David Earl
David Earl Bogucki, Surrey CA
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20080287454 | CXCR4 ANTAGONISTS - The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes. | 11-20-2008 |
20150038509 | Chemokine Receptor Binding Heterocyclic Compounds With Enhanced Efficacy - The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV). | 02-05-2015 |
David Earl Caln, New Braunfels, TX US
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20090032241 | Thru diverter wellhead with direct connecting downhole control - A single or multi-bowl wellhead may be positioned in a diverter housing over the wellbore. Protrusions on the wellhead may be installed after the diverter housing is removed. The wellhead accommodates the direct connection of hydraulic lines to a hanger seated therein. An overshot running tool protects the wellhead during placement and certain operations. | 02-05-2009 |
David Earl Doser, Jr., Fenton, MO US
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20110153471 | EQUIPMENT MANAGEMENT SYSTEM - The invention is a system and method of managing equipment. The system incorporates a tagging device to attach identification tags to each piece of equipment. A scanning device is used to read the identification tags and relay this information to an equipment server. An input device is used to input information to the equipment server. The equipment server runs the equipment management program. The system flags a potential asset assigned to an asset creating individual. Equipment is designated an asset after use in an asset creating event. | 06-23-2011 |
20130147607 | EQUIPMENT MANAGEMENT SYSTEM - The invention is a system and method of managing equipment. The system incorporates a tagging device to attach identification tags to each piece of equipment. A scanning device is used to read the identification tags and relay this information to an equipment server. An input device is used to input information to the equipment server. The equipment server runs the equipment management program. The system flags a potential asset assigned to an asset creating individual. Equipment is designated an asset after use in an asset creating event. | 06-13-2013 |
David Earl Heckerman, Santa Monica, CA US
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20100191513 | REFINING HLA DATA - A system described herein includes a receiver component that receives an HLA data set, wherein the HLA data set comprises low resolution HLA data. An HLA refinement component comprises a statistical model that automatically refines the HLA data set to transform the low resolution HLA data to high resolution HLA data. | 07-29-2010 |
20110300226 | PEPTIDE PARTICLE FORMULATION - A composition as disclosed is comprised of a plurality of groups of particles. The particles are comprised of a biocompatible polymer which maybe a co-polymer such as PLGA combined with a peptide of a sequence of interest, e.g. a sequence which corresponds to a sequence presented on a surface of a cell infected with a virus. A plurality of different groups of particles are provided in the formulation wherein the particles within any single group include peptides of identical amino acid sequence. The particles are sized such that they are sufficiently large so as to prevent more than the contents of a single particle from being presented to a single immune system cell. | 12-08-2011 |
20130142878 | PEPTIDE PARTICLE FORMULATION - A composition as disclosed is comprised of a plurality of groups of particles. The particles are comprised of a biocompatible polymer which may be a co-polymer such as PLGA combined with a peptide of a sequence of interest, e.g. a sequence which corresponds to a sequence presented on a surface of a cell infected with a virus. A plurality of different groups of particles are provided in the formulation wherein the particles within any single group include peptides of identical amino acid sequence. The particles are sized such that they are sufficiently large so as to prevent more than the contents of a single particle from being presented to a single immune system cell. | 06-06-2013 |
20130246017 | COMPUTING PARAMETERS OF A PREDICTIVE MODEL - A computer-executable algorithm that estimates parameters of a predictive model in computation time of less than O(n | 09-19-2013 |
20130246033 | PREDICTING PHENOTYPES OF A LIVING BEING IN REAL-TIME - Described herein are technologies pertaining to predicting whether a living being, such as a human being, an animal, or a plant, has a phenotype or set of phenotypes in real-time or near real-time. A filter set of genetic markers are determined heuristically, by first univariately computing scores for respective genetic markers that are indicative of their predictive ability with respect to the phenotype or the set of phenotypes. Thereafter, during training, the filter set is initially selected and thereafter expanded based upon the scores, until predictive accuracy for the phenotype or set of phenotypes reaches a threshold or is optimized. The filter set, which includes a relatively small number of genetic markers, is subsequently employed for real-time or near-real time phenotype prediction. | 09-19-2013 |
20140066320 | IDENTIFYING CAUSAL GENETIC MARKERS FOR A SPECIFIED PHENOTYPE - Described herein are technologies pertaining to computationally-efficiently performing genome-wide association studies. Feature selection methods are used to identify genetic markers for addressing potential confounding in the data. Then, single SNPs, or groups of genetic markers are analyzed to ascertain whether such groups are causal or tagging of causal as to a specified phenotype, after taking in to account the feature-selected SNPs. Group and univariate analysis is accomplished by way of analyzing a group of genetic markers conditioned upon other genetic markers that are found to be predictive of the specified phenotype. | 03-06-2014 |
