Patent application number | Description | Published |
20080300652 | Systems and Methods for Inducing Intelligible Hearing - The present invention comprises systems and methods for inducing auditory sensations in patients by stimulating the inferior colliculus of the mammalian midbrain. In some embodiments, the invention comprises an auditory prosthesis system comprising a microphone, a sound processor, a current stimulator, and one or more stimulating electrodes disposed in the inferior colliculus of a mammal. At least one of the stimulating electrodes may be comprised of one or more shanks, each shank comprised of one or more stimulation sites. In some embodiments, without limitation, the invention comprises methods of inducing auditory sensation in a mammal, comprising the steps of providing a microphone, a sound processor, and a current stimulator; providing one or more stimulating electrodes each comprised of two or more shanks, each shank comprised of one or more stimulation sites; disposing at least one stimulating electrode in the inferior colliculus of a mammal; and stimulating at least one isofrequency lamina of the inferior colliculus by applying an electrical signal through at least one of the stimulation sites. | 12-04-2008 |
20090234426 | IMPLANTABLE ELECTRODE AND METHOD OF MAKING THE SAME - The implantable electrode system of the preferred embodiments include a conductor, an interconnect coupled to the conductor, an insulator that insulates the interconnect, and an anchor that is connected to both the conductor and the insulating element, wherein the anchor is mechanically interlocked with at least one of the conductor and the insulator. | 09-17-2009 |
20110093052 | NEURAL INTERFACE SYSTEM - A neural interface system including an electrode array and a carrier that supports the electrode array, in which the electrode array includes a substrate rolled into a three-dimensional shape, a plurality of conductive traces patterned on the substrate and adapted to transmit electrical signals, and a plurality of elliptically shaped, externally facing electrode sites coupled to the plurality of conductive traces that electrically communicate with their surroundings. The plurality of electrodes are arranged in a triangular lattice circumferentially around and axially along the carrier, and the substrate includes an edge that extends axially along the carrier and is constrained between a first axial row portion of the plurality of electrode sites and a second axial row portion of the plurality of electrode sites adjacent to the first axial row portion. | 04-21-2011 |
20110154655 | Modular multichannel microelectrode array and methods of making same - Some embodiments of the invention comprise a customizable multichannel microelectrode array with a modular planar microfabricated electrode array attached to a carrier and a high density of recording and/or stimulation electrode sites disposed thereon. Novel methods of making and using same are also disclosed. | 06-30-2011 |
20130158639 | Implantable Electrode and Method of Making the Same - The implantable electrode system of the preferred embodiments includes a conductor, an interconnect coupled to the conductor, an insulator that insulates the interconnect, and an anchor that is connected to both the conductor and the insulating element. The anchor is mechanically interlocked with at least one of the conductor and the insulator. | 06-20-2013 |
20140296951 | Neural Interface System - The neural interface system of the preferred embodiments includes an electrode array having a plurality of electrode sites and a carrier that supports the electrode array. The electrode array is coupled to the carrier such that the electrode sites are arranged both circumferentially around the carrier and axially along the carrier. A group of the electrode sites may be simultaneously activated to create an activation pattern. The system of the preferred embodiment is preferably designed for deep brain stimulation, and, more specifically, for deep brain stimulation with fine electrode site positioning, selectivity, tunability, and precise activation patterning. The system of the preferred embodiments, however, may be alternatively used in any suitable environment (such as the spinal cord, peripheral nerve, muscle, or any other suitable anatomical location) and for any suitable reason. | 10-02-2014 |
20150201855 | IMPLANTABLE ELECTRODE AND METHOD OF MAKING THE SAME - The implantable electrode system of the preferred embodiments includes a conductor, an interconnect coupled to the conductor, an insulator that insulates the interconnect, and an anchor that overlaps a peripheral edge of the electrode layer. The anchor is mechanically interlocked with the insulator. This structure is particularly useful with the electrode layer being a neural interface that is configured to provide either a recording and stimulating function. | 07-23-2015 |
Patent application number | Description | Published |
20080311588 | NEUROGENIN - The invention relates to novel neurogenin proteins, nucleic acids and antibodies. | 12-18-2008 |
20090087434 | NFIA IN GLIAL FATE DETERMINATION, GLIOMA THERAPY AND ASTROCYTOMA TREATMENT - Disclosed herein are compositions comprising NFIA inhibitors, as well as methods of using the same to treat glioma and astrocytomas. | 04-02-2009 |
20100130419 | Artery- and Vein-Specific Proteins and Uses Therefor - Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. This distinction can be used to advantage in methods to alter angiogenesis, methods to assess the effect of drugs on artery cells and vein cells, and methods to identify and isolate artery cells and vein cells, for example. | 05-27-2010 |
20100266615 | D1-1 NUCLEIC ACIDS, POLYPEPTIDES AND RELATED METHODS - The disclosure provides, among other things, novel angiogenesis-related nucleic acids, polypeptides and methods of use. | 10-21-2010 |
20110150769 | IDENTIFICATION AND USE OF COMPOUNDS FOR TREATING PERSISTENT PAIN - The present application provides methods and compositions that can be used to treat persistent pain and to identify compounds that can be used for treating persistent pain. More specifically, agonists of members of the Mrgpr receptor family, particularly agonists of MrgprX1, can identified and screened for use in treating persistent pain, such as pain caused by inflammation or nerve injury. | 06-23-2011 |
20110195901 | ARTERY- AND VEIN-SPECIFIC PROTEINS AND USES THEREFOR - Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. This distinction can be used to advantage in methods to alter angiogenesis, methods to assess the effect of drugs on artery cells and vein cells, and methods to identify and isolate artery cells and vein cells, for example. | 08-11-2011 |
20110287480 | NEUROGENIN - The invention relates to novel neurogenin proteins, nucleic acids and antibodies. | 11-24-2011 |
20120073001 | METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS - The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents. | 03-22-2012 |
20130091591 | ARTERY- AND VEIN-SPECIFIC PROTEINS AND USES THEREFOR - Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. This distinction can be used to advantage in methods to alter angiogenesis, methods to assess the effect of drugs on artery cells and vein cells, and methods to identify and isolate artery cells and vein cells, for example. | 04-11-2013 |
20130165385 | NEUROGENIN - The invention relates to novel neurogenin proteins, nucleic acids and antibodies. | 06-27-2013 |
