Patent application number | Description | Published |
20110313519 | Accommodating Intraocular Lens - An intraocular lens for insertion into a capsular bag of an eye comprises: an optic; and at least one plate haptic coupled to the optic by one or more flexible connecting members. The plate haptic with flexible finger extensions is designed to engage the periphery of the capsular bag. An increase in radial pressure upon constriction of the ciliary muscle causes the rigid posteriorly vaulted plate haptics to move centrally to further increase the vitreous cavity pressure with constriction of the ciliary muscle: the optic with its thin stretchable hinge across the connecting member is then displaced anteriorly along the axis of the eye. The haptic includes a longitudinally rigid frame to restrict deformation of the haptic in a longitudinal direction while permitting deformation in a transverse direction. Furthermore, the flexible connecting members include one or more hinged straps that extend radially and/or longitudinally from the optic. The optic can move forwards and backwards, relative to both the distal and proximal ends of the plate haptics, in response to ciliary muscle contraction and relaxation with an increase and decrease of vitreous cavity pressure. Finger-like projection extends from the plate haptic to engage the capsular bag to center and fixate the accommodating lens within the capsular bag. | 12-22-2011 |
20110313524 | Vitreous Compressing Plate Haptic - A plate haptic is used with an intraocular lens optic displaceable in response to vitreous pressure changes. The plate haptic comprises: a plurality of opposing lateral portions; a distal portion having a plurality of opposing projections extending substantially laterally therefrom; and a proximal portion comprising a strap across which is a hinge connecting the lens optic to the haptic. The intersection of the proximal portion with each lateral portion forms a plurality of appendages, or paddles, to partially surround the optic. The appendages, projections, and hinged straps combine to substantially aid displacement of the lens optic in response to changes in vitreous pressure. | 12-22-2011 |
20110313525 | Tilt Stabilizing Accommodating Intraocular Lens - An intraocular lens for insertion into a capsular bag of an eye. A plurality of flexible connecting members couples a lens optic to a pair of opposing of plate haptics. The coupling members stabilize the optic with respect to the haptics. The coupling members are spaced apart straps having grooves that increase lens response to changes in vitreous pressure. | 12-22-2011 |
20110313526 | Semi-Rigid Framework For A Plate Haptic Accommodating Intraocular Lens - A plate haptic for an accommodating intraocular lens. The plate haptic has a haptic body that is substantially rigid in a longitudinal direction and substantially flexible in a transverse direction. A chassis is integral to the haptic body. The chassis causes the haptic body to be substantially more rigid in a longitudinal direction than in a transverse direction. | 12-22-2011 |
20120296425 | Variable Focus Intraocular Lens - A variable focus intraocular lens comprises an optic coupled to at least one haptic at a flexion that sets a non-zero angle between the optic and the haptic. | 11-22-2012 |
20120310344 | Biased accommodating intraocular lens - An accommodating intraocular lens has a lens optic that is coupled to at least one haptic and is anteriorly biased with respect thereto. | 12-06-2012 |
20140088699 | TORSION BAR ACCOMMODATING INTRAOCULAR LENS - An accommodating intraocular lens comprising a lens optic coupled to at least one haptic and a torsion bar positioned between the lens optic and the at least one haptic such that the torsion bar facilitates accommodation by deforming in response to a vitreous pressure change. | 03-27-2014 |
20140094909 | ACCOMMODATING INTRAOCULAR LENS - An accommodating intraocular lens comprising a lens optic coupled to at least one haptic and at least one deformable connecting bar positioned between the lens optic and the at least one haptic such that the connecting bar facilitates accommodation by deforming in response to a vitreous pressure change. | 04-03-2014 |
20140155871 | METHOD FOR PREPARING CORNEAL DONOR TISSUE FOR REFRACTIVE EYE SURGERY UTILIZING THE FEMTOSECOND LASER - A method of accurately fabricating a non-human donor corneal tissue for implantation into a recipient human cornea, the method comprising the steps of: removing corneal tissue from a donor with a femtosecond laser; placing the corneal tissue in a fixative solution for a selected time interval to cross-link the collagen fibrils in the tissue and prevent swelling of the corneal tissue; and shaping the tissue to provide a conical inlay of a selected shape and thickness having one or more radial extensions. The method is such that the corneal inlay may be attached to the peripheral corneal and/or the sclera. The method is such that the corneal inlay may be stored for a period of up to two years prior to attachment. | 06-05-2014 |
20140172093 | INTRAOCULAR LENS - A variable focus intraocular lens comprises an optic coupled to at least one haptic at a rigid flexion that sets a non-zero angle between the optic and the haptic. | 06-19-2014 |
20150012088 | SEMI-RIGID FRAMEWORK FOR A PLATE HAPTIC ACCOMMODATING INTRAOCULAR LENS - A plate haptic for an accommodating intraocular lens. The plate haptic has a haptic body that is substantially rigid in a longitudinal direction and substantially flexible in a transverse direction. A chassis is integral to the haptic body. The chassis causes the haptic body to be substantially more rigid in a longitudinal direction than in a transverse direction. | 01-08-2015 |
