Patent application number | Description | Published |
20110257171 | NOVEL IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS - The invention relates to the novel products of formula (I): in which: Ra is H, Hal, aryl or heteroaryl, which are optionally substituted; Rb is H, Rc, —COORc-CO-Rc or —CO—NRcRd; where Rc is alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, all optionally substituted; Rd is H, alk or cycloalkyl; these products being in all the isomer forms and the salts, as medicaments, in particular as MET inhibitors. | 10-20-2011 |
20110263594 | NOVEL TRIAZOLO(4,3-A)PYRIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE, IN PARTICULAR AS MET INHIBITORS - The invention relates to the novel products of formula (I): in which: Ra represents H, Hal, aryl or heteroaryl, which is optionally substituted; Rb represents H, Rc, —COORc-CO-Rc or —CO—NRcRd; where Rc represents alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, all optionally substituted; Rd represents H, alk or cycloalkyl; these products being in all the isomer forms and the salts, as medicaments, in particular as MET inhibitors. | 10-27-2011 |
20120165326 | DERIVATIVES OF 6-(6-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) 5-FLUORO BENZOTHIAZOLES AND 5-FLUORO BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS - The invention relates to novel products of the formula (I) where: (II) is a single or double bond; F is a fluorine atom, Ra is H, HaI, alkoxy, O-cycloalkyl, —O— heterocycloalkyl; —NH-heterocycloalkyl, heteroaryl, phenyl, NHCOalk NHCOcycloalk or NR1 R2; X is S, SO or SO2, A is NH or S; W is H, alkyl, or COR with R being cycloalkyl; alkyl optionally substituted by NR3R4, alkoxy, hydroxy, phenyl, heteroaryl or heterocycloalkyl; alkoxy optionally substituted by NR3R4, i.e. a O—(CH2)n-NR3R4 radical, an O-phenyl or an O—(CH2)n-phenyl radical, with phenyl optionally substituted and n=1 to 4; or the NR1 R2 radical; R1 is H or alk and R2 is H, cycloalkyl or alkyl; R3 and R4 are H, alk, cycloalkyl, heteroaryl or phenyl; R1, R2 and/or R3, R4 form a cycle together with N optionally containing O, S, N and/or NH; heterocycloalkyl, heteroaryl and phenyl and cycles all being optionally substituted; wherein said products can be in any isomer or salt form, and can be used as drugs, in particular as MET inhibitors. | 06-28-2012 |
Patent application number | Description | Published |
20100109670 | DETECTION SYSTEM SUITABLE FOR IDENTIFYING AND TRACKING BURIED PIPES OR OTHER BODIES BURIED IN THE GROUND OR EMBEDDED IN CIVIL ENGINEERING WORKS - The invention relates to a detection system suitable for identifying and tracking buried pipes or other bodies buried the ground or embedded in civil engineering works, which comprises: a coding device affixed to or integrated into the objects ( | 05-06-2010 |
20100112882 | Flame-retardant plastic composition, yarn and textile structure coated therewith - A halogen-free flame retardant plastic composition, for coating a substrate, comprising an acrylic resin and an intumescent agent. It is in the form of plastisol, and comprises therefore a plasticizing medium wherein the acrylic resin and the intumescent agent are dispersed, said plastisol being formulated such that, in combination: the viscosity remains not more than 6000 mPa's, measured with a Brookfiled RVT viscometer at 20 revolutions per minute, its rheological behaviour is pseudo-plastic and Newtonian. | 05-06-2010 |
20110250370 | COMPOSITION AND METHOD OF PRODUCING AN ELASTIC BAND, SHEET, STRIP OR FIBRILLATED FILM - This composition comprises at least two thermoplastic elastomers belonging to two separate classes of thermoplastic elastomer, selected from the following three classes: a thermoplastic elastomer of polyethylene type with a partially or totally vulcanized rubber phase (TPV), an olefinic thermoplastic elastomer of ethylene-propylene copolymer type (TPO), and a thermoplastic elastomer based on styrene (TPE); and at least one compatibilizer and/or surfactant. | 10-13-2011 |
Patent application number | Description | Published |
20100228982 | FAST-RECONNECTION OF NEGOTIABLE AUTHENTICATION NETWORK CLIENTS - Modern network communications often require a client application requesting data to authenticate itself to an application providing the data. Such authentication requests can be redundant, especially in the case of stateless network protocols. When a full authentication is performed, a conversation identifier and one or more encryption keys can be agreed upon. Subsequent authentication requests can be answered with a fast reconnect token comprising the conversation identifier and a cryptographically signed version of it using the one or more encryption keys. Should additional security be desirable, a sequence number can be established and incremented in a pre-determined or a random manner to enable detection of replayed fast reconnect tokens. If the recipient can verify the fast reconnect token, the provider can be considered to have been authenticated based on the prior authentication. If an aspect of the fast re-authentication should fail, recourse can be had to the original full authentication process. | 09-09-2010 |
