TRANSCRANIAL MAGNET STIMULATION OF DEEP BRAIN TARGETS - The treatment of specific neurological and psychiatric illnesses using Transcranial Magnetic Stimulation (TMS) requires that specific neuroanatomical structures are targeted using specific pulse parameters. Described herein are methods of positioning and powering TMS electromagnets to selectively stimulate a deep brain target region while minimizing the impact on non-target regions between the TMS electromagnet and the target. Use of these configurations may involve a combination of physical, spatial and/or temporal summation. Specific approaches to achieving temporal summation are detailed. | 12-06-2012 |
20130066239 | ULTRASOUND NEUROMODULATION OF THE BRAIN, NERVE ROOTS, AND PERIPHERAL NERVES - Disclosed are methods and systems for non-invasive ultrasound neuromodulation of superficial cortex of the brain or stimulation of nerve roots or peripheral nerves. Such stimulation is used for such purposes as determination of motor threshold, demonstrating whether connectivity to peripheral nerves or motor neurons exists and performing nerve conduction-speed studies. Neuromodulation of the brain allows treatment of conditions such as depression via stimulating superficial neural structures that have connections to deeper involved centers. Imaging is optional. | 03-14-2013 |
20130066350 | TREATMENT PLANNING FOR DEEP-BRAIN NEUROMODULATION - Disclosed are methods and systems for treatment planning for deep brain or superficial neuromodulation using ultrasound and other treatment modalities impacting one or multiple points in a neural circuit to produce acute effects or Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. Ultrasound transducers or other energy sources are positioned and the anticipated effects on up-regulation and/or down-regulation of their direction of energy emission, intensity, frequency, firing/timing pattern, and phase/intensity relationships mapped onto the recommended treatment-planning targets. The maps of treatment-planning targets onto which the mapping occurs can be atlas (e.g., Tailarach Atlas) based or image (e.g., fMRI or PET) based. Atlas and imaged-based maps may be representative and applied directly or scaled for the patient or may be specific to the patient. | 03-14-2013 |
20130096363 | NEUROMODULATION OF DEEP-BRAIN TARGETS BY TRANSCRANIAL MAGNETIC STIMULATION ENHANCED BY TRANSCRANIAL DIRECT CURRENT STIMULATION - Described herein are methods, devices and systems for neuromodulation of deep brain targets using a combination of transcranial magnetic stimulation (TMS) and transcranial direct current (DC) stimulation to reduce or eliminate side-effects when modulating one or more deep brain targets. For example, transcranial magnetic stimulation of a deep brain target may be synchronized with modulation of more superficially located cortical brain regions using transcranial direct current stimulation to prevent seizures and other side effects. Systems configured to regulate (or synchronize) the application of transcranial magnetic stimulation of deep brain targets and transcranial direct current stimulation are also described. | 04-18-2013 |
20130096469 | ULTRASOUND NEUROMODULATION TREATMENT OF OBESITY AND EATING DISORDERS - Disclosed are methods and systems for non-invasive neuromodulation using ultrasound to treat obesity and eating disorders. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, pulse pattern, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 04-18-2013 |
20130178765 | ULTRASOUND NEUROMODULATION OF SPINAL CORD - Methods and systems for non-invasive neuromodulation of the spinal cord utilize a transducer to deliver pulsed ultrasound energy to up regulate or down regulate neural targets for the treatment of pain and other disease conditions. The systems provide control of direction of the energy emission, intensity, frequency, pulse duration, pulse pattern, mechanical perturbation, and phase/intensity relationships to achieve up regulation and/or down regulation. One embodiment focuses an elongate tubular ultrasound beam which can be aligned with a target region of the spinal cord. | 07-11-2013 |
20130184728 | Ultrasound Neuromodulation for Diagnosis and Other-Modality Preplanning - Disclosed are methods and systems for non-invasive neuromodulation using ultrasound for diagnosis to evaluate the feasibility of and preplan neuromodulation treatment using other modalities. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training Included is control of direction of the energy emission, intensity, frequency, pulse duration, pulse pattern, mechanical perturbation, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 07-18-2013 |
20130261506 | ULTRASOUND NEUROMODULATION TREATMENT OF POST-TRAUMATIC STRESS SYNDROME - Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat Post-Traumatic Stress Disorder (PTSD). The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 10-03-2013 |
20130267763 | TRANSVERSE TRANSCRANIAL MAGNETIC STIMULATION COIL PLACEMENT FOR IMPROVED ANALGESIA - Described herein are methods for neuromodulating brain activity of one or more target brain regions, the methods using Transcranial Magnetic Stimulation (TMS) to produce robust analgesia. In particular, described herein are systems for arranging one or more (e.g., a plurality) of TMS electromagnets oriented in a transverse direction, perpendicular to the posterior-anterior axis of the head, and applying sufficient energy to neuromodulate the target deep brain region. | 10-10-2013 |
20130281890 | NEUROMODULATION DEVICES AND METHODS - Disclosed are methods and systems for deep or superficial deep-brain stimulation using multiple therapeutic modalities, including up-regulation or down-regulation using ultrasound impacting one or multiple points in a neural circuit to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Also disclosed are: methods and systems for patient-feedback control of non-invasive deep brain or superficial neuromodulation; devices for producing shaped or steered ultrasound for non-invasive deep brain or superficial neuromodulation; methods and systems using intersecting ultrasound beams; non-invasive ultrasound-neuromodulation techniques to control the permeability of the blood-brain barrier; non-invasive neuromodulation of the spinal cord by ultrasound energy; methods and systems for non-invasive neuromodulation using ultrasound for evaluating the feasibility of neuromodulation treatment using non-ultrasound/ultrasound modalities; and method and systems for neuromodulation using ultrasound delivered in sessions. | 10-24-2013 |