20150073550 | BIASED ACCOMMODATING INTRAOCULAR LENS - An accommodating intraocular lens has a lens optic that is coupled to at least one haptic and is anteriorly biased with respect thereto. | 03-12-2015 |
20150088254 | ANTERIOR CAPSULE DEFLECTOR RIDGE - An accommodating intraocular lens designed to provide a space in front of the lens optic, to allow it to move forward with accommodation, by stretching its connections to opposing plate haptics, to provide the patient with seamless vision from distance to near. The lens is designed to separate and prevent fibrosis of the anterior capsular rim with the posterior capsule where it surrounds the optic. | 03-26-2015 |
20150182327 | FOLDABLE INTRAOCULAR LENS WITH RIGID HAPTICS - An non-accommodating intraocular lens comprises a flexible optic and at least one haptic connected to the optic. The at least one haptic comprises a rigid structure. | 07-02-2015 |
20150182328 | SEMI-FLEXIBLE POSTERIORLY VAULTED ACRYLIC INTRAOCULAR LENS FOR THE TREATMENT OF PRESBYOPIA - An intraocular lens having a single-focus, acrylic optic and at least one semi-rigid, acrylic haptic connected to the optic. The intraocular lens can have a fixed longitudinal length, e.g., the same fixed length pre-operatively and post-operatively. The intraocular lens can resist deformation, despite contraction and relaxation of the ciliary muscle and fibrosis within the capsular bag, after implantation into the eye using, for example, by the semi-rigid haptics. The intraocular lens can be sufficiently flexible to be compressed from an original configuration to a compressed configuration for insertion into the eye through a small incision and return to the original configuration after implantation into the eye. | 07-02-2015 |
20150245904 | INTRAOCULAR LENS - An intraocular lens including a flexible optic and at least one rigid plate haptic connected to the optic. The at least one rigid plate haptic can include a rigid structure. The at least one rigid plate haptic can be resistant to bending from pressure exerted on a distal end of the at least one haptic by contraction of the ciliary muscle. The intraocular lens can be a non-accommodating IOL having a longitudinal length that is fixed and configured to resist deformation by the action of the ciliary muscle. Various embodiments also include accommodating intraocular lenses. | 09-03-2015 |
20150245905 | SEAMLESS-VISION, TILTED INTRAOCULAR LENS - A plate haptic for an accommodating intraocular lens. The plate haptic has a haptic body that is substantially rigid in a longitudinal direction and substantially flexible in a transverse direction. A chassis is integral to the haptic body. The chassis causes the haptic body to be substantially more rigid in a longitudinal direction than in a transverse direction. | 09-03-2015 |
20150272726 | INTRAOCULAR LENS - An accommodating intraocular lens comprising a lens optic coupled to at least one haptic and at least one deformable connecting bar positioned between the lens optic and the at least one haptic such that the connecting bar facilitates accommodation by deforming in response to a vitreous pressure change. | 10-01-2015 |
Patent application number | Description | Published |
20080200445 | Heterocyclic aspartyl protease inhibitors -
Disclosed are compounds of the formula I
| 08-21-2008 |
20090258868 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 10-15-2009 |
20090306047 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 12-10-2009 |
20090312341 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A HETEROCYCLIC SUBSTITUENT - Disclosed are novel compounds of the formula | 12-17-2009 |
20100152138 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT - Disclosed are compounds of the formula | 06-17-2010 |
20100292203 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 11-18-2010 |
20110218194 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 09-08-2011 |
20120148603 | PENTAFLUOROSULFUR IMINO HETEROCYCLIC COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides provides certain pentafluorosulfur imino heterocyclic compounds, including compounds Formula (I): and tautomers thereof, and solvates, prodrugs, esters, and deuterates of said compounds and said tautomers, and pharmaceutically acceptable salts of said compounds, tautomers, solvates, prodrugs, esters, and deuterates, wherein each of R | 06-14-2012 |
20120183563 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): (I) and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R | 07-19-2012 |
20120189642 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (a) and include tautomers, solvates, prodrugs, esters, and deuterates thereof, and pharmaceutically acceptable salts of said compounds, tautomers, solvates, prodrugs, esters, and deuterates, wherein each of R | 07-26-2012 |
20120195881 | PENTAFLUOROSULFUR IMINO HETEROCYCLIC COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS AND THEIR USE - In its many embodiments, the present invention provides certain pentafluorosulfur imino heterocyclic compounds, including compounds Formula (a) and pharmaceutically acceptable salts thereof. Compounds of Formula (a) have the general structure: (a) wherein each variable is selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimers Disease, are also disclosed. | 08-02-2012 |
20120231017 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 09-13-2012 |
20120231018 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 09-13-2012 |
20120232064 | ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of formula I | 09-13-2012 |
20120276118 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 11-01-2012 |
20130004518 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT - Disclosed are compounds of the formula | 01-03-2013 |
20130018066 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 01-17-2013 |