20140178305 | IDENTIFICATION AND USE OF ANXIOLYTIC COMPOUNDS - The present disclosure provides methods and compositions that can be used to identify anxiolytic compounds, and to treat anxiety in a subject. Methods and compositions for identifying activating stimuli for sensory neurons, for example MrgprB4 | 06-26-2014 |
20140303231 | METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS - The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents. | 10-09-2014 |
20140351960 | ARTERY- AND VEIN-SPECIFIC PROTEINS AND USES THEREFOR - Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. This distinction can be used to advantage in methods to alter angiogenesis, methods to assess the effect of drugs on artery cells and vein cells, and methods to identify and isolate artery cells and vein cells, for example. | 11-27-2014 |
Patent application number | Description | Published |
20080256044 | Method And System For Searching An Information Retrieval System According To User-Specified Location Information - A method and system for searching an information retrieval system for items of interest that are in proximity to geographical locations provided by the user. The information retrieval system can perform a search for specified types of businesses or items of interest that surround or are in close proximity to the user's present geographical location, or a geographical location that the user has pre-configured in a database. The system receives geographical location information concerning the user's position from the wireless network carrier, which tracks the location of the user's mobile communications device. When the user desires to store a geographical location and geographical name for a future search, the information is entered into the pre-configured database. When conducting an information search at a later time, the user can narrow a search request to a geographical area in the vicinity of the stored geographical location. | 10-16-2008 |
20090028310 | Automatic contextual media recording and processing utilizing speech analytics - Embodiments are provided for the automatic real-time recording and processing of media in a communications network based on the context of the media. In one embodiment, a media stream is received in an analysis module in a service platform in the communications network. The media stream may represent a communication session between a calling party and a call center in the network. The incoming media steam is analyzed to identify words comprising a context of the communication session. A determination is then made as to whether the context of the communication session is related to a set of business rules associated with the service platform which may automatically trigger the retention of a recording of the communication session. If the context of the communication session is related to the set of business rules, the retention of the communication session is automatically triggered in real-time at a recording module. | 01-29-2009 |
20090034693 | Automatic message management utilizing speech analytics - Embodiments are provided for utilizing speech analytics for automatically managing messages in a communications network. A message from a calling party to an unavailable called party is recorded in a messaging management module. The messaging management module automatically identifies a category for assigning to the content of the message based on information associated with the unavailable called party or a calling party and associates a language model with the message content based on the category. An analysis module utilizes the language model to identify grammar making up the message content. The messaging management module automatically performs a messaging management function on the message content based on a set of rules. The messaging management function may include automatically determining a priority for the message (enabling the message to be retrieved out of order) or automatically triggering an action in response to the message which is directed to the unavailable called party. | 02-05-2009 |
20100074421 | METHOD AND SYSTEM FOR PERFORMING AUTOMATED TELEMARKETING - A method for performing automated telemarketing is disclosed. The method includes receiving potential customer data that includes a telephone number; initiating a telephone call to the telephone number using an auto-dialing technology; receiving notification that the potential customer has answered the telephone call; sending a verbal greeting to the potential customer in response to receiving the notification; conversing with the potential customer using speech recognition technology, the conversing including receiving a message from the potential customer; and updating the potential customer data responsive to the message received from the potential customer. | 03-25-2010 |
20120288072 | Automatic Message Management Utilizing Speech Analytics - Embodiments are provided for utilizing speech analytics for automatically managing messages in a communications network. A message from a calling party to an unavailable called party is recorded in a messaging management module. The messaging management module automatically identifies a category for assigning to the content of the message based on information associated with the unavailable called party or a calling party and associates a language model with the message content based on the category. An analysis module utilizes the language model to identify grammar making up the message content. The messaging management module automatically performs a messaging management function on the message content based on a set of rules. The messaging management function may include automatically determining a priority for the message (enabling the message to be retrieved out of order) or automatically triggering an action in response to the message which is directed to the unavailable called party. | 11-15-2012 |
20150229769 | Automatic Message Management Utilizing Speech Analytics - Embodiments are provided for utilizing speech analytics for automatically managing messages in a communications network. A message from a calling party to an unavailable called party is recorded in a messaging management module. The messaging management module automatically identifies a category for assigning to the content of the message based on information associated with the unavailable called party or a calling party and associates a language model with the message content based on the category. An analysis module utilizes the language model to identify grammar making up the message content. The messaging management module automatically performs a messaging management function on the message content based on a set of rules. The messaging management function may include automatically determining a priority for the message (enabling the message to be retrieved out of order) or automatically triggering an action in response to the message which is directed to the unavailable called party. | 08-13-2015 |
Patent application number | Description | Published |
20090123945 | CHOLINERGIC/SEROTONINERGIC RECEPTOR AND USES THEREOF - The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors. | 05-14-2009 |
20110118301 | Amino-Aza-Adamantane Derivatives and Methods of Use - The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. | 05-19-2011 |
20110190314 | PHARMACEUTICAL COMPOSITIONS AND THEIR METHODS OF USE - The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture. | 08-04-2011 |
20120219967 | CHOLINERGIC/SEROTONINERGIC RECEPTOR AND USES THEREOF - The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors. | 08-30-2012 |