20110314326 | MONITORING SERVICE ENDPOINTS - Today, data networks are ever increasing in size and complexity. For example, a datacenter may comprise hundreds of thousands of service endpoints configured to perform work. To reduce network wide degradation, a load balancer may send work requests to healthy service endpoints, as opposed to unhealthy and/or inoperative service endpoints. Accordingly, among other things, one or more systems and/or techniques for monitoring service endpoints, which may be scalable for large scale networks, are provided. In particular, a consistent hash function may be performed to generate a monitoring scheme comprising assignments of service endpoints to monitoring groups. In this way, multiple monitoring components may monitor a subset of endpoints to ascertain health status. Additionally, the monitoring components may communicate between one another so that a monitoring component may know heath statuses of service endpoints both assigned and not assigned to the monitoring component. | 12-22-2011 |
Patent application number | Description | Published |
20140187528 | TAZOBACTAM ARGININE ANTIBIOTIC COMPOSITIONS - This disclosure provides compositions comprising a beta-lactam compound and crystalline tazobactam arginine, and related methods and uses of these compositions. | 07-03-2014 |
20140206659 | TAZOBACTAM ARGININE ANTIBIOTIC COMPOSITIONS - This disclosure provides compositions comprising a beta-lactam compound and crystalline tazobactam arginine, and related methods and uses of these compositions. | 07-24-2014 |
20140213567 | TAZOBACTAM ARGININE ANTIBIOTIC COMPOSITIONS - This disclosure provides compositions comprising a beta-lactam compound and crystalline tazobactam arginine, and related methods and uses of these compositions. | 07-31-2014 |
20140262868 | CEFTOLOZANE-TAZOBACTAM PHARMACEUTICAL COMPOSITIONS - Pharmaceutical compositions are provided in unit dosage forms comprising ceftolozane and tazobactam in separate unit dosage form containers, ceftolozane prepared in the absence of tazobactam, tazobactam prepared in the absence of ceftolozane, and/or compositions where ceftolozane and tazobactam are first combined within a unit dosage form container. | 09-18-2014 |
20140274989 | MANUFACTURING BETA-LACTAM COMBINATION PRODUCTS - This disclosure relates to the manufacture of pharmaceutical compositions comprising an antibiotic compound and a beta-lactamase inhibitor compound when both compounds have a chemical structure that includes a beta-lactam ring, as well as resulting pharmaceutical compositions. | 09-18-2014 |
20140274990 | CEFTOLOZANE PHARMACEUTICAL COMPOSITIONS - Pharmaceutical compositions can include an amount of sodium chloride effective to stabilize ceftolozane in a lyophilized formulation. | 09-18-2014 |
20140274991 | CEFTOLOZANE PHARMACEUTICAL COMPOSITIONS - Pharmaceutical compositions can include ceftolozane and an amount of sodium chloride effective to provide improved ceftolozane stability. | 09-18-2014 |
20140274992 | CEFTOLOZANE PHARMACEUTICAL COMPOSITIONS - Pharmaceutical formulations can include ceftolozane and an alkalizing agent such as L-arginine. | 09-18-2014 |
20140274993 | CEFTOLOZANE-TAZOBACTAM PHARMACEUTICAL COMPOSITIONS - Pharmaceutical compositions can include ceftolozane lyophilized in the absence of tazobactam. | 09-18-2014 |
20140274994 | STABILIZING CEFTOLOZANE - Pharmaceutical compositions can include an amount of a ceftolozane and a stabilizing agent in a formulation for parenteral administration. | 09-18-2014 |
20140274995 | PARENTERAL CEFTOLOZANE ANTIBIOTIC COMPOSITIONS - Parenteral pharmaceutical compositions including ceftolozane and tazobactam can be formulated to provide desired levels of osmolality, pH and ceftolozane stability. | 09-18-2014 |
20140274996 | TAZOBACTAM AND CEFTOLOZANE ANTIBIOTIC COMPOSITIONS - This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of making those compositions, and related methods and uses of these compositions. | 09-18-2014 |
20140274997 | CEPHALOSPORIN PHARMACEUTICAL COMPOSITIONS - Pharmaceutical compositions including a cephalosporin disclosed herein as having the structure of formula (III). | 09-18-2014 |