20140105970 | ADJUVANT AND ANTIGEN PARTICLE FORMULATION - A composition as disclosed is comprised of a plurality of particles and a pharmaceutically acceptable carrier. The particles are comprised of (1) an adjuvant; (2) a biocompatible polymer which maybe a co-polymer such as PLGA, and (3) a peptide of a sequence of interest, e.g. a sequence which corresponds to a sequence presented on a surface of a cell infected with a virus. The carrier includes an adjuvant such as a monophosphoryl lipid A (MPL) different from the adjuvant in the particles. The particles may be sized such that they are sufficiently large so as to prevent more than the contents of a single particle from being presented to a single immune system cell. | 04-17-2014 |
David Earl James, Orem, UT US
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20140067147 | Dimming Control Including An Adjustable Output Response - The present disclosure provides improved dimming or dimmer assemblies/modules for controlling lights or loads (e.g., as part of a control or automation system). More particularly, the present disclosure provides for systems and methods for utilizing dimmer control assemblies/modules advantageously having: (i) an adjustable output response, (ii) enhanced thermal management, (iii) a voltage detector to determine amplitude and zero-crossing, and/or (iv) an estimation of power consumption for multiple loads (e.g., using a single sensor). | 03-06-2014 |
David Earl Kaelin, Jr., East Brunswick, NJ US
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20150344500 | C2,C6 OXACYCLIC-FUSED THIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain C2-ring-substituted iminothiazine compounds, including compounds Formula (I): (structurally represented) or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and, wherein R1, R2, R3, R4, X, ring A, RA, m, -L1-, and RL are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed. | 12-03-2015 |
David Earl Tomblin, Gastonia, NC US
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20100231394 | CARBON MONOXIDE DETECTION AND DISSIPATION APPARATUS - A carbon monoxide detection and dissipation apparatus is provided. The apparatus includes a carbon monoxide detector adapted to detect air-entrained carbon monoxide above a predetermined threshold within an enclosure in detection communication with the carbon monoxide detector, an alarm responsively associated with the carbon monoxide detector for providing an audible signal indicating that the carbon monoxide detector has detected carbon monoxide above the predetermined threshold, and a fan responsively associated with the carbon monoxide detector for exhausting air from the enclosure sufficient to reduce the carbon monoxide to below the predetermined threshold. | 09-16-2010 |
David Earl Weller, Jr., Littleton, CO US
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20120190264 | SELF-ADHESIVE FIBER MAT - A self-adhesive fiber mat may include glass and/or polymer fibers and bi-component fibers intermixed therewith. The bi-component fibers may include a core material and an outer material surrounding the core material. The outer material may have a low melting point temperature relative to the core material that may soften when exposed to heat enabling the bi-component fiber to bond with fibers and/or surfaces adjacent to the bi-component fibers. Alternatively, the self-adhesive fiber mat may use a heat sensitive resin (bonding resin) as a binder instead of, or in addition to, the bi-component fibers. The heat sensitive resin may bind the fibers together and may also bond the self-adhesive fiber mat with an adjacent film or sheet. Bonding between the film or sheet and the self-adhesive fiber mat may occur as a result of the bi-component fibers or heat sensitive resin being exposed to heat and/or pressure. | 07-26-2012 |
David Earl Weller, Jr., Greencastle, PA US
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20140030946 | GLASS FIBER REINFORCED FACER MAT - Embodiments of the invention provide fiber mat facers, ceiling panels, and method of manufacturing the same. A fiber mat facer may include a non-woven web of fibers having a first group of fibers with an average fiber diameter from about 6 μm to about 20 μm and a second group of fibers with an average fiber diameter from about 0.5 μm to about 5 μm. The fiber mat facer may also include a binder to bond together the non-woven web of fibers into the fiber mat. The binder may include a water repellant additive. The binder and/or fiber mat facer may further include an additive that enhances the opacity of the fiber mat facer. The fiber mat facer may also include a paint applied to an outer surface of the facer. The paint may include an additive that enhances the visual appeal of the facer and/or ceiling panel. | 01-30-2014 |
David Earl Weller, Jr., Lakewood, CO US
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20090007340 | Fiberglass fire barrier for mattresses - Provided is a mattress with a fire resistant layer. The layer is strategically placed in the mattress, preferably protecting its core materials, and comprises biosoluble glass microfibers having an average diameter ranging from 1.0 to 5.0 microns. | 01-08-2009 |