Patent application number | Description | Published |
20090011511 | Single-Point Genome Signature Tags - Disclosed is a method for analyzing the organismic complexity of a sample through analysis of the nucleic acid in the sample. In the disclosed method, through a series of steps, including digestion with a type II restriction enzyme, ligation of capture adapters and linkers and digestion with a type IIS restriction enzyme, genome signature tags are produced. The sequences of a statistically significant number of the signature tags are determined and the sequences are used to identify and quantify the organisms in the sample. Various embodiments of the invention described herein include methods for using single point genome signature tags to analyze the related families present in a sample, methods for analyzing sequences associated with hyper- and hypo-methylated CpG islands, methods for visualizing organismic complexity change in a sampling location over time and methods for generating the genome signature tag profile of a sample of fragmented DNA. | 01-08-2009 |
20090258355 | Nanoscale Clusters and Methods of Making Same - The present invention is a method of making a nanocluster. The method comprises providing a surface comprising at least one anchoring biomolecule, wherein the surface is in a solution; adding an initial recognition-nano-component to the solution wherein the initial recognition-nano-component comprises i) a nanoparticle and one specifically-bindable-biomolecule, or ii) a nanoparticle and two different types of specifically-bindable-biomolecules, wherein a biomolecule of the initial recognition-nano-component specifically binds to the anchoring biomolecule; and adding a releasing biomolecule to the solution, wherein the releasing biomolecule binds to the anchoring biomolecule with a greater binding strength than the anchoring biomolecule binds to the initial recognition-nano-component, or wherein the releasing biomolecule binds to the initial recognition-nano-component with a greater binding strength than anchoring biomolecule binds to the initial recognition-nano-component, thereby making a nanocluster. | 10-15-2009 |
20090275465 | DNA-Guided Nanoparticle Assemblies - In some embodiments, DNA-capped nanoparticles are used to define a degree of crystalline order in assemblies thereof. In some embodiments, thermodynamically reversible and stable body-centered cubic (bcc) structures, with particles occupying <˜10% of the unit cell, are formed. Designs and pathways amenable to the crystallization of particle assemblies are identified. In some embodiments, a plasmonic crystal is provided. In some aspects, a method for controlling the properties of particle assemblages is provided. In some embodiments a catalyst is formed from nanoparticles linked by nucleic acid sequences and forming an open crystal structure with catalytically active agents attached to the crystal on its surface or in interstices. | 11-05-2009 |
20110196130 | CONTROLLABLE ASSEMBLY AND DISASSEMBLY OF NANOPARTICLE SYSTEMS VIA PROTEIN AND DNA AGENTS - The invention relates to the use of peptides, proteins, and other oligomers to provide a means by which normally quenched nanoparticle fluorescence may be recovered upon detection of a target molecule. Further, the inventive technology provides a structure and method to carry out detection of target molecules without the need to label the target molecules before detection. In another aspect, a method for forming arbitrarily shaped two- and three-dimensional protein-mediated nanoparticle structures and the resulting structures are described. Proteins mediating structure formation may themselves be functionalized with a variety of useful moieties, including catalytic functional groups. | 08-11-2011 |
Patent application number | Description | Published |
20130137602 | ARBITRARY ASSEMBLY OF NANO-OBJECTS INTO DESIGNED 1D AND 2D ARRAYS - The present invention is directed to nanoscale fabrication of nano-materials with application in electronics, energy conversion, bio-sensing and others. Specifically, the invention is directed to arbitrary, that is periodic and non-periodic, assembly of nano-objects on I D and 2D arrays. The present invention utilizes self-organization properties of nanoscale bio-encoded building blocks, programmability of biomolecular interactions, and simple processing techniques for providing arbitrary by-design fabrication capability. Specifically, the present invention utilizes double stranded DNA attached to a surface and intercalating PNA-DNA hybrids attached to nano-objects to bind the nano-objects to the dsDNA in a site specific manner. The present invention allows for an integration of a large number of nano-components in unified well-defined systems. Accordingly, the present invention is applicable for fabrication of I D and 2D structures of various by-design placements of nano-objects of multiple types, including metal, semiconducting and organic nano-objects. | 05-30-2013 |
20130150240 | ENTEROBACTER SP- 638 AND METHODS OF USE THEREOF - The present invention relates to a novel species of | 06-13-2013 |
20130261292 | DNA-Guided Nanoparticle Assemblies - In some embodiments, DNA-capped nanoparticles are used to define a degree of crystalline order in assemblies thereof. In some embodiments, thermodynamically reversible and stable body-centered cubic (bcc) structures, with particles occupying <˜10% of the unit cell, are formed. Designs and pathways amenable to the crystallization of particle assemblies are identified. In some embodiments, a plasmonic crystal is provided. In some aspects, a method for controlling the properties of particle assemblages is provided. In some embodiments a catalyst is formed from nanoparticles linked by nucleic acid sequences and forming an open crystal structure with catalytically active agents attached to the crystal on its surface or in interstices. | 10-03-2013 |
20140308520 | Methods for the Bio-programmable Crystallization of Multi-component Functional Nanoparticle Systems - The bio-programmable crystallization of multi-component functional nanoparticle systems is Ascribed, as well as methods for such bio-programmable crystallization, and the products resultant from such methods. Specifically, the systems disclosed and taught herein are directed to improved strategies for the DNA-mediated self-assembly of multi-component functionalized nanoparticles into three-dimensional order surperlattices, wherein the functionalization of the nanoparticles with DNA is independent of either the composition of the material, or the shape of the nanoparticles. | 10-16-2014 |