20130317281 | TRANSCRANIAL MAGNETIC STIMULATION FOR IMPROVED ANALGESIA - Described herein are methods for neuromodulating brain activity of one or more target brain regions, the methods using Transcranial Magnetic Stimulation (TMS) to produce robust analgesia. In particular, described herein are systems for arranging one or more (e.g., a plurality) of TMS electromagnets in a configuration and applying sufficient energy to neuromodulate the dorsal anterior cingulate gyrus relative to cortical brain regions to significant modulate pain, including the pain of fibromyalgia. | 11-28-2013 |
20140088462 | ULTRASOUND NEUROMODULATION TREATMENT OF GASTROINTESTINAL MOTILITY DISORDERS - Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat gastrointestinal motility disorders. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, pulse pattern, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 03-27-2014 |
20140094719 | ULTRASOUND NEUROMODULATION TREATMENT OF SCHIZOPHRENIA - Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat schizophrenia. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, pulse pattern, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 04-03-2014 |
20140107533 | ULTRASOUND NEUROMODULATION TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER - Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat Attention Deficit Hyperactivity Disorder. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training Included is control of direction of the energy emission, intensity, carrier frequency, amplitude-modulation frequency, pulse duration, pulse pattern, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 04-17-2014 |
20140120505 | SYSTEM FOR COSMETIC AND THERAPEUTIC TRAINING - Systems and methods are disclosed for an apparatus and method for practicing injection techniques through an injectable apparatus. The injectable apparatus may contain a camera that is configured to detect the intensity and color of light attenuated from a testing tool after it is injected into a simulated human or animal body parts. A training tool may be connected to a user display device to generate a display of the injection apparatus as well as the performance parameters of a trainee. | 05-01-2014 |
20140138294 | Portable Dialysis Machine - The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface, a heater in thermal communication with the planar surface, and a sodium sensor in electromagnetic communication with the planar surface. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features. | 05-22-2014 |
20140194726 | Ultrasound Neuromodulation for Cognitive Enhancement - Disclosed are methods and systems for non-invasive neuromodulation using ultrasound for cognitive enhancement. Cognitive enhancement can be used for mitigation of abnormal conditions such as Alzheimer's Disease, Parkinson's Disease or stroke, or for enhancement in a normal individual. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, pulse pattern, mechanical perturbation, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. | 07-10-2014 |
20140221725 | SHAPED COILS FOR TRANSCRANIAL MAGNETIC STIMULATION - Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation. | 08-07-2014 |
20140315165 | SYSTEM FOR COSMETIC AND THERAPEUTIC TRAINING - Systems and methods are disclosed for an apparatus and method for practicing injection techniques through an injectable apparatus. The injectable apparatus may contain a camera that is configured to detect the intensity and color of light attenuated from a testing tool after it is injected into a simulated human or animal body parts. A training tool may be connected to a user display device to generate a display of the injection apparatus as well as the performance parameters of a trainee. | 10-23-2014 |
20140323924 | TARGETED OPTOGENETIC NEUROMODULATION FOR TREATMENT OF CLINICAL CONDITIONS - Disclosed are methods and systems and methods for methods for neuromodulation of deep-brain and other neural targets in mammals using optogenetics to treat clinical conditions or achievement of a physiological state. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of optical intensity/amplitude, pulse width, pulse shape, pulse rate, burst frequency, pulse pattern, burst rate, burst width, and optical-fiber configuration including through the stimulation of incorporated opsins in the target neural membranes accomplishing up-regulation and/or down-regulation. | 10-30-2014 |
20140343463 | ULTRASOUND NEUROMODULATION TREATMENT OF CLINICAL CONDITIONS - Disclosed are methods and systems for non-invasive ultrasound neuromodulation of neural targets for the treatment of clinical conditions. These include neuromodulation of the occipital nerves to treat migraine and cluster headaches in their multiple variations as well other pain and tension conditions, the Sphenopalatine Ganglion and associated neural structures vidian nerve and/or sphenopalatine nerve to treat migraine and cluster headaches as well as other indications such as neurologic and psychiatric conditions, and the Reticular Activating System for a variety of clinical purposes such as reversibly putting a patient to sleep or waking them up (for example, for the purpose of anesthesia) or reversibly putting a patient into a coma (for example for the purpose of protecting or rehabilitating the brain of the patient after a stroke or head injury). Other clinical applications include neuromodulation of the Motor Cortex and other areas of the brain impacted by stroke for mitigating the effects of stroke and/or in stroke rehabilitation, pain-related targets to treat acute or chronic pain, tinnitus-related targets to treat that condition, and targets for the treatment of Post-Traumatic Stress Disorder. Use of ultrasound neuromodulation in sessions can enhance the effects. | 11-20-2014 |
20140364774 | ULTRASOUND NEUROMODULATION FOR CLINICAL EFFECTS - Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat Traumatic Brain Injury including Concussion, Compulsive Sexual Behavior (sometimes called Compulsive Sexual Disorder), meningitis, and also provide for the elicitation of emotional catharsis. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training Included is control of direction of the energy emission, intensity, frequency, pulse duration, pulse pattern, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation. Use of ultrasound neuromodulation in sessions can enhance the effects. | 12-11-2014 |