20140023668 | C5-C6 OXACYCLIC-FUSED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula: (I) and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein each of ring A, ring B, ring C, R | 01-23-2014 |
20140057910 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 02-27-2014 |
20140128361 | CYCLIC AMIDE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT - Disclosed are compounds of the formula | 05-08-2014 |
20140128382 | 5-SUBSTITUTED IMINOTHIAZINES AND THEIR MONO- AND DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - The present invention discloses certain iminothiazine compounds and mono- and dioxides thereof, including compounds Formula (I): and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomers and said stereoisomers, wherein each of variables shown in the formula are as defined herein. The compounds of the invention may be useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and uses, including Alzheimer's disease, are also disclosed. | 05-08-2014 |
20140200213 | 2-SPIRO-SUBSTITUTED IMINOTHIAZINES AND THEIR MONO-AND DIOXIDES AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE - In its many embodiments, the present invention provides certain iminothiazine dioxide compounds, including compounds Formula (I): | 07-17-2014 |
20140206675 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): (I) and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R | 07-24-2014 |
20140296221 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): | 10-02-2014 |
20140296222 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): | 10-02-2014 |
20150105354 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 04-16-2015 |
20150274716 | TRICYCLIC SUBSTITUTED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE - In its many embodiments, the present invention provides certain iminothiazine dioxide compounds, including compounds Formula (I): and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein the middle ring (referred to herein as “ring B”) of the tricyclic substituent is an optionally substituted 5-membered ring, and each of the remaining variables shown in the formula are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including Alzheimer's disease, are also disclosed. | 10-01-2015 |
20150284379 | TRICYCLIC SUBSTITUTED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE - In its many embodiments, the present invention provides certain iminothiazine dioxide compounds, including compounds Formula (I): (I) and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomers and said stereoisomers, wherein the middle ring (referred to herein as “ring B”) of the tricyclic substituent is an optionally substituted 6-membered ring, and each of the remaining variables shown in the formula are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including Alzheimer's disease, are also disclosed. | 10-08-2015 |
20150307465 | Iminothiadiazine Dioxide Compounds as BACE Inhibitors, Compositions and Their Use - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): | 10-29-2015 |
20150344500 | C2,C6 OXACYCLIC-FUSED THIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain C2-ring-substituted iminothiazine compounds, including compounds Formula (I): (structurally represented) or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and, wherein R1, R2, R3, R4, X, ring A, RA, m, -L1-, and RL are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed. | 12-03-2015 |
20150353516 | IMINOTHIADIAZINE DIOXIDES CONTAINING A THIOAMIDE, AMIDINE, OR AMIDE OXIME GROUP AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain C2-ring-substituted iminothiadiazine compounds, or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers. The novel compounds of the invention are as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed. | 12-10-2015 |
20160043774 | C6-AZASPIRO IMINOTHIADIAZINE DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain C2-ring-substituted thiadiazine compounds, including compounds Formula (I): (structure represented) or tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R | 02-11-2016 |
Patent application number | Description | Published |
20090299259 | Head trauma cap bandage and method - An emergency head trauma cap bandage and method of use, which, when applied, applies compression pressure to stop bleeding, doesn't compromise cervical spine immobilization, doesn't come apart during treatment and transport, and doesn't require a caregiver to re-wrap the dressing. | 12-03-2009 |
20100016775 | Head trauma bandage and method - An emergency head trauma bandage and method of use, which, when applied, applies minimal pressure to stop bleeding, doesn't compromise cervical spine immobilization, allows for fast and effective application of ice/cold packs to control intracranial/internal swelling, doesn't come apart during treatment and transport, and doesn't require a caregiver to re-wrap the dressing. | 01-21-2010 |
20100331752 | Helmet trauma bandage and method - An emergency helmet trauma bandage and method of use, which, when applied, applies minimal pressure to stop bleeding, doesn't compromise cervical spine immobilization, allows for fast and effective application of ice/cold packs to control intracranial/internal swelling, doesn't come apart during treatment and transport, and doesn't require a caregiver to re-wrap the dressing. | 12-30-2010 |
20120296252 | Head Trauma Bandage Cap and Method - An emergency head trauma bandage cap with a detachable strap system and method of use, which, when applied to the head, delivers minimal pressure to control bleeding, doesn't compromise cervical spine immobilization, allows for fast and effective application of cold packs to control intracranial/internal swelling or hot packs to prevent hypothermia in non-trauma situations, doesn't come apart during treatment and transport, and doesn't require a caregiver to re-wrap the dressing. | 11-22-2012 |