20140274998 | CEFTOLOZANE-TAZOBACTAM PHARMACEUTICAL COMPOSITIONS - Pharmaceutical compositions can include ceftolozane lyophilized in the absence of tazobactam. | 09-18-2014 |
20140275000 | CEFTOLOZANE PHARMACEUTICAL COMPOSITIONS - Pharmaceutical compositions can include an amount of sodium chloride effective to stabilize ceftolozane in an antibiotic formulation. | 09-18-2014 |
20140303136 | CEFTOLOZANE ANTIBIOTIC COMPOSITIONS - This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions. | 10-09-2014 |
20140309205 | CEFTOLOZANE ANTIBIOTIC COMPOSITIONS - This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions. | 10-16-2014 |
20150072957 | Tazobactam Arginine Compositions - This disclosure provides compositions containing solid forms of tazobactam arginine, and methods of manufacturing and using these compositions. | 03-12-2015 |
20150094293 | SOLID FORMS OF CEFTOLOZANE - Novel solid forms of ceftolozane are described, as well as methods for the preparation and use of these solid forms. | 04-02-2015 |
20150150883 | CEFTOLOZANE-TAZOBACTAM PHARMACEUTICAL COMPOSITIONS - Pharmaceutical compositions can include ceftolozane lyophilized in the absence of tazobactam. | 06-04-2015 |
20150306076 | TAZOBACTAM ARGININE ANTIBIOTIC COMPOSITIONS - This disclosure provides compositions comprising a beta-lactam compound and crystalline tazobactam arginine, and related methods and uses of these compositions. | 10-29-2015 |
20160000921 | CEFTOLOZANE ANTIBIOTIC COMPOSITIONS - This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions. | 01-07-2016 |
Patent application number | Description | Published |
20100040710 | Stimulation of the synthesis and of the activity of an isoform of lysyl oxidase-like LOXL for stimulating the formation of elastic fibers. - The invention relates to the stimulation of the synthesis and of the activity of an isoform of lysyl oxidase, and more particularly of the LOXL (lysyl oxidase-like) isoform. | 02-18-2010 |
20110014175 | STIMULATION OF THE SYNTHESIS OF THE ACTIVITY OF AN ISOFORM OF LYSL OXIDASE-LIKE LOXL FOR STIMULATING THE FORMATION OF ELASTIC FIBRES - The invention relates to the stimulation of the synthesis and of the activity of an isoform of lysyl oxidase, and more particularly of the LOXL (lysyl oxidase-like) isoform. | 01-20-2011 |
20110066238 | RECONSTRUCTED CORNEA AND MUCOUS MEMBRANE - The invention relates to a model of reconstructed cornea, which may be used especially in tissue engineering, to a biomaterial that may be used for preparing a reconstructed cornea, and also to a culture device allowing better reproducibility of the cultures of the model of reconstructed cornea. | 03-17-2011 |
20110223264 | Substancefor Restoring Normal Co-expression and Interaction Between the LOX and NRAGE Proteins - The invention relates to a substance for restoring normal co-expression and interaction between the LOX and NRAGE proteins. | 09-15-2011 |
20120225141 | SUBSTANCE FOR RESTORING NORMAL CO-EXPRESSION AND INTERACTION BETWEEN THE LOX AND NRAGE PROTEINS - The disclosed substance restores normal co-expression and interaction between the LOX and NRAGE proteins. Particularly, an effective amount of the substance that modulates the expression and/or activity of LOX of SEQ ID NO: 1 and/or that modulates the expression and/or activity of NRAGE of SEQ ID NO: 2, may be used for the manufacture of a composition for modulating the interaction between the LOX and NRAGE proteins to regulate the balance between the cellular phenomena of proliferation, differentiation and apoptosis, particularly in cases where the balance between these phenomena is disturbed, and especially in cases where the interaction between LOX and NRAGE is absent or altered. The invention makes it possible especially to treat and/or prevent skin ageing, lichen planus, graft-versus-host reaction (GVH), eczema, psoriasis and a cancer, particularly an epithelial cancer and more particularly a cutaneous epithelial cancer of basocellular or spinocellular type. | 09-06-2012 |
20130011902 | STIMULATION OF THE SYNTHESIS OF THE ACTIVITY OF AN ISOFORM OF LYSYL OXIDASE-LIKE LOXL FOR STIMULATING THE FORMATION OF ELASTIC FIBERS - The invention relates to the stimulation of the synthesis and of the activity of an isoform of lysyl oxidase, and more particularly of the LOXL (lysyl oxidase-like) isoform. The invention relates notably to a method of identifying an active principle which stimulates the formation of elastic fibers. The aim of the invention is mainly to provide such a method of identification so as to provide compositions which enable stimulating the formation of elastic fibers. | 01-10-